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Structure formation of membranes in nonequilibrium

Research Project

Project/Area Number 21K03481
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
Research InstitutionThe University of Tokyo

Principal Investigator

Noguchi Hiroshi  東京大学, 物性研究所, 准教授 (00514564)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords生物物理 / ソフトマター / 生体膜 / 曲率誘導タンパク質 / シミュレーション / 反応拡散波
Outline of Research at the Start

非平衡下で生体膜がとる多様な形状変化、パターン形成について、主に数値シミュレーションを用いて研究する。曲率誘導タンパク質および、その制御因子の膜への吸着、アクチンなどタンパク質繊維の伸長と膜変形のカップリングなどによって、生体内で、生体膜は、非平衡の環境にある。これらの様々な非平衡条件下で、膜の構造やゆらぎがどのように変わるかについて研究する。それにより、生体膜の非平衡現象を多面的に探求し、系統的な理解を目指す。

Outline of Final Research Achievements

Shape transformations of biomembranes were studied by using theory and simulations. We clarified (1) reaction waves and membrane deformation in reaction-diffusion dynamics on membranes, (2) binding equilibrium of several types of curvature-inducing proteins using mean-field theory, (3) membrane tubulation induced by curvature-inducing proteins consisting of chiral crescent binding and intrinsically disordered domains, (4) domain formation by protein binding onto both membrane surfaces, and (5) conformation of ultra-long-chain fatty acids in bilayer membranes.

Academic Significance and Societal Importance of the Research Achievements

細胞内の生命活動における静的や動的な膜構造はタンパク質によって制御されている。これらのタンパク質の欠損は細胞小器官の構造異常や細胞機能不全につながり、その機能を理解することは非常に重要である。しかし、生体内は非平衡状態であり、その制御機構は多くのことがよく理解されていない。本研究では曲率誘導タンパク質がどのように生体膜と相互作用し、反応拡散波など動的構造を制御しているかについて重要な知見を明らかにした。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (37 results)

All 2024 2023 2022 2021 Other

All Int'l Joint Research (4 results) Journal Article (13 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 12 results,  Open Access: 3 results) Presentation (17 results) (of which Int'l Joint Research: 6 results,  Invited: 4 results) Remarks (3 results)

  • [Int'l Joint Research] BarcelonaTech(スペイン)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Univ. Paris City(フランス)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] BarcelonaTech(スペイン)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] BarcelonaTech(スペイン)

    • Related Report
      2021 Research-status Report
  • [Journal Article] Curvature sensing of curvature-inducing proteins with internal structure2024

    • Author(s)
      Noguchi Hiroshi
    • Journal Title

      Physical Review E

      Volume: 109 Issue: 2

    • DOI

      10.1103/physreve.109.024403

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Estimation of anisotropic bending rigidities and spontaneous curvatures of crescent curvature-inducing proteins from tethered-vesicle experimental data2023

    • Author(s)
      Noguchi Hiroshi、Walani Nikhil、Arroyo Marino
    • Journal Title

      Soft Matter

      Volume: 19 Issue: 28 Pages: 5300-5310

    • DOI

      10.1039/d3sm00340j

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Membrane domain formation induced by binding/unbinding of curvature-inducing molecules on both membrane surfaces2023

    • Author(s)
      Noguchi Hiroshi
    • Journal Title

      Soft Matter

      Volume: 19 Issue: 4 Pages: 679-688

    • DOI

      10.1039/d2sm01536f

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Disappearance, division, and route change of excitable reaction-diffusion waves in deformable membranes2023

    • Author(s)
      Noguchi Hiroshi
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1

    • DOI

      10.1038/s41598-023-33376-9

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Binding of anisotropic curvature-inducing proteins onto membrane tubes2022

    • Author(s)
      H. Noguchi, C. Tozzi, and M. Arroyo
    • Journal Title

      Soft Matter

      Volume: 18 Issue: 17 Pages: 3384-3394

    • DOI

      10.1039/d2sm00274d

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Excitable reaction-diffusion waves of curvature-inducing proteins on deformable membrane tubes2022

    • Author(s)
      N. Tamemoto and H. Noguchi
    • Journal Title

      Physical Review E

      Volume: 106 Issue: 2

    • DOI

      10.1103/physreve.106.024403

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Membrane shape deformation induced by curvature-inducing proteins consisting of chiral crescent binding and intrinsically disordered domains2022

    • Author(s)
      H. Noguchi
    • Journal Title

      Journal of Chemical Physics

      Volume: 157 Issue: 3

    • DOI

      10.1063/5.0098249

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] onformations of three types of ultra-long-chain fatty acids in multi-component lipid bilayers2022

    • Author(s)
      K. Kawaguchi, H. Nagao, H. Shindou, and H. Noguchi
    • Journal Title

      Journal of Physical Chemistry B

      Volume: 126 Issue: 45 Pages: 9316-9324

    • DOI

      10.1021/acs.jpcb.2c06189

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pattern Formation of Biomembrane Induced by Reaction-diffusion Dynamics of Curvature-inducing Proteins2022

    • Author(s)
      野口博司,爲本尚樹
    • Journal Title

      Seibutsu Butsuri

      Volume: 62 Issue: 6 Pages: 338-340

    • DOI

      10.2142/biophys.62.338

    • ISSN
      0582-4052, 1347-4219
    • Related Report
      2022 Research-status Report
    • Open Access
  • [Journal Article] Nonequilibrium dynamics of a fluid vesicle: Turing patterns and traveling waves2022

    • Author(s)
      H. Noguchi and N. Tamemoto
    • Journal Title

      J. Phys.: Conf. Ser.

      Volume: 2207 Issue: 1 Pages: 012017-012017

    • DOI

      10.1088/1742-6596/2207/1/012017

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reaction-Diffusion Waves Coupled with Membrane Curvature2021

    • Author(s)
      N. Tamemoto and H. Noguchi
    • Journal Title

      Soft Matter

      Volume: 17 Issue: 27 Pages: 6589-6596

    • DOI

      10.1039/d1sm00540e

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Vesicle budding induced by binding of curvature-inducing proteins2021

    • Author(s)
      H. Noguchi
    • Journal Title

      Phys. Rev. E

      Volume: 104 Issue: 1

    • DOI

      10.1103/physreve.104.014410

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Binding of curvature-inducing proteins onto tethered vesicles2021

    • Author(s)
      H. Noguchi
    • Journal Title

      Soft Matter

      Volume: 17 Issue: 46 Pages: 10469-10478

    • DOI

      10.1039/d1sm01360b

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] サイクリックポッツ模型における時空間パターン2024

    • Author(s)
      野口博司
    • Organizer
      日本物理学会 2024 年春季大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Reaction-diffusion dynamics coupled with membrane deformation2023

    • Author(s)
      Hiroshi Noguchi
    • Organizer
      Mini symposium for self-organization of fluidic systems
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reaction-Diffusion Dynamics Coupled with Membrane Deformation2023

    • Author(s)
      Hiroshi Noguchi
    • Organizer
      34th IUPAP Conference on Computational Physics (CCP2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reaction-diffusion dynamics in deformable membrane2023

    • Author(s)
      Hiroshi Noguchi
    • Organizer
      The 7th International Soft Matter Conference (ISMC2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 膜両面への曲率誘導分子の吸着による膜ドメイン形成2023

    • Author(s)
      野口博司
    • Organizer
      日本物理学会 第78 回年次大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 曲率誘導タンパク質の吸着による生体膜のパターン形成2023

    • Author(s)
      野口博司
    • Organizer
      「細胞を創る」研究会 16.0
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 分子シミュレーションにおける自由エネル ギー計算手法の再重プロセスの高次内挿による改良2023

    • Author(s)
      冨山翔平, 樋口祐次, 野口博司
    • Organizer
      第37回分子シミュレーション討論会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 膜変形を伴う反応拡散波2023

    • Author(s)
      野口博司
    • Organizer
      日本物理学会 2023年春季大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 曲率誘導タンパク質の反応拡散と膜変形2022

    • Author(s)
      野口博司,爲本尚樹
    • Organizer
      第32回日本数理生物学会年会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 天然変性領域を持つ曲率誘導タンパク質による膜変形2022

    • Author(s)
      野口博司
    • Organizer
      日本物理学会 2022 年秋季大会
    • Related Report
      2022 Research-status Report
  • [Presentation] Mean field theories of curvature sensing and generation of isotropic and anisotropic curvature-inducing proteins2022

    • Author(s)
      H. Noguchi
    • Organizer
      日本生物物理学会 第60回年会
    • Related Report
      2022 Research-status Report
  • [Presentation] Non-Equilibrium Dynamics of Fluid Membranes2022

    • Author(s)
      H. Noguchi
    • Organizer
      YITP workshop 25th Anniversary Symposium of German-Japanese Joint Research Project on Nonequilibrium Statistical Physics Perspectives for Future Collaboration
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 外力で引き伸ばされたベシクルにおける曲率誘導タンパク質の吸着平衡2022

    • Author(s)
      野口博司
    • Organizer
      日本物理学会第77回年次大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Calculation method of coefficients of bending energy and non-uniqueness of local stress field2021

    • Author(s)
      H. Noguchi
    • Organizer
      KITP Program: The Physics of Elastic Films: from Biological Membranes to Extreme Mechanics (FILMS21)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Non-equilibrium dynamics of fluid membranes: traveling wave, Turing pattern, and membrane undulation2021

    • Author(s)
      H. Noguchi and N. Tamemoto
    • Organizer
      XXXII IUPAP Conference on Computational Physics (CCP2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 繊維成長により移動中の生体膜の非平衡ゆらぎ2021

    • Author(s)
      野口博司
    • Organizer
      日本物理学会2021年秋季大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Deformation of tubular membranes with excitable reaction-diffusion waves of curvature-inducing proteins2021

    • Author(s)
      N. Tamemoto and H. Noguchi
    • Organizer
      日本生物物理学会第59回年会
    • Related Report
      2021 Research-status Report
  • [Remarks]

    • URL

      https://noguchi.issp.u-tokyo.ac.jp

    • Related Report
      2023 Annual Research Report
  • [Remarks]

    • URL

      https://noguchi.issp.u-tokyo.ac.jp

    • Related Report
      2022 Research-status Report
  • [Remarks]

    • URL

      https://noguchi.issp.u-tokyo.ac.jp

    • Related Report
      2021 Research-status Report

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Published: 2021-04-28   Modified: 2025-01-30  

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