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Optimizing Depression Prevention Strategies in College Students Using Smart Phone Cognitive Behavioral Therapy

Research Project

Project/Area Number 21K03049
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 10030:Clinical psychology-related
Research InstitutionKyoto University

Principal Investigator

Sakata Masatsugu  京都大学, 医学研究科, 助教 (40593653)

Co-Investigator(Kenkyū-buntansha) 白石 直  名古屋市立大学, 医薬学総合研究院(医学), 講師 (30632989)
堀越 勝  国立研究開発法人国立精神・神経医療研究センター, 認知行動療法センター, 特命部長 (60344850)
古川 壽亮  京都大学, 医学研究科, 教授 (90275123)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsうつ病予防 / 認知行動療法 / 大学生 / スマートフォン / ランダム化比較試験 / 最適化
Outline of Research at the Start

大学生のうつ病は学業や学生生活全体に重大な影響を与えるため、治療のみならず予防が課題となっている。一方、各大学で対応する人的、経済的資源は限られている。そこで本研究では、スマートフォン認知行動療法を用いて大学生へのうつ病予防効果を検証し、その最適な構成要素の組み合わせを導き出すことを目的とする。
複数大学の健常大学生1,088名に対してスマートフォン認知行動療法を構成する5つの要素および順序の組合せ64通りにランダムに割り付け、8週間の介入の後1年間追跡し、うつ病発症率を比較する。
それらの結果をもとに最新の情報技術を用いた大学生へのメンタルヘルス介入の普及
を目指すものである。

Outline of Final Research Achievements

Depression among university students significantly impacts academic performance and overall student life. In this study, we investigated the optimal components of smartphone cognitive behavioral therapy (iCBT) for preventing depression among university students. We randomly assigned 1,627 healthy university students to presence or absence of five components of iCBT. After an 8-week intervention, we followed them for one year. Acute analysis of 1,093 participants revealed that depression symptoms improved in all groups by the 8th week. A similar trend was observed in the total 1,627 participants at the one-year follow-up. However, no significant differences were found based on the presence or absence of specific CBT elements in terms of depressive symptoms or major depressive episodes. Despite this, our results provide valuable insights for designing clinical trials aimed at identifying effective iCBT components.

Academic Significance and Societal Importance of the Research Achievements

本研究は大学生に対するメンタルヘルス増進、またうつ病予防のためのスマートフォン認知行動療法の有効要素を要因デザインによって探索した世界初の臨床試験である。介入の完遂率は各要素ともに80~90%であり、第8週の抑うつアウトカムは92%,1年後うつ病発生アウトカムも80%の追跡率であった。長期追跡の臨床試験では高い水準の追跡率といえる。結果としてはスマートフォン認知行動療法の有効要素を検出することはできなかったが、今後の認知行動療法の最適化を試みる研究デザインに関して豊富な示唆を得ることができた。本研究の結果を報告した論文は、その後国際学術誌に掲載された複数の後続研究によって引用されている。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (17 results)

All 2024 2023 2022 2021 Other

All Int'l Joint Research (6 results) Journal Article (6 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (4 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Remarks (1 results)

  • [Int'l Joint Research] New York University/Vanderbilt University(米国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] University of Essex/Newcastle University(英国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Vanderbilt University/New York University(米国)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] University of Exeter/Newcastle University(英国)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] Vanderbilt University/New York University(米国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] University of Exeter/Newcastle University(英国)

    • Related Report
      2021 Research-status Report
  • [Journal Article] Dynamics of depressive states among university students in Japan during the COVID-19 pandemic: an interrupted time series analysis2023

    • Author(s)
      Shiraishi N.、Sakata M.、Toyomoto R.、Yoshida K.、Luo Y.、Nakagami Y.、Tajika A.、Watanabe T.、Sahker E.、Uwatoko T.、Shimamoto T.、Iwami T.、Furukawa T. A.
    • Journal Title

      Annals of General Psychiatry

      Volume: 22 Issue: 1 Pages: 38-38

    • DOI

      10.1186/s12991-023-00468-9

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three types of university students with subthreshold depression characterized by distinctive cognitive behavioral skills2023

    • Author(s)
      Shiraishi Nao、Sakata Masatsugu、Toyomoto Rie、Yoshida Kazufumi、Luo Yan、Nakagami Yukako、Tajika Aran、Suga Hidemichi、Ito Hiroshi、Sumi Michihisa、Muto Takashi、Ichikawa Hiroshi、Ikegawa Masaya、Watanabe Takafumi、Sahker Ethan、Uwatoko Teruhisa、Noma Hisashi、Horikoshi Masaru、Iwami Taku、Furukawa Toshi A.
    • Journal Title

      Cognitive Behaviour Therapy

      Volume: 53 Issue: 2 Pages: 207-219

    • DOI

      10.1080/16506073.2023.2288557

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic factors and effect modifiers for personalisation of internet-based cognitive behavioural therapy among university students with subthreshold depression: A secondary analysis of a factorial trial2023

    • Author(s)
      Toyomoto Rie、Sakata Masatsugu, et al.
    • Journal Title

      Journal of Affective Disorders

      Volume: 322 Pages: 156-162

    • DOI

      10.1016/j.jad.2022.11.024

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Components of smartphone cognitive-behavioural therapy for subthreshold depression among 1093 university students: a factorial trial2022

    • Author(s)
      Sakata Masatsugu, et al.
    • Journal Title

      Evidence Based Mental Health

      Volume: 25 Issue: e1 Pages: e18-e25

    • DOI

      10.1136/ebmental-2022-300455

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Validation of the Japanese Big Five Scale Short Form in a University Student Sample2022

    • Author(s)
      Toyomoto Rie、Sakata Masatsugu、Yoshida Kazufumi、Luo Yan、Nakagami Yukako、Iwami Taku、Aoki Shuntaro、Irie Tomonari、Sakano Yuji、Suga Hidemichi、Sumi Michihisa、Ichikawa Hiroshi、Watanabe Takafumi、Tajika Aran、Uwatoko Teruhisa、Sahker Ethan、Furukawa Toshi A.
    • Journal Title

      Frontiers in Psychology

      Volume: 13 Pages: 862646-862646

    • DOI

      10.3389/fpsyg.2022.862646

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development and validation of the Cognitive Behavioural Therapy Skills Scale among college students2021

    • Author(s)
      Sakata Masatsugu、Toyomoto Rie、Yoshida Kazufumi、Luo Yan、Nakagami Yukako、Aoki Shuntaro、Irie Tomonari、Sakano Yuji、Suga Hidemichi、Sumi Michihisa、Muto Takashi、Shiraishi Nao、Sahker Ethan、Uwatoko Teruhisa、Furukawa Toshi A
    • Journal Title

      Evidence Based Mental Health

      Volume: 24 Issue: 2 Pages: 70-76

    • DOI

      10.1136/ebmental-2020-300217

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Exploring optimal components of internet-based CBT for subthreshold depression2024

    • Author(s)
      Masatsugu Sakata
    • Organizer
      8th Asian CBT Congress
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Exploring effective components of internet-based cognitive-behavioral therapy for subthreshold depression in university students: A factorial trial2024

    • Author(s)
      Masatsugu Sakata, Rie Toyomoto, Kazufumi Yoshida, Yan Luo, Yukako Nakagami, Teruhisa Uwatoko...Toshi A Furukawa
    • Organizer
      8th Asian CBT Congress
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optimal smartphone intervention for subthreshold depression: Accumulating iCBT evidence in Japan2023

    • Author(s)
      Masatsugu Sakata
    • Organizer
      10th World Congress of Cognitive Behavioral Therapies
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 大学生におけるインターネット認知行動療法の5つの構成要素の治療脱落予測因子の探索的検討2023

    • Author(s)
      吉田 和史, 坂田 昌嗣, 豊本 莉恵, 羅 妍, 中神 由香子, 上床 輝久, 石見 拓, 古川 壽亮
    • Organizer
      日本疫学会
    • Related Report
      2023 Annual Research Report
  • [Remarks] Healthy Campus Trial

    • URL

      http://ebmh.med.kyoto-u.ac.jp/hct/index.html

    • Related Report
      2023 Annual Research Report

URL: 

Published: 2021-04-28   Modified: 2025-01-30  

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