• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Clinical pharmacology for clinical implementation of pharmacogenomic testing

Research Project

Project/Area Number 21K06665
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 47060:Clinical pharmacy-related
Research InstitutionKyoto University

Principal Investigator

Terada Tomohiro  京都大学, 医学研究科, 教授 (10324641)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords個別医療 / 遺伝子多型 / 薬物動態 / ファーマコゲノミクス
Outline of Research at the Start

遺伝子多型に基づく薬剤選択・投与量調節を行うファーマコゲノミクス (PGx) 検査は、Precision Medicineの実現に大きく貢献することが期待されている。本研究では、PGxデータベースを用いた有用性検証研究を実施するとともに、これまでに有用性が見いだされた経口抗凝固薬アピキサバンについて、前向き介入臨床研究を実施し、PGx検査臨床実装の基盤構築を目指す。
本研究により、PGx検査に基づいた個別化投与指針を構築することができれば、治療効果の向上や副作用軽減といった医学的なメリットに加え、投与量最適化による薬価負担の軽減や有害事象制御による医療費の軽減といった薬剤経済学的なメリットも期待される。

Outline of Final Research Achievements

Pharmacogenomics (PGx) testing enables prediction of drug efficacy and side effects by analyzing genetic polymorphisms of drug-metabolizing enzymes and drug transporters. Therefore, PGx is an effective tool to realize “Precision Medicine”. In this study, we conducted a retrospective clinical study using a PGx database implemented in electronic medical records, aiming at the clinical dissemination of PGx tests.
Clopidogrel, antiplatelet drug, is metabolically activated by CYP2C19. Conversely, prasugrel is considered to be less involved in CYP2C19. In the present study, we analyzed the impact of PGx testing before antiplatelet therapy on therapeutic efficacy, adverse event occurrence, and pharmacoeconomic effects. It was founded that the utility of PGx testing for appropriate drug selection.

Academic Significance and Societal Importance of the Research Achievements

PGxに関する研究は数多く報告があるが、実臨床におけるPGx検査の有用性に関する検証は充分ではなく、そのため臨床普及も進まないというジレンマに陥っている。本研究計画では臨床業務の一環として実施されているPGx検査のデータベースに基づき、個々の患者に合わせた適切な薬剤選択・投与量決定につながる知見を得た。これにより、治療効率の向上や有害事象の回避などの医学的なメリットに加え、投与量の最適化による薬剤経済学的なメリットが期待できることから、社会的意義も大きいと考える。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (10 results)

All 2023 2022 2021

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 4 results)

  • [Journal Article] Decreased Analgesic Effect of Tramadol in Japanese Patients with CYP2D6 Intermediate Metabolizers after Orthopedic Surgery2023

    • Author(s)
      Kamiya Takaki、Hira Daiki、Nakajima Ryo、Shinoda Kazuha、Motomochi Atsuko、Morikochi Aya、Ikeda Yoshito、Isono Tetsuichiro、Akabane Michiya、Ueshima Satoshi、Kakumoto Mikio、Imai Shinji、Morita Shin-ya、Terada Tomohiro
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 46 Issue: 7 Pages: 907-913

    • DOI

      10.1248/bpb.b23-00030

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2023-07-01
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single-Nucleotide Polymorphisms, c.415C &gt; T (Arg139Cys) and c.416G &gt; A (Arg139His), in the <i>NUDT15</i> Gene Are Associated with Thiopurine-Induced Leukopenia2023

    • Author(s)
      Isono Tetsuichiro、Hira Daiki、Ikeda Yoshito、Kawahara Masahiro、Noda Satoshi、Nishida Atsushi、Inatomi Osamu、Fujimoto Noriki、Andoh Akira、Terada Tomohiro、Morita Shin-ya
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 46 Issue: 3 Pages: 412-418

    • DOI

      10.1248/bpb.b22-00686

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2023-03-01
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exploratory analysis of target concentration of lenvatinib in the treatment of hepatocellular carcinoma2021

    • Author(s)
      Noda Satoshi、Iida Hiroya、Fujimoto Takehide、Wakasugi Yoshinori、Yabuta Naoki、Sudou Masatomo、Hira Daiki、Tani Masaji、Andoh Akira、Morita Shin-ya、Terada Tomohiro
    • Journal Title

      Cancer Chemotherapy and Pharmacology

      Volume: . Issue: 2 Pages: 281-288

    • DOI

      10.1007/s00280-021-04286-2

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] High incidence of major bleeding with off-label use of edoxaban2021

    • Author(s)
      Fukui Rika、Hira Daiki、Kunitsu Yuki、Isono Tetsuichiro、Tabuchi Yohei、Ikuno Yoshihiro、Ueshima Satoshi、Itoh Hideki、Tanaka Toshihiro、Terada Tomohiro
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 69 Issue: 3 Pages: 311-316

    • DOI

      10.3164/jcbn.21-9

    • NAID

      130008110266

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Pharmacogenomics of tramadol in Japanese orthopedic surgery patients.2023

    • Author(s)
      Tomohiro Terada, Takaki Kamiya, Daiki Hira, Ryo Nakajima, Kazuha Shinoda, Atsuko Motomochi, Aya Morikouchi, Yoshito Ikeda, Tetsuichiro Isono, Michiya Akabane, Satoshi Ueshima, Shinji Imai, Mikio Kakumoto
    • Organizer
      21st International Congress of Therapeutic Drug Monitoring & Clinical Toxicology
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ファーマコゲノミクス検査の臨床実装に向けた現状と課題 診療における薬理遺伝学検査の運用に関する提言について2023

    • Author(s)
      寺田智祐
    • Organizer
      第33回日本医療薬学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ゲノム情報と薬物療法2022

    • Author(s)
      寺田智祐
    • Organizer
      医療薬学フォーラム2022
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] Pharmacotherapy Management of High-alert Medication in Japan2022

    • Author(s)
      Tomohiro Terada
    • Organizer
      2022 World Patient Safety Day Webinar : Using Technology to Improve Medication Safety
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] リアルワールドデータとしてのPGx検査の活用2021

    • Author(s)
      寺田智祐, 森田真也
    • Organizer
      医療薬学フォーラム2021/第29回クリニカルファーマシーシンポジウム,
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] ファーマコゲノミクス検査の臨床実装2021

    • Author(s)
      寺田智祐, 森田真也
    • Organizer
      第31回日本医療薬学会年会
    • Related Report
      2021 Research-status Report
    • Invited

URL: 

Published: 2021-04-28   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi