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Elucidation of Genetic Specificity between Anxiety Disorders and Major Depressive Disorder using Intermediate Phenotypes

Research Project

Project/Area Number 21K07497
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionGifu University

Principal Investigator

Shioiri Toshiki  岐阜大学, 大学院医学系研究科, 教授 (40235487)

Co-Investigator(Kenkyū-buntansha) 大井 一高  岐阜大学, 医学部附属病院, 准教授 (70629203)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords中間表現型 / 不安症 / パニック症 / うつ病 / ゲノム / 遺伝的共通性 / 遺伝的疾患特異性 / ポリジェニックリスクスコア
Outline of Research at the Start

本研究では、不安症、うつ病、種々の中間表現型のゲノムデータを用いて、Polygenic risk score解析やLD score regression解析にて疾患共通性・特異性に着目した遺伝要因を検討しつつ、不安症とうつ病を判別可能な遺伝的疾患特異性の解明を目指す。

Outline of Final Research Achievements

Anxiety disorders and major depressive disorder are complex psychiatric disorders with a multifactorial genetic inheritance and a heritability rate of 30-50%, exhibiting clinical and genetic heterogeneity. We investigated the genetic commonalities and specificities between these disorders utilizing intermediate phenotypes such as personality traits, cognitive functions, and sleep. It demonstrated genetic commonalities between these disorders as well as their association with adjustment disorder, suicidal attempts, neuroticism, cognitive functions, and ages of first sexual intercourse and first childbirth. In contrast, in children, genetic risks for anxiety were associated with sleep disturbances and nightmares, while depression was associated with difficulties in falling asleep, nocturnal awakenings, and hypersomnia. Furthermore, by integrating various polygenic risk scores through machine learning, we showed improvements in distinguishing anxiety disorder.

Academic Significance and Societal Importance of the Research Achievements

不安症とうつ病間の遺伝的共通性や、神経症などの中間表現型との遺伝的共通性の検討はこれまでに行われてきたが、不安症とうつ病間の遺伝的疾患特異性を検討した研究は存在しなかった。本研究では、神経症などの中間表現型以外にも、不安症とうつ病間で遺伝的共通性を呈する中間表現型がいくつか存在することを示した。一方で、幼少時の悪夢や入眠困難、中途覚醒などの中間表現型は、不安症とうつ病間で遺伝的疾患特異性が存在することを明らかにした。また、生殖関連行動が早いことが不安症において双方向性の因果関係を有することを示し、これは不安症の発症年齢が広範囲に渡ることに起因し、発症前後ともに介入が可能であることを示唆している

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (50 results)

All 2024 2023 2022 2021

All Journal Article (29 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 28 results,  Open Access: 13 results) Presentation (20 results) (of which Int'l Joint Research: 1 results,  Invited: 8 results) Book (1 results)

  • [Journal Article] Tissue-specific gene expression of genome-wide significant loci associated with major depressive disorder subtypes2024

    • Author(s)
      Torii Kaai、Ohi Kazutaka、Fujikane Daisuke、Takai Kentaro、Kuramitsu Ayumi、Muto Yukimasa、Sugiyama Shunsuke、Shioiri Toshiki
    • Journal Title

      Progress in Neuro-Psychopharmacology and Biological Psychiatry

      Volume: - Pages: 111019-111019

    • DOI

      10.1016/j.pnpbp.2024.111019

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discrimination between healthy participants and people with panic disorder based on polygenic scores for psychiatric disorders and for intermediate phenotypes using machine learning2024

    • Author(s)
      Ohi Kazutaka、Tanaka Yuta、Otowa Takeshi、Shimada Mihoko、Kaiya Hisanobu、Nishimura Fumichika、Sasaki Tsukasa、Tanii Hisashi、Shioiri Toshiki、Hara Takeshi
    • Journal Title

      Australian & New Zealand Journal of Psychiatry

      Volume: - Issue: 7 Pages: 603-614

    • DOI

      10.1177/00048674241242936

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide DNA methylation risk scores for schizophrenia derived from blood and brain tissues further explain the genetic risk in patients stratified by polygenic risk scores for schizophrenia and bipolar disorder2024

    • Author(s)
      Ohi K, Shimada M, Soda M, Nishizawa D, Fujikane D, Takai K, Kuramitsu A, Muto Y, Sugiyama S, Hasegawa J, Kitaichi K, Ikeda K, Shioiri T
    • Journal Title

      BMJ Ment Health

      Volume: 27(1) Issue: 1 Pages: e300936-e300936

    • DOI

      10.1136/bmjment-2023-300936

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic correlations between suicide attempts and psychiatric and intermediate phenotypes adjusting for mental disorders2023

    • Author(s)
      Fujikane Daisuke、Ohi Kazutaka、Kuramitsu Ayumi、Takai Kentaro、Muto Yukimasa、Sugiyama Shunsuke、Shioiri Toshiki
    • Journal Title

      Psychological Medicine

      Volume: 54 Issue: 3 Pages: 488-494

    • DOI

      10.1017/s0033291723002015

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is adjustment disorder genetically correlated with depression, anxiety, or risk-tolerant personality trait?2023

    • Author(s)
      Ohi Kazutaka、Fujikane Daisuke、Kuramitsu Ayumi、Takai Kentaro、Muto Yukimasa、Sugiyama Shunsuke、Shioiri Toshiki
    • Journal Title

      Journal of Affective Disorders

      Volume: 340 Pages: 197-203

    • DOI

      10.1016/j.jad.2023.08.019

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial genetic variants associated with bipolar disorder and schizophrenia in a Japanese population2023

    • Author(s)
      Tachi R, Ohi K, Nishizawa D, Soda M, Fujikane D, Hasegawa J, Kuramitsu A, Takai K, Muto Y, Sugiyama S, Kitaichi K, Hashimoto R, Ikeda K, Shioiri T
    • Journal Title

      Int J Bipolar Disord

      Volume: 11(1) Issue: 1 Pages: 26-26

    • DOI

      10.1186/s40345-023-00307-6

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Shared genetic correlation and causal association between major depressive disorder and breast cancer2023

    • Author(s)
      Ohi Kazutaka
    • Journal Title

      BMC Medicine

      Volume: 21 Issue: 1

    • DOI

      10.1186/s12916-023-02905-8

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Olfactory identification ability among schizophrenia patients, their first-degree relatives and healthy subjects.2023

    • Author(s)
      Fukuda S, Ohi K, Fujikane D, Takai K, Kuramitsu A, Fujita K, Muto Y, Sugiyama S, Shioiri T.
    • Journal Title

      Aust N Z J Psychiatry.

      Volume: - Issue: 10 Pages: 1367-1374

    • DOI

      10.1177/00048674231164568

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sex differences in brainstem structure volumes in patients with schizophrenia2023

    • Author(s)
      Aoyama Shintaro、Okuda Hiroto、Furuzawa Natsu、Yoneda Hirokage、Fujikane Daisuke、Takai Kentaro、Kuramitsu Ayumi、Muto Yukimasa、Sugiyama Shunsuke、Shioiri Toshiki、Ohi Kazutaka
    • Journal Title

      Schizophrenia

      Volume: 9 Issue: 1

    • DOI

      10.1038/s41537-023-00345-0

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prediction of individuals with any psychiatric disorders and first- or second-degree relatives of individuals with psychiatric disorders among university students using schizotypal personality traits, autism-spectrum traits and emotional intelligence.2023

    • Author(s)
      Sakaida Y, Ohi K, Fujikane D, Takai K, Kuramitsu A, Fujita K, Muto Y, Sugiyama S, Shioiri T
    • Journal Title

      Asian J Psychiatr.

      Volume: 83 Pages: 103549-103549

    • DOI

      10.1016/j.ajp.2023.103549

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higher polygenic risk scores for anxiety disorders are associated with reduced area in the anterior cingulate gyrus.2023

    • Author(s)
      Fujikane D, Ohi K, Nemoto K, Horibe Y, Ogawa Y, Taguchi R, Toba R, Shioiri T.
    • Journal Title

      J Affect Disord.

      Volume: 320 Pages: 291-297

    • DOI

      10.1016/j.jad.2022.09.041

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cognitive performances across individuals at high genetic risk for schizophrenia, high genetic risk for bipolar disorder, and low genetic risks: a combined polygenic risk score approach2022

    • Author(s)
      Ohi K, Nishizawa D, Sugiyama S, Takai K, Fujikane D, Kuramitsu A, Hasegawa J, Soda M, Kitaichi K, Hashimoto R, Ikeda K, Shioiri T
    • Journal Title

      Psychol Med

      Volume: 16 Issue: 10 Pages: 1-10

    • DOI

      10.1017/s0033291722001271

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Investigating genetic overlaps of the genetic factor differentiating schizophrenia from bipolar disorder with cognitive function and hippocampal volume2022

    • Author(s)
      Ohi Kazutaka、Muto Yukimasa、Takai Kentaro、Sugiyama Shunsuke、Shioiri Toshiki
    • Journal Title

      BJPsych Open

      Volume: 8 Issue: 1 Pages: 103549-103549

    • DOI

      10.1192/bjo.2021.1086

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences in subcortical brain volumes among patients with schizophrenia and bipolar disorder and healthy controls2022

    • Author(s)
      Ohi Kazutaka、Ishibashi Miori、Torii Kaai、Hashimoto Mayuka、Yano Yurika、Shioiri Toshiki
    • Journal Title

      Journal of Psychiatry and Neuroscience

      Volume: 47 Issue: 2 Pages: 16-16

    • DOI

      10.1503/jpn.210144

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Common Brain Cortical Abnormality in Smoking Behavior and Bipolar Disorder: Discriminant Analysis Using Cortical Thickness and Surface Area2022

    • Author(s)
      Ohi Kazutaka、Takai Kentaro、Kuramitsu Ayumi、Sugiyama Shunsuke、Shioiri Toshiki
    • Journal Title

      Cerebral Cortex

      Volume: - Issue: 20 Pages: 4386-4396

    • DOI

      10.1093/cercor/bhab490

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Switching from blonanserin oral tablets/powders to transdermal patches alleviates extrapyramidal symptoms in patients with schizophrenia: A 52-week open-label study2022

    • Author(s)
      Ohi Kazutaka、Takai Kentaro、Kuramitsu Ayumi、Sugiyama Shunsuke、Shioiri Toshiki
    • Journal Title

      Progress in Neuro-Psychopharmacology and Biological Psychiatry

      Volume: 113 Pages: 110470-110470

    • DOI

      10.1016/j.pnpbp.2021.110470

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 精神疾患と中間表現型間における遺伝的共通性と特異性2022

    • Author(s)
      大井一高
    • Journal Title

      日本生物学的精神医学会誌

      Volume: ー

    • Related Report
      2021 Research-status Report
  • [Journal Article] Suppression of Low-Frequency Gamma Oscillations by Activation of 40-Hz Oscillation2021

    • Author(s)
      Sugiyama Shunsuke、Taniguchi Tomoya、Kinukawa Tomoaki、Takeuchi Nobuyuki、Ohi Kazutaka、Shioiri Toshiki、Nishihara Makoto、Inui Koji
    • Journal Title

      Cerebral Cortex

      Volume: - Issue: 13 Pages: 2785-2796

    • DOI

      10.1093/cercor/bhab381

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gray matter volume differences between transgender men and cisgender women: A voxel-based morphometry study2021

    • Author(s)
      Fukao Taku、Ohi Kazutaka、Shioiri Toshiki
    • Journal Title

      Australian & New Zealand Journal of Psychiatry

      Volume: 56 Issue: 5 Pages: 535-541

    • DOI

      10.1177/0004867421998801

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intelligence decline across major depressive disorder, bipolar disorder, and schizophrenia2021

    • Author(s)
      Ohi Kazutaka、Takai Kentaro、Sugiyama Shunsuke、Kitagawa Hiromi、Kataoka Yuzuru、Soda Midori、Kitaichi Kiyoyuki、Kawasaki Yasuhiro、Ito Munechika、Shioiri Toshiki
    • Journal Title

      CNS Spectrums

      Volume: - Pages: 1-7

    • DOI

      10.1017/s1092852921000298

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Causal associations of intelligence with schizophrenia and bipolar disorder: A Mendelian randomization analysis2021

    • Author(s)
      Ohi Kazutaka、Takai Kentaro、Kuramitsu Ayumi、Sugiyama Shunsuke、Soda Midori、Kitaichi Kiyoyuki、Shioiri Toshiki
    • Journal Title

      European Psychiatry

      Volume: 64 Issue: 1 Pages: 4103-4112

    • DOI

      10.1192/j.eurpsy.2021.2237

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Genome-Wide Neuroticism-Associated Variants on Five-Factor Model Personality Traits in Schizophrenia2021

    • Author(s)
      Ohi Kazutaka、Sugiyama Shunsuke、Soda Midori、Kitaichi Kiyoyuki、Kawasaki Yasuhiro、Shioiri Toshiki
    • Journal Title

      Neuroscience Research

      Volume: - Pages: 87-91

    • DOI

      10.1016/j.neures.2021.04.004

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Polygenic Risk Scores Differentiating Schizophrenia From Bipolar Disorder Are Associated With Premorbid Intelligence in Schizophrenia Patients and Healthy Subjects2021

    • Author(s)
      Ohi Kazutaka、Nishizawa Daisuke、Sugiyama Shunsuke、Takai Kentaro、Kuramitsu Ayumi、Hasegawa Junko、Soda Midori、Kitaichi Kiyoyuki、Hashimoto Ryota、Ikeda Kazutaka、Shioiri Toshiki
    • Journal Title

      International Journal of Neuropsychopharmacology

      Volume: 24 Issue: 7 Pages: 562-569

    • DOI

      10.1093/ijnp/pyab014

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Shared Trans-ancestry Genetic Etiology between Panic Disorder and Anxiety Disorders.2021

    • Author(s)
      Ohi K, Otowa T, Shimada M, Sugiyama S, Muto Y, Tanahashi S, Kaiya H, Nishimura F, Sasaki T, Tanii H, Shioiri T
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: 75 Issue: 6 Pages: 1-2

    • DOI

      10.1111/pcn.13214

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alterations in hippocampal subfield volumes among schizophrenia patients, their first-degree relatives and healthy subjects2021

    • Author(s)
      Ohi Kazutaka、Nemoto Kiyotaka、Kataoka Yuzuru、Sugiyama Shunsuke、Muto Yukimasa、Shioiri Toshiki、Kawasaki Yasuhiro
    • Journal Title

      Progress in Neuro-Psychopharmacology and Biological Psychiatry

      Volume: 110 Pages: 110291-110291

    • DOI

      10.1016/j.pnpbp.2021.110291

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Polygenic risk scores for major psychiatric and neurodevelopmental disorders contribute to sleep disturbance in childhood: Adolescent Brain Cognitive Development (ABCD) Study2021

    • Author(s)
      Ohi Kazutaka、Ochi Ryo、Noda Yoshihiro、Wada Masataka、Sugiyama Shunsuke、Nishi Akira、Shioiri Toshiki、Mimura Masaru、Nakajima Shinichiro
    • Journal Title

      Translational Psychiatry

      Volume: 11 Issue: 1 Pages: 187-187

    • DOI

      10.1038/s41398-021-01308-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Auditory Steady-State Response: Electrophysiological Index for Sensory Processing Dysfunction in Psychiatric Disorders2021

    • Author(s)
      Sugiyama S, Ohi K, Kuramitsu A, Takai K, Muto Y, Taniguch T, Kinukawa T, Takeuchi N, Motomura E, Nishihara M, Shioiri T, Inui K.
    • Journal Title

      Front Psychiatry

      Volume: 12 Pages: 644541-644541

    • DOI

      10.3389/fpsyt.2021.644541

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Shared transethnic genetic basis of panic disorder and psychiatric and related intermediate phenotypes.2021

    • Author(s)
      Ohi K, Otowa T, Shimada M, Sugiyama S, Muto Y, Tanahashi S, Kaiya H, Nishimura F, Sasaki T, Tanii H, Shioiri T
    • Journal Title

      Eur Neuropsychopharmacol

      Volume: 42 Pages: 87-96

    • DOI

      10.1016/j.euroneuro.2020.11.003

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] パニック症と精神疾患や中間表現型間における民族差を超えた共通の遺伝的基盤2021

    • Author(s)
      大井 一高, 音羽 健司, 嶋多 美穂子, 杉山 俊介, 棚橋 俊介, 貝谷 久宣, 西村 文親, 佐々木 司, 谷井 久志, 塩入 俊樹
    • Journal Title

      不安症研究

      Volume: ー

    • NAID

      130008141613

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] Shared Genetic Basis between Reproductive Behaviors and Anxiety-Related Disorders.2023

    • Author(s)
      Ohi K, Kuramitsu A, Fujikane D, Takai K, Sugiyama S, Shioiri T
    • Organizer
      2023 Congress of the Schizophrenia International Research Society, Toronto, Canada.
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生殖関連行動と不安関連障害間の遺伝的な共通性2023

    • Author(s)
      大井一高, Kuramitsu A, Fujikane D, Takai K, Sugiyama S, Shioiri T
    • Organizer
      第33回日本臨床精神神経薬理学会学術集会、愛媛
    • Related Report
      2023 Annual Research Report
  • [Presentation] ゲノムによる不安症の病態解明と診断補助の可能性2023

    • Author(s)
      大井一高
    • Organizer
      第42回日本精神科診断学会、富山
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 生殖関連行動と不安関連障害間の遺伝的な共通性 Shared genetic basis between reproductive behaviors and anxiety-related disorders2023

    • Author(s)
      大井一高
    • Organizer
      岐阜医学奨励賞受賞講演、岐阜
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 生殖関連行動と不安関連障害間の遺伝的な共通性2023

    • Author(s)
      大井一高, Kuramitsu A, Fujikane D, Takai K, Sugiyama S, Shioiri T.
    • Organizer
      第15回日本不安症学会学術大会、東京
    • Related Report
      2023 Annual Research Report
  • [Presentation] ゲノムによる不安症の病態解明と診断補助の可能性2023

    • Author(s)
      大井一高
    • Organizer
      NCNP精神病態セミナー
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 不安症のゲノム研究最前線2022

    • Author(s)
      大井一高
    • Organizer
      第19回Psychiatry Club研究会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 精神疾患のポリジェニックリスクスコアは小児期の睡眠障害に寄与する:ABCD研究2022

    • Author(s)
      大井一高、越智涼、野田賀大、和田真孝、杉山俊介、西晃、塩入俊樹、三村 將、中島振一郎
    • Organizer
      第19回日本うつ病学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 精神疾患のポリジェニックリスクスコアは小児期の睡眠障害に寄与する:ABCD研究2022

    • Author(s)
      大井一高、越智涼、野田賀大、和田真孝、杉山俊介、西晃、塩入俊樹、三村 將、中島振一郎
    • Organizer
      Neuro2022
    • Related Report
      2022 Research-status Report
  • [Presentation] 不安症と双極性障害の併存 ~ゲノムから考える~2022

    • Author(s)
      大井一高
    • Organizer
      第14回日本不安症学会学術大会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 精神疾患のポリジェニックリスクスコアは小児期の睡眠障害に寄与する:ABCD研究2022

    • Author(s)
      大井一高、越智涼、野田賀大、和田真孝、杉山俊介、西晃、塩入俊樹、三村 將、中島振一郎
    • Organizer
      第14回日本不安症学会学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 不安症とうつ病が併存する病態~ゲノムから考える~2022

    • Author(s)
      大井一高
    • Organizer
      CNS Lecture meeting at 埼玉
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] Polygenetic Risk Scores for Major Psychiatric Disorders Among Schizophrenia Patients, Their First-Degree Relatives and Healthy Subjects2022

    • Author(s)
      大井一高
    • Organizer
      第16回日本統合失調症学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Cognitive Performances across Individuals at High Genetic Risk for Schizophrenia, High Genetic Risk for Bipolar Disorder, and Low Genetic Risks: A Combined Polygenic Risk Score Approach2022

    • Author(s)
      Ohi K, Nishizawa D, Sugiyama S, Takai K, Fujikane D, Kuramitsu A, Hasegawa J, Soda M, Kitaichi K, Hashimoto R, Ikeda K, Shioiri T
    • Organizer
      2021年度新学術領域研究 学術研究支援基盤形成先端モデル動物支援プラットフォーム 成果発表会
    • Related Report
      2021 Research-status Report
  • [Presentation] Intelligence Decline across Major Depressive Disorder, Bipolar Disorder and Schizophrenia2021

    • Author(s)
      Ohi K, Takai K, Sugiyama S, Kitagawa H, Kataoka Y, Soda M, Kitaichi K, Kawasaki Y, Ito M, Shioiri T
    • Organizer
      2021 Congress of the Schizophrenia International Research Society
    • Related Report
      2021 Research-status Report
  • [Presentation] Polygenic Risk Scores for Late Smoking Initiation Associated with the Risk of Schizophrenia2021

    • Author(s)
      Ohi K, Nishizawa D, Muto Y, Sugiyama S, Hasegawa J, Soda M, Kitaichi K, Hashimoto R, Shioiri T, Ikeda K
    • Organizer
      2021 Congress of the Schizophrenia International Research Society
    • Related Report
      2021 Research-status Report
  • [Presentation] Polygenetic Risk Scores for Major Psychiatric Disorders Among Schizophrenia Patients, Their First-Degree Relatives and Healthy Subjects2021

    • Author(s)
      Ohi K, Nishizawa D, Shimada T, Kataoka Y, Hasegawa J, Shioiri T, Kawasaki Y, Hashimoto R, Ikeda K
    • Organizer
      32nd World Congress of Neuropsychopharmacology
    • Related Report
      2021 Research-status Report
  • [Presentation] 精神疾患と中間表現型間における遺伝的共通性と特異性2021

    • Author(s)
      大井一高
    • Organizer
      第43回日本生物学的精神医学会・第51回日本神経精神薬理学会合同大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 日本人パニック症と欧米人精神疾患や中間表現型間における民族間差異を超えた遺伝的要因の共通性2021

    • Author(s)
      大井一高
    • Organizer
      第13回日本不安症学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 不安症のゲノム研究最前線2021

    • Author(s)
      大井一高
    • Organizer
      第13回日本不安症学会学術大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Book] 不安症のゲノム研究最前線2021

    • Author(s)
      大井一高
    • Publisher
      精神科ResidentVol3No1特集 不安症
    • Related Report
      2021 Research-status Report

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Published: 2021-04-28   Modified: 2025-01-30  

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