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Clinicopathological and moleclar biological study of renal cell carcinoma of novel and rare histologca types

Research Project

Project/Area Number 21K06914
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 49020:Human pathology-related
Research InstitutionTokyo Women's Medical University

Principal Investigator

Nagashima Yoji  東京女子医科大学, 医学部, 教授 (10217995)

Co-Investigator(Kenkyū-buntansha) 加藤 生真  横浜市立大学, 医学部, 助教 (80644939)
近藤 恒徳  東京女子医科大学, 医学部, 教授 (50301544)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsRenal cellcarcinoma / Pathology / TFE3-rearranged RCC / FH-deficient RCC / ACD-associated RCC / Immunohistochemistry / Break apart FISH / Diagnosstic algorithm / 腎癌(腎細胞癌) / TFE3再構成性腎細胞癌 / TFEB変異性腎細胞癌 / コハク酸脱水素応訴(SDH)欠損性腎細胞癌 / フマル酸ヒドラターゼ(FH)欠損性腎細胞癌 / 透析関連腎細胞癌 / 腎細胞癌 / MiT転座型 / FH欠損性 / 透析関連 / 腎癌 / 転座型腎細胞癌 / 酵素欠損型腎細胞癌 / 新規・稀少組織型
Outline of Research at the Start

東京女子医科大学病院で切除された腎細胞癌症例組織標本を見直し、①転座型、②透析関連、③酵素欠損型腎細胞癌症例を抽出する。必要に応じて分子生物学的検討を行って診断を確定、臨床病理学的性質を明らかにする。透析関連腎細胞癌に対しては背景の前駆、早期病変の形態、免疫組織化学的性格付けを併せて行う。さらに前向きに新鮮凍結試料の蓄積や、培養細胞株の樹立を試み、さらなる研究に備える。インフォームドコンセントをベースとして網羅的ゲノム解析を行い、診断のためのバイオマーカー、治療標的の探索を行う。

Outline of Final Research Achievements

Pathological classification of renal cell carcinoma (RCC) contains various histological and genetic types. This research aimed to reveal clinicopathological features. The cases examined were RCCs surgically resected at the Tokyo Women's Medical University Hospital and subjected for pathological consultation to the PI. We revealed the facts as follows; ①TFE3-rearranged RCC occurs not only in younger population but also in elder population and in patients receiving long-term diaysis, ②Although fumarate hydratase-deficient RCC presents morphological overlapping with papilary RCC, precise differential diagnosis is required, considering unfavorable prognoses and possibility of a hereditary background. ③Acquired cystic disease-associated RCC possesses similar methylation profile with papillary RCC. ⑤Additionally, algorithm for histopathological diagnosis of RCCs mainly based on immunohistochemistry.

Academic Significance and Societal Importance of the Research Achievements

2023年に出版されたWHO腎細胞癌分類では新規組織型、特に分子生物学的に定義される組織型が導入され、本邦で用いられている腎癌取扱い規約(第5版、2020年出版)との間にギャップが生じている。本研究では新たに導入された新規組織型の性質を明らかにすることができた。また、分子生物学的手法の使用に制約のある施設であっても、ルチーン化されていr免疫染色を用いて、正確な診断が可能となるアルゴリズムを確立することができた。これらを通じて腎細胞癌の稀少組織型を集積し、大規模な臨床病理学的検討への進展が期待される。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (77 results)

All 2024 2023 2022 2021 Other

All Journal Article (39 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 36 results,  Open Access: 32 results) Presentation (30 results) (of which Invited: 5 results) Book (4 results) Remarks (4 results)

  • [Journal Article] Advanced Renal Cell Carcinoma With Inferior Vena Cava Thrombus Treated With a Combination of Preoperative Lenvatinib and Pembrolizumab2024

    • Author(s)
      NAGAHISA CHIKA、YOSHIDA KAZUHIKO、KONDO HANAE、NAKAYAMA TAKAYUKI、MIZOGUCHI SHINSUKE、MINODA RYO、FUKUDA HIRONORI、KOBARI YUKI、IIZUKA JUNPEI、NAGASHIMA YOJI、ISHIDA HIDEKI、TAKAGI TOSHIO
    • Journal Title

      Anticancer Research

      Volume: 44 Issue: 3 Pages: 1317-1321

    • DOI

      10.21873/anticanres.16927

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 腎細胞癌の病理学的予後因子2024

    • Author(s)
      三上修治、大江知里、大橋瑠子、長嶋洋治
    • Journal Title

      病理と臨床

      Volume: 42 Pages: 459-464

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Bilateral fumarate hydratase deficient renal cell carcinoma in a patient with hereditary leiomyomatosis and renal cell cancer syndrome2024

    • Author(s)
      Ono Akihiro、Nakamura Masaki、Takada Takuya、Miura Sakiko、Tsuru Ibuki、Izumi Taro、Kusakabe Masashi、Mitarai Sachiko、Nagashima Yoji、Kume Haruki、Morikawa Teppei、Shiga Yoshiyuki
    • Journal Title

      IJU Case Reports

      Volume: 7 Issue: 2 Pages: 144-147

    • DOI

      10.1002/iju5.12688

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Renal cell carcinoma outcomes in end‐stage renal disease: A 40‐year study from two Japanese institutions2023

    • Author(s)
      Ishihara Hiroki、Ikeda Takashi、Fukuda Hironori、Yoshida Kazuhiko、Kobayashi Hirohito、Iizuka Junpei、Nagashima Yoji、Kondo Tsunenori、Takagi Toshio
    • Journal Title

      International Journal of Urology

      Volume: 31 Issue: 1 Pages: 73-81

    • DOI

      10.1111/iju.15314

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pulmonary interstitial glycogenosis in Birt‐Hogg‐Dube syndrome‐associated lung cysts: A new insight into the pathogenesis?2023

    • Author(s)
      Kawachi Riken、Nakatani Yukio、Furuya Mitsuko、Nakamura Naoya、Kondo Yusuke、Nagashima Yoji、Nakayama Tomohiro、Okada Masahiro、Sakurai Hiroyuki、Masuda Shinobu
    • Journal Title

      Pathology International

      Volume: 73 Issue: 12 Pages: 601-608

    • DOI

      10.1111/pin.13383

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Current Knowledge and Prospects for Renal Hemangioblastoma and Renal Cell Carcinoma with Hemangioblastoma-like Features2023

    • Author(s)
      Kojima Fumiyoshi、Musangile Fidele Y.、Matsuzaki Ibu、Yorita Kenji、Kuroda Naoto、Nagashima Yoji、Murata Shin-ichi
    • Journal Title

      Biomedicines

      Volume: 11 Issue: 5 Pages: 1467-1467

    • DOI

      10.3390/biomedicines11051467

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of Combined Pembrolizumab and Pelvic Radiotherapy for Bladder Cancer With Rectal Metastases2023

    • Author(s)
      NAGAHISA CHIKA、IIZUKA JUNPEI、KOBARI YUKI、MINODA RYO、FUKUDA HIRONORI、YOSHIDA KAZUHIKO、OKUDA HISASHI、ISHIDA HIDEKI、NAGASHIMA YOJI、TAKAGI TOSHIO
    • Journal Title

      In Vivo

      Volume: 37 Issue: 2 Pages: 912-915

    • DOI

      10.21873/invivo.13162

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
  • [Journal Article] Electronic patient-reported outcome (e-PRO) monitoring for adverse event management during cabozantinib treatment in patients with advanced renal cell carcinoma: protocol for a three-arm, randomised, multicentre phase II trial (e-PRO vs paper-PRO or usual care)2023

    • Author(s)
      Osawa Takahiro、Fujii Yasuhisa、Kimura Go、Kitamura Hiroshi、Nagashima Yoji、Iizumi Sakura、Osaka Tsuyoshi、Tsubouchi Ryoichi、Shinohara Nobuo
    • Journal Title

      BMJ Open

      Volume: 13 Issue: 7 Pages: e070275-e070275

    • DOI

      10.1136/bmjopen-2022-070275

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiple Small Bowel Gastrointestinal Stromal Tumors Associated with Neurofibromatosis Type 1 that Were Not Detected by Endoscopy: A Case Report2023

    • Author(s)
      Saito Satomi、Omori Teppei、Murasugi Shun、Yonezawa Maria、Takayama Yukiko、Ohki Takeshi、Onizuka Hiromi、Nagashima Yoji、Tokushige Katsutoshi
    • Journal Title

      Case Reports in Gastroenterology

      Volume: 17 Issue: 1 Pages: 167-174

    • DOI

      10.1159/000529340

    • Related Report
      2023 Annual Research Report
  • [Journal Article] ロボット支援腎部分切除術を施行された腎類上皮性血管筋脂肪腫の3例2023

    • Author(s)
      矢代麻友佳,関敦子,高木敏男,鬼塚裕美,増井憲太,山本智子,長嶋洋治
    • Journal Title

      診断病理

      Volume: 40 Pages: 65-72

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oncocytic and chromophobe renal tumor の鑑別診断2023

    • Author(s)
      大橋瑠子、大江知里、橋立英樹、大月寛郎、山田鉄也、宮崎龍彦、都築豊徳、長嶋洋治
    • Journal Title

      診断病理

      Volume: 40 Pages: 18-31

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Overexpression of Plasmalemmal Vesicle-Associated Protein-1 Reflects Glomerular Endothelial Injury in Cases of Proliferative Glomerulonephritis with Monoclonal IgG Deposits2023

    • Author(s)
      Sawada Anri、Kawanishi Kunio、Igarashi Yuto、Taneda Sekiko、Hattori Motoshi、Ishida Hideki、Tanabe Kazunari、Koike Junki、Honda Kazuho、Nagashima Yoji、Nitta Kosaku
    • Journal Title

      Kidney International Reports

      Volume: 8 Issue: 1 Pages: 151-163

    • DOI

      10.1016/j.ekir.2022.10.010

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effectiveness of Retzius-Sparing Robot-Assisted Radical Prostatectomy in a Renal Transplant Recipient: a Case Report2022

    • Author(s)
      Kobari Yuki、Iizuka Junpei、Hata Keisuke、Kato Shinya、Minoda Ryo、Yoshida Kazuhiko、Ishida Hideki、Nagashima Yoji、Tanabe Kazunari、Takagi Toshio
    • Journal Title

      Transplantation Proceedings

      Volume: 54 Issue: 2 Pages: 525-527

    • DOI

      10.1016/j.transproceed.2021.08.063

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] High Expression of p62 and ALDH1A3 Is Associated With Poor Prognosis in Luminal B Breast Cancer2022

    • Author(s)
      OZAKI AYAKA、MOTOMURA HITOMI、TAMORI SHOMA、ONAGA CHOTARO、NAGASHIMA YUKA、KOTORI MAHO、MATSUDA CHIKA、MATSUDA AKARI、MOCHIZUKI NANAKO、SATO TSUGUMICHI、HARA YASUSHI、SATO KEIKO、MIYAGI YOHEI、NAGASHIMA YOJI、HANAWA TAKEHISA、HARADA YOHSUKE、XIONG YUYUN、SASAKI KAZUNORI、OHNO SHIGEO、AKIMOTO KAZUNORI
    • Journal Title

      Anticancer Research

      Volume: 42 Issue: 7 Pages: 3299-3312

    • DOI

      10.21873/anticanres.15818

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular Characterization of Metanephric Adenoma, Epithelial Wilms Tumor, and Overlap Lesions: An Integrated Whole-exome and Transcriptome Sequencing Analysis2022

    • Author(s)
      Pan Chin-Chen、Tseng Chih-En、Kuroda Naoto、Yano Mitsutake、Yasuda Masanori、Nagashima Yoji、Yeh Yi-Chen、Wang Yu-Chao、Chang Yen-Hwa、Epstein Jonathan I.
    • Journal Title

      Applied Immunohistochemistry & Molecular Morphology

      Volume: 30 Issue: 4 Pages: 257-263

    • DOI

      10.1097/pai.0000000000000996

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pituicytoma with pleomorphism: A case report with cytological findings2022

    • Author(s)
      Shimizu Ayako、Nonami Yuji、Kanamuro Toshiko、Masui Kenta、Yamamoto Tomoko、Amano Kosaku、Kawamata Takakazu、Ichihara Atsuhiro、Nagashima Yoji
    • Journal Title

      Diagnostic Cytopathology

      Volume: 51 Issue: 1

    • DOI

      10.1002/dc.25045

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immune Checkpoint Inhibitor Combination Therapy for Renal Cell Carcinomas With Concomitant Inferior Vena Cava Thrombi2022

    • Author(s)
      YOSHIDA KAZUHIKO、HATA KEISUKE、IIZUKA JUNPEI、KONDO TSUNENORI、ISHIHARA HIROKI、ISHIDA HIDEKI、NAGASHIMA YOJI、TANABE KAZUNARI、TAKAGI TOSHIO
    • Journal Title

      In Vivo

      Volume: 36 Issue: 2 Pages: 1030-1034

    • DOI

      10.21873/invivo.12798

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 5-Aminolevulinic acid-based photodynamic diagnosis for detection of urothelial carcinoma cells in bladder washing sediment suspension: A pilot study2022

    • Author(s)
      Yokoyama Takashi、Toguchi Makoto、Iizuka Junpei、Horita Shigeru、Ishizuka Tsutomu、Chu-Su Yu、Nagashima Yoji、Takagi Toshio、Tanabe Kazunari、Tokuoka Yoshikazu
    • Journal Title

      Photodiagnosis and Photodynamic Therapy

      Volume: 40 Pages: 103072-103072

    • DOI

      10.1016/j.pdpdt.2022.103072

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 針生検で診断に難渋したFumarate hydratase欠損性腎細胞癌の一例2022

    • Author(s)
      岡崎ななせ, 清水亜衣, 桑原 健; 高桑恵美, 岡田宏美, 安部崇重, 三橋智子, 篠原信雄; 長嶋洋治, 松野吉宏
    • Journal Title

      診断病理

      Volume: 39 Pages: 340-348

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] 腎細胞癌の病理診断2022

    • Author(s)
      長嶋洋治、池口歩美、稲垣茉里子、高木敏男
    • Journal Title

      日本臨床検査医学会雑誌

      Volume: 70 Pages: 537-542

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 透析腎癌の遺伝子解析2022

    • Author(s)
      石原弘喜、長嶋洋治、近藤恒徳、高木敏男
    • Journal Title

      Urology Today

      Volume: 29 Pages: 11-17

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prominent atrial fibrosis and its correlation with atrial tachyarrhythmia and dilated atrium long after classic Fontan surgery2022

    • Author(s)
      Takeuchi Daiji、Uto Kenta、Inai Kei、Nagashima Yoji、Shinkawa Takeshi
    • Journal Title

      Journal of Cardiology

      Volume: 79 Issue: 5 Pages: 671-677

    • DOI

      10.1016/j.jjcc.2021.12.005

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiple intestinal lymphangiomas with episodic hemorrhage requiring partial laparoscopic resection: a case report2022

    • Author(s)
      Kondo Hiroka、Ohki Takeshi、Ogawa Shimpei、Omori Teppei、Onizuka Hiromi、Nagashima Yoji、Yamaguchi Shigeki
    • Journal Title

      Surgical Case Reports

      Volume: 8 Issue: 1 Pages: 56-56

    • DOI

      10.1186/s40792-022-01411-y

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diagnostic Utility of Polymerase Chain Reaction for Paraffin-embedded Sinus Specimens for Rhinocerebral Mucormycosis Complicated by Internal Carotid Artery Thrombosis and Cerebral Infarction2021

    • Author(s)
      Maeda Yukiko、Toda Kunio、Toi Sono、Yano Tetsundo、Iijima Mutsumi、Shimizu Yuko、Nagashima Yoji、Itakura Yasutomo、Iguchi Shigekazu、Kikuchi Ken、Shibuya Kazutoshi、Nonaka Manabu、Kitagawa Kazuo
    • Journal Title

      Internal Medicine

      Volume: 60 Issue: 16 Pages: 2683-2686

    • DOI

      10.2169/internalmedicine.6809-20

    • NAID

      130008074645

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2021-08-15
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recurrent spindle cell carcinoma of the lung successfully treated by chemoimmunotherapy2021

    • Author(s)
      Akaba Tomohiro、Shiota Yuno、Onizawa Fumi、Isaka Tamami、Nagashima Yoji、Tagaya Etsuko
    • Journal Title

      Respirology Case Reports

      Volume: 9 Issue: 6

    • DOI

      10.1002/rcr2.757

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunochemical analysis of iron transporters and M2 macrophages in ovarian endometrioma and clear cell adenocarcinoma2021

    • Author(s)
      Akashi Keiko、Nagashima Yoji、Tabata Tsutomu、Oda Hideaki
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 15 Issue: 2

    • DOI

      10.3892/mco.2021.2321

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ovarian metastasis from breast cancer mimicking a primary ovarian neoplasm: A case report2021

    • Author(s)
      Akizawa Yoshika、Kanno Toshiyuki、Horibe Yu、Shimizu Yumi、Noguchi Eiichiro、Yamamoto Tomoko、Okamoto Takahiro、Nagashima Yoji、Tabata Tsutomu
    • Journal Title

      Molecular and Clinical Oncology

      Volume: 15 Issue: 1

    • DOI

      10.3892/mco.2021.2297

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metastatic mucinous tubular and spindle cell carcinoma of the kidney responding to nivolumab plus ipilimumab2021

    • Author(s)
      Fuchizawa Hirotaka、Kijima Toshiki、Takada‐Owada Atsuko、Nagashima Yoji、Okazaki Akihito、Yokoyama Megumi、Nishihara Daisaku、Ishida Kazuyuki、Kamai Takao
    • Journal Title

      IJU Case Reports

      Volume: 4 Issue: 5 Pages: 333-337

    • DOI

      10.1002/iju5.12342

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protective effect of SGL5213, a potent intestinal sodium-glucose cotransporter 1 inhibitor, in nonalcoholic fatty liver disease in mice2021

    • Author(s)
      Honda Yasushi、Ozaki Anna、Iwaki Michihiro、Kobayashi Takashi、Nogami Asako、Kessoku Takaomi、Ogawa Yuji、Tomeno Wataru、Imajo Kento、Yoneda Masato、Saito Satoru、Nagashima Yoji、Nakajima Atsushi
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 147 Issue: 2 Pages: 176-183

    • DOI

      10.1016/j.jphs.2021.07.002

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induced Pluripotent Stem Cell-Derived Cardiomyocytes with SCN5A R1623Q Mutation Associated with Severe Long QT Syndrome in Fetuses and Neonates Recapitulates Pathophysiological Phenotypes2021

    • Author(s)
      Hayama Emiko、Furutani Yoshiyuki、Kawaguchi Nanako、Seki Akiko、Nagashima Yoji、Okita Keisuke、Takeuchi Daiji、Matsuoka Rumiko、Inai Kei、Hagiwara Nobuhisa、Nakanishi Toshio
    • Journal Title

      Biology

      Volume: 10 Issue: 10 Pages: 1062-1062

    • DOI

      10.3390/biology10101062

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Outcome of advanced renal cell carcinoma arising in end-stage renal disease: comparison with sporadic renal cell carcinoma2021

    • Author(s)
      Ishihara Hiroki、Fukuda Hironori、Tachibana Hidekazu、Yoshida Kazuhiko、Kobayashi Hirohito、Takagi Toshio、Iizuka Junpei、Ishida Hideki、Nagashima Yoji、Kondo Tsunenori、Tanabe Kazunari
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 25 Issue: 6 Pages: 674-682

    • DOI

      10.1007/s10157-021-02038-3

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surgical resection of a rapidly growing pulmonary spindle cell carcinoma by robot-assisted thoracoscopic surgery: a case report2021

    • Author(s)
      Koen Akihiro、Maeda Hideyuki、Nagashima Yoji、Kanzaki Masato
    • Journal Title

      Surgical Case Reports

      Volume: 7 Issue: 1 Pages: 222-222

    • DOI

      10.1186/s40792-021-01305-5

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gastric Signet-Ring Cell Carcinoma That Presented as an Elevated Lesion due to Fibromuscular Obliteration in the Lamina Propria2021

    • Author(s)
      Misumi Yoshitsugu、Ichihara Shin、Nonaka Kouichi、Onizuka Hiromi、Nagashima Yoji
    • Journal Title

      Case Reports in Gastrointestinal Medicine

      Volume: 2021 Pages: 1-4

    • DOI

      10.1155/2021/2887256

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glyoxalase 1 and protein kinase Cλ as potential therapeutic targets for late-stage breast cancer.2021

    • Author(s)
      Motomura H, Ozaki A, Tamori S, Onaga C, Nozaki Y, Waki Y, Takasawa R, Yoshizawa K, Mano Y, Sato T, Sasaki K, Ishiguro H, Miyagi Y, Nagashima Y, Yamamoto K, Sato K, Hanawa T, Tanuma SI, Ohno S, Akimoto K
    • Journal Title

      Oncol Lett.

      Volume: 22 Issue: 1 Pages: 547-547

    • DOI

      10.3892/ol.2021.12808

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] t(6; 11) renal cell carcinoma. A case report successfully diagnosed by using fluorescence in situ hybridization.2021

    • Author(s)
      Nishizawa H, Baba M, Furuya M, Kato I, Kurahashi R, Honda Y, Mikami Y, Nagashima Y, Eto M, Kamba T.
    • Journal Title

      IJU Case Rep.

      Volume: 4 Issue: 6 Pages: 375-378

    • DOI

      10.1002/iju5.12353

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Monoclonal and polyclonal immunoglobulin G deposits on tubular basement membranes of native and pretransplant kidneys: A retrospective study2021

    • Author(s)
      Sawada Anri、Okumi Masayoshi、Horita Shigeru、Tamura Tomomi、Taneda Sekiko、Ishida Hideki、Hattori Motoshi、Tanabe Kazunari、Nitta Kosaku、Honda Kazuho、Koike Junki、Nagashima Yoji、Shimizu Akira
    • Journal Title

      Pathology International

      Volume: . Issue: 6 Pages: 406-14

    • DOI

      10.1111/pin.13092

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of a peritumoral pseudocapsule in patients with renal cell carcinoma undergoing robot-assisted partial nephrectomy using enhanced MDCT2021

    • Author(s)
      Toguchi Makoto、Takagi Toshio、Ogawa Yuko、Morita Satoru、Yoshida Kazuhiko、Kondo Tsunenori、Iizuka Junpei、Ishida Hideki、Nagashima Yoji、Tanabe Kazunari
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-81922-0

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiac metastasis after esophagogastrectomy for esophageal adenocarcinoma with an antemortem diagnosis2021

    • Author(s)
      Yagawa Yohsuke、Narumiya Kosuke、Kudo Kenji、Maeda Shinsuke、Toyoshima Yukinori、Ogawa Kyohei、Tanigawa Keishi、Hashimoto Yaichiro、Nagashima Yoji、Osugi Harushi、Egawa Hiroto
    • Journal Title

      Clinical Journal of Gastroenterology

      Volume: 15 Issue: 1 Pages: 77-84

    • DOI

      10.1007/s12328-021-01557-6

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Review of TFEB-amplified renal cell carcinoma with focus on clinical and pathobiological aspects2021

    • Author(s)
      Kuroda Naoto、Sugawara Emiko、Ohe Chisato、Kojima Fumiyoshi、Ohashi Riuko、Mikami Shuji、Nagashima Yoji、Peckova Kvetoslava、Michal Michal、Hes Ondrej
    • Journal Title

      Polish Journal of Pathology

      Volume: 72 Issue: 3 Pages: 197-199

    • DOI

      10.5114/pjp.2021.111769

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Papillary renal neoplasm with reverse polarity (PRNRP). 17 例 の臨床病理学的検討2023

    • Author(s)
      長嶋洋治、関敦子、井藤奈央子、吉澤佐恵子、種田積子、 鬼塚裕美、増井憲太、山本智子、倉田厚、大橋瑠子
    • Organizer
      第112回日本病理学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Xp11.2転座型腎細胞癌(Xp11.2RCC)の臨床病理学的特徴2023

    • Author(s)
      福田洋典、長嶋洋治、加藤生真、古屋充子、石原弘喜、吉田一彦、近藤恒徳、高木敏男
    • Organizer
      第53回腎癌研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 最近20年間の透析腎癌に対する治療アウトカムの検討2023

    • Author(s)
      石原弘喜、池田啓至、福田洋典、吉田一彦、小林博人、飯塚淳平、近藤恒徳、長嶋洋治、高木敏男
    • Organizer
      第53回腎癌研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] レンバチニブ・ペンブロリズマブ併用療法によりロボット支援腎摘除術が可能となった右房 に達する下大静脈腫瘍塞栓を伴う進行性腎細胞癌の一例2023

    • Author(s)
      永久知佳、吉田一彦、中山貴之、溝口晋輔、蓑田 亮、福田洋典、 小針悠希、飯塚淳平、長嶋洋治、髙木敏男
    • Organizer
      第88回日本泌尿器科学会東部総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 右心房内へ進展した腫瘍塞栓を伴う右腎盂癌の一例2023

    • Author(s)
      雲野陽大、羽田圭佑、新井貴博、子安洋輝、鈴木正章、長嶋洋治
    • Organizer
      第88回日本泌尿器科学会東部総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 遺伝性平滑筋腫症腎細胞癌症候群と診断し得たFH欠損腎細胞癌の1例2023

    • Author(s)
      高田拓弥、三浦咲子、香田弘知、増田芳雄、橋本浩次、中村真樹、長嶋洋治、森川鉄平
    • Organizer
      第113回日本病理学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] VHL変異を有する淡明細胞乳頭状腫瘍の臨床病理学的特徴:VHL変異のない淡明細胞乳頭状腫瘍との比較2023

    • Author(s)
      目 佳那子、小島史好、松崎生笛、村田晋一、林 博之、 大橋瑠子、大江知里、長嶋 洋治
    • Organizer
      第113回日本病理学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Fumarate hydratase (FH)欠損性腎細胞癌と考えられた一例2023

    • Author(s)
      藤田千佳、兵頭俊紀、長嶋洋治、西岡 遵、兵頭洋二、 藤澤正人、伊藤智雄
    • Organizer
      第113回日本病理学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 微小乳頭状構造を伴う粘液管状紡錘細胞癌様の腎細胞癌の一症例2023

    • Author(s)
      大谷方子、相田真介、藪崎 亮、石川雄一、長嶋洋治
    • Organizer
      第113回日本病理学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 末期腎不全患者に認めた腎原発肉腫の一例2023

    • Author(s)
      関 敦子、蓑田 亮、渡邉 俊、高木敏男、長嶋洋治
    • Organizer
      第113回日本病理学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 腎Low-grade oncocytic tumor(LOT)の1例2023

    • Author(s)
      矢津田 旬二、元島 崇信、神波 大己、大倉 航平、大園 一隆、 三上 芳喜、長嶋 洋治
    • Organizer
      第11回日本泌尿器病理研究会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] TFEB転座型腎細胞癌と鑑別が困難であった類上皮性血管筋脂肪腫の一例2023

    • Author(s)
      佐藤勇一郎、長安真由美、村嶋隆哉、川添智浩、向井尚一郎、賀本敏行、田中弘之、長嶋洋治、加藤生真
    • Organizer
      第11回日本泌尿器病理研究会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 腎混合性上皮性間質腫瘍の一例2023

    • Author(s)
      堀麻琴、渡邉孝太、橋詰典弘、村上大軌、瀬戸武仁、村瀬悠也、藤澤英文、松原英司、本間まゆみ、根本哲生、長嶋洋治
    • Organizer
      第459回日本医学放射線学会関東地方定期大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 腎癌取扱い規約第 5 版と WHO 分類第 5 版の改訂ポイント 、臓器系統別ワークショップ 11 最近の泌尿器・生殖器腫瘍の話題 ~改訂された癌取扱い規約とWHO分類を中心に~2022

    • Author(s)
      大江知里 、林博之、三上修治 、都築豊徳 、長嶋洋治
    • Organizer
      第111回日本病理学会総会
    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Invited
  • [Presentation] FH欠損腎細胞癌の2例(第2報)2022

    • Author(s)
      鳥山茜、佐伯春美、泉浩、冨田茂樹、辻村晃、長嶋洋治
    • Organizer
      第111回日本病理学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 癌の詳細な検索より遺伝子的な検討に至り判明した遺伝性平滑筋腫症腎細胞癌症候群随伴性腎細胞癌の一例2022

    • Author(s)
      白井裕介、畑中佳奈子、長嶋洋治、柴田有花、矢部一郎 、 宮田遙、加瀬貴美 、篠原敏也、太田聡
    • Organizer
      第111回日本病理学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 管状嚢胞状の構築を示した嫌色素性腎細胞癌好酸性亜型の一例2022

    • Author(s)
      本間志功、松沢春華、三宅美佐代、佐藤峻、廣岡信一、長嶋洋治、鷹橋浩幸
    • Organizer
      第111回日本病理学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 腎細胞がんにおける腫瘍免疫微小環境のフローサイトメトリーによる解析2022

    • Author(s)
      福田洋典、雑賀寛、時田大輔、石山亮、池田敬至、石原弘喜、立花秀和、吉田一彦、小林博人、飯塚淳平、平井敏仁、山下万喜子、北野滋久、長嶋洋治、溝口幸宏、青木一教、近藤恒徳、高木敏男
    • Organizer
      第52回腎癌研究会
    • Related Report
      2022 Research-status Report
  • [Presentation] 粘液管状紡錘細胞癌における15例の臨床的検討、2022

    • Author(s)
      小針悠希、吉田一彦、蓑田亮、福田洋典、飯塚淳平、長嶋洋治、高木敏男
    • Organizer
      第52回腎癌研究会
    • Related Report
      2022 Research-status Report
  • [Presentation] 腎芽腫治療後に対側腎に生じた転座型腎細胞癌に対してロボット支援下腎部分切除術を施行した1例2022

    • Author(s)
      藤澤俊介,原琢人,平田淳一郎,板東由加里,岡田桂輔,寺川智章,千葉公嗣,古川順也,重村克巳,中野雄造,藤澤正人,兵頭俊紀,長嶋洋治
    • Organizer
      第250回日本泌尿器科学会関西地方会
    • Related Report
      2022 Research-status Report
  • [Presentation] 腎腫瘍の分子生物学と surrogate marker を用いた診断,2022

    • Author(s)
      長嶋洋治,鬼塚裕美,増井憲太
    • Organizer
      第61回日本臨床細胞学会秋期大会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 腎癌の詳細な検索より遺伝子的な検討に至り判明した遺伝性平滑筋腫症腎細胞癌症候群随伴性腎細胞癌の一例2022

    • Author(s)
      白井裕介、畑中佳奈子、長嶋洋治、柴田有花、矢部一郎 、 宮田遙、加瀬貴美 6、篠原敏也、太田聡
    • Organizer
      第111回日本病理学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 多発性嫌色素性腎細胞癌の2例2021

    • Author(s)
      長嶋洋治、山本智子、高木敏男、吉田一彦、田邉一成
    • Organizer
      第110回日本病理学会総会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Low grade oncocytic tumor of the kidneyの2症例2021

    • Author(s)
      荻野有加、鬼塚裕美、増井憲太、山本智子、高木敏男、長嶋洋治
    • Organizer
      第110回日本病理学会総会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 腎類上皮性血管筋脂肪腫の3例2021

    • Author(s)
      矢代真友佳、鬼塚裕美、山本智子、高木敏男、長嶋洋治
    • Organizer
      Low grade oncocytic tumor of the kidneyの2症例
    • Related Report
      2021 Research-status Report
  • [Presentation] hybrid oncocytic/ chromophobe tumor (HOCT):10症例の臨床病理学的検討2021

    • Author(s)
      稲垣茉利子、山本智子、高木敏男、長嶋洋治
    • Organizer
      第110回日本病理学会総会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 令和の腎腫瘍病理~遺伝子異常を含めてシンポジウム 形態診断と遺伝子情報2021

    • Author(s)
      長嶋洋治
    • Organizer
      日本臨床検査医学会 関東甲信越支部 第76回例会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 胸水中に出現したFumarate hydratase-deficient renal cell carcinoma(フマル酸ヒドラターゼ欠損腎細胞癌)の2例2021

    • Author(s)
      佐川弘美、宇野絵梨、本野紀夫、西尾由紀子、岩下広道、山中正二、長嶋洋治、藤井誠志
    • Organizer
      第62回日本臨床細胞学会総会(春期大会)
    • Related Report
      2021 Research-status Report
  • [Presentation] 腎癌取扱い規約(第5版)の改訂点と腎腫瘍病理診断の考え方2021

    • Author(s)
      長嶋洋治
    • Organizer
      第47回茨城病院病理医の会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 病理診断特別講演「腎腫瘍の病理ー腎細胞癌(RCC) 4組織型を主軸とした診断アルゴリズムと、新規・希少腎腫瘍の診断クルーー」2021

    • Author(s)
      長嶋洋治
    • Organizer
      第67回日本病理学会秋期特別総会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Book] 正常画像と比べてわかる病理アトラス 第3版 マクロとミクロの対応で捉える病態2024

    • Author(s)
      下 正宗、 長嶋 洋治
    • Total Pages
      389
    • Publisher
      羊土社
    • ISBN
      9784758124089
    • Related Report
      2023 Annual Research Report
  • [Book] 腎癌 第2版(腫瘍病理鑑別診断アトラス)2023

    • Author(s)
      大江 知里、長嶋 洋治
    • Total Pages
      292
    • Publisher
      文光堂
    • ISBN
      9784830622663
    • Related Report
      2023 Annual Research Report
  • [Book] 病理診断に直結する切り出しのキモ2022

    • Author(s)
      亀山香織
    • Total Pages
      176
    • Publisher
      文光堂
    • ISBN
      9784830604874
    • Related Report
      2022 Research-status Report
  • [Book] 解明病理学第4版 病気のメカニズムを解く2021

    • Author(s)
      青笹 克之、加藤 光保、金井 弥栄、菅野 祐幸
    • Total Pages
      884
    • Publisher
      医歯薬出版
    • ISBN
      9784263732038
    • Related Report
      2021 Research-status Report
  • [Remarks] 東京女子医科大学病理診断学分野

    • URL

      https://www.twmu.ac.jp/univ/medical/subject/detail.php?id=02030

    • Related Report
      2023 Annual Research Report
  • [Remarks]

    • URL

      https://researchmap.jp/read0019986/

    • Related Report
      2022 Research-status Report
  • [Remarks]

    • URL

      https://nrid.nii.ac.jp/ja/nrid/1000010217995/

    • Related Report
      2022 Research-status Report
  • [Remarks] 東京女子医科大学 病理診断学分野

    • URL

      https://www.twmu.ac.jp/univ/medical/subject/detail.php?id=02030

    • Related Report
      2021 Research-status Report

URL: 

Published: 2021-04-28   Modified: 2025-01-30  

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