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Development of bio-inspired hydrogel focusing on hierarchical and anisotropic structure of articular cartilage

Research Project

Project/Area Number 21K03840
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 18040:Machine elements and tribology-related
Research InstitutionKyushu University (2022-2023)
Tokyo Metropolitan University (2021)

Principal Investigator

Yarimitsu Seido  九州大学, 工学研究院, 准教授 (90723205)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsハイドロゲル / 摩擦 / 階層構造 / 固液二相潤滑 / 軟骨 / 透水率 / 固液二相性潤滑 / 弾性率 / 温湿度制御 / 高強度ゲル / 低摩擦 / 低摩耗 / 傾斜構造 / バイオインスパイアード / 階層性 / 異方性
Outline of Research at the Start

本研究では,ハイドロゲルの摺動面材料としての応用を目指し,その規範材料として関節
軟骨に着目し,その特異的階層性・異方性構造に焦点を当て,主に二相性潤滑機能を最大限活用可能なハイドロゲルの創製を目指す.軟骨は,関節の運動を滑らかに行うために生物が進化や個体成熟の過程において獲得した一種の最適解とみることも可能である.その高度に最適化された機能・構造は摺動面材料用ハイドロゲルを開発する上では規範となりうるものであり,本研究では軟骨の特異的階層性・異方性構造を規範としたバイオインスパイアードハイドロゲルの設計基盤を構築し,究極的には軟骨の潤滑機能を凌駕する極低摩擦・低摩耗ハイドロゲルの創製を目指す.

Outline of Final Research Achievements

This study focused on the role of hierarchical structure in the lubricating function of hydrogels, aiming at the development of bioinspired hydrogels focusing on the structure of articular cartilage. We developed a hierarchical hydrogel with a low elastic modulus and high permeability on the friction side and a high elastic modulus and low permeability on the lower layer, referring to the structure of cartilage. It was found that the frictional properties change depending on the thickness and ratio of the low and high elastic layers. When the frictional contact area moves, the thinner low elasticity layer suppresses lateral deformation and water flow, resulting in reduced friction. However, when the contact area does not move, friction increase due to increased contact pressure and squeezing out of interstitial water of hydrogel.
These results indicated the possibility of controlling friction and improving friction properties by imparting a hierarchical structure to hydrogels.

Academic Significance and Societal Importance of the Research Achievements

ハイドロゲルは水潤滑下で優れた潤滑機能を発揮しうる材料であり,機械要素の摩擦面材料としての応用の可能性が提唱されている.本研究は,ハイドロゲルを用いた超潤滑システム構築のために,天然のハイドロゲルであり水潤滑下で超潤滑が実現可能な関節軟骨に着目し,その特異的構造が潤滑機能において果たす役割を明らかにし,その機能のハイドロゲルへの実装を目指すものである.本研究により示された階層構造による摩擦低減効果およびその仕組みを活用することにより,機械的構造の制御によるハイドロゲルの低摩擦化が可能となり,ハイドロゲルを用いた超潤滑摩擦システムの構築へとつながる可能性を有している.

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (20 results)

All 2024 2023 2022 2021

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results) Presentation (16 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results)

  • [Journal Article] On the replacement of articular cartilage: The friction of PVA hydrogel layer in hip simulator test2023

    • Author(s)
      Necas David、Yarimitsu Seido、Rebenda David、Shinmori Hironori、Vrbka Martin、Sawae Yoshinori、Murakami Teruo、Krupka Ivan
    • Journal Title

      Tribology International

      Volume: 178 Pages: 108100-108100

    • DOI

      10.1016/j.triboint.2022.108100

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Influence of collagen fibre orientation on the frictional properties of articular cartilage2021

    • Author(s)
      Yarimitsu Seido、Ito Kei、Fujie Hiromichi
    • Journal Title

      Biosurface and Biotribology

      Volume: 7 Issue: 2 Pages: 90-97

    • DOI

      10.1049/bsb2.12005

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of influence of changes in permeability with aging on friction and biphasic behaviors of artificial hydrogel cartilage2021

    • Author(s)
      Murakami Teruo、Sakai Nobuo、Yarimitsu Seido、Nakashima Kazuhiro、Yamaguchi Tetsuo、Sawae Yoshinori、Suzuki Atsushi
    • Journal Title

      Biotribology

      Volume: 26 Pages: 100178-100178

    • DOI

      10.1016/j.biotri.2021.100178

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rheological and frictional analysis of viscosupplements towards improved lubrication of human joints2021

    • Author(s)
      Rebenda David、Vrbka Martin、Ne?as David、Toropitsyn Evgeniy、Yarimitsu Seido、??pek Pavel、Pravda Martin、Hartl Martin
    • Journal Title

      Tribology International

      Volume: 160 Pages: 107030-107030

    • DOI

      10.1016/j.triboint.2021.107030

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 固液二相性材料の水分流出入が摩擦特性に及ぼす影響2024

    • Author(s)
      塩満紘也,新盛弘法,澤江義則,鎗光清道
    • Organizer
      日本機械学会九州支部第77期総会・講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 階層構造ハイドロゲルの潤滑メカニズムに関する研究2024

    • Author(s)
      和田 晴翔,吉田 弘一郎,鎗光 清道,澤江 義則
    • Organizer
      日本機械学会 九州支部 九州学生会第55回学生員卒業研究発表講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 軟骨モデル材料を用いた固液二相性潤滑における水分流出入と摩擦特性の関連の検討2023

    • Author(s)
      鎗光清道,塩満紘也,澤江義則
    • Organizer
      第44 回バイオメカニズム学術講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Tribological Properties of Physically-crosslinked Poly(vinyl alcohol) Hydrogels for Cartilage Implant2023

    • Author(s)
      Seido Yarimitsu, Yoshinori Sawae
    • Organizer
      9th International Tribology Conference
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Friction Properties of Composite-type Poly(Vinyl Alcohol) Hydrogels2023

    • Author(s)
      Seido Yarimitsu, Shuto Watanabe, Yoshinori Sawae
    • Organizer
      Biotribology Fukuoka 2023
    • Related Report
      2023 Annual Research Report
  • [Presentation] 複合型PVAハイドロゲルの低摩擦メカニズムに関する研究2023

    • Author(s)
      渡邊 嵩士,鎗光 清道,澤江 義則
    • Organizer
      日本機械学会2023年度年次大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ハイドロゲルの階層化が摩擦特性に及ぼす影響2023

    • Author(s)
      吉田 弘一郎,鎗光 清道,澤江 義則
    • Organizer
      日本機械学会2023年度年次大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 固液二相性材料の摩擦界面における水分流出入と摩擦特性の関2023

    • Author(s)
      塩満 紘也,鎗光 清道,澤江義則
    • Organizer
      日本機械学会2023年度年次大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 複合型PVA ハイドロゲルの摩擦特性に関する研究2023

    • Author(s)
      渡邊嵩士, 鎗光清道, 澤江義則
    • Organizer
      日本機械学会 九州支部 九州学生会第54回学生員卒業研究発表講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] 階層構造ハイドロゲルの摩擦特性に関する研究2023

    • Author(s)
      吉田弘一郎, 鎗光清道, 澤江義則
    • Organizer
      日本機械学会 九州支部 九州学生会第54回学生員卒業研究発表講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] 微結晶構造制御によるPVAハイドロゲルの低摩擦化2022

    • Author(s)
      鎗光清道, 澤江義則
    • Organizer
      トライボロジー会議2022秋福井
    • Related Report
      2022 Research-status Report
  • [Presentation] Development of PVA Hydrogels for Artificial Cartilage with Superior Lubricity2022

    • Author(s)
      Seido Yarimitsu, Yoshinori Sawae
    • Organizer
      International Conference on Materials & Processing 2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Influence of Drying Condition on Tribological Property of Poly(Vinyl Alcohol) Hydrogel2022

    • Author(s)
      Seido Yarimitsu, Teruo Murakami, Atsushi Suzuki
    • Organizer
      7th World Tribology Congress
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 関節軟骨水和層の摩擦特性2022

    • Author(s)
      菊地啓敏, 鎗光清道, 藤江裕道
    • Organizer
      第41回バイオトライボロジシンポジウム
    • Related Report
      2021 Research-status Report
  • [Presentation] Influence of Surface Morphology on Tribological Properties of Poly(vinyl alcohol) Hydrogels as Artificial Cartilage2021

    • Author(s)
      Seido Yarimitsu, Teruo Murakami, Atsushi Suzuki
    • Organizer
      5th International Conference on BioTribology
    • Related Report
      2021 Research-status Report
  • [Presentation] ポリビニルアルコールハイブリッドゲルの摩擦・摩耗特性に及ぼす乾燥温湿度の影響(第2報)2021

    • Author(s)
      鎗光清道, 村上輝夫, 鈴木淳史
    • Organizer
      トライボロジー会議2021 秋 別府 2021年10月29日
    • Related Report
      2021 Research-status Report

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Published: 2021-04-28   Modified: 2025-01-30  

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