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elderly-onset inflammatory diseases-inflammageing & epigenome-

Research Project

Project/Area Number 21K07326
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52010:General internal medicine-related
Research InstitutionSaitama Medical University

Principal Investigator

三村 俊英  埼玉医科大学, 医学部, 教授 (30260491)

Project Period (FY) 2021-04-01 – 2025-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2023: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2022: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords高齢発症炎症疾患 / 関節リウマチ / エピゲノム / リウマチ性多発筋痛症 / エピゲノム制御 / inflammageing
Outline of Research at the Start

我が国を始め多くの先進国では高齢人口の増加が大きな問題となり、高齢者の疾患も注目を集めている。高齢発症慢性炎症性疾患(高齢発症関節リウマチやリウマチ性多発筋痛症)は近年発症の増加が明らかで、共通する症状や病態があるが、病態の基盤となる原因は不明である。
本研究は、遺伝子変化によらずにタンパク発現変化をきたし病態に関与するエピゲノムの異常と高齢になると来しやすい炎症状態(inflammageing)の観点から、関節リウマチやリウマチ性多発筋痛症患者検体から得られるエピゲノムに関するbig dataを用いて高齢発症慢性炎症性疾患の共通病態を解明し、高齢者の健康寿命の改善に貢献することを目的とする。

Outline of Annual Research Achievements

令和5年度には、高齢者(70歳以上)と非高齢者(70歳未満)に分けて、関節リウマチ(RA)患者対照疾患としての変形性関節症(OA)患者の滑膜線維芽細胞におけるヒストンメチル化の程度と疾患の特徴及び活動性を確認した。今年度に紙面での同意の下に収集し得た患者滑膜組織;高齢RA =10例、非高齢 = 10例、高齢OA = 7、非高齢OA = 3。非高齢OAは患者数が少ないため、解析結果には注意を要する。
今まで確認してこなかった高齢者群と非高齢群に分けてのRAとOAとの間での比較を行い、ヒストン3の36番のリシンのジメチル化(H3K36me2)に関して、RAのみで行ってきた内容とは異なる結果を得た。解析遺伝子に関しては、RAとOA間にmRNA発現の有意差を示した遺伝子に絞って確認した。その結果の概略を以下に示す。
1)H3K36のジメチル化に関与するメチル化酵素のNSD2のmRNA発現をRAとOA間で比較したところ、RAにおいて有意に発現の亢進が認められた。このRAとOAにおけるNSD2mRNA発現量の比を、高齢者と非高齢者に分けて比較してみると、高齢者においてはRA/OA=1.33であるが、非高齢者においては、RA/OA=2.29と非高齢者群においてRAとOA間に有意な開きのあることが明らかになった。
2)H3K36me2のChIPにおいて、非高齢患者群での比較では、%INPUTにおいてRA/OAはMMP-13、IL-8、CCL2において有意にRAで高値であった。一方、高齢者群ではこれらの差は消失していた。
3)高齢RAと非高齢RA患者における、自己抗体を検討した。その結果、リウマトイド因子(RF)は高齢RAのと非高齢RAの平均値には有意差はなかった。一方、抗CCP抗体価に関しては、高齢RA(213.2)と非高齢RA(104.2)の比較では、有意差をもって高齢RA患者群で高値であった。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

前年までは、同意取得患者数が比較的少なく、RAのみにおける解析が主であったが、令和5年度にはリクルートできた患者数も増え、RAとOAにおいて、高齢群と非高齢群とに分けて比較することが可能となった。この意味で、進捗はおおむね順調に進んでいると判断した。しかし、上記したように想定していなかった新たな知見が得られた。この結果が臨床的にどのような意味を持つのかをさらに検討する必要があり、次年度に本研究を延長して、epigenomeとinflammagingの関係を明らかにするという最終的な結論を得たいと考えた。

Strategy for Future Research Activity

滑膜組織を用いた、RAとOAにおける高齢群と非高齢群間でのepigeneticな比較を進めることと、この明かな差異を臨床データと付き合わせることで、inflammagingに関連する臨床的な意味を検討し、epigenomeとinflammagingの関係を明らかにすることができると考えている。患者末梢血に関しては、収集を進め、70から75例ほどになれば血中サイトカインやケモカインの測定を開始する。

Report

(3 results)
  • 2023 Research-status Report
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (42 results)

All 2024 2023 2022 2021 Other

All Journal Article (19 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 19 results,  Open Access: 18 results) Presentation (17 results) (of which Int'l Joint Research: 5 results) Book (5 results) Remarks (1 results)

  • [Journal Article] Successful Treatment of Diffuse Large B-cell Lymphoma Involving Multiple Renal and Bone Infiltrations Presenting with Giant Cell Arteritis-like Manifestations2024

    • Author(s)
      Yokota Kazuhiro、Morimoto Kota、Yazawa Hiroaki、Tsuzuki Wada Takuma、Sakamoto Tomoyuki、Terui Yasuhito、Kaneko Satoru、Inoue Tsutomu、Okada Hirokazu、Akiyama Yuji、Mimura Toshihide
    • Journal Title

      Internal Medicine

      Volume: 63 Issue: 11 Pages: 1645-1652

    • DOI

      10.2169/internalmedicine.2377-23

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2024-06-01
    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epigenetic Dysregulation in the Pathogenesis of Systemic Lupus Erythematosus2024

    • Author(s)
      Araki Yasuto、Mimura Toshihide
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 25 Issue: 2 Pages: 1019-1019

    • DOI

      10.3390/ijms25021019

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of cytokine and chemokine expression by histone lysine methyltransferase MLL1 in rheumatoid arthritis synovial fibroblasts2024

    • Author(s)
      Okamoto Keita、Araki Yasuto、Aizaki Yoshimi、Tanaka Shinya、Kadono Yuho、Mimura Toshihide
    • Journal Title

      Scientific Reports

      Volume: 14 Issue: 1

    • DOI

      10.1038/s41598-024-60860-7

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] New-onset Immune-mediated Necrotizing Myopathy and Trigeminal Neuropathy after SARS-CoV-2 mRNA Vaccination in a Patient with Rheumatoid Arthritis and Sjögren's Syndrome2023

    • Author(s)
      Tsuzuki Wada Takuma、Yokota Kazuhiro、Inayoshi Fumito、Sakai Sakon、Okumura Nobuhito、Matsuda Mayumi、Osawa Iichiro、Araki Yasuto、Funakubo Asanuma Yu、Akiyama Yuji、Mimura Toshihide
    • Journal Title

      Internal Medicine

      Volume: 62 Issue: 24 Pages: 3699-3706

    • DOI

      10.2169/internalmedicine.2551-23

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2023-12-15
    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Encapsulating Peritoneal Sclerosis in Systemic Lupus Erythematosus, Rheumatoid Arthritis, and Systemic Sclerosis2023

    • Author(s)
      Matsuda Mayumi、Yokota Kazuhiro、Ichimura Takaya、Sakai Sakon、Maruyama Takashi、Tsuzuki Wada Takuma、Araki Yasuto、Funakubo Asanuma Yu、Akiyama Yuji、Sasaki Atsushi、Mimura Toshihide
    • Journal Title

      Internal Medicine

      Volume: 62 Issue: 11 Pages: 1683-1689

    • DOI

      10.2169/internalmedicine.9793-22

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2023-06-01
    • Related Report
      2023 Research-status Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relapsing Polychondritis and Aseptic Meningoencephalitis2023

    • Author(s)
      Yokota Kazuhiro、Tachibana Hideyuki、Miyake Akifumi、Yamamoto Toshimasa、Mimura Toshihide
    • Journal Title

      Internal Medicine

      Volume: 62 Issue: 3 Pages: 481-486

    • DOI

      10.2169/internalmedicine.9411-22

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2023-02-01
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] New-onset Adult-onset Still's Disease Following COVID-19 Vaccination: Three Case Reports and a Literature Review2023

    • Author(s)
      Matsuda Mayumi、Funakubo Asanuma Yu、Yokota Kazuhiro、Sakai Sakon、Yazawa Hiroaki、Maruyama Takashi、Tsuzuki Wada Takuma、Araki Yasuto、Mimura Toshihide
    • Journal Title

      Internal Medicine

      Volume: 62 Issue: 2 Pages: 299-305

    • DOI

      10.2169/internalmedicine.0590-22

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2023-01-15
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Essentiality of Nfatc1 short isoform in osteoclast differentiation and its self-regulation2023

    • Author(s)
      Omata Yasuhiro、Tachibana Hideyuki、Aizaki Yoshimi、Mimura Toshihide、Sato Kojiro
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 18797-18797

    • DOI

      10.1038/s41598-023-45909-3

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synovial Tissue Heterogeneity in Japanese Patients With Rheumatoid Arthritis Elucidated Using a <scp>Cell‐Type</scp> Deconvolution Approach2023

    • Author(s)
      Nakajima Sotaro, Tsuchiya Haruka, Ota Mineto, Ogawa Megumi, Yamada Saeko, Yoshida Ryochi, Maeda Junko, Shirai Harumi, Kasai Taro, Hirose Jun, Ninagawa Keita, Fujieda Yuichiro, Iwasaki Takeshi, Aizaki Yoshimi, Kajiyama Hiroshi et al.,
    • Journal Title

      Arthritis & Rheumatology

      Volume: 75 Issue: 12 Pages: 2130-2136

    • DOI

      10.1002/art.42642

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of anti-severe acute respiratory syndrome coronavirus 2 antibody levels in coronavirus disease breakthrough infection during immunosuppressive therapy in a patient with connective tissue disease-related interstitial lung disease2023

    • Author(s)
      Wada TT, Yokota K, Sakai S, Soma M, Kajiyama H, Tarumoto N, Maesaki S, Maeda T, Nagata M, Mimura T
    • Journal Title

      Mod Rheumatol Case Rep

      Volume: 7 Issue: 1 Pages: 288-292

    • DOI

      10.1093/mrcr/rxac052

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Branched chain amino acids in the treatment of polymyositis and dermatomyositis: a phase II/III, multi-centre, randomized controlled trial2022

    • Author(s)
      Kimura Naoki、Kawahara Takuya、Uemura Yukari、Atsumi Tatsuya、Sumida Takayuki、Mimura Toshihde、Kawaguchi Yasushi、Amano Hirofumi、et al.
    • Journal Title

      Rheumatology

      Volume: 61 Issue: 11 Pages: 4445-4454

    • DOI

      10.1093/rheumatology/keac101

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the Validity of SARS-CoV-2 Infection Control Measures through Antibody Testing for Employees of a University and Hospital2022

    • Author(s)
      Wada Takuma Tsuzuki、Yokota Kazuhiro、Tarumoto Norihito、Maesaki Shigefumi、Tomiya Tomoaki、Maeda Takuya、Mimura Toshihide
    • Journal Title

      International Journal of Clinical Medicine

      Volume: 13 Issue: 03 Pages: 83-89

    • DOI

      10.4236/ijcm.2022.133007

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improvement in Glucocorticoid-Induced Osteoporosis on Switching from Bisphosphonates to Once-Weekly Teriparatide: A Randomized Open-Label Trial2022

    • Author(s)
      Nanki Toshihiro、Kawazoe Mai、Uno Kiyoko、Hirose Wataru、Dobashi Hiroaki、Kataoka Hiroshi、Mimura Toshihide、Hagino Hiroshi、Kono Hajime
    • Journal Title

      Journal of Clinical Medicine

      Volume: 12 Issue: 1 Pages: 292-292

    • DOI

      10.3390/jcm12010292

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Abatacept ameliorates both glandular and extraglandular involvements in patients with Sjogren’s syndrome associated with rheumatoid arthritis: Findings from an open-label, multicentre, 1-year, prospective study: The ROSE (Rheumatoid Arthritis with Orencia Trial Toward Sj?gren’s Syndrome Endocrinopathy) and ROSE II trials2022

    • Author(s)
      Tsuboi H, Toko H, Honda F, Abe S, Takahashi H, Yagishita M, Hagiwara S, Ohyama A, Kondo Y, Nakano K, Tanaka Y, Shimizu T, Nakamura H, Kawakami A, Fujieda Y, Atsumi T, Suzuki Y, Kawano M, Nishina N, Kaneko Y, Takeuchi T, Kobayashi H, Takei M, Ogasawara M, Tamura N, Takasaki Y, Yokota K, Akiyama Y, Mimura T, et al.
    • Journal Title

      Modern Rheumatology

      Volume: 33 Issue: 1 Pages: 160-168

    • DOI

      10.1093/mr/roac011

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induction of memory-like CD8+ T cells and CD4+ T cells from human naive T cells in culture2022

    • Author(s)
      Yasuhito Tokumoto, Yasuto Araki, Yusuke Narizuka, Yosuke Mizuno, Susumu Ohshima, Toshihide Mimura
    • Journal Title

      Clinical and Experimental Immunology

      Volume: 207 Issue: 1 Pages: 95-103

    • DOI

      10.1093/cei/uxab012

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dual effects of interleukin-10 on natural killer cells and monocytes and the implications for adult-onset Still's disease2021

    • Author(s)
      Aizaki Yoshimi、Yazawa Hiroaki、Sato Kojiro、Mimura Toshihide
    • Journal Title

      Clinical and Experimental Rheumatology

      Volume: 39 Issue: 5 Pages: 22-29

    • DOI

      10.55563/clinexprheumatol/2vdem0

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization and Function of Tumor Necrosis Factor alpha and Interleukin‐6‐Induced Osteoclasts in Rheumatoid Arthritis2021

    • Author(s)
      Yokota Kazuhiro、Sato Kojiro、Miyazaki Takashi、Aizaki Yoshimi、Tanaka Shinya、Sekikawa Miyoko、Kozu Noritsune、Kadono Yuho、Oda Hiromi、Mimura Toshihide
    • Journal Title

      Arthritis & Rheumatology

      Volume: in press Issue: 7 Pages: 1145-1154

    • DOI

      10.1002/art.41666

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy, safety, and adherence of tocilizumab therapy in elderly patients with rheumatoid arthritis: A real-world observational study.2021

    • Author(s)
      Nakao Y, Asanuma YF, Wada TT, Matsuda M, Yazawa H, Yoshida Y, Todoriki A, Shintani A, Mimura T.
    • Journal Title

      European Journal of I Inflammation

      Volume: 19 Pages: 1-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Texture analysis of muscle MRI: machine learning-based classifications in idiopathic inflammatory myopathies2021

    • Author(s)
      Nagawa Keita、Suzuki Masashi、Yamamoto Yuuya、Inoue Kaiji、Kozawa Eito、Mimura Toshihide、Nakamura Koichiro、Nagata Makoto、Niitsu Mamoru
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-89311-3

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 関節リウマチ滑膜線維芽細胞における転写 因子SOX11 によるサイトカインとケモカイン遺伝子発現の制御異常2023

    • Author(s)
      荒木靖人,岡元啓太,相崎良美,横田和浩, 梶山浩,舟久保ゆう,秋山雄次,門野夕峰, 三村俊英
    • Organizer
      第67回日本リウマチ学会総会・学術集会
    • Related Report
      2023 Research-status Report
  • [Presentation] Filgotinib Inhibits the Differentiation and Function of Tumor Necrosis Factor alpha and Interleukin-6- Induced Osteoclasts Derived from Peripheral Blood Monocytes in Patients with Rheumatoid Arthritis2023

    • Author(s)
      Kazuhiro Yokota,Yoshimi Aizaki,Hiroshi Kajiyama,Yasuto Araki,Yuji Akiyama,Toshihide Mimura
    • Organizer
      第67回日本リウマチ学会総会・学術集会
    • Related Report
      2023 Research-status Report
  • [Presentation] Janus Kinase Inhibitor Suppresses the Differentiation and Function of Tumor Necrosis Factor-alpha and Interleukin-6-Induced Osteoclasts in Peripheral Blood Monocytes from Patients with Rheumatoid Arthritis2023

    • Author(s)
      Yokata,K, Aizaki Y, Kajiyama H, Araki Y, Yazawa H, Akiyama Y, Mimura T
    • Organizer
      EULAR 2023
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] RANKL誘導性破骨細胞とTNF-αとIL-6誘導性破骨細胞に対するJAK阻害薬の作用2023

    • Author(s)
      横田和浩,相崎良美,和田琢,矢澤宏晃,梶山浩,荒木靖人,秋山雄次,三村俊英
    • Organizer
      第51回日本臨床免疫学会総会
    • Related Report
      2023 Research-status Report
  • [Presentation] Effects of Janus Kinase Inhibitor on TNF-a and IL-6-Induced Osteoclasts and RANKL-Induced Osteoclasts in Peripheral Blood Monocytes from Patients with Rheumatoid Arthritis2023

    • Author(s)
      Kazuhiro Yokota, Yoshimi Aizaki, Takuma Tsuzuki Wada, Hiroshi Kajiyama, Yasuto Araki, Hiroaki Yazawa, Yuji Akiyama, Toshihide Mimura
    • Organizer
      ACR Convergence 2023
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] ヤヌスキナーゼ阻害剤によるin vitroでの 細胞死抑制効果2023

    • Author(s)
      梶山浩,相崎良美,矢澤宏晃,横田和浩, 荒木靖人,秋山雄次,三村俊英
    • Organizer
      ヤヌスキナーゼ阻害剤によるin vitroでの 細胞死抑制効果
    • Related Report
      2023 Research-status Report
  • [Presentation] WDR5阻害薬における関節リウマチ滑膜線維芽細胞におけるケモカインの発現抑制2022

    • Author(s)
      岡元啓太,荒木靖人,相崎良美,門野夕峰,舟久保ゆう,三村俊英
    • Organizer
      第66回日本リウマチ学会総会・学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] Interleukin-6 Induces Osteoblastic Differentiation in Human Peripheral Blood Mononuclear Cells2022

    • Author(s)
      Kazuhiro Yokota, Yoshimi Aizaki, Shinya Tanaka, Hiroshi Kajiyama, Yasuto Araki, Yuho Kadono, Hiromi Oda, Toshihide Mimura
    • Organizer
      第66回日本リウマチ学会総会・学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] Ninja2020におけるRA患者の慢性腎臓病の有病率2022

    • Author(s)
      梶山浩,松井利浩,當間重人,三村俊英
    • Organizer
      66回日本リウマチ学会総会・学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] Characteristics of Tumor Necrosis Factor-alpha and Interleukin-6-Induced Osteoclasts in Peripheral Blood and Bone Tissue from Patients with Rheumatoid Arthritis2022

    • Author(s)
      Kazuhiro Yokota, Miyoko Sekikawa, Shinya Tanaka, Yoshimi Aizaki, Yuho Kadono, Hiromi Oda, Toshihide Mimura
    • Organizer
      EULAR 2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 関節リウマチ患者の末梢血と骨組織におけるTNF-αとIL-6誘導性破骨細胞の特徴2022

    • Author(s)
      横田和弘,関川三四子,田中伸哉,相崎良美,門野夕峰,織田弘美,秋山雄次,三村俊英
    • Organizer
      第50回日本臨床免疫学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] Effectiveness of Combination Therapy with Tocilizumab and Low-Dose Prednisolone as an Induction Therapy in Biologics-Naive Patients with Rheumatoid Arthritis: A Prospective, Randomized, Controlled, Open-Label, Multicenter Study2022

    • Author(s)
      Kazuhiro Yokota, Hayato Nagasawa, Yuji Akiyama and Toshihide Mimura
    • Organizer
      2022 ACR
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Functional Differences Between RANKL-Induced Osteoclasts and Tumor Necrosis Factor alpha and Interleukin-6- Induced Osteoclasts Differentiated From Peripheral Blood Mononuclear Cells in Patients With Rheumatoid Arthritis.2021

    • Author(s)
      Kazuhiro Yokota, Kojiro Sato, Yoshimi Aizaki, Shinya Tanaka, Noritsune Kozu, Yuho Kadono, Hiromi Oda, Toshihide Mimura
    • Organizer
      第65回日本リウマチ学会総会・学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] ヒト肝細胞cell line Hep3B からのCRP産生に関わる因子の解析.2021

    • Author(s)
      矢澤宏晃,佐藤浩二郎,荒木靖人,三村俊英
    • Organizer
      第65回日本リウマチ学会総会・学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 関節リウマチ滑膜線維芽細胞におけるWDR5阻害剤によるケモカインの発現抑制.2021

    • Author(s)
      岡元啓太,荒木靖人,相崎良美,田中伸哉,門野夕峰,舟久保ゆう,三村俊英
    • Organizer
      第49回日本臨床免疫学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Characterization and Function of Tumor Necrosis Factor α and Interleukin-6-Induced Osteoclasts in Rheumatoid Arthritis.2021

    • Author(s)
      Kazuhiro Yokota, Kojiro Sato, Yoshimi Aizaki, Shinya Tanaka, Miyoko Sekikawa, Noritsune Kozu, Yuho Kadono, Hiromi Oda and Toshihide Mimura
    • Organizer
      2021 ACR/ARP Annual Meeting
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 関節リウマチ滑膜線維芽細胞におけるMLL1阻害剤によるケモカインの発現抑制.2021

    • Author(s)
      岡元啓太,荒木靖人,相崎良美,田中伸哉,門野夕峰,舟久保ゆう,三村俊英
    • Organizer
      第8回JCRベーシックリサーチカンファレンス
    • Related Report
      2021 Research-status Report
  • [Book] Epigenetic in Human Disease2023

    • Author(s)
      Yasuto Araki, Toshihide Mimura
    • Total Pages
      577
    • Publisher
      Elsevier
    • Related Report
      2023 Research-status Report
  • [Book] 臨床検査データブック 2023-20242023

    • Author(s)
      高久 史麿、黒川 清、春日 雅人、北村 聖、大西 宏明、三村 俊英
    • Total Pages
      1200
    • Publisher
      医学書院
    • ISBN
      9784260050098
    • Related Report
      2022 Research-status Report
  • [Book] 最新関節リウマチ学 第2版(Ⅴ-3:関節リウマチの臓器障害と合併症・薬剤副作用対策-肝、胆、膵、消化管障害(HB/C肝炎、薬剤性を含む))2022

    • Author(s)
      三村 俊英
    • Total Pages
      681
    • Publisher
      日本臨牀社
    • Related Report
      2022 Research-status Report
  • [Book] 腎臓症候群(第3版)III(Ⅸ-4-(9):各種病態にみられる腎障害-膠原病,血管炎-結節性多発動脈炎)2022

    • Author(s)
      三村 俊英
    • Total Pages
      451
    • Publisher
      日本臨牀社
    • Related Report
      2022 Research-status Report
  • [Book] 内科学 第12版(13-2-5:成人Still病)2022

    • Author(s)
      三村 俊英
    • Total Pages
      2572
    • Publisher
      朝倉書店
    • ISBN
      4254322801
    • Related Report
      2021 Research-status Report
  • [Remarks]

    • URL

      http://www.saitama-med.ac.jp/uinfo/riumachi/index.html

    • Related Report
      2022 Research-status Report

URL: 

Published: 2021-04-28   Modified: 2024-12-25  

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