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Application of multi-task deep learning with brain MRI to psychiatric and neurological disorders

Research Project

Project/Area Number 21K07593
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKyoto University

Principal Investigator

Oishi Naoya  京都大学, 医学研究科, 准教授 (40526878)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords深層学習 / MRI / 脳 / 精神神経疾患 / マルチタスク / セグメンテーション / クラス分類 / 精神・神経疾患 / 精神疾患 / 神経疾患
Outline of Research at the Start

脳MRIは精神・神経疾患の臨床・研究に大きく寄与しており、その応用例として、関心領域同定、疾患の診断などがある。熟練者はこれらの問題を同時かつ相補的に遂行することで精度向上を果たすと考えられるが、従来の機械学習では実現が困難であった。申請者は、2つの問題を同時かつ相補的に学習することで精度向上を図るマルチタスク深層学習の手法を開発・報告した。本研究では、この手法を多種・多次元にわたる脳MRIに発展させるとともに診断等の判断根拠を関心領域同定により向上させる手法開発を行う。さらにこれらを健常者および精神・神経疾患患者の脳MRIに応用し、その有用性を明らかにする。

Outline of Final Research Achievements

To further improve the accuracy of segmentation and classification in neuroimaging research, we have newly developed a wide range of multi-task deep learning algorithms for brain MRI. The algorithm not only accurately identifies micro brain structures that have been suggested to be important in psychiatric and neurological disorders but are difficult to identify with conventional techniques due to their minute size, but also enables more accurate identification of foci in patients with traumatic brain injury and brain tumors by using multiple sequences of MRI data. Thus, we have demonstrated the usefulness of the multi-tasking deep learning algorithm developed in the project.

Academic Significance and Societal Importance of the Research Achievements

柔軟性・拡張性の高いマルチタスク深層学習アルゴリズムを新規に開発し、健常者における微小脳領域の正確な同定や精神・神経疾患における病巣の正確な同定などに成功した点は学術的意義が高いと考えられる。また、本手法はMRIに限定される技術ではなく、様々な波形(1次元)、画像(2~3次元)、動画(3~4次元)研究において応用可能であり、多岐にわたる臨床応用可能性があるという観点で社会的意義も高いと考えられる。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (24 results)

All 2024 2023 2022 2021

All Journal Article (21 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 21 results,  Open Access: 18 results) Presentation (3 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results)

  • [Journal Article] Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice2024

    • Author(s)
      Li Haiyan、Kawatake-Kuno Ayako、Inaba Hiromichi、Miyake Yuka、Itoh Yukihiro、Ueki Takatoshi、Oishi Naoya、Murai Toshiya、Suzuki Takayoshi、Uchida Shusaku
    • Journal Title

      Neuron

      Volume: 112 Issue: 5 Pages: 00934-0

    • DOI

      10.1016/j.neuron.2023.12.004

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons2024

    • Author(s)
      Kawatake-Kuno Ayako、Li Haiyan、Inaba Hiromichi、Hikosaka Momoka、Ishimori Erina、Ueki Takatoshi、Garkun Yury、Morishita Hirofumi、Narumiya Shuh、Oishi Naoya、Ohtsuki Gen、Murai Toshiya、Uchida Shusaku
    • Journal Title

      Neuron

      Volume: Feb 19 Issue: 8 Pages: 00049-7

    • DOI

      10.1016/j.neuron.2024.01.023

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Validation of Wistar-Kyoto rats kept in solitary housing as an animal model for depression using voxel-based morphometry2024

    • Author(s)
      Yoshii Takanobu、Oishi Naoya、Sotozono Yasutaka、Watanabe Anri、Sakai Yuki、Yamada Shunji、Matsuda Ken-Ichi、Kido Masamitsu、Ikoma Kazuya、Tanaka Masaki、Narumoto Jin
    • Journal Title

      Scientific Reports

      Volume: 14 Issue: 1 Pages: 3601-3601

    • DOI

      10.1038/s41598-024-53103-2

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Segmentation and volume estimation of habenula using deep-learning in patients with depression2024

    • Author(s)
      Kyuragi Yusuke、Oishi Naoya、Hatakoshi Momoko、Hirano Jinichi、Noda Takamasa、Yoshihara Yujiro、Ito Yuri、Igarashi Hiroyuki、Miyata Jun、Takahashi Kento、Kamiya Kei、Matsumoto Junya、Okada Tomohisa、Fushimi Yasutaka、Nakagome Kazuyuki、Mimura Masaru、Murai Toshiya、Suwa Taro
    • Journal Title

      Biological Psychiatry Global Open Science

      Volume: - Issue: 4 Pages: 100314-100314

    • DOI

      10.1016/j.bpsgos.2024.100314

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] GPCR-mediated calcium and cAMP signaling determines psychosocial stress susceptibility and resiliency2023

    • Author(s)
      Inaba Hiromichi、Li Haiyan、Kawatake-Kuno Ayako、Dewa Ken-ichi、Nagai Jun、Oishi Naoya、Murai Toshiya、Uchida Shusaku
    • Journal Title

      Science Advances

      Volume: 9(14) Issue: 14

    • DOI

      10.1126/sciadv.ade5397

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlation between trait emotional intelligence and prefrontal activation during a verbal fluency task: A functional near-infrared spectroscopy study2023

    • Author(s)
      Fukumoto T, Amitani H, Wada M, Oishi N, *Asakawa A
    • Journal Title

      Medicine

      Volume: 102 Issue: 29 Pages: e34418-e34418

    • DOI

      10.1097/md.0000000000034418

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Voxel‐based clustered imaging by multiparameter diffusion tensor images for predicting the grade and proliferative activity of meningioma2023

    • Author(s)
      Takahashi Yuki、Oishi Naoya、Yamao Yukihiro、Kunieda Takeharu、Kikuchi Takayuki、Fukuyama Hidenao、Miyamoto Susumu、Arakawa Yoshiki
    • Journal Title

      Brain and Behavior

      Volume: 13 Issue: 10

    • DOI

      10.1002/brb3.3201

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy and safety of cilostazol in mild cognitive impairment: a randomized clinical trial2023

    • Author(s)
      Saito S, Oishi N, et al (他35名、25番目)
    • Journal Title

      JAMA Network Open

      Volume: 6 Issue: 12 Pages: e2344938-e2344938

    • DOI

      10.1001/jamanetworkopen.2023.44938

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differences between subclinical attention-deficit/hyperactivity and autistic traits in default mode, salience, and frontoparietal network connectivities in young adult Japanese2023

    • Author(s)
      Hirata Risa、Yoshimura Sayaka、Kobayashi Key、Aki Morio、Shibata Mami、Ueno Tsukasa、Miyagi Takashi、Oishi Naoya、Murai Toshiya、Fujiwara Hironobu
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 19724-19724

    • DOI

      10.1038/s41598-023-47034-7

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Disorganization of semantic brain networks in schizophrenia revealed by fMRI.2023

    • Author(s)
      Matsumoto Y, Nishida S, Hayashi R, Son S, Murakami A, Yoshikawa N, Ito H, Oishi N, Masuda N, Murai T, Friston K, Nishimoto S, *Takahashi H.
    • Journal Title

      Schizophrenia Bulletin.

      Volume: 49 Issue: 2 Pages: 498-506

    • DOI

      10.1093/schbul/sbac157

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A model for estimating the brainstem volume in normal healthy individuals and its application to diffuse axonal injury patients.2023

    • Author(s)
      *Fujimoto G, Ubukata S, Sugihara G, Oishi N, Aso T, Murai T, Ueda K.
    • Journal Title

      Scientific Reports.

      Volume: 13 Issue: 1 Pages: 33-33

    • DOI

      10.1038/s41598-022-27202-x

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Information flow and dynamic functional connectivity during electroconvulsive therapy in patients with depression.2023

    • Author(s)
      Kyuragi Y, *Oishi N, Yamasaki S, Hazama M, Miyata J, Shibata M, Fujiwara H, Fushimi Y, Murai T, Suwa T.
    • Journal Title

      J Affect Disord.

      Volume: 328 Pages: 141-152

    • DOI

      10.1016/j.jad.2023.02.060

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A pictorial review of structural neuroimaging at 7T.2022

    • Author(s)
      *Okada T, Fujimoto K, Fushimi Y, Akasaka T, Thuy DHD, Shima A, Sawamoto N, Oishi N, Zhang Z, Funaki T, Nakamoto Y, Murai T, Miyamoto S, Takahashi R, Isa T.
    • Journal Title

      Quantitative Imaging in Medicine and Surgery

      Volume: 12 Issue: 6 Pages: 3406-3435

    • DOI

      10.21037/qims-21-969

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Altered white matter microstructure and neurocognitive function of HIV-infected patients with low nadir CD4.2022

    • Author(s)
      *Yoshihara Y, Kato T, Watanabe D, Fukumoto M, Wada K, Oishi N, Nakakura T, Kuriyama K, Shirasaka T, Murai T.
    • Journal Title

      J Neurovirol.

      Volume: 28 Issue: 3 Pages: 355-366

    • DOI

      10.1007/s13365-022-01053-8

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Combining multiple indices of diffusion tensor imaging can better differentiate patients with traumatic brain injury from healthy subjects.2022

    • Author(s)
      *Abdelrahman H, Ubukata S, Ueda K, Fujimoto G, Oishi N, Aso T, Murai T.
    • Journal Title

      Neuropsychiatr Dis Treat.

      Volume: 18 Pages: 1801-1814

    • DOI

      10.2147/ndt.s354265

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of a new speech support application on intensive speech therapy and changes in functional brain connectivity in patients with poststroke aphasia.2022

    • Author(s)
      Katsuno, Y., Ueki, Y., Ito, K., Murakami, S., Aoyama, K., Oishi, N., ... & Tatsumi, H. Effects of a new speech support application on intensive speech therapy and changes in functional brain connectivity in patients with poststroke aphasia. Frontiers in Human Neuroscience, 654.
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 16 Pages: 870733-870733

    • DOI

      10.3389/fnhum.2022.870733

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Altered resting state network in adolescents with problematic internet use.2022

    • Author(s)
      Siste K, *Pandelaki J, Miyata J, Oishi N, Tsurumi K, Fujiwara H, Murai T, Nasrun MW, Wiguna T, Bardosono S, Sekartini R, Sarasvita R, Murtani BJ, Sen LT, Firdaus KK.
    • Journal Title

      J. Clin. Med.

      Volume: 11 Issue: 19 Pages: 5838-5838

    • DOI

      10.3390/jcm11195838

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Predicting cerebral infarction in patients with atrial fibrillation using machine learning: The Fushimi AF Registry.2022

    • Author(s)
      Nishi H, *Oishi N, Ogawa H,Natsue K, Doi K, Kawakami O, Aoki T, Fukuda S, Akao M, Tsukahara T, on behalf of the Fushimi AF Registry investigators.
    • Journal Title

      J Cereb Blood Flow Metab.

      Volume: 42 Issue: 5 Pages: 746-756

    • DOI

      10.1177/0271678x211063802

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Machine learning trained with quantitative susceptibility mapping to detect mild cognitive impairment in Parkinson's disease2022

    • Author(s)
      Shibata Haruto、Uchida Yuto、Inui Shohei、Kan Hirohito、Sakurai Keita、Oishi Naoya、Ueki Yoshino、Oishi Kenichi、Matsukawa Noriyuki
    • Journal Title

      Parkinsonism and Related Disorders

      Volume: 94 Pages: 104-110

    • DOI

      10.1016/j.parkreldis.2021.12.004

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Life habits and mental health: behavioural addiction, health benefits of daily habits, and the reward system.2022

    • Author(s)
      *Fujiwara H, Tsurumi K, Shibata M, Kobayashi K, Miyagi T, Ueno T, Oishi N, Murai T.
    • Journal Title

      Front. Psychiatry.

      Volume: 27 Pages: 813507-813507

    • DOI

      10.3389/fpsyt.2022.813507

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extracting Apathy From Depression Syndrome in Traumatic Brain Injury Using a Clustering Method2021

    • Author(s)
      Ubukata Shiho、Ueda Keita、Fujimoto Gaku、Ueno Senkei、Murai Toshiya、Oishi Naoya
    • Journal Title

      The Journal of Neuropsychiatry and Clinical Neurosciences

      Volume: e-collection Issue: 2 Pages: 19-19

    • DOI

      10.1176/appi.neuropsych.21020046

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 微小脳構造を核とした安静時機能結合MRI2024

    • Author(s)
      大石 直也
    • Organizer
      第26回日本ヒト脳機能マッピング学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] ハイパースペクトルイメージングの脳領域への応用2023

    • Author(s)
      大石 直也
    • Organizer
      第25回日本ヒト脳機能マッピング学会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] Denoising in non-invasive medical imaging2022

    • Author(s)
      Naoya Oishi
    • Organizer
      Practical inverse problems and their prospects
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2021-04-28   Modified: 2025-01-30  

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