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Development of Microencapsulation System for Functional Nanoparticles via Carbohydrate Polymer

Research Project

Project/Area Number 21K05451
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 38050:Food sciences-related
Research InstitutionHokkaido University

Principal Investigator

Shimizu Naoto  北海道大学, 農学研究院, 准教授 (70323251)

Project Period (FY) 2021-04-01 – 2025-03-31
Project Status Completed (Fiscal Year 2024)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords微細加工技術 / ナノろ過 / 米澱粉 / 階層構造 / ケルセチン / 価値化 / マイクロカプセル / 電子線トモグラフィ / システム / 機能性 / 凍結乾燥 / 材料 / 機能性成分
Outline of Research at the Start

本研究では,糖質高分子を用いる機能性ナノ粒子のマイクロカプセル化システムの確立をめざして,ナノメートルスケールの微粒子における糖質高分子鎖や階層構造が多様な動的・静的性質の変化に及ぼす影響を明らかにする。具体的にはⅠ 糖質高分子の分岐―線状トポロジ(一次構造)と物性解析法の構築,Ⅱ 玉ねぎ外皮からのケルセチン等ナノろ過による抽出・濃縮の検討,Ⅲ 機能性ナノ粒子分散調製液のマイクロカプセル化システムの開発を進める。各種複合プロセスにより機能性ナノ粒子を調製し,噴霧乾燥機を用いてマイクロカプセル化するシステムへと統合して汎用性の高い微粒子調製の基盤技術の開発につながる知見を提供する。

Outline of Final Research Achievements

To establish a microencapsulation system for functional nanoparticles using carbohydrate polymers, samples were prepared using microparticle preparation technology, and physiologically active functional components were extracted and concentrated. In the large-sized finely divided starch in the starch nanoparticle dispersion, a high-order hierarchical structure was maintained along with branching, which influenced the expression of a variety of physical properties. Nanofiltration of the functional components in onion skins made it possible to improve the purity and concentrate quercetin. Microencapsulation was performed using quercetin as the core material and finely divided starch as the wall material. From the above, we obtained knowledge that suggests the use of starch as a wall material that takes advantage of its hierarchical structure, as well as the use of stabilized flavonoids as materials in foods and medicines.

Academic Significance and Societal Importance of the Research Achievements

生体高分子や生理活性を有する成分を対象として、これらを含む食品分散系の性質の解明のため、米澱粉の微細構造の解析方法を構築した。さらに、玉ねぎ外皮に含まれるケルセチン成分の抽出、及びナノろ過による濃縮方法を検討した。以上より、微細加工技術に基づく澱粉の階層構造を生かしたwall素材としての活用、ならびにフラボノイドの食品や医薬品への素材利用による価値化についての成果が得られた。

Report

(5 results)
  • 2024 Annual Research Report   Final Research Report ( PDF )
  • 2023 Research-status Report
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (9 results)

All 2025 2024 2023 2022

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] 生物資源の価値化:素材の微細加工技術とナノバイオ工学からの展望2025

    • Author(s)
      清水直人
    • Journal Title

      アグリバイオ

      Volume: 9 Pages: 45-48

    • Related Report
      2024 Annual Research Report
  • [Journal Article] Techno economic analysis of the production of potato powder applying potato starch purification system in Japan2024

    • Author(s)
      Sato Nagohira、Shimizu Naoto、Nakajima Mitsutoshi
    • Journal Title

      Discover Applied Sciences

      Volume: 6 Issue: 5 Pages: 253-253

    • DOI

      10.1007/s42452-024-05937-8

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Early-Stage Life Cycle Assessment and Optimization of Aqueous Crude Glycerol Extraction and Nanofiltration Concentration of Tomato Leaf Residue2024

    • Author(s)
      Xiaojue Li, Yongheng Yuan, Faqinwei Li, Naoto Shimizu
    • Journal Title

      ACS Sustainable Chemistry & Engineering

      Volume: 12 Issue: 7 Pages: 2646-2655

    • DOI

      10.1021/acssuschemeng.3c06655

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Buckwheat waste depolymerization using a subcritical ethanol solution for extraction of bioactive components: from the laboratory to pilot scale2023

    • Author(s)
      Yuan Yongheng、Shimizu Naoto、Li Faqinwei、Magana Jorge、Li Xiaojue
    • Journal Title

      Journal of Environmental Chemical Engineering

      Volume: 11 Issue: 3 Pages: 109807-109807

    • DOI

      10.1016/j.jece.2023.109807

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pilot-scale extraction of polyphenols from spent black tea by semi-continuous subcritical solvent extraction2022

    • Author(s)
      Rajapaksha Surakshi、Shimizu Naoto
    • Journal Title

      Food Chemistry: X

      Volume: 13 Pages: 100200-100200

    • DOI

      10.1016/j.fochx.2021.100200

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 玉ねぎ外皮からの機能性フラボノイドの加圧溶媒抽出と利用法の開発2024

    • Author(s)
      佐藤 和平・ 清水 直人・ 伊藤 浩哉
    • Organizer
      化学工学会 第55回秋季大会
    • Related Report
      2024 Annual Research Report
  • [Presentation] 粗製グリセロール水溶液を用いたトマト葉残渣からのフェノール類の抽出と濃縮2024

    • Author(s)
      Li Xiaojue・ 清水 直人
    • Organizer
      化学工学会 第55回秋季大会
    • Related Report
      2024 Annual Research Report
  • [Presentation] Extraction Optimization and Concentration through Nanofiltration of Aqueous Crude Glycerol Extract from Tomato Leaf Residue (TLR)2022

    • Author(s)
      Li Xiaojue、Yuan Yongheng、Li Faqinwei、Shimizu Naoto
    • Organizer
      The XX CIGR World Congress 2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 玉ねぎ外皮の機能性成分のナノろ過の検討2022

    • Author(s)
      逢坂悠希、清水直人
    • Organizer
      日本食品工学会第23回(2022年度)年次大会
    • Related Report
      2022 Research-status Report

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Published: 2021-04-28   Modified: 2026-01-16  

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