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Development of unbiased evaluation method of predicted dose distribution by the event-mixing technique

Research Project

Project/Area Number 21K07565
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionTeikyo University (2023)
Hiroshima University (2021-2022)

Principal Investigator

KOGANEZAWA Akito  帝京大学, 理工学部, 准教授 (20528062)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2023: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2022: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsイベントミキシング / 予測精度 / 品質管理 / 品質保証 / 放射線計測 / 医学物理 / 放射線治療 / 線量分布 / ガンマパス率 / event-mixing / Event-mixing
Outline of Research at the Start

強度変調放射線治療 (IMRT) の事前検証は、これまで線量分布測定が唯一の手段であったが、近年の人工知能技術の発展により検証結果の予測が可能になってきたが、異なる施設間での予測精度の絶対評価は確立されていない。本研究では素粒子原子核物理実験で用いられる event-mixing の考え方を導入し、達成し得る予測精度の下限値と上限値をシステム毎に与える理論的枠組を構築し、予測精度の絶対評価を行う。

Outline of Final Research Achievements

This study developed an unbiased method to evaluate the predicted gamma passing rate (agreement of measured and simulated dose distributions) by introducing the best and worst limits of evaluation metrics. Specifically, the worst limit was estimated by applying the event-mixing technique that was originally developed in the particle and nuclear physics experiments to estimate the continuum background in invariant-mass spectroscopy to the pairs of measured and predicted gamma passing rates. Normalized achievement scores were defined for four different evaluation metrics (standard deviation, correlation coefficient, mean absolute error, and mean squared error) and confirmed their consistency. We also estimated the alert frequency for the cases requiring verification measurement, as a function of achieved precision. This alert frequency helps give a specific goal of predicting the performance to achieve.

Academic Significance and Societal Importance of the Research Achievements

本研究では放射線治療の精度検証結果の予測精度を、素粒子原子核実験で開発された event-mixing 法を用いて評価する全く新しい手法を開発した。近年の人工知能関連技術の爆発的な普及により様々な物が生成され、その精度や完成度が急速に向上しているが、本研究は予測または生成された物の精度を評価する際に、予測対象の精度を差し引いて、予測モデルそのものの能力をバイアスをかけずに評価する方法を与えるものである。本研究で扱った予測対象は数値のみであるが、この考え方を一般化することにより数値以外の予測対象を扱う際の予測能力の定量的評価が可能になることが期待される。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (16 results)

All 2023 2022 2021 Other

All Journal Article (12 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 6 results) Presentation (3 results) (of which Int'l Joint Research: 3 results,  Invited: 1 results) Remarks (1 results)

  • [Journal Article] Unbiased evaluation of predicted gamma passing rate by an event-mixing technique2023

    • Author(s)
      AS Koganezawa, T Matsuura, D Kawahara, T Nakashima, E Shiba, Y Murakami, Y Nagata
    • Journal Title

      Medical Physics

      Volume: 51 Issue: 1 Pages: 5

    • DOI

      10.1002/mp.16848

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physical and biological dosimetric margin according to prescription method for stereotactic body radiation therapy2023

    • Author(s)
      Daisuke Kawahara, Akito Saito, Yasushi Nagata
    • Journal Title

      Journal of Radiation Research

      Volume: 64 Issue: 2 Pages: 328

    • DOI

      10.1093/jrr/rrac097

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A synthesized gamma distribution-based patient-specific VMAT QA using a generative adversarial network2023

    • Author(s)
      Takaaki Matsuura, Daisuke Kawahara, Akito Saito, Kiyoshi Yamada, Shuichi Ozawa, Yasushi Nagata
    • Journal Title

      Medical Physics

      Volume: 50 Issue: 4 Pages: 2488

    • DOI

      10.1002/mp.16210

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of different air CT numbers for IVDT on the dose distribution in TomoTherapy MVCT2022

    • Author(s)
      Shogo Tsunemine, Shuichi Ozawa, Minoru Nakao, Hideharu Miura, Akito Saito, Daisuke Kawahara, Yasuhiko Onishi, Takashi Onishi, Taiki Hashiguchi, Yoshihisa Matsumoto, Tsutomu Maruta, Yuji Murakami, Yasushi Nagata
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 24 Issue: 2

    • DOI

      10.1002/acm2.13835

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictive gamma passing rate of 3D detector array-based volumetric modulated arc therapy quality assurance for prostate cancer via deep learning2022

    • Author(s)
      Takaaki Matsuura, Daisuke Kawahara, Akito Saito, Hideharu Miura, Kiyoshi Yamada, Shuichi Ozawa, Yasushi Nagata
    • Journal Title

      Physical and Engineering Sciences in Medicine

      Volume: 45 Issue: 4 Pages: 1073

    • DOI

      10.1007/s13246-022-01172-w

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Image synthesis of effective atomic number images using a deep convolutional neural network-based generative adversarial network2022

    • Author(s)
      Daisuke Kawahara, Shuichi Ozawa, Akito Saito, Yasushi Nagata
    • Journal Title

      Reports of Practical Oncology & Radiotherapy

      Volume: 27 Issue: 5 Pages: 848

    • DOI

      10.5603/rpor.a2022.0093

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Improved biological dosimetric margin model for different PTV margins with stereotactic body radiation therapy in homogeneous and nonhomogeneous tumor regions2022

    • Author(s)
      Daisuke Kawahara, Akito Saito, Yasushi Nagata
    • Journal Title

      Reports of Practical Oncology & Radiotherapy

      Volume: 27 Issue: 5 Pages: 768

    • DOI

      10.5603/rpor.a2022.0086

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] DNA strand breaks based on Monte Carlo simulation in and around the Lipiodol with flattening filter and flattening filter-free photon beams2022

    • Author(s)
      Daisuke Kawahara, Akito Saito, Hisashi Nakano, Yasushi Nagata
    • Journal Title

      Reports of Practical Oncology & Radiotherapy

      Volume: 27 Issue: 3 Pages: 392

    • DOI

      10.5603/rpor.a2022.0067

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stepwise deep neural network (stepwise-net) for head and neck auto-segmentation on CT images2022

    • Author(s)
      Kawahara Daisuke、Tsuneda Masato、Ozawa Shuichi、Okamoto Hiroyuki、Nakamura Mitsuhiro、Nishio Teiji、Saito Akito、Nagata Yasushi
    • Journal Title

      Computers in Biology and Medicine

      Volume: 143 Pages: 105295-105295

    • DOI

      10.1016/j.compbiomed.2022.105295

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Baseline drift vector of multiple points on body surface using a near-infrared camera2022

    • Author(s)
      Ohashi Atsuyuki、Nishio Teiji、Saito Akito、Hashimoto Daiki、Maekawa Hidemasa、Murakami Yuji、Ozawa Shuichi、Suitani Makiko、Tsuneda Masato、Watanabe Hiroshi、Ikenaga Koji、Nagata Yasushi
    • Journal Title

      Physical and Engineering Sciences in Medicine

      Volume: 45 Issue: 1 Pages: 143

    • DOI

      10.1007/s13246-021-01097-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extended Migdal-Watson formula to evaluate background strength in binary breakup reactions2021

    • Author(s)
      R. Nakamoto, M. Ito, A. Saito and S. Shimoura
    • Journal Title

      Physical Review C

      Volume: 104 Issue: 3 Pages: 034602-034602

    • DOI

      10.1103/physrevc.104.034602

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Predicting the local response of esophageal squamous cell carcinoma to neoadjuvant chemoradiotherapy by radiomics with a machine learning method using<sup>18</sup>f-fdg pet images2021

    • Author(s)
      Murakami Yuji、Kawahara Daisuke、Tani Shigeyuki、Kubo Katsumaro、Katsuta Tsuyoshi、Imano Nobuki、Takeuchi Yuki、Nishibuchi Ikuno、Saito Akito、Nagata Yasushi
    • Journal Title

      Diagnostics

      Volume: 11 Issue: 6 Pages: 1049-1049

    • DOI

      10.3390/diagnostics11061049

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Generating fully random prediction results of patient-specific quality assurance2023

    • Author(s)
      A Saito, D Kawahara, T Matsuura, E Shiba, Y Nagata
    • Organizer
      The 2nd International Conference on Radiological Physics and Technology
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Accuracy of the gamma analysis for head-and-neck volumetric-arc radiation therapy2023

    • Author(s)
      A Saito, D Kawahara, T Matsuura, E Shiba, Y Nagata
    • Organizer
      The 65th Annual Meeting & Exhibition of American Association of Physicists in Medicine
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transition from nucleus to medicine2023

    • Author(s)
      Akito Saito
    • Organizer
      International Symposium on Nuclear Spectroscopy for Exteme Quantum Systems (NUSPEQ2023)
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] Predictive Gamma Passing Rate

    • URL

      https://sites.google.com/view/koganezawa-lab/research/predictive-gamma-passing-rate

    • Related Report
      2023 Annual Research Report

URL: 

Published: 2021-04-28   Modified: 2025-01-30  

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