| Project/Area Number |
21K07554
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52030:Psychiatry-related
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| Research Institution | Okinawa Institute of Science and Technology Graduate University |
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Principal Investigator |
TAOUFIQ Zacharie 沖縄科学技術大学院大学, 細胞分子シナプス機能ユニット, スタッフサイエンティスト (10549348)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Project Status |
Granted (Fiscal Year 2022)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2023: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | Synapse / Deep proteomics / Schizophrenia / Mental disorders / iPS-derived neurons / iPSC-derived neurons / proteomics / psychiatry / diagnosis / biomarkers |
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| Outline of Research at the Start |
At present, there is no way of getting early high precision patient-personalized ND diagnosis. This research project will create data to address whether synapse proteomics combined with stem cell reprogramming is able to see synapse proteome alterations from patients diagnosed with schizophrenia.
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| Outline of Annual Research Achievements |
In collaboration with the Budapest Research Center for Natural Sciences, I have received analyzed 3 new iPSC samples coming from Caucasian family having a living schizophrenia individual. The synapse proteomics analysis revealed significant impaired expression of some specific lipid metabolic enzymes compared healthy.
I have started a collaboration with RIKEN AIP for building AI/Machine learning tools to interpret and analyze synapse proteomics data from our psychiatric patient cohort.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
I have succeed the analysis of 3 new iPSC samples.
The collaboration with RIKEN AIP for building AI/Machine learning tools is on going.
I plan a second travel to visit collaborators next month.
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| Strategy for Future Research Activity |
I am planning to receive new schizophrenia samples and start comparing them with bipolar disease.
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