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Research on the development of soft mobile microrobotic fluid carrier system

Research Project

Project/Area Number 21K03931
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 20010:Mechanics and mechatronics-related
Research InstitutionThe University of Tokyo

Principal Investigator

Hwang Gilgueng  東京大学, 生産技術研究所, 国際研究員 (60870673)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2023: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywordsマイクロ流体システム / マイクロスイマー / 磁気駆動 / 流体マニピュレーション / バイオメディカル応用 / 病理検査診断 / 病理的検査・診断 / ソフトモバイルマイクロロボット / 流体キャリア
Outline of Research at the Start

本研究では磁気駆動ソフトモバイルマイクロロボティック流体キャリアによる「ラボオンロボット」システムの開発と応用を目標とする。応用としては、ロボットの遠隔操作により検体採取と病理検査、そして薬物搬送などが上げられる。このような実生活への応用を実現するために必要である、複数環境に適応可能な柔軟性を有し、ロバストで持続可能なマイクロロボットの開発を目指す。また本研究では新たな材料の選定から設計、クリーンルームでの微細加工技術により開発するデバイスの物理的特性分析と評価実験、ロボット制御技術による駆動制御及びその応用までの全開発プロセスを行う。

Outline of Final Research Achievements

This research aims to develop a soft micro-mobile robotic swimmer for bioanalytical applications, and is studying magnetically driven tunable mobile micro-robotic fluid carrier systems and their bio-applications. The main results are summarized as follows.
(1) Miniaturized soft deformable swimmers for environmentally friendly and sustainable fluid carriers. (2) Miniaturization of soft micro-swimmers by 3D printing. (3) Magnetically reconfigurable microfractal pipette array by 3D printing. (4) Optical probe array fabricated by 4D printing. (5) Fabrication of 4D printed optical probe array with nanometer aperture and variable optical spot size.

Academic Significance and Societal Importance of the Research Achievements

現代社会における感染症や病気などの早期診断は医療や社会・経済システムに最も重要である。特に近年新型コロナウイルス(COVID-19)などの高い感染力と致死率を持つ未知のウィルスによる感染の早期診断が強く求められている。本研究の成果はこのようなバイオ分析への貢献が期待できる。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (13 results)

All 2024 2023 2022 2021 Other

All Int'l Joint Research (3 results) Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 6 results) Remarks (1 results) Funded Workshop (1 results)

  • [Int'l Joint Research] CNRS/Paris-Saclay University(フランス)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] CNRS/Paris-Saclay University(フランス)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] CNRS/Paris-Saclay University(フランス)

    • Related Report
      2021 Research-status Report
  • [Journal Article] Fabrication of high aspect ratio microfluidic devices for long term in vitro culture of 3D tumor models2023

    • Author(s)
      Ugrinic Martina、Decanini Dominique、Bidan Nad?ge、Lazzari Gianpiero、Harouri Abdelmounaim、Hwang Gilgueng、Haghiri-Gosnet Anne-Marie、Mura Simona
    • Journal Title

      Microelectronic Engineering

      Volume: 267-268 Pages: 111898-111898

    • DOI

      10.1016/j.mee.2022.111898

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Self-Deformable Flexible MEMS Tweezer Composed of Poly(Vinylidene Fluoride)/Ionic Liquid Gel for Electrical Measurements and Soft Gripping2022

    • Author(s)
      Yamaguchi Takafumi、Usami Naoto、Misumi Kei、Toyokura Atsushi、Higo Akio、Ono Shimpei、Hwang Gilgueng、Larrieu Guilhem、Ikeuchi Yoshiho、Tixier-Mita Agnes、Saito Ken、Levi Timothee、Mita Yoshio
    • Journal Title

      Journal of Microelectromechanical Systems

      Volume: 31 Issue: 5 Pages: 802-812

    • DOI

      10.1109/jmems.2022.3187428

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Novel Fabrication of 4D Printed Optical Probe Array with Nanometer Aperture and Optical Spot Size Tunning2024

    • Author(s)
      D. Decanini, A. Harouri, A. Mizushima, J. Park, B. J. Kim, Y. Mita, G. Hwang
    • Organizer
      2024 IEEE 37th International Conference on Micro Electro Mechanical Systems (MEMS)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 3D Printed Miniaturized Soft Microswimmer for Multimodal 3D Air-Liquid Navigation and Manipulation2023

    • Author(s)
      D. Decanini, A. Harouri, A. Mizushima, B. J. Kim, Y. Mita, G. Hwang
    • Organizer
      2023 IEEE 36th International Conference on Micro Electro Mechanical Systems (MEMS)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel Fabrication of Arbitrary Optical Probe Array by 4D Printing2023

    • Author(s)
      D. Decanini, A. Harouri, A. Mizushima, J. Park, B. J. Kim, Y. Mita, G. Hwang
    • Organizer
      MNE 2023 Micro and Nano Engineering Conference
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 3D Printed Miniaturized Soft Microswimmer for Multimodal 3D Air-Liquid Navigation and Manipulation2023

    • Author(s)
      D. Decanini, A. Harouri, A. Mizushima, B. J. Kim, Y. Mita, G. Hwang
    • Organizer
      IEEE MEMS
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Manufacturing of magnetically reconfigurable 3D printed micro fractal pipette array2022

    • Author(s)
      D. Decanini, A. Harouri, B. Kim, Y. Mita, G. Hwang
    • Organizer
      French symposium on emerging Technologies for Micro-Nanofabrication (JNTE 2022)
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Miniaturized Soft Transformable Swimmer for Environmentally Friendly and Sustainable Fluidic Carrier2021

    • Author(s)
      G. Hwang, A. Toyokura, A. Higo, B. Kim, Y. Mita
    • Organizer
      Design, Test, Integration & Packaging of MEMS/MOEMS (DTIP 2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Remarks] Micro-nanorobotics Lab

    • URL

      https://www.micro-nanorobotics.com/

    • Related Report
      2022 Research-status Report 2021 Research-status Report
  • [Funded Workshop] JFK 2023 Japan France Korea Workshop on Emerging Biomedical Science and Technology2023

    • Related Report
      2023 Annual Research Report

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Published: 2021-04-28   Modified: 2025-01-30  

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