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Modulation of priming TBS with NMES on neuroplasticity and clinical rehabilitation effects on focal hand dystonia

Research Project

Project/Area Number 21J10563
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section国内
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionThe University of Tokyo

Principal Investigator

曹 娜  東京大学, 総合文化研究科, 特別研究員(DC2)

Project Period (FY) 2021-04-28 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2022: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2021: ¥800,000 (Direct Cost: ¥800,000)
KeywordsTheta burst stimulation / Neuroplasticity / NMES / Dose effect / Concurrent / Plasticity / Priming
Outline of Research at the Start

The current sutdy is to systematically elucidate neural mechanisms and treatment effects for neuroplasticity enhancement to achieve a better motor function recovery in dystonia patients using associated neurophysiological techniques including noninvasive brain stimulation and neuromuscular electrical stimulation, which is a brand new system for rehabilitation based to address neuroplasticity in patients with focal hand dystonia.The research will lead to the development of a neuromodulation method that improve our understanding of sensorimotor integration.

Outline of Annual Research Achievements

Two studies have been completed this year. The first study, which associate cortical and peripheral stimulations concurrently, has been published in the
journal Neuroscience Letters and aslo been shared in the international conference whcih been held in San Diego. The second study, the dose effect of the concurrent and associative electrical stimulation, which its
preliminary results has been presented in the conference “International Functional Electrical Stimulation Society (IFESS) RehabWeek” last year, has been completed and finished the manuscript this year and will be submitted to the international journal soon. All the project will lead to the development of new neuromodulation method that uses non-invasive brain stimaltions to achieve a better neuroplasticity.

Research Progress Status

令和4年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和4年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (4 results)

All 2022

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Effective corticospinal excitability neuromodulation elicited by short-duration concurrent and synchronized associative cortical and neuromuscular stimulations2022

    • Author(s)
      Cao Na、Sasaki Atsushi、Yuasa Akiko、Popovic Milos R.、Milosevic Matija、Nakazawa Kimitaka
    • Journal Title

      Neuroscience Letters

      Volume: 790 Pages: 136910-136910

    • DOI

      10.1016/j.neulet.2022.136910

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Short-term facilitation effects elicited by cortical priming through theta burst stimulation and functional electrical stimulation of upper-limb muscles2022

    • Author(s)
      Cao Na、Sasaki Atsushi、Yuasa Akiko、Popovic Milos R.、Milosevic Matija、Nakazawa Kimitaka
    • Journal Title

      Experimental Brain Research

      Volume: In press Issue: 5 Pages: 1565-1578

    • DOI

      10.1007/s00221-022-06353-3

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Simultaneous but not delayed repetitive paired cortical and neuromuscular electrical stimulations effectively facilitate corticospinal excitability2022

    • Author(s)
      Na Cao
    • Organizer
      2022 Society for Neuroscience (SfN)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Longer duration cortical and peripheral stimulation may enhance corticospinal facilitation2022

    • Author(s)
      Na Cao
    • Organizer
      2021 International Functional Electrical Stimulation Society (IFESS) RehabWeek virtual
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research

URL: 

Published: 2021-05-27   Modified: 2024-03-26  

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