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Neurocognitive mechanism of behavioral flexibility, social anxiety and shifting of attention

Research Project

Project/Area Number 21K07544
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionKyoto University

Principal Investigator

鄭 志誠  京都大学, 医学研究科, 客員研究員 (00621575)

Co-Investigator(Kenkyū-buntansha) 藤野 純也  東京医科歯科大学, 大学院医歯学総合研究科, 講師 (90783340)
Project Period (FY) 2021-04-01 – 2025-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2023: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords注意切替 / 共感 / 柔軟性 / 注意 / 社交不安 / 視点切替 / 側頭頭頂接合部 / 視点
Outline of Research at the Start

自閉症スペクトラムや社交不安の先行研究では, 相手の考えを推測する際の認知バイアズや,知覚のバイアス等の報告がある。しかしこれらのバイアズがどの様に影響しあい,柔軟な行動の低下や社交恐怖という心境をもたらすのかについては, 未解明な部分が多い。本研究では, 社交不安や自閉症などにおいて,自己と他者の視点を柔軟に切替える「低次」の注意が, 過度な恐怖や頑固さを低減し,円滑なコミュニケーション等の「高次」な社会適応に不可欠, という仮説のもと, 社交恐怖や行動の柔軟性に関する認知・脳神経メカニズムの解明を心理・行動実験・脳画像解析を用いて進める.

Outline of Annual Research Achievements

今年度は、共感や柔軟さなどの社交性の要素が関与する意思決定の認知メカニズムを、fMRI実験や行動実験、心理検査によって、より詳細に調査した。ここでは、健常群とASD群を対象にし、特に注意や視点の柔軟な切替が社会認知機能に寄与しうるという、従来の仮説を支持する脳活動と行動指標の相関関係を示すデータを得ることができた(Tei et al., 2023 Journal of Psychiatric Research)。そして、これまで我々が注目してきた側頭頭頂接合部(TPJ)の役割にも焦点を当てることができた。具体的には、TPJは柔軟に注意や視点を切り替え、自発的に相手の意図や社会状況を把握し、対人場面の適応行動をサポートする可能性が指摘されてきたが、今回の知覚課題を用いた実験でも、注意の切り替えにTPJや前頭前野が深く関与し、さらに共感や失感情の気質のレベルにも有意に関わる可能性が示された。この結果は、当初から着目していた注意や知覚のバイアスが、高次の柔軟な行動の低下や社交恐怖という心境に寄与しうるという仮説とよく一致している。さらに本年度は、これらの脳活動と社交的気質の関係に関わる知見に基づき、共感や認知の柔軟性に関する書籍の出版も進めた(Tei and Fujino, 2025 IGI Global)。次年度は国際学会での発表を含めた社会発信を行い、これらの知見をさらに進展させ、論文化や書籍化も継続する予定である。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

データ解析、実験の取りまとめも進み、研究は概ね順調に進展している。

Strategy for Future Research Activity

今後は、国際学会での発表や議論などで知見を深めたうえで、データのとりまとめや論文化などもを進める予定である。

Report

(3 results)
  • 2023 Research-status Report
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (36 results)

All 2024 2023 2022 2021

All Journal Article (17 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 17 results,  Open Access: 14 results) Presentation (18 results) (of which Int'l Joint Research: 16 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Explicit and implicit effects of gaming content on social media on the behavior of young adults2024

    • Author(s)
      Jitoku Daisuke、Kobayashi Nanase、Fujimoto Yuka、Qian Chenyu、Okuzumi Shoko、Tei Shisei、Matsuyoshi Daisuke、Tamura Takehiro、Takahashi Hidehiko、Ueno Takefumi、Yamada Makiko、Fujino Junya
    • Journal Title

      Frontiers in Psychology

      Volume: 15 Pages: 1332462-1332462

    • DOI

      10.3389/fpsyg.2024.1332462

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Associations of conservatism and jumping to conclusions biases with aberrant salience and default mode network2024

    • Author(s)
      Miyata Jun、Sasamoto Akihiko、Ezaki Takahiro、Isobe Masanori、Kochiyama Takanori、Masuda Naoki、Mori Yasuo、Sakai Yuki、Sawamoto Nobukatsu、Tei Shisei、Ubukata Shiho、Aso Toshihiko、Murai Toshiya、Takahashi Hidehiko
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: - Issue: 5 Pages: 322-331

    • DOI

      10.1111/pcn.13652

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adverse effects of empathy and cognitive inflexibility on social trauma2023

    • Author(s)
      Tei Shisei、Fujino Junya
    • Journal Title

      Frontiers in Psychology

      Volume: 14

    • DOI

      10.3389/fpsyg.2023.1090297

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neural correlates of perceptual switching and their association with empathy and alexithymia in individuals with and without autism spectrum disorder2023

    • Author(s)
      Tei Shisei、Itahashi Takashi、Aoki Yuta Y.、Kubota Manabu、Hashimoto Ryu-ichiro、Nakamura Motoaki、Okuzumi Shoko、Takahashi Hidehiko、Ohta Haruhisa、Fujino Junya
    • Journal Title

      Journal of Psychiatric Research

      Volume: 164 Pages: 322-328

    • DOI

      10.1016/j.jpsychires.2023.06.035

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased glutamate and glutamine levels and their relationship to astrocytes and dopaminergic transmissions in the brains of adults with autism2023

    • Author(s)
      Oya Masaki、Matsuoka Kiwamu、Kubota Manabu、Fujino Junya、Tei Shisei、... Higuchi Makoto
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 11655-11655

    • DOI

      10.1038/s41598-023-38306-3

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phantasm and suicide2023

    • Author(s)
      Tei Shisei、Fujino Junya
    • Journal Title

      The British Journal of Psychiatry

      Volume: 223 Issue: 5 Pages: 517-517

    • DOI

      10.1192/bjp.2023.108

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of cognitive flexibility with neural activation during the theory of mind processing2023

    • Author(s)
      Sami Hyotaro、Tei Shisei、Takahashi Hidehiko、Fujino Junya
    • Journal Title

      Behavioural Brain Research

      Volume: 443 Pages: 114332-114332

    • DOI

      10.1016/j.bbr.2023.114332

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Grace is Gone: Rediscovery of Grief.2023

    • Author(s)
      Tei Shisei
    • Journal Title

      Journal of Palliative Medicine

      Volume: 26 Issue: 1 Pages: 153-153

    • DOI

      10.1089/jpm.2022.0400

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neural correlates of a mindfulness-based intervention in anorexia nervosa2023

    • Author(s)
      Noda Tomomi、Isobe Masanori、Mishima Ryo、Tose Keima、Kawabata Michiko、Aso Toshihiko、Tei Shisei、Noma Shun'ichi、Murai Toshiya
    • Journal Title

      BJPsych Open

      Volume: 9 Issue: 1 Pages: 1-3

    • DOI

      10.1192/bjo.2022.637

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Social ties, fears and bias during the COVID-19 pandemic: Fragile and flexible mindsets2022

    • Author(s)
      Tei Shisei、Fujino Junya
    • Journal Title

      Humanities and Social Sciences Communications

      Volume: 9 Issue: 1

    • DOI

      10.1057/s41599-022-01210-8

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intergroup bias in punishing behaviors of adults with autism spectrum disorder2022

    • Author(s)
      Qian Chenyu、Tei Shisei、Itahashi Takashi、Aoki Yuta Y.、Ohta Haruhisa、Hashimoto Ryu-ichiro、Nakamura Motoaki、Takahashi Hidehiko、Kato Nobumasa、Fujino Junya
    • Journal Title

      Frontiers in Psychiatry

      Volume: 13 Pages: 0-0

    • DOI

      10.3389/fpsyt.2022.884529

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The educational value of sense of coherence for grief care2022

    • Author(s)
      Tei Shisei、Fujino Junya
    • Journal Title

      Frontiers in Psychology

      Volume: 13 Pages: 1037637-1037637

    • DOI

      10.3389/fpsyg.2022.1037637

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decision flexibilities in autism spectrum disorder: an fMRI study of moral dilemmas2022

    • Author(s)
      Tei Shisei、Tanicha Mizuki、Itahashi Takashi、Aoki Yuta Y、Ohta Haruhisa、Qian Chenyu、Hashimoto Ryu-ichiro、Nakamura Motoaki、Takahashi Hidehiko、Kato Nobumasa、Fujino Junya
    • Journal Title

      Social Cognitive and Affective Neuroscience

      Volume: - Issue: 10 Pages: 1-8

    • DOI

      10.1093/scan/nsac023

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural brain correlates of burnout severity in medical professionals: A voxel-based morphometric study2022

    • Author(s)
      Abe Kohya、Tei Shisei、Takahashi Hidehiko、Fujino Junya
    • Journal Title

      Neuroscience Letters

      Volume: 772 Pages: 136484-136484

    • DOI

      10.1016/j.neulet.2022.136484

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] The right temporoparietal junction during a cooperation dilemma: An rTMS study2021

    • Author(s)
      Tei Shisei、Fujino Junya、Itahashi Takashi、Aoki Yuta Y.、Ohta Haruhisa、Kubota Manabu、Sawajiri Shuji、Hashimoto Ryu-ichiro、Takahashi Hidehiko、Kato Nobumasa、Nakamura Motoaki
    • Journal Title

      Neuroimage: Reports

      Volume: 1 Issue: 3 Pages: 100033-100033

    • DOI

      10.1016/j.ynirp.2021.100033

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A single session of navigation-guided repetitive transcranial magnetic stimulation over the right anterior temporoparietal junction in autism spectrum disorder2021

    • Author(s)
      Fujino Junya、Tei Shisei、Itahashi Takashi、Aoki Yuta Y.、Ohta Haruhisa、Izuno Takuji、Nakamura Hironobu、Shimizu Masaaki、Hashimoto Ryu-ichiro、Takahashi Hidehiko、Kato Nobumasa、Nakamura Motoaki
    • Journal Title

      Brain Stimulation

      Volume: 14 Issue: 3 Pages: 682-684

    • DOI

      10.1016/j.brs.2021.04.009

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Historical reflection on Taijin-ky?fush? during COVID-19: a global phenomenon of social anxiety?2021

    • Author(s)
      Tei Shisei、Wu Harry Yi-Jui
    • Journal Title

      History and Philosophy of the Life Sciences

      Volume: 43 Issue: 2

    • DOI

      10.1007/s40656-021-00392-9

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Elevated glutamine levels and activation of astrocytes involved in excessive excitatory neurotransmissions in autism spectrum disorder2023

    • Author(s)
      Manabu Kubota
    • Organizer
      ISMRM (International Society for Magnetic Resonance in Medicine) Annual Meeting
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Social anxiety, connections, and needs during the coronavirus disease 2019 pandemic2022

    • Author(s)
      Shisei Tei
    • Organizer
      22nd WPA World Congress of Psychiatry
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] The dark side of social ties: coronavirus 2019-induced fear and intergroup conflicts2022

    • Author(s)
      Shisei Tei
    • Organizer
      European Congress of Psychiatry
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of prolonged social isolation on individuals with neurodegenerative disorders and their caregivers due to the COVID-19 pandemic2022

    • Author(s)
      Shisei Tei
    • Organizer
      35th European college of neuropsychopharmacology (ECNP) congress
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Social isolation during the COVID-19 pandemic: the mental health of patients with dementia and their caregivers2022

    • Author(s)
      Shisei Tei
    • Organizer
      33rd World Congress of Neuropsychopharmacology (CINP 2022)
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neurobiological mechanisms of burnout in medical professionals2022

    • Author(s)
      Fujino Junya
    • Organizer
      33rd World Congress of Neuropsychopharmacology (CINP 2022)
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Social anxiety and individual variation in human behaviors2022

    • Author(s)
      Shisei Tei
    • Organizer
      Congress at Konrad Lorenz Institute for Evolution and Cognition Research (Austria)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Cognitive bias in intergroup contexts: a resource for the study of autism and related psychiatric conditions2022

    • Author(s)
      Shisei Tei
    • Organizer
      早稲田大学応用脳科学研究所カンファレンス2022
    • Related Report
      2021 Research-status Report
  • [Presentation] Burnout levels and brain structural features in healthcare worker2022

    • Author(s)
      Shisei Tei
    • Organizer
      早稲田大学応用脳科学研究所カンファレンス2022
    • Related Report
      2021 Research-status Report
  • [Presentation] The right temporoparietal junction and cooperation dilemma2021

    • Author(s)
      Shisei Tei
    • Organizer
      29th European Congress of Psychiatry
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Roles of trait resilience, flexibility, and volitional self-control in social adaptation: An fMRI study2021

    • Author(s)
      Shisei Tei
    • Organizer
      29th European Congress of Psychiatry
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Reduced sensitivity to situational change in individuals with autism spectrum condition2021

    • Author(s)
      Shisei Tei
    • Organizer
      29th European Congress of Psychiatry
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] An fMRI study of decision-making under conflict in individuals with autism spectrum condition2021

    • Author(s)
      Shisei Tei
    • Organizer
      29th European Congress of Psychiatry
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Social anxiety in the COVID-19 pandemic2021

    • Author(s)
      Shisei Tei
    • Organizer
      21st WPA World Congress of Psychiatry
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Theory of mind and flexible behavior in individuals with autism spectrum disorder2021

    • Author(s)
      Junya Fujino
    • Organizer
      21st WPA World Congress of Psychiatry
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cognitive and affective flexibility in autism: an fMRI study2021

    • Author(s)
      Shisei Tei
    • Organizer
      21st WPA World Congress of Psychiatry
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Brain moderator buffering the relationship between anxiety and distress2021

    • Author(s)
      Shisei Tei
    • Organizer
      34th European college of neuropsychopharmacology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Atypical automatic processing and behavioural rigidity in autism spectrum disorder2021

    • Author(s)
      Shisei Tei
    • Organizer
      34th European college of neuropsychopharmacology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Book] Neuropsychological Features of Gaming Disorder and Psychiatric Comorbidities2023

    • Author(s)
      Shisei Tei Junya Fujino
    • Total Pages
      18
    • Publisher
      IGI Global
    • Related Report
      2023 Research-status Report

URL: 

Published: 2021-04-28   Modified: 2024-12-25  

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