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Constructive approach to neural basis for predictive control of gait and posture

Research Project

Project/Area Number 21K03932
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 20010:Mechanics and mechatronics-related
Research InstitutionThe University of Electro-Communications

Principal Investigator

Funato Tetsuro  電気通信大学, 大学院情報理工学研究科, 准教授 (40512869)

Co-Investigator(Kenkyū-buntansha) 柳原 大  東京大学, 大学院総合文化研究科, 教授 (90252725)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsモデル予測制御 / 予期的姿勢調節 / 姿勢制御 / 小脳 / 学習 / 予測制御 / 姿勢 / 歩行 / ラット
Outline of Research at the Start

ヒトや動物は歩行中に将来の状態を予測して動作を生成することで、動作の切り替わりや環境の変化に柔軟に対応する。神経系の研究から、予測及び予測に使われる動作モデルの神経回路の存在が指摘されているが、これらの知見を統合して予測動作を説明するシステムモデルはこれまで提案されていなかった。本研究では、機械学習と制御理論による数理モデルの構築、ラットを用いた直立・歩行実験を通して、予測制御系の構成原理に迫る。

Outline of Final Research Achievements

The study aimed to elucidate the mechanisms of movement control based on state prediction exhibited by humans and animals. We hypothesized that the neural control system is structured based on model predictive control and tested this through predictive experiments and mathematical simulations with both humans and rats. In human experiments, predictive movements were observed when disturbances were introduced after a cue, and simulations using model predictive control showed behaviors consistent with these predictive movements. Furthermore, similar predictive experiments in rats revealed that the predictive movements seen in healthy rats were absent in cerebellum-injured rats. These results suggest that control laws similar to model predictive control are utilized by the nervous system, including the cerebellum, in generating movements.

Academic Significance and Societal Importance of the Research Achievements

本研究の学術的意義は、予測制御メカニズムと神経系の関係を明らかにした点にある。ヒトの実験では、モデル予測制御がヒトの予測動作を説明できることが示され、小脳障害ラットの実験では、小脳の予測制御における役割が明らかになった。これにより、モデル予測制御の理論が神経制御に適用可能であることが示唆された。本研究の成果は、ヒトの動作制御の原理を人工物に応用する有効な知見となるとともに、小脳に障害を持つ患者の運動障害メカニズムに知見を与えるものである。これにより障害メカニズムに基づく効果的な診断とリハビリテーションにつながることが期待できる。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (20 results)

All 2024 2023 2022 2021

All Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (14 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Roles of the cerebellar vermis in predictive postural controls against external disturbances2024

    • Author(s)
      Konosu Akira、Matsuki Yuma、Fukuhara Kaito、Funato Tetsuro、Yanagihara Dai
    • Journal Title

      Scientific Reports

      Volume: 14 Issue: 1 Pages: 3162-3162

    • DOI

      10.1038/s41598-024-53186-x

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 特集 関節間トレードオフ シナジー解析と関節間協調性2023

    • Author(s)
      舩戸 徹郎
    • Journal Title

      理学療法ジャーナル

      Volume: 57 Issue: 5 Pages: 526-530

    • DOI

      10.11477/mf.1551203046

    • ISSN
      0915-0552, 1882-1359
    • Year and Date
      2023-05-15
    • Related Report
      2022 Research-status Report
  • [Journal Article] Computational prediction of muscle synergy using a finite element framework for a musculoskeletal model on lower limb2023

    • Author(s)
      Wang Sentong、Hase Kazunori、Funato Tetsuro
    • Journal Title

      Frontiers in Bioengineering and Biotechnology

      Volume: 11 Pages: 1-13

    • DOI

      10.3389/fbioe.2023.1130219

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Muscle synergy analysis yields an efficient and physiologically relevant method of assessing stroke2022

    • Author(s)
      Funato Tetsuro、Hattori Noriaki、Yozu Arito、An Qi、Oya Tomomichi、Shirafuji Shouhei、Jino Akihiro、Miura Kyoichi、Martino Giovanni、Berger Denise、Miyai Ichiro、Ota Jun、Ivanenko Yury、d’Avella Andrea、Seki Kazuhiko
    • Journal Title

      Brain Communications

      Volume: 4 Issue: 4

    • DOI

      10.1093/braincomms/fcac200

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Model of Predictive Postural Control Against Floor Tilting in Rats2021

    • Author(s)
      Konosu Akira、Funato Tetsuro、Matsuki Yuma、Fujita Akihiro、Sakai Ryutaro、Yanagihara Dai
    • Journal Title

      Frontiers in Systems Neuroscience

      Volume: 15 Pages: 141-141

    • DOI

      10.3389/fnsys.2021.785366

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative evaluation of posture control in rats with inferior olive lesions2021

    • Author(s)
      Funato Tetsuro、Sato Yota、Sato Yamato、Fujiki Soichiro、Aoi Shinya、Tsuchiya Kazuo、Yanagihara Dai
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 20362-20362

    • DOI

      10.1038/s41598-021-99785-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Effect of Pharmacological Inactivation of the Cerebellum on Learning Function for Predictive Postural Control in Rat2023

    • Author(s)
      Kaito Fukuhara, Akira Konosu, Tetsuro Funato, Dai Yanagihara
    • Organizer
      International Symposium on Micro-NanoMechatronics and Human Science
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Predictive postural controls in bipedal rats: roles of cerebellar vermis and mathematical simulation2023

    • Author(s)
      Akira Konosu, Kaito Fukuhara, Tetsuro Funato, Dai Yanagihara
    • Organizer
      HypAd2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳卒中回復評価における筋シナジー解析の応用可能性2023

    • Author(s)
      舩戸 徹郎
    • Organizer
      第60回日本リハビリテーション医学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 反射系に基づくヒト歩行の筋骨格シミュレーションの構築2023

    • Author(s)
      杉岡 潤, Wang Sentong, 舩戸 徹郎
    • Organizer
      第35回自律分散システム・シンポジウム
    • Related Report
      2022 Research-status Report
  • [Presentation] 脊髄小脳変性症の筋シナジーに注目した運動制御法2022

    • Author(s)
      西田 大輔, 宮崎 裕大, 板東 杏太, 辻本 憲吾, 原 貴敏, 舩戸 徹郎, 関 和彦, 水野 勝広
    • Organizer
      第52回日本臨床神経生理学会学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 脳卒中回復評価動作の筋シナジー解析2022

    • Author(s)
      舩戸 徹郎
    • Organizer
      第20回日本神経理学療法学会学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 床傾斜に対する直立姿勢系の予測動作の解析2022

    • Author(s)
      小川 翠帆, Wang Sentong, 舩戸 徹郎
    • Organizer
      第40回 日本ロボット学会学術講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] 予測的姿勢制御における小脳虫部の役割2022

    • Author(s)
      鴻巣暁, 舩戸徹郎, 松木勇磨, 酒井隆太郎, 柳原大
    • Organizer
      日本小脳学会 第12回学術集会・総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 予測的姿勢制御における小脳虫部の役割2022

    • Author(s)
      鴻巣暁、舩戸徹郎、松木勇磨、酒井隆太郎、柳原大
    • Organizer
      日本小脳学会 第12回学術集会・総会
    • Related Report
      2021 Research-status Report
  • [Presentation] ヒトの直立予測姿勢系の構築による予測的姿勢調節(APA)の解明2022

    • Author(s)
      小川 翠帆,舩戸 徹郎
    • Organizer
      第34回自律分散システム・シンポジウム
    • Related Report
      2021 Research-status Report
  • [Presentation] 腱再配置に対する適応機能解明のための筋骨格モデルの構築2022

    • Author(s)
      内田 菜津美,関 和彦,荻原 直道,大屋 知徹,舩戸 徹郎
    • Organizer
      第34回自律分散システム・シンポジウム
    • Related Report
      2021 Research-status Report
  • [Presentation] ラットの歩行運動制御系の解明のための筋骨格モデルの構築2022

    • Author(s)
      遠藤 啓輔,酒井 隆太郎,柳原 大,舩戸 徹郎
    • Organizer
      第34回自律分散システム・シンポジウム
    • Related Report
      2021 Research-status Report
  • [Presentation] Synergy Analysis of Musculoskeletal Model for Adaptation Mechanism of Monkey with Tendon Transfer2021

    • Author(s)
      Natsumi Uchida, Kazuhiko Seki, Naomichi Ogihara, Tomomichi Oya, Tetsuro Funato
    • Organizer
      IEEE International Symposium on Micro-NanoMechatronics and Human Science
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Modelling Posture Control to Predictable Perturbation in Rats2021

    • Author(s)
      Yuma Matsuki, Akira Konosu, Akihiro Fujita, Tetsuro Funato, Dai Yanagihara
    • Organizer
      HypAd2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research

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Published: 2021-04-28   Modified: 2025-01-30  

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