Development of supercritical carbon dioxide mediated microparticles of juvenile hormone analogues (JHAs) for the elimination of mosquito-borne diseases
| Project/Area Number |
21K04758
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 27010:Transport phenomena and unit operations-related
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| Research Institution | Fukuoka University |
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Principal Investigator |
シャーミン タンジナ 福岡大学, 工学部, 助教 (00794182)
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| Co-Investigator(Kenkyū-buntansha) |
相田 卓 福岡大学, 工学部, 助教 (00466541)
三島 健司 福岡大学, 工学部, 教授 (40190623)
佐藤 朝光 福岡大学, 薬学部, 教授 (90369025)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Project Status |
Granted (Fiscal Year 2022)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2023: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | supercritical CO2 / JHA / Pyriproxyfen / microencapsulation / control release / carbon dioxide / Protein microparticles / supercritical fluids / hormone analogues / microparticles / mosquito-borne diseases |
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| Outline of Research at the Start |
In this study we introduce highly advance technology of supercritical carbon dioxide (ScCO2) to manufacture Juvenile hormone analogues (JHAs) microcapsules which will be very light to float and enable releasing effective doses just at the place of need. Parameters like pressure (8~14MPa) and temperature (313~343K), polymer ratio, and antisolvent to solvent ratio will be varied to adjust the output. To ensure their controlled release for a longer time, JHAs will be encapsulated with a biodegradable polymer. Evaluation of the encapsulated JHAs particles in Aedes vectors will be carried out.
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| Outline of Annual Research Achievements |
We have examined the Development of several supercritical carbon dioxide-mediated microparticles of proteins and JHA hormones using the PGSS process and the liquid-liquid two-phase separation. Our experimental data on Microencapsulation of insect growth regulator in poly-(ε-caprolactones) by PGSS process were presented in the 化学工学会 第53回秋季大会 (2022, 9) and the 7th International Conference on the Characterization and Control of Interfaces for High-Quality Advanced Materials ICCCI 2022 (2022,11) was highly evaluated. An article on “Microencapsulation of pyriproxyfen using the particles from gas-saturated solutions process as a controlled-release system” is submitted in the Journal: Powder Technology (Ref: POWTEC-D-23-00573) is under review process. An article on ‘Recognition of liquid-liquid two-phase separation by digital image processing’ was successfully published in July 2022 in the Journal of the Institute of Industrial Applications Engineers.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
This fund provided enough financial support to purchase all equipment's and chemical required for the research making the smooth execution of this research project.
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| Strategy for Future Research Activity |
The bioassay on larval mortality (laboratory scale) assay has been successfully carried out in the Faculty of Pharmaceutical Sciences, Fukuoka University using 4th instar larvae of Aedes albopictus. By this time we have achieved enough data to publish the result of this investigation. In parallels, we will try to develop a PEG-PCL diblock copolymer microencapsulation system composed of poly(ethylene glycol) (PEG) and poly(ε-caprolactone, PCL) using the PGSS process to minimize the hydrophobicity of the polymer PCL. The effect of process conditions, i.e., pre-expansion temperature and pressure, and pyriproxyfen/polymer mass ratio, on the morphology of particles and the efficiency of encapsulation will be analyzed.
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Report
(2 results)
Research Products
(6 results)
