The role of cMaf on the development of IL-17-producing invariant NKT cells.

• Project/Area Number: 21K07066
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49070:Immunology-related
• Research Institution: Kanazawa University
• Principal Investigator: D NYAMBAYAR 金沢大学, 医学系, 准教授 (50443057)
• Co-Investigator(Kenkyū-buntansha): 渡会 浩志 金沢大学, 医学系, 教授 (70415339)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Project Status: Granted (Fiscal Year 2021)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: invariant NKT / thymus / differentiation / development / function

Outline of Research at the Start

The recent advances in the iNKT cell research field has uncovered many important features of iNKT cell development and function. However, the mechanisms driving the differentiation of iNKT cell functional subsets remains still incompletely understood. Here, the applicant proposes to investigate the role and function of the transcription factor cMaf and B lymphoid kinase (Blk) on the development of IL-17A-producing iNKT cell subset differentiation.