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Epigenetic approach for the muscle function-related gene analysis

Research Project

Project/Area Number 21K06367
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 45060:Applied anthropology-related
Research InstitutionFukui National College of Technology

Principal Investigator

kawamura Toshiyuki  福井工業高等専門学校, 物質工学科, 准教授 (80413772)

Co-Investigator(Kenkyū-buntansha) 松井 一洋  福井工業高等専門学校, 一般科目(自然系), 准教授 (10805055)
東 章弘  福井工業高等専門学校, 一般科目(自然系), 教授 (50546257)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2023: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2021: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
KeywordsACTN3遺伝子多型 / 体力 / 速筋線維 / エピジェネティクス / ACTN3 / 体力テスト / Muscle strength / 脚伸展 / Stretching / 筋線維 / スポーツ / Epigenetics / Physical fitness test / Mechanical efficiency / αアクチニン3
Outline of Research at the Start

従前の遺伝子診断は遺伝子型のみでそのタイプを区分するため,遺伝子型と筋力発揮パフォーマンスとが必ずしも合致しないケースが見受けられる.しかしながら,エピジェネティクスを診断に取り入れれば,筋力発揮のパフォーマンスを精度よく予測する診断が実現できると考えられる.本研究では,エピジェネティクスを加味した遺伝子解析の結果とフィールドテストやラボテストにおける筋力発揮パフォーマンスとの関連を明らかにすることを目的とし,スポーツトレーニングや介護予防の観点から個人差を意識した筋力トレーニングに必要とされる遺伝子型情報の新たな提供法の確立を目指す.

Outline of Final Research Achievements

Although an association between ACTN3 gene polymorphisms and sprint/power abilities has been reported in athletes, we found no difference in static muscle strength between R alleles (RR and RX types) and XX types in the general population (Azuma et al., 2021), but the R allele group was superior in sprint/power abilities in physical fitness tests (Matsui et al., 2023). However, the effect sizes were small, suggesting an association with epigenetic effects (Kawamura et al., 2024). On the other hand, mechanical changes in the muscle-tendon complex induced by PNF stretching were not found to be detrimental to RR-type flexibility (Azuma et al., 2023; Azuma et al., 2024).

Academic Significance and Societal Importance of the Research Achievements

速筋線維に特異的に発現するACTN3遺伝子多型はアスリートにおけるスプリント/パワー系運動能力との関連が数多く報告されてきたが、一般人の多型と運動能力との関連に関する報告は希少である。我が国におけるコホート研究によれば一般人のRR型における柔軟性が低いことが指摘されるが、一般人の多型と体力全般との関連については海外報告にとどまる。我々の研究によって国内一般人の体力テストにおけるスプリント/パワー系種目と多型との関連が認められたほか、エピジェネティックな効果によりACTN3の性質の発現が抑制される可能性が示唆されたことから、余暇活動での運動選択や健康管理に活用し得る遺伝子解析の意義が認められた。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (6 results)

All 2024 2023 2021 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] University of the Philippines Diliman(フィリピン)

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Latent Trait and Epigenetic Analysis of ACTN3 Gene Polymorphism Homo-RR in Japanese College Students2024

    • Author(s)
      Toshiyuki Kawamura , Akihiro Azuma, Kazuhiro Matsui
    • Journal Title

      Gazzetta Medica Italiana - Archivio per le Scienze Mediche

      Volume: in print

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of ACTN3 R577X Genotype with Physical Fitness in Japanese Male College Students2023

    • Author(s)
      Kazuhiro Matsui、Toshiyuki Kawamura、Akihiro Azuma、Christian Wisdom M. Valleser、Francis Carlos B. Diaz
    • Journal Title

      International Journal of Human Movement and Sports Sciences

      Volume: 11 Issue: 4 Pages: 908-913

    • DOI

      10.13189/saj.2023.110427

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a Proprioceptive Neuromuscular Facilitation Stretching System Using a Low-Speed, High-Torque Motor2023

    • Author(s)
      Akihiro Azuma, Kazuhiro Matsui, Toshiyuki Kawamura
    • Journal Title

      European Journal of Human Movement

      Volume: 50 Pages: 45-51

    • DOI

      10.21134/eurjhm.2023.50.5

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Is ACTN3 R577X genotype associated with weight-bearing index in male college students?2021

    • Author(s)
      Azuma A, Kawamura T, Matsui K.
    • Journal Title

      In W. Spratford, C. Coltman, N. Brown, & J. Warmenhoven (Eds.), Proceedings of the 39th International Conference of Biomechanics in Sports

      Volume: 39th Pages: 380-383

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Is ACTN3 R577X genotype associated with weight-bearing index in male college students?2021

    • Author(s)
      Azuma A, Kawamura T, Matsui K.
    • Organizer
      39th Conference of the International Society of Biomechanics in Sports
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research

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Published: 2021-04-28   Modified: 2025-01-30  

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