Application of multi-task deep learning with brain MRI to psychiatric and neurological disorders

• Project/Area Number: 21K07593
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kyoto University
• Principal Investigator: 大石 直也 京都大学, 医学研究科, 特定准教授 (40526878)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2023: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: MRI / 脳 / 深層学習 / マルチタスク / 精神・神経疾患 / 精神疾患 / 神経疾患

Outline of Research at the Start

脳MRIは精神・神経疾患の臨床・研究に大きく寄与しており、その応用例として、関心領域同定、疾患の診断などがある。熟練者はこれらの問題を同時かつ相補的に遂行することで精度向上を果たすと考えられるが、従来の機械学習では実現が困難であった。申請者は、2つの問題を同時かつ相補的に学習することで精度向上を図るマルチタスク深層学習の手法を開発・報告した。本研究では、この手法を多種・多次元にわたる脳MRIに発展させるとともに診断等の判断根拠を関心領域同定により向上させる手法開発を行う。さらにこれらを健常者および精神・神経疾患患者の脳MRIに応用し、その有用性を明らかにする。

Outline of Annual Research Achievements

非侵襲的脳画像法の代表である脳MRIは、ハード・ソフトウェアの進歩により精神・神経疾患の臨床・研究に大きく寄与してきた。申請者はこれまでに2つの問題を同時かつ相補的に学習することで精度向上を図るマルチタスク深層学習の手法を開発し、その臨床的有用性を明らかにしてきた。本研究の目的は、MRIの多岐にわたるシーケンス画像および課題に適したマルチタスク深層学習アルゴリズムを開発し、健常者および精神・神経疾患患者に適応することで各タスク精度の向上性を明らかにすることである。
2023年度では、昨年度開発した複数シーケンスのMRI画像（multiple 3D）を組み合わせたマルチタスク深層学習手法を前庭神経鞘腫患者に対する検証を新たに実施した。約60名の前庭神経鞘腫患者に対して、T1強調, T2強調, Gd-T1画像を組み合わせることで単一シーケンスと比べて腫瘍領域の同定精度が向上することを検証しえた。さらに、生成AIの基盤技術を応用することでT1強調画像からT2強調画像への画像-画像変換、あるいはノイズ除去などの精度が向上することも明らかにした。
また、精神・神経疾患において重要であることが示唆されているが微細なため従来の技術では同定困難であった手綱核の正確な同定技術を深層学習により成功し、責任著者として論文報告（Kyuragi et al., Biological Psychiatry: Global Open Science., in press）するなど複数の学術的成果を得た。

Research Products

• [Journal Article] Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice (2024)
  • Author(s): Li Haiyan、Kawatake-Kuno Ayako、Inaba Hiromichi、Miyake Yuka、Itoh Yukihiro、Ueki Takatoshi、Oishi Naoya、Murai Toshiya、Suzuki Takayoshi、Uchida Shusaku
  • Journal Title: Neuron Volume: 112 Issue: 5 Pages: 00934-0
  • DOI: 10.1016/j.neuron.2023.12.004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons (2024)
  • Author(s): Kawatake-Kuno Ayako、Li Haiyan、Inaba Hiromichi、Hikosaka Momoka、Ishimori Erina、Ueki Takatoshi、Garkun Yury、Morishita Hirofumi、Narumiya Shuh、Oishi Naoya、Ohtsuki Gen、Murai Toshiya、Uchida Shusaku
  • Journal Title: Neuron Volume: Feb 19 Issue: 8 Pages: 00049-7
  • DOI: 10.1016/j.neuron.2024.01.023
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Validation of Wistar-Kyoto rats kept in solitary housing as an animal model for depression using voxel-based morphometry (2024)
  • Author(s): Yoshii Takanobu、Oishi Naoya、Sotozono Yasutaka、Watanabe Anri、Sakai Yuki、Yamada Shunji、Matsuda Ken-Ichi、Kido Masamitsu、Ikoma Kazuya、Tanaka Masaki、Narumoto Jin
  • Journal Title: Scientific Reports Volume: 14 Issue: 1 Pages: 3601-3601
  • DOI: 10.1038/s41598-024-53103-2
  • Peer Reviewed / Open Access
• [Journal Article] Segmentation and volume estimation of habenula using deep-learning in patients with depression (2024)
  • Author(s): Kyuragi Yusuke、Oishi Naoya、Hatakoshi Momoko、Hirano Jinichi、Noda Takamasa、Yoshihara Yujiro、Ito Yuri、Igarashi Hiroyuki、Miyata Jun、Takahashi Kento、Kamiya Kei、Matsumoto Junya、Okada Tomohisa、Fushimi Yasutaka、Nakagome Kazuyuki、Mimura Masaru、Murai Toshiya、Suwa Taro
  • Journal Title: Biological Psychiatry Global Open Science Volume: - Issue: 4 Pages: 100314-100314
  • DOI: 10.1016/j.bpsgos.2024.100314
  • Peer Reviewed / Open Access
• [Journal Article] GPCR-mediated calcium and cAMP signaling determines psychosocial stress susceptibility and resiliency (2023)
  • Author(s): Inaba Hiromichi、Li Haiyan、Kawatake-Kuno Ayako、Dewa Ken-ichi、Nagai Jun、Oishi Naoya、Murai Toshiya、Uchida Shusaku
  • Journal Title: Science Advances Volume: 9(14) Issue: 14
  • DOI: 10.1126/sciadv.ade5397
  • Peer Reviewed / Open Access
• [Journal Article] Correlation between trait emotional intelligence and prefrontal activation during a verbal fluency task: A functional near-infrared spectroscopy study (2023)
  • Author(s): Fukumoto T, Amitani H, Wada M, Oishi N, *Asakawa A
  • Journal Title: Medicine Volume: 102 Issue: 29 Pages: e34418-e34418
  • DOI: 10.1097/md.0000000000034418
  • Peer Reviewed / Open Access
• [Journal Article] Voxel‐based clustered imaging by multiparameter diffusion tensor images for predicting the grade and proliferative activity of meningioma (2023)
  • Author(s): Takahashi Yuki、Oishi Naoya、Yamao Yukihiro、Kunieda Takeharu、Kikuchi Takayuki、Fukuyama Hidenao、Miyamoto Susumu、Arakawa Yoshiki
  • Journal Title: Brain and Behavior Volume: 13 Issue: 10
  • DOI: 10.1002/brb3.3201
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and safety of cilostazol in mild cognitive impairment: a randomized clinical trial (2023)
  • Author(s): Saito S, Oishi N, et al (他35名、25番目）
  • Journal Title: JAMA Network Open Volume: 6 Issue: 12 Pages: e2344938-e2344938
  • DOI: 10.1001/jamanetworkopen.2023.44938
  • Peer Reviewed / Open Access
• [Journal Article] Differences between subclinical attention-deficit/hyperactivity and autistic traits in default mode, salience, and frontoparietal network connectivities in young adult Japanese (2023)
  • Author(s): Hirata Risa、Yoshimura Sayaka、Kobayashi Key、Aki Morio、Shibata Mami、Ueno Tsukasa、Miyagi Takashi、Oishi Naoya、Murai Toshiya、Fujiwara Hironobu
  • Journal Title: Scientific Reports Volume: 13 Issue: 1 Pages: 19724-19724
  • DOI: 10.1038/s41598-023-47034-7
  • Peer Reviewed / Open Access
• [Journal Article] Disorganization of semantic brain networks in schizophrenia revealed by fMRI. (2023)
  • Author(s): Matsumoto Y, Nishida S, Hayashi R, Son S, Murakami A, Yoshikawa N, Ito H, Oishi N, Masuda N, Murai T, Friston K, Nishimoto S, *Takahashi H.
  • Journal Title: Schizophrenia Bulletin. Volume: 49 Issue: 2 Pages: 498-506
  • DOI: 10.1093/schbul/sbac157
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A model for estimating the brainstem volume in normal healthy individuals and its application to diffuse axonal injury patients. (2023)
  • Author(s): *Fujimoto G, Ubukata S, Sugihara G, Oishi N, Aso T, Murai T, Ueda K.
  • Journal Title: Scientific Reports. Volume: 13 Issue: 1 Pages: 33-33
  • DOI: 10.1038/s41598-022-27202-x
  • Peer Reviewed / Open Access
• [Journal Article] Information flow and dynamic functional connectivity during electroconvulsive therapy in patients with depression. (2023)
  • Author(s): Kyuragi Y, *Oishi N, Yamasaki S, Hazama M, Miyata J, Shibata M, Fujiwara H, Fushimi Y, Murai T, Suwa T.
  • Journal Title: J Affect Disord. Volume: 328 Pages: 141-152
  • DOI: 10.1016/j.jad.2023.02.060
  • Peer Reviewed / Open Access
• [Journal Article] A pictorial review of structural neuroimaging at 7T. (2022)
  • Author(s): *Okada T, Fujimoto K, Fushimi Y, Akasaka T, Thuy DHD, Shima A, Sawamoto N, Oishi N, Zhang Z, Funaki T, Nakamoto Y, Murai T, Miyamoto S, Takahashi R, Isa T.
  • Journal Title: Quantitative Imaging in Medicine and Surgery Volume: 12 Issue: 6 Pages: 3406-3435
  • DOI: 10.21037/qims-21-969
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Altered white matter microstructure and neurocognitive function of HIV-infected patients with low nadir CD4. (2022)
  • Author(s): *Yoshihara Y, Kato T, Watanabe D, Fukumoto M, Wada K, Oishi N, Nakakura T, Kuriyama K, Shirasaka T, Murai T.
  • Journal Title: J Neurovirol. Volume: 28 Issue: 3 Pages: 355-366
  • DOI: 10.1007/s13365-022-01053-8
  • Peer Reviewed
• [Journal Article] Combining multiple indices of diffusion tensor imaging can better differentiate patients with traumatic brain injury from healthy subjects. (2022)
  • Author(s): *Abdelrahman H, Ubukata S, Ueda K, Fujimoto G, Oishi N, Aso T, Murai T.
  • Journal Title: Neuropsychiatr Dis Treat. Volume: 18 Pages: 1801-1814
  • DOI: 10.2147/ndt.s354265
  • Peer Reviewed / Open Access
• [Journal Article] Effects of a new speech support application on intensive speech therapy and changes in functional brain connectivity in patients with poststroke aphasia. (2022)
  • Author(s): Katsuno, Y., Ueki, Y., Ito, K., Murakami, S., Aoyama, K., Oishi, N., ... & Tatsumi, H. Effects of a new speech support application on intensive speech therapy and changes in functional brain connectivity in patients with poststroke aphasia. Frontiers in Human Neuroscience, 654.
  • Journal Title: Frontiers in Human Neuroscience Volume: 16 Pages: 870733-870733
  • DOI: 10.3389/fnhum.2022.870733
  • Peer Reviewed / Open Access
• [Journal Article] Altered resting state network in adolescents with problematic internet use. (2022)
  • Author(s): Siste K, *Pandelaki J, Miyata J, Oishi N, Tsurumi K, Fujiwara H, Murai T, Nasrun MW, Wiguna T, Bardosono S, Sekartini R, Sarasvita R, Murtani BJ, Sen LT, Firdaus KK.
  • Journal Title: J. Clin. Med. Volume: 11 Issue: 19 Pages: 5838-5838
  • DOI: 10.3390/jcm11195838
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Predicting cerebral infarction in patients with atrial fibrillation using machine learning: The Fushimi AF Registry. (2022)
  • Author(s): Nishi H, *Oishi N, Ogawa H,Natsue K, Doi K, Kawakami O, Aoki T, Fukuda S, Akao M, Tsukahara T, on behalf of the Fushimi AF Registry investigators.
  • Journal Title: J Cereb Blood Flow Metab. Volume: 42 Issue: 5 Pages: 746-756
  • DOI: 10.1177/0271678x211063802
  • Peer Reviewed
• [Journal Article] Machine learning trained with quantitative susceptibility mapping to detect mild cognitive impairment in Parkinson's disease (2022)
  • Author(s): Shibata Haruto、Uchida Yuto、Inui Shohei、Kan Hirohito、Sakurai Keita、Oishi Naoya、Ueki Yoshino、Oishi Kenichi、Matsukawa Noriyuki
  • Journal Title: Parkinsonism and Related Disorders Volume: 94 Pages: 104-110
  • DOI: 10.1016/j.parkreldis.2021.12.004
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Life habits and mental health: behavioural addiction, health benefits of daily habits, and the reward system. (2022)
  • Author(s): *Fujiwara H, Tsurumi K, Shibata M, Kobayashi K, Miyagi T, Ueno T, Oishi N, Murai T.
  • Journal Title: Front. Psychiatry. Volume: 27 Pages: 813507-813507
  • DOI: 10.3389/fpsyt.2022.813507
  • Peer Reviewed / Open Access
• [Journal Article] Extracting Apathy From Depression Syndrome in Traumatic Brain Injury Using a Clustering Method (2021)
  • Author(s): Ubukata Shiho、Ueda Keita、Fujimoto Gaku、Ueno Senkei、Murai Toshiya、Oishi Naoya
  • Journal Title: The Journal of Neuropsychiatry and Clinical Neurosciences Volume: e-collection Issue: 2 Pages: 19-19
  • DOI: 10.1176/appi.neuropsych.21020046
  • Peer Reviewed / Open Access
• [Presentation] 微小脳構造を核とした安静時機能結合MRI (2024)
  • Author(s): 大石 直也
  • Organizer: 第26回日本ヒト脳機能マッピング学会
  • Invited
• [Presentation] ハイパースペクトルイメージングの脳領域への応用 (2023)
  • Author(s): 大石 直也
  • Organizer: 第25回日本ヒト脳機能マッピング学会
  • Invited
• [Presentation] Denoising in non-invasive medical imaging (2022)
  • Author(s): Naoya Oishi
  • Organizer: Practical inverse problems and their prospects
  • Int'l Joint Research / Invited