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二重放物面集束構造を有する導波路型振動子(DPLUS)による医用応用デバイス

Research Project

Project/Area Number 21J10822
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section国内
Review Section Basic Section 21060:Electron device and electronic equipment-related
Research InstitutionThe University of Tokyo

Principal Investigator

CHEN KANG  東京大学, 大学院工学系研究科(工学部), 特別研究員(DC2)

Project Period (FY) 2021-04-28 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2022: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2021: ¥900,000 (Direct Cost: ¥900,000)
KeywordsDPLUS / Therapeutic ultrasound / Acoustic cavitation / High-power ultrasound / Piezoelectric vibration / Two parabolic reflectors
Outline of Research at the Start

This research reveals the basic characteristics of DPLUS as a novel ultrasonic device for biomedical ultrasound applications, from the working mechanism, design concerns, to mechanical and acoustic output limits, and demonstrations for therapeutic ultrasound.

Outline of Annual Research Achievements

This research proposes a novel ultrasonic transducer named DPLUS that outputs powerful ultrasound from a thin waveguide using double parabolic reflections, and its basic characteristics are studied.

In this year, optimal design of the DPLUS thin waveguide for therapeutic ultrasound was firstly studied. Quantitative modeling for the vibration in the thin waveguide, the acoustic and thermal fields in the tissue was conducted. It was found that for inducing tumor ablation, the optimal ratio of the thin waveguide radius to the wavelength is 0.2392, e.g., the optimal frequency is 2.2 MHz if the radius is 0.6 mm. Under the optimal design, ex-vivo chicken tissue ablation experiments were successfully conducted using DPLUS with a 0.6-mm radius and 1-m long low-loss fused quartz thin waveguide. The ablated area was very precise, and the size increases from 1 mm to 2 mm under the ultrasound exposure time of 10 s to 30 s. The experimental results are significant that it is the first time in the literature showing tissue thermal ablation is possible by an acoustic waveguide. Compared with common tumor ablation methods like HIFU, DPLUS has the advantages of realizing precise and minimally invasive treatment. In addition, using one DPLUS device for realizing wide-band (from 20 kHz to 1 MHz) acoustic cavitation has also been demonstrated, and such feature is impossible for traditional HIFU transducers. Therefore, using wide-band acoustic cavitation, DPLUS is possible to open up new research directions such as studying the frequency dependence of tumor ablation, chemical reaction, etc.

Research Progress Status

令和4年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和4年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • Research Products

    (10 results)

All 2023 2022 2021

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results) Presentation (3 results) (of which Int'l Joint Research: 1 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Optimization of the Thin Waveguide for Double-Parabolic-Reflectors Ultrasonic Transducers (DPLUS) for Thermal Ablation2023

    • Author(s)
      Chen Kang、Irie Takasuke、Iijima Takashi、Miyake Susumu、Morita Takeshi
    • Journal Title

      IEEE Transactions on Biomedical Engineering

      Volume: 70 Issue: 2 Pages: 553-564

    • DOI

      10.1109/tbme.2022.3197213

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tube-type double-parabolic-reflector ultrasonic transducer (T-DPLUS)2022

    • Author(s)
      Yamada Kyohei、Chen Kang、Irie Takasuke、Iijima Takashi、Miyake Susumu、Morita Takeshi
    • Journal Title

      Acoustical Science and Technology

      Volume: 43 Issue: 5 Pages: 287-290

    • DOI

      10.1250/ast.43.287

    • ISSN
      0369-4232, 1346-3969, 1347-5177
    • Year and Date
      2022-09-01
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low-Loss Ultrasound Transmission Through Waveguide From Double Parabolic Reflectors (DPLUS) for Thermal Ablation2022

    • Author(s)
      Chen Kang、Irie Takasuke、Iijima Takashi、Miyake Susumu、Morita Takeshi
    • Journal Title

      IEEE Access

      Volume: 10 Pages: 113678-113689

    • DOI

      10.1109/access.2022.3216707

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hard-Type Piezoelectric Materials Based Double-Parabolic-Reflectors Ultrasonic Transducer (DPLUS) for High-Power Ultrasound2022

    • Author(s)
      Chen Kang、Irie Takasuke、Iijima Takashi、Kasashima Takashi、Yokoyama Kota、Miyake Susumu、Morita Takeshi
    • Journal Title

      IEEE Access

      Volume: 10 Pages: 26117-26126

    • DOI

      10.1109/access.2022.3156609

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-Power Ultrasonic Transducer for Effective Hemolysis2022

    • Author(s)
      Wu Xiaogang、Chen Kang、Hoshijima Yasushi、Hariu Taro、Yamazaki Hiroki、Miyake Susumu、Morita Takeshi
    • Journal Title

      IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control

      Volume: 69 Issue: 1 Pages: 181-186

    • DOI

      10.1109/tuffc.2021.3116977

    • NAID

      130008084260

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selection criteria of piezoelectric materials for double-parabolic-reflectors ultrasonic transducers (DPLUS) for high-power ultrasound2021

    • Author(s)
      Chen Kang、Irie Takasuke、Iijima Takashi、Kasashima Takashi、Yokoyama Kota、Morita Takeshi
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 60 Issue: 10 Pages: 106504-106504

    • DOI

      10.35848/1347-4065/ac1fb9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Presentation] Optimization of the thin waveguide for double-parabolic-reflectors ultrasonic transducers (DPLUS) for minimally invasive thermal treatments2022

    • Author(s)
      Kang Chen, Takasuke Irie, Takashi Iijima, Susumu Miyake, and Takeshi Morita
    • Organizer
      第43回超音波エレクトロニクスの基礎と応用に関するシンポジウム (USE2022)
    • Related Report
      2022 Annual Research Report
  • [Presentation] Multimode Excitation by a Double-Parabolic-Reflectors Ultrasonic Transducer (DPLUS) with hard type piezoelectric materials2021

    • Author(s)
      Kang Chen, Takasuke Irie, Takashi Iijima, Takashi Kasashima, Kota Yokoyama, Susumu Miyake and Takeshi Morita
    • Organizer
      IEEE International Ultrasonics Symposium (IUS 2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reveal the vibration characteristics of DPLUS: the selection criteria of piezoelectric materials2021

    • Author(s)
      陳康, 入江喬介, 飯島高志, 笠島崇, 横山広大, 三宅奏, 森田剛
    • Organizer
      超音波研究会
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] Ultrasonic generator2021

    • Inventor(s)
      森田 剛, 陳 康, 飯島 高志, 喬介 入江
    • Industrial Property Rights Holder
      森田 剛, 陳 康, 飯島 高志, 喬介 入江
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Acquisition Date
      2023
    • Related Report
      2022 Annual Research Report
    • Overseas

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Published: 2021-05-27   Modified: 2024-03-26  

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