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Reveling the intra-cellular replication machinery of Severe fever with thrombocytopenia syndrome virus by using live-cell imaging.

Research Project

Project/Area Number 21K07059
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 49060:Virology-related
Research InstitutionNagasaki University

Principal Investigator

TAKAMATSU Yuki  長崎大学, 熱帯医学研究所, 准教授 (00750407)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsSFTSV / RNP形成 / RNP輸送 / NPモチーフ / 転写・複製 / ウイルス様粒子 / ライブセルイメージング / リバースジェネティクス / 細胞内動態 / ウイルス粒子形成 / 重症熱性血小板減少症候群 / RNP / live-cell imaging / intra-cellular dynamics / replication
Outline of Research at the Start

ライブセルイメージング技術は病原体の細胞内複製機構を理解するために非常に有用である。本研究では本邦で重要な高病原性ウイルスであるSFTSVの複製機構を、ライブセルイメージングで解明する。SFTSVの細胞内動態はほとんどわかっておらず、移動に関わる宿主因子も不明である。病原体の細胞内動態を解明することは、侵入経路・輸送経路や介在タンパク質、出芽制御因子を介した治療法を開発するための基盤となることが期待される。
本研究では、SFTSVのライブイメージングシステムを構築し、SFTSVの細胞内動態について、宿主因子を含めて解明することで、新たな作用機序の治療薬開発に貢献することを目指す。

Outline of Final Research Achievements

In this study, we aimed to establish a basis for the development of new therapeutics that regulate the intracellular replication mechanism of severe fever with thrombocytopenia syndrome virus (SFTSV). First, peptide motif mutants of nucleoproteins (NPs) were generated, and a mini-genome assay system was constructed to evaluate transcription and replication of viral genome. This system identified the amino acid region of NPs that regulates transcription and replication. Furthermore, we constructed an infectious and non-infectious live-cell imaging system to elucidate the intracellular dynamics of ribonucleoprotein complexes (RNPs) and viral particles in infected cells and their molecular mechanisms. Finally, recombinant viruses were constructed using reverse genetics to evaluate the effects of NP mutations on the mechanisms of RNP and viral particle formation.

Academic Significance and Societal Importance of the Research Achievements

本研究により、RNPのコアを形成するNPタンパク質における転写・複製を制御するペプチドモチーフを同定し、RNPの形成及び他のウイルスタンパク質との相互作用に関わる領域を同定した。本研究を通して、ウイルスゲノムの転写・複製機能を評価するレポーターアッセイ、感染細胞およびタンパク質発現系を用いたライブセルイメージングアッセイ系を構築した。これらのアッセイ系により、感染細胞におけるRNP・感染性ウイルスの侵入・形成・輸送・出芽過程の分子機構を解明することが可能になり、ウイルスの複製を制御する新しい治療薬開発の基盤を構築することができた。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (52 results)

All 2024 2023 2022 2021

All Journal Article (20 results) (of which Int'l Joint Research: 13 results,  Peer Reviewed: 18 results,  Open Access: 18 results) Presentation (32 results) (of which Int'l Joint Research: 12 results,  Invited: 2 results)

  • [Journal Article] Role of pre-existing immunity in driving the dengue virus serotype 2 genotype shift in the Philippines: A retrospective analysis of serological data2024

    • Author(s)
      Balingit JC, Dimamay MPS, Suzuki R, Matsuda M, Xayavong D, Ngwe Tun MM, Matias RR, Natividad FF, Moi ML, Takamatsu Y, Culleton R, Buerano CC, Morita K.
    • Journal Title

      Int J Infect Dis.

      Volume: 139 Pages: 59-68

    • DOI

      10.1016/j.ijid.2023.11.025

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mutations in the 3' non-coding region of a no-known vector flavivirus Yokose virus increased its replication ability in mosquito C6/36 cells2024

    • Author(s)
      Tajima S, Kataoka M, Takamatsu Y, Ebihara H, Lim CK
    • Journal Title

      Virology

      Volume: 589:109928 Pages: 1-13

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical factors associated with SFTS diagnosis and severity in cats2024

    • Author(s)
      Hiromu Osako, Qiang Xu, Takeshi Nabeshima, Jean Claude Balingit, Khine Mya Nwe, Fuxun Yu, Shingo Inoue, Daisuke Hayasaka, Mya Myat Ngwe Tun, Kouichi Morita, Yuki Takamatsu
    • Journal Title

      bioRxiv

      Volume: March 12, 2024 Pages: 1-51

    • DOI

      10.1101/2024.03.06.583784

    • Related Report
      2023 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Journal Article] A Novel, Comprehensive A129 Mouse Model for Investigating Dengue Vaccines and Evaluating Pathogenesis2023

    • Author(s)
      Ngwe Tun MM, Nwe KM, Balingit JC, Takamatsu Y, Inoue S, Pandey BD, Urano T, Kohara M, Tsukiyama-Kohara K, Morita K
    • Journal Title

      Vaccines (Basel)

      Volume: 11(12):1857 Issue: 12 Pages: 59-68

    • DOI

      10.3390/vaccines11121857

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] An outbreak of a novel lineage of dengue virus 2 in Vietnam in 20222023

    • Author(s)
      Nabeshima T, Ngwe Tun MM, Thuy NTT, Hang NLK, Mai LTQ, Hasebe F, Takamatsu Y; Nagasaki University Vietnam Research Group
    • Journal Title

      J Med Virol.

      Volume: 95(11):e29255 Issue: 11 Pages: 1-6

    • DOI

      10.1002/jmv.29255

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Serological and Molecular Epidemiology of Chikungunya Virus Infection in Vietnam, 2017-20192023

    • Author(s)
      Nguyen TV, Ngwe Tun MM, Cao MT, Dao HM, Luong CQ, Huynh TKL, Nguyen TTT, Hoang TND, Morita K, Le TQM, Pham QD, Takamatsu Y, Hasebe F.
    • Journal Title

      Viruses

      Volume: 15(10):2065 Issue: 10 Pages: 1-19

    • DOI

      10.3390/v15102065

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical, Virological, and Immunological Features in Cosmopolitan Genotype DENV-2-Infected Patients during a Large Dengue Outbreak in Sri Lanka in 20172023

    • Author(s)
      Nwe KM, Ngwe Tun MM, Muthugala R, Nabeshima T, Balingit JC, Rajamanthri L, Jayawardana D, Attanayake S, Inoue S, Takamatsu Y, Urano T, Morita K.
    • Journal Title

      Am J Trop Med Hyg.

      Volume: 109(4) Issue: 4 Pages: 917-925

    • DOI

      10.4269/ajtmh.22-0780

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Burden of Chikungunya Virus Infection during an Outbreak in Myanmar2023

    • Author(s)
      Ngwe Tun MM, Kyaw AK, Nwe KM, Myaing SS, Win YT, Inoue S, Takamatsu Y, Urano T, Thu HM, Hmone SW, Thant KZ, Morita K
    • Journal Title

      Viruses

      Volume: 15(8):1734 Issue: 8 Pages: 1-11

    • DOI

      10.3390/v15081734

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Markerless bacterial artificial chromosome manipulation method by red proteins of phage λ mediated homologous recombination utilizing fluorescent proteins for both positive and counter selection2023

    • Author(s)
      Yoshikawa Tomoki、Misu Masayasu、Kurosu Takeshi、Takamatsu Yuki、Sugimoto Satoko、Shimojima Masayuki、Ebihara Hideki、Saijo Masayuki
    • Journal Title

      Heliyon

      Volume: 9 Issue: 8 Pages: 1-13

    • DOI

      10.1016/j.heliyon.2023.e18983

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epidemiological evidence of acute transmission of Zika virus infection in dengue suspected patients in Sri-Lanka2023

    • Author(s)
      Ngwe Tun MM, Raini SK, Fernando L, Gunawardene Y, Inoue S, Takamatsu Y, Urano T, Muthugala R, Hapugoda M, Morita K
    • Journal Title

      J Infect Public Health.

      Volume: 16(9) Issue: 9 Pages: 1435-1442

    • DOI

      10.1016/j.jiph.2023.07.014

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Coinfection and circulation of chikungunya virus and dengue virus in pediatric patients in Myanmar, 20192023

    • Author(s)
      Ngwe Tun MM, Kyaw AK, Nabeshima T, Dumre SP, Soe AM, Nwe KM, Myaing SS, Lwin EP, Win YT, Inoue S, Takamatsu Y, Urano T, Thu HM, Thant KZ, Htun ZT, Morita K
    • Journal Title

      Microbes Infect.

      Volume: 25(6):105129 Issue: 6 Pages: 1-9

    • DOI

      10.1016/j.micinf.2023.105129

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] How an Outbreak of COVID-19 Circulated Widely in Nepal: A Chronological Analysis of the National Response to an Unprecedented Pandemic2022

    • Author(s)
      Pandey Basu Dev、Ngwe Tun Mya Myat、Pandey Kishor、Dumre Shyam Prakash、Nwe Khin Mya、Shah Yogendra、Culleton Richard、Takamatsu Yuki、Costello Anthony、Morita Kouichi
    • Journal Title

      Life

      Volume: 12 Issue: 7 Pages: 1087-1087

    • DOI

      10.3390/life12071087

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corrigendum to “The novel therapeutic target and inhibitory effects of PF-429242 against Zika virus infection” [Antivir. Res. vol 192 (2021) 1?13/105121]2022

    • Author(s)
      Raini Sandra Kendra、Takamatsu Yuki、Dumre Shyam Prakash、Urata Shuzo、Mizukami Shusaku、Moi Meng Ling、Hayasaka Daisuke、Inoue Shingo、Morita Kouichi、Ngwe Tun Mya Myat
    • Journal Title

      Antiviral Research

      Volume: 199 Pages: 105245-105245

    • DOI

      10.1016/j.antiviral.2022.105245

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural insight into Marburg virus nucleoprotein?RNA complex formation2022

    • Author(s)
      Fujita-Fujiharu Yoko、Sugita Yukihiko、Takamatsu Yuki、Houri Kazuya、Igarashi Manabu、Muramoto Yukiko、Nakano Masahiro、Tsunoda Yugo、Taniguchi Ichiro、Becker Stephan、Noda Takeshi
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41467-022-28802-x

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of VP30 Phosphorylation in Ebola Virus Nucleocapsid Assembly and Transport2022

    • Author(s)
      Takamatsu Yuki、Yoshikawa Tomoki、Kurosu Takeshi、Fukushi Shuetsu、Nagata Noriyo、Shimojima Masayuki、Ebihara Hideki、Saijo Masayuki、Noda Takeshi
    • Journal Title

      Journal of Virology

      Volume: 96 Issue: 17 Pages: 1-17

    • DOI

      10.1128/jvi.01083-22

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neutralizing mAbs against SFTS Virus Gn Protein Show Strong Therapeutic Effects in an SFTS Animal Model2022

    • Author(s)
      Shimojima Masayuki、Sugimoto Satoko、Umekita Kunihiko、Onodera Taishi、Sano Kaori、Tani Hideki、Takamatsu Yuki、Yoshikawa Tomoki、Kurosu Takeshi、Suzuki Tadaki、Takahashi Yoshimasa、Ebihara Hideki、Saijo Masayuki
    • Journal Title

      Viruses

      Volume: 14 Issue: 8 Pages: 1665-1665

    • DOI

      10.3390/v14081665

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ウイルス粒子の形成過程を視る ─ ライブセルイメージングシステムを用いた高病原性ウイルス細胞内動態の解明2022

    • Author(s)
      髙松 由基
    • Journal Title

      医学のあゆみ

      Volume: 280 Pages: 926-932

    • Related Report
      2021 Research-status Report
  • [Journal Article] CP100356 Hydrochloride, a P-Glycoprotein Inhibitor, Inhibits Lassa Virus Entry: Implication of a Candidate Pan-Mammarenavirus Entry Inhibitor2021

    • Author(s)
      Takenaga T, Zhang Z, Muramoto Y, Fehling SK, Hirabayashi A, Takamatsu Y, Kajikawa J, Miyamoto S, Nakano M, Urata S, Groseth A, Strecker T, Noda T.
    • Journal Title

      Viruses

      Volume: 13 Issue: 9 Pages: 1763-1763

    • DOI

      10.3390/v13091763

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The novel therapeutic target and inhibitory effects of PF-429242 against Zika virus infection.2021

    • Author(s)
      Sandra Kendra Raini, Yuki Takamatsu, Shyam Prakash Dumre, Shuzo Urata, Shusaku Mizukami, Meng Ling Moi, Dasuke Haysaka, Shingo Inoue, Kouichi Morita, Mya Myat Ngwe Tun.
    • Journal Title

      Antiviral Research.

      Volume: 192 Pages: 1-13

    • DOI

      10.1016/j.antiviral.2021.105121

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of an RT-LAMP Assay for the Rapid Detection of SFTS Virus.2021

    • Author(s)
      Shiori Sano, Shutetsu Fukushi, Souichi Yamada, Shizuko Harada, Hitomi Kinoshita, Satoko Sugimoto, Tomoki Yoshikawa, Takeshi Kurosu, Yuki Takamatsu, Masayuki Shimojima, Shoichi Toda, Yuka Hamada, Naoki Fujisawa, Takayuki Sugimoto, Masayuki Saijo.
    • Journal Title

      Viruses

      Volume: 13(4) Issue: 4 Pages: 1-11

    • DOI

      10.3390/v13040693

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Clinical manifestations of dengue in relation to dengue serotype in Vung Tau province, Vietnam 2020 to 20212023

    • Author(s)
      Nguyen Thi Thanh Ngan, Stefania Fraenkel Calcena, Takeshi Nabeshima, Dalouny Xayavong, Jean Claude Balingit Palma, Mya Myat Ngwe Tun, Kouichi Morita, Futoshi Hasebe, and Yuki Takamatsu
    • Organizer
      第29回トガ・フラビ・ペスチウイルス研究会プログラム
    • Related Report
      2023 Annual Research Report
  • [Presentation] Development of new RT-PCR primers largely utilized in Asian dengue epidemics2023

    • Author(s)
      Stefania Fraenkel Calcena, Takeshi Nabeshima, Dalouny Xayavong, Jean Claude Balingit Palma, Mya Myat Ngwe Tun, Kouichi Morita, Futoshi Hasebe, and Yuki Takamatsu
    • Organizer
      第57回日本脳炎ウイルス生態学研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Clinical manifestations of dengue in relation to dengue serotype in Vung Tau province, Vietnam 2020 to 20212023

    • Author(s)
      Nguyen Thi Thanh Ngan, Taichiro Takemura, Takeshi Nabeshima, Yuki Takamatsu, Futoshi Hasebe, etc.
    • Organizer
      第57回日本脳炎ウイルス生態学研究会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Dynamics of Dengue virus in Vung Tau, Southern Vietnam2023

    • Author(s)
      Nabeshima T, Ngwe Tun MM, Thuy NTT, Hang NLK, Mai LTQ, Hasebe F, Takamatsu Y; Nagasaki University Vietnam Research Group
    • Organizer
      第70回日本ウイルス学会学術集会
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The important motif of nucleocapsid protein to reveal the molecular machinery of SFTSV2023

    • Author(s)
      Qiang Xu, Satoshi Taniguchi, Jean Claude Balingit, Takeshi Nabeshima, Mya Myat Ngwe Tun, Masayuki Shimojima, Yuki Takamatsu
    • Organizer
      第70回日本ウイルス学会学術集会
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Coinfection and circulation of chikungunya virus and dengue virus in pediatric patients in Myanmar, 20192023

    • Author(s)
      Mya Myat Ngwe Tun, Aung Kyaw Kyaw, Takeshi Nabeshima, Shyam Prakash Dumre, Aung Min Soe, Khine Mya Nwe, Su Su Myaing, Ei Phyu Lwin, Ye Thu Win, Shingo Inoue, Yuki Takamatsu, Takeshi Urano, Hlaing Myat Thu, Kyaw Zin Thant, Zaw Than Htun, Kouichi Morita
    • Organizer
      第70回日本ウイルス学会学術集会
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Insights on the mechanism of dengue virus serotype 2 genotype shift in the Philippines2023

    • Author(s)
      Jean Claude Balingit, Mark Pierre Dimamay, Ryosuke Suzuki, Mami Matsuda, Dalouny Xayavong, Mya Myat Ngwe Tun, Ronald Matias, Filipinas Natividad, Richard Culleton, Meng Ling Moi, Yuki Takamatsu, Corazon Buerano, Kouichi Morita
    • Organizer
      第70回日本ウイルス学会学術集会
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characterization of cross-reactive peptides with SARS-CoV-2 VOCs in Vietnam before COVID-19 pandemic.2023

    • Author(s)
      Ngan Thi Thanh Nguyen, Linh Ngoc Nguyen, Hau Thi Bich Vu, Thuy Thi Thu Nguyen, Thanh Thi Le, Phuong Vu Mai Hoang, Hang Le Khanh Nguyen, Anh Duc Dang, Mai Thi Quynh Le, Meng Ling Moi, Yuki Takamatsu, Hasebe Futoshi, Morita Kouichi
    • Organizer
      第70回日本ウイルス学会学術集会
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ベトナムにおけるデングウイルス感染症研究2023

    • Author(s)
      Yuki Takamatsu
    • Organizer
      グローバルヘルス合同大会2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chikungunya virus infection in blood donors and patients during outbreak, Mandalay, Myanmar, 2019.2022

    • Author(s)
      Mya Myat Ngwe Tun, Aung Kyaw Kyaw, Takeshi Nabeshima, Khine Mya Nwe, shingo Inoue, Basu Dev Pandey, Yuki Takamatsu, Kyaw Zin Thant, Kouichi Morita
    • Organizer
      第56回日本脳炎ウイルス生態学研究会
    • Related Report
      2022 Research-status Report
  • [Presentation] The Potential Role of Antigenic Variation in Driving the Dengue Virus Serotype 2 Genotype Shift in the Philippines in the Early 2000.2022

    • Author(s)
      Jean Claude Palma Balingit, Ryosuke Suzuki, Mark Pierre Dimamay, Ronald Matias, Filipinas Natividad, Corazon Buerano, Yuki Takamatsu, Meng Ling Moi, Kouichi Morita
    • Organizer
      第56回日本脳炎ウイルス生態学研究会
    • Related Report
      2022 Research-status Report
  • [Presentation] Analysis of Dengue outbreak during the 2020 epidemic in Myanmar.2022

    • Author(s)
      Khine Mya Nwe, Mya Myat Ngwe Tun, Aung Kyaw Kyaw, Rina Iraha, Takeshi Nabeshima, Shingo Inoue, Basu Dev Pandey, Yuki Takamatsu, Kyaw Zin Thant, Kouichi Morita
    • Organizer
      第56回日本脳炎ウイルス生態学研究会
    • Related Report
      2022 Research-status Report
  • [Presentation] ライブセルイメージングによる高病原性ウイルス細胞内動態の解明2022

    • Author(s)
      髙松 由基
    • Organizer
      日本顕微鏡 学会第78回学術講演会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] フィロウイルスヌクレオカプシドのアセンブル機構2022

    • Author(s)
      髙松由基, 野田岳志
    • Organizer
      九州微生物研究フォーラム
    • Related Report
      2022 Research-status Report
  • [Presentation] ライブセルイメージングシステムを用いた高病原性ウイルス細胞内動態の解明2022

    • Author(s)
      Yuki Takamatsu, Takeshi Noda, Stephan Becker
    • Organizer
      第63回日本熱帯医学会大会
    • Related Report
      2022 Research-status Report
  • [Presentation] Serological and molecular epidemiology of chikungunya virus infection in Vietnam, 2015 to 20192022

    • Author(s)
      Nguyen Thanh Vu, Ngwe Tun My Myat, Takamatsu Yuki, Moi Meng Ling, Le Thi Quynh Mai, Morita Kouichi, Hasebe Futosh
    • Organizer
      第63回日本熱帯医学会大会
    • Related Report
      2022 Research-status Report
  • [Presentation] The Potential Role of Antigenic Variation in Driving the Dengue Virus Serotype 2 Genotype Shift in the Philippines in the Early 20002022

    • Author(s)
      Balingit Jean Claude, Ryosuke Suzuki, Dimamay Mark Pierre, Matias Ronald, Natividad Filipinas, Buerano Corazon, Yuki Takamatsu,Moi Meng Ling, Kouichi Morita
    • Organizer
      第63回日本熱帯医学会大会
    • Related Report
      2022 Research-status Report
  • [Presentation] Anti-SARS-CoV-2 activity of various PET-bottled Japanese green teas and tea compounds in vitro2022

    • Author(s)
      Ngwe Tun Mya Myat, Luvai Elizabeth, Nwe Khine Mya, Toume Kazufumi, Mizukami Shusaku, Takamatsu Yuki, Hirayama Kenji, Komatsu Katsuko, Morita Kouichi
    • Organizer
      第63回日本熱帯医学会大会
    • Related Report
      2022 Research-status Report
  • [Presentation] ウイルスタンパク質VP30に着目したフィロウイルス粒子形成機構の解明2022

    • Author(s)
      Yuki Takamatsu, Takeshi Noda, Becker Stephan
    • Organizer
      第69回日本ウイルス学会学術集会
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] The discovery of herbal drugs and natural compounds as inhibitors of SARS-CoV-2 infection in vitro2022

    • Author(s)
      Mya Myat Ngwe Tun, Kazufumi Toume, Elizabeth Luvai, Khine Mya Nwe, Yuki Takamatsu, Shusaku Mizukami, Kenji Hirayama, Katsuko Komatsu, Kouichi Morita
    • Organizer
      第69回日本ウイルス学会学術集会
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] The potential role of antigenic variation in driving the dengue virus serotype 2 genotype shift in the Philippines in the early 20002022

    • Author(s)
      Jean Claude Palma Balingit, Ryosuke Suzuki, Mark Pierre Dimamay, Ronald Matias, Filipinas Natividad, Corazon Buerano, Yuki Takamatsu, Meng Ling Moi, Kouichi Morita
    • Organizer
      第69回日本ウイルス学会学術集会
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Seroprevalence of Chikungunya virus infection during its emergence in Myanmar2022

    • Author(s)
      Khine Mya Nwe, Mya Myat Ngwe Tun, Aung Kyaw Kyaw, Saw Wut Hmone, Yuki Takamatsu, Shingo Inoue, Kyaw Zin Thant, Kouichi Morita
    • Organizer
      第69回日本ウイルス学会学術集会
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Serological and molecular epidemiology of chikungunya virus infection in Vietnam. 2015-20192022

    • Author(s)
      Vu Thanh Nguyen, Mya Myat Ngwe Tun, Yuki Takamatsu , 面gLing Moi, Mai Thi Quynh Le, Kouichi Moirta , Futoshi Hasebe
    • Organizer
      第69回日本ウイルス学会学術集会
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Lost in transcription: How VP30 regulates filoviral RNA synthesis2022

    • Author(s)
      Lennart Kaemper, Yuki Takamatsu, Thomas Kruse, Jakob Nilsson, Nadine Biedenkopf
    • Organizer
      10th International Filovirus Symposium, San Diego
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] フィロウイルスヌクレオカプシド形成機構の解明2021

    • Author(s)
      高松 由基、Olga Dolnik、野田 岳志、西條 政幸、Stephan Becker
    • Organizer
      第68回日本ウイルス学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] オートファジー誘導によるリンパ球性脈絡髄膜炎ウイルス感染細胞の細胞死回避2021

    • Author(s)
      梶川 純一, 平林  愛, 宮本  翔, 高松 由基, 胡  上帆, 野澤 孝志, 中川 一路, 浦田 秀造, 安田 二朗, 遊佐 宏介, 中野 雅博, 村本裕紀子, 野田 岳志
    • Organizer
      第68回日本ウイルス学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] エストロゲン受容体作動薬はラッサウイルスの細胞侵入を阻害する2021

    • Author(s)
      張  子涵, 武長  徹, 村本 裕紀子, Katharina Fehling Sarah, 平林  愛, 髙松 由基, 梶川 純一, 宮本  翔, 中野 雅博, 浦田 秀造, Groseth Allison、Strecker Thomas, 野田 岳志
    • Organizer
      第68回日本ウイルス学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 迅速・簡便かつ正確なRNAウイルスの全ゲノム配列決定法の確立2021

    • Author(s)
      三須 政康, 吉河 智城, 黒須  剛, 高松 由基, 王寺 幸輝, 下島 昌幸、吉川 正英, 西條 政幸
    • Organizer
      第68回日本ウイルス学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] SFTSウイルス遺伝子を保持する高度弱毒化痘そうワクチン株LC16m8を免疫したマウスで誘導される液性免疫のワクチン効果への寄与2021

    • Author(s)
      吉河 智城, 三須 政康, 黒須  剛, 高松 由基, 杉元 聡子, 下島 昌幸, 西條 政幸
    • Organizer
      第68回日本ウイルス学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] SFTSウイルスの新規病原因子の同定2021

    • Author(s)
      下島 昌幸, 米満 研三, 網  康至, 杉元 聡子, 髙松 由基, 吉河 智城, 黒須  剛, 西條 政幸
    • Organizer
      第68回日本ウイルス学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 致死性デング出血熱マウスモデルを用いた高サイトカイン産生誘導による重症化機序の解明2021

    • Author(s)
      黒須  剛、 奥崎 大介, 下島 昌幸, 吉河 智城, 髙松 由基, 西條 政幸
    • Organizer
      第68回日本ウイルス学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] マールブルグウイルス 核タンパク質-RNA複合体の構造解析2021

    • Author(s)
      藤田 陽子, 杉田 征彦, 髙松 由基, 祝部 和也, 五十嵐 学, 角田 優伍, 村本裕紀子, 中野 雅博, Becker Stephan, 野田 岳志
    • Organizer
      第68回日本ウイルス学会学術集会
    • Related Report
      2021 Research-status Report

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Published: 2021-04-28   Modified: 2025-01-30  

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