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Novel sensing system based on morphological change in molecule-responsive gel

Research Project

Project/Area Number 21K04088
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 21030:Measurement engineering-related
Research InstitutionKitami Institute of Technology

Principal Investigator

Kanekiyo Yasumasa  北見工業大学, 工学部, 准教授 (40435748)

Co-Investigator(Kenkyū-buntansha) 青木 寛  国立研究開発法人産業技術総合研究所, エネルギー・環境領域, 研究グループ長 (00392580)
吉田 裕  北見工業大学, 工学部, 教授 (30626122)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsゲル / 刺激応答 / 分子機械 / 導電性 / スイッチ / エタノール / センサ / 計測 / 蛍光
Outline of Research at the Start

複数のセンサから得られる情報を統合的に処理して高度の認識機能を発現するウェアラブルデバイスを実現するには、我々の身の回りに存在する多様な化学物質を、選択的かつ高感度に連続モニタリングできるセンサが不可欠である。そこで本研究では、化学情報を力学的エネルギーに変換し、光および電気シグナルとして取り出すことのできる新規センシングシステムの実現に取り組む。そのために、特定の分子に応答して形状が変化する分子刺激応答性ゲルを合成し、その機械的強度向上と異方的形状変化を実現した上で、蛍光基の導入や電気回路との複合化を行い、それらの分光学的および電気化学的応答を明らかにしていく。

Outline of Final Research Achievements

We succeeded in fabricating a conductive bilayer gel with aluminum foil sandwiched between the layers. When the gel was immersed in aqueous ethanol solutions, a remarkable change in the degree of curvature was observed in response to the ethanol concentration. We then fabricated an electric circuit using the conductive bilayer gel as a switch and confirmed its operation in response to ethanol. As a result, it was clarified that the circuit turns on and off depending on the ethanol concentration and functions as a sensor device that can measure the concentration by lighting a lamp. Furthermore, we achieved a significant improvement in the toughness of the bilayer gel by changing the monomer composition, and were able to clarify the path to improving the durability of the switching device using this gel.

Academic Significance and Societal Importance of the Research Achievements

層間に金属箔を挟み込むことにより導電性二層構造ゲルを作製する手法は、従来知られていない新規の方法論であり、作製の簡便さ、モノマーや金属の種類の選択肢の多様さなど、種々の利点を有することから、その学術的意義は大きい。本研究で開発したセンサは、感染症対策として一般に広く使用されているエタノール消毒液の濃度測定に最適な応答特性を有している。また、他の化学物質や温度・光などの物理的刺激にもターゲットを拡張し得る手法である。よって、人類の福祉向上につながる新技術としての社会的意義も大きい。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (29 results)

All 2024 2023 2022 2021

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 10 results,  Open Access: 6 results) Presentation (17 results) (of which Int'l Joint Research: 1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Assessing microbial stability and predicting biogas production in full-scale thermophilic dry methane fermentation of municipal solid waste2024

    • Author(s)
      Sato Yuya、Hasemi Kentaro、Machikawa Kazunori、Kinjo Hisato、Yashiro Naohisa、Iimura Yosuke、Aoki Hiroshi、Habe Hiroshi
    • Journal Title

      Bioresource Technology

      Volume: 402 Pages: 130766-130766

    • DOI

      10.1016/j.biortech.2024.130766

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a New Sportswear with a Pattern That Changes in Response to Lactic Acid in Sweat2023

    • Author(s)
      兼清泰正
    • Journal Title

      DESCENTE SPORTS SCIENCE

      Volume: 44 Issue: 0 Pages: 16-27

    • DOI

      10.57488/descente.44.0_16

    • ISSN
      0285-5739, 2758-4429
    • Year and Date
      2023-02-22
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct color changes in hydrogen peroxide-responsive thin films consisting of boronic acid-containing polymers2023

    • Author(s)
      Nakahashi Hitoshi、Takeshima Kan、Matsubara Shizuka、Kanekiyo Yasumasa
    • Journal Title

      Dyes and Pigments

      Volume: 218 Pages: 111450-111450

    • DOI

      10.1016/j.dyepig.2023.111450

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Conformational Variability on Seasonable Thermal Stability and Cell Entry of Omicron Variants2023

    • Author(s)
      Izumi Hiroshi、Aoki Hiroshi、Nafie Laurence A.、Dukor Rina K.
    • Journal Title

      ACS Omega

      Volume: 8 Issue: 7 Pages: 7111-7118

    • DOI

      10.1021/acsomega.2c08075

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Urine protein quantification in human urine on boron-doped diamond electrodes based on the electrochemical reaction of Coomassie brilliant blue2023

    • Author(s)
      Aoki Hiroshi、Miyazaki Risa、Ohama Miho、Murata Michio、Asai Kai、Ogata Genki、Einaga Yasuaki
    • Journal Title

      The Analyst

      Volume: 148 Issue: 18 Pages: 4396-4405

    • DOI

      10.1039/d3an01000g

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simplified capture, extraction, and amplification of cellular DNA from water samples2023

    • Author(s)
      Kawaguchi Mai、Aoki Hiroshi、Kamo Hiroki、Miura Kazuki、Hiruta Yuki、Simizu Siro、Citterio Daniel
    • Journal Title

      Analytical Sciences

      Volume: 40 Issue: 3 Pages: 501-510

    • DOI

      10.1007/s44211-023-00482-7

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Material-Specific Determination Based on Microscopic Observation of Single Microplastic Particles Stained with Fluorescent Dyes2022

    • Author(s)
      Hiroshi Aoki
    • Journal Title

      Sensors

      Volume: 22 Issue: 9 Pages: 3390-3390

    • DOI

      10.3390/s22093390

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sensors with Highly Ordered Nucleotides2021

    • Author(s)
      Aoki, Hiroshi
    • Journal Title

      Analytical Sciences

      Volume: 37 Issue: 9 Pages: 1191-1192

    • DOI

      10.2116/analsci.highlights2109

    • NAID

      130008087343

    • ISSN
      0910-6340, 1348-2246
    • Year and Date
      2021-09-10
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Label-free Ratiometric Electrochemical DNA Sensing Based on β-Cyclodextrin-modified Probe Immobilized on Ferrocene Monolayers2021

    • Author(s)
      Hiroshi Aoki
    • Journal Title

      Sensors and Materials

      Volume: 33 Issue: 8 Pages: 2857

    • DOI

      10.18494/SAM.2021.3450

    • ISSN
      0914-4935, 2435-0869
    • Year and Date
      2021-08-24
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spectroscopic Investigation of Increased Fluorescent Intensity of Fluorescent Dyes When Adsorbed onto Polystyrene Microparticles2021

    • Author(s)
      AOKI Hiroshi、TORIMURA Masaki、HABE Hiroshi
    • Journal Title

      Analytical Sciences

      Volume: 37 Issue: 5 Pages: 773-779

    • DOI

      10.2116/analsci.20SCP22

    • NAID

      130008036579

    • ISSN
      0910-6340, 1348-2246
    • Year and Date
      2021-05-10
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 乳酸に応答して図柄が変化する布地の作製と応答特性解析2023

    • Author(s)
      兼清泰正、佐藤里咲
    • Organizer
      第83回分析化学討論会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 乳酸に応答して図柄が変化する布地の作製と特性解析2023

    • Author(s)
      兼清泰正、佐藤里咲
    • Organizer
      2023年繊維学会年次大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Deformation Behavior of Ethanol-Responsive Bilayer Hydrogels Combined with Electric Conductors2023

    • Author(s)
      Yasumasa Kanekiyo, Keisuke Nampo, Hayato Inamura
    • Organizer
      The 7th International Soft Matter Conference
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 次亜塩素酸濃度を表示形状変化により測定できる分析チップの簡便・迅速応答化2023

    • Author(s)
      兼清泰正、松原静香、大内一敏
    • Organizer
      日本分析化学会第72年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 高強度NIPAAmゲルの生産に向けた液中引張試験治具の開発2023

    • Author(s)
      石井洋己、山本彩羽、吉田裕、兼清泰正
    • Organizer
      日本設計工学会2023年度秋季研究発表講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] エタノール応答性二層構造ゲルの強靭化2023

    • Author(s)
      稲村颯人、兼清泰正
    • Organizer
      化学系学協会北海道支部2023年冬季研究発表会
    • Related Report
      2022 Research-status Report
  • [Presentation] 乳酸を感知して模様が変化する布地の応答特性解析2023

    • Author(s)
      佐藤里咲、兼清泰正
    • Organizer
      化学系学協会北海道支部2023年冬季研究発表会
    • Related Report
      2022 Research-status Report
  • [Presentation] Pattern changes in cotton fabrics conjugated with lactate-responsive polymers2023

    • Author(s)
      兼清泰正、佐藤里咲
    • Organizer
      日本化学会第103春季年会
    • Related Report
      2022 Research-status Report
  • [Presentation] 導電性二層構造ゲルの湾曲挙動を利用したエタノールセンシング2022

    • Author(s)
      兼清泰正、南保圭祐、山岸遼平
    • Organizer
      第82回分析化学討論会
    • Related Report
      2022 Research-status Report
  • [Presentation] 汗中の乳酸に応答して図柄が変化する衣類の開発2022

    • Author(s)
      兼清泰正、松原静香、藤村祐大、茂垣寿美麗
    • Organizer
      2022年繊維学会年次大会
    • Related Report
      2022 Research-status Report
  • [Presentation] PVAダブルネットワークヒドロゲルの機械特性2022

    • Author(s)
      中山翔太、兼清泰正、石井洋己、吉田裕
    • Organizer
      日本機械学会M&M2022材料力学カンファレンス
    • Related Report
      2022 Research-status Report
  • [Presentation] 次亜塩素酸の濃度を表示形状変化により測定できる試験紙の開発2022

    • Author(s)
      兼清泰正、松原静香、大内一敏
    • Organizer
      日本分析化学会第71年会
    • Related Report
      2022 Research-status Report
  • [Presentation] 乳酸に応答して模様が変化する布地の作製2022

    • Author(s)
      松原静香、茂垣寿美麗、兼清泰正
    • Organizer
      化学系学協会北海道支部2022年冬季研究発表会
    • Related Report
      2021 Research-status Report
  • [Presentation] 導電体と複合化した二層構造ゲルの作製2022

    • Author(s)
      南保圭佑、山岸遼平、兼清泰正
    • Organizer
      化学系学協会北海道支部2023年冬季研究発表会
    • Related Report
      2021 Research-status Report
  • [Presentation] 導電体と複合化した二層構造ゲルの変形挙動2022

    • Author(s)
      兼清泰正、南保圭佑、山岸遼平
    • Organizer
      日本化学会第102春季年会
    • Related Report
      2021 Research-status Report
  • [Presentation] 次亜塩素酸消毒液の濃度を色調および表示形状の変化により測定できるセンサーの開発2021

    • Author(s)
      兼清泰正、加藤匠、及川勝太、三谷裕、三島木葉月
    • Organizer
      第81回分析化学討論会
    • Related Report
      2021 Research-status Report
  • [Presentation] 乳酸に応答して図柄の変化する木綿布の作製2021

    • Author(s)
      兼清泰正、藤村祐大、加藤匠、三谷裕
    • Organizer
      2021年繊維学会年次大会
    • Related Report
      2021 Research-status Report
  • [Patent(Industrial Property Rights)] 濃度判定部材、および次亜塩素酸濃度の判定方法2023

    • Inventor(s)
      大内一敏、兼清泰正
    • Industrial Property Rights Holder
      大内一敏、兼清泰正
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-121787
    • Filing Date
      2023
    • Related Report
      2023 Annual Research Report
  • [Patent(Industrial Property Rights)] 濃度判定部材,濃度判定キット,および次亜塩素酸濃度の判定方法2021

    • Inventor(s)
      大内一敏、兼清泰正
    • Industrial Property Rights Holder
      大内一敏、兼清泰正
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-215106
    • Filing Date
      2021
    • Related Report
      2021 Research-status Report

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Published: 2021-04-28   Modified: 2025-01-30  

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