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Imaging Biomarkers as New Predictors of Breast Cancer Prognosis Using Diffusion MRI

Research Project

Project/Area Number 21K07618
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKyoto University

Principal Investigator

Iima Mami  京都大学, 医学研究科, 特定講師 (60748797)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2023: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords拡散MRI / 乳がん / 予後予測
Outline of Research at the Start

本研究では、拡散MRIから様々な定量値を算出し、乳がんのサブタイプを始めとする分子生物学的因子と関連付けることにより、臨床において汎用性の高いイメージングバイオマーカーを探索する。さらに、再発、転移や予後、治療効果情報と関連付けることにより、従来法と比較して飛躍的に信頼度の高い個別化診断技術の開発を目指す。臨床医が時間成約のある現場で利用可能な使いやすい診断法を開発することで、より信頼性の高いがんの臨床診断、治療に役立てる。

Outline of Final Research Achievements

By correlating quantitative values from diffusion MRI with clinical information, such as molecular-biological and pathological factors, we explored imaging biomarkers that are versatile in clinical practice and useful for predicting prognosis. Using several mouse tumor models, we demonstrated that diffusion MRI parameters, such as ADC shift and ADC change rate, correlate with the N/C ratio and Ki67 labeling rate. We also explored the potential for tumor apoptosis and differences in therapeutic effects by tumor type by comparing groups treated with an anti-PD-1 antibody to untreated groups. In clinical studies, we compared several types of high-resolution diffusion-weighted images and showed that the quantitative value (kurtosis) calculated using a non-Gaussian diffusion model could be a biomarker for predicting metastasis.

Academic Significance and Societal Importance of the Research Achievements

マウス腫瘍モデルにおいてshifted ADCやADC変化率がN/C比やKi67標識率と相関することを示し、拡散MRI定量値ががんにおける病理情報を一部推測可能であることが示唆された。非ガウス拡散の定量値であるK値が高い乳がん患者群でDDFS(無遠隔転移生存期間)が短かったことは、K値が乳がんの予後予測可能なバイオマーカーとなり得ることを示唆する。また異なる拡散強調像(SPEN、SS-EPI、RESOLVE)を用いた評価では、異なる撮影技術が乳房病変の可視性に及ぼす影響を検証し、より高解像度で病変を詳細に評価可能であると考えられる。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (18 results)

All 2024 2023 2022 2021

All Journal Article (4 results) (of which Open Access: 3 results,  Peer Reviewed: 1 results) Presentation (14 results) (of which Int'l Joint Research: 2 results,  Invited: 6 results)

  • [Journal Article] The Clinical Usefulness of DWI Using Spatiotemporal Encoding (SPEN) : Results of Observer Study Depending on the Experience [Presidential Award Proceedings]2024

    • Author(s)
      中 山 怜 那 ,飯 間 麻 美,片 岡 正 子 ,本 田 茉 也, Otikovs Martins, Nissan Noam, Frydman Lucio, 漆 畑 勇 太 , 岡 澤 藍 夏 , 辻 和 貴 , 戸 井 雅 和, 中 本 裕 士
    • Journal Title

      Japanese Journal of Magnetic Resonance in Medicine

      Volume: 44 Issue: 3 Pages: 85-88

    • DOI

      10.2463/jjmrm.2024-1811

    • ISSN
      0914-9457, 2434-0499
    • Year and Date
      2024-08-15
    • Related Report
      2023 Annual Research Report
    • Open Access
  • [Journal Article] Development of a New Cancer Diagnostic Method Using Diffusion MRI2023

    • Author(s)
      Iima Mami
    • Journal Title

      Journal of The Society of Japanese Women Scientists

      Volume: 23 Issue: 0 Pages: 16-21

    • DOI

      10.5939/sjws.230004

    • ISSN
      1349-4449, 2186-3776
    • Related Report
      2023 Annual Research Report
    • Open Access
  • [Journal Article] 時間依存性拡散MRIの腫瘍イメージングへの応用2023

    • Author(s)
      飯間麻美
    • Journal Title

      JSMI Report

      Volume: 16 Pages: 2-5

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Biomarkers Predictive of Distant Disease-free Survival Derived from Diffusion-weighted Imaging of Breast Cancer2023

    • Author(s)
      Honda Maya、Iima Mami、Kataoka Masako、Fukushima Yasuhiro、Ota Rie、Ohashi Akane、Toi Masakazu、Nakamoto Yuji
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 22 Issue: 4 Pages: 469-476

    • DOI

      10.2463/mrms.mp.2022-0060

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Associations between non-Gaussian diffusion parameters and Ki-67 expression in a PDX model of human triple negative breast cancer2024

    • Author(s)
      Sawako Hayami, Mami Iima, Tomomi Nobashi, Yuko Someya, Hirohiko Imai, Denis Le Bihan, Yuji Nakamoto
    • Organizer
      The 11th Takeda Science Foundation Symposium on PharmaSciences
    • Related Report
      2023 Annual Research Report
  • [Presentation] Effectiveness of DW/IVIM MRI parameters in evaluating anti-PD-1 antibody treatment response in xenograft models2023

    • Author(s)
      Sawako Hayami, Mami Iima, Tomomi Nobashi, Yuko Someya, Hirohiko Imai, Denis Le Bihan, Yuji Nakamoto
    • Organizer
      the 8th ISMRM-Japanese Chapter Annual Scientific Meeting
    • Related Report
      2023 Annual Research Report
  • [Presentation] SPENの臨床的有用性:経験度に基づく解析結果について2023

    • Author(s)
      中山 怜那, 飯間 麻美, 片岡 正子, 本田 茉也, Martins Otikovs, Noam Nissan, Lucio Frydma, 漆畑 勇太, 岡澤 藍夏, 戸井 雅和, 中本 裕士
    • Organizer
      第51回日本磁気共鳴医学会大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] High-resolution DWI in the breast by Spatiotemporal encoding (SPEN): clinical utility in comparison with SS-EPI and RESOLVE2023

    • Author(s)
      Rena Nakayama, Mami Iima, Masako Kataoka, Maya Honda, Martin Otikovs, Noam Nissan, Lucio Frydman, Yuta Urushibata, Rie Ota, Aika Okazawa, Masakazu Toi, Yuji Nakamoto
    • Organizer
      ISMRM & ISMRT 32nd Annual Meeting, Toronto, Canada
    • Related Report
      2023 Annual Research Report
  • [Presentation] Recent issues in breast diffusion weighted images2023

    • Author(s)
      Mami Iima
    • Organizer
      38th Unpa memorial symposium
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] ミクロとマクロを繋ぐ拡散強調画像による新たな乳癌診断の可能性2023

    • Author(s)
      飯間 麻美
    • Organizer
      第51回断層映像研究会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 乳房DWIの役割2023

    • Author(s)
      飯間 麻美
    • Organizer
      第56回 Radiology Update Fukuoka 学術講演会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Diagnostic value of 5b and 2b-value-DWI in breast tumors: comparison with combined MRI.2023

    • Author(s)
      Aika Okazawa , Mami Iima , Masako Kataoka , Ryosuke Okumura , Sachiko Takahara , Tomotaka Noda , Taro Nishi , Takayoshi Ishimori , Maya Honda , Yuji Nakamoto
    • Organizer
      ISMRM & ISMRT 32nd Annual Meeting, Toronto, Canada
    • Related Report
      2023 Annual Research Report
  • [Presentation] 腫瘍細胞のN/C比を反映可能なADC変化率の有用性2022

    • Author(s)
      染矢祐子, 飯間麻美, 瀧嶋宏章, 今井宏彦, 野橋智美, Denis Le Bihan, 中本裕士
    • Organizer
      第50回日本磁気共鳴医学会大会
    • Related Report
      2022 Research-status Report
  • [Presentation] Effects of fitting methods on IVIM parameter estimates in a melanoma xenograft model2022

    • Author(s)
      Hiroaki Takishima; Mami Iima; Yuko Someya; Hirohiko Imai; Denis Le Bihan; Yuji Nakamoto
    • Organizer
      第7回国際磁気共鳴医学会・日本支部学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] Diffusion-weighted Imaging Derived Parameters Of Breast Cancer As A Predictive Biomarker Of Distant Metastasis-free Survival2021

    • Author(s)
      Maya Honda, Mami Iima, Masako Kataoka, Rie Ota, Akane Ohashi, Yasuhiro Fukushima, Masakazu Toi, Yuji Nakamoto
    • Organizer
      北米放射線学会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 定量的拡散MRIでは足元にご注意を:アーチファクトとピットフォール2021

    • Author(s)
      飯間麻美
    • Organizer
      日本磁気共鳴医学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Diffusion-weighted Imaging of the Breast: state-of-the art and beyond2021

    • Author(s)
      Mami Iima
    • Organizer
      国際磁気共鳴医学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Diffusion MRI of the breast: Potential and challenges2021

    • Author(s)
      Mami Iima
    • Organizer
      アジア太平洋放射線学会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2021-04-28   Modified: 2025-01-30  

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