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A fundamental research on curation and verification methods of learning data to promote AI-CAD development

Research Project

Project/Area Number 21K07636
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionNational Hospital Organization, Kyushu Medical Center (Clinical Institute)

Principal Investigator

Noguchi Tomoyuki  独立行政法人国立病院機構九州医療センター(臨床研究センター), その他部局等, 放射線部長 (40380448)

Co-Investigator(Kenkyū-buntansha) 松下 由実  国立研究開発法人国立国際医療研究センター, 臨床研究センター, 臨床研究統括部 室長 (50450599)
志多 由孝  国立研究開発法人国立国際医療研究センター, センター病院, 放射線診療部門・放射線管理室医長 (50774668)
山下 孝二  九州大学, 医学研究院, 助教 (80546565)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsDeep learning / 機械学習 / 深層学習 / 医用画像 / 人工知能 / 腹部CT / 骨格筋 / 画像診断 / 医用画像用部位分類 / 虫垂炎 / AI
Outline of Research at the Start

自律的に学習・判断を行う「深層学習型AI」は、画像判定について飛躍的な発展を遂げている。その反面、AIの基礎知見について体系的に研究・検証されないまま、AI実装システムの製品化が先行している。こうした実用先行型開発は、間違った判定によるシステムエラーに対し脆弱である。このリスクを避けるためAI判定プロセスを理解する基盤的研究が不可欠であると考えている。本研究では①学習データキュレーションの研究、②AI-CAD性能適正検証法の研究、③医療側の立場からAI-CAD開発を支援できる医療系AIジェネラリスト従事者の育成、を推進する。

Outline of Final Research Achievements

AI technology that enables computers to perform "intelligent judgment" tasks typically carried out by humans has been attracting significant attention. Particularly, "deep learning AI," which autonomously learns and makes decisions, has made remarkable advancements in image recognition. However, the decision-making process of AI is often referred to as a "black box," and the commercialization of AI systems has progressed without sufficient foundational research and verification. This makes the systems vulnerable to errors. To mitigate this risk, it is crucial to conduct fundamental research to understand AI's decision-making processes. In this study, we promoted the following initiatives: 1) Curation of training data for medical information, 2) Development of objective and efficient performance validation methods for AI-CAD, and 3) Training medical AI generalists capable of supporting AI-CAD development from a healthcare perspective.

Academic Significance and Societal Importance of the Research Achievements

本基礎研究では、医用画像などの医療情報について学習データをを収集・選別・調整する方法を深く探求するとともに、AI-CADの客観的かつ効率的に性能を適正に検証する方法を見出した。こうしたAI-CAD開発技術者との共同研究を通じ、医療側からAI-CAD開発を支援できる医療系AIジェネラリストの育成を推進した。今後は共同研究者らによる次世代AI開発が発展していくものと思われ、それを引き続き指導者として支援を目指す。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (42 results)

All 2023 2022 2021

All Journal Article (17 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 17 results,  Open Access: 10 results) Presentation (23 results) (of which Int'l Joint Research: 1 results) Book (2 results)

  • [Journal Article] Assessment of skeletal muscle using deep learning on low-dose CT images2023

    • Author(s)
      Matsushita Y、Yokoyama T、Noguchi T、Nakagawa T.
    • Journal Title

      Global Health & Medicine

      Volume: 5 Issue: 5 Pages: 278-284

    • DOI

      10.35772/ghm.2023.01050

    • ISSN
      2434-9186, 2434-9194
    • Year and Date
      2023-10-31
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of "visible in retrospect" to monitor false-negative findings in radiological reports2023

    • Author(s)
      Noguchi T, Yamashita K, Matsuura S, Kamei R, Maehara J, Furuya K, Harada S, Adachi S, Okada Y
    • Journal Title

      Jpn J Radiol

      Volume: 41(2) Issue: 2 Pages: 219-27

    • DOI

      10.1007/s11604-022-01338-2

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Current status and challenges of percutaneous vertebroplasty (PVP)2023

    • Author(s)
      Noguchi Tomoyuki、Yamashita Koji、Kamei Ryotaro、Maehara Junki
    • Journal Title

      Japanese Journal of Radiology

      Volume: 41 Issue: 1 Pages: 1-13

    • DOI

      10.1007/s11604-022-01322-w

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Different hemodynamics of basal ganglia between moyamoya and non-moyamoya diseases using intravoxel incoherent motion imaging and single-photon emission computed tomography2023

    • Author(s)
      Yamashita K, Sugimori H, Nakamizo A, Amano T, Kuwashiro T, Watanabe T, Kawamata K, Furuya K, Harada S, Kamei R, Maehara J, Okada Y, Noguchi T
    • Journal Title

      Acta Radiol

      Volume: 64(2) Issue: 2 Pages: 769-75

    • DOI

      10.1177/02841851221092895

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Unusual imaging characteristics of cystic meningioma in cerebellopontine angle2022

    • Author(s)
      Adachi S, Yamashita K, Nakamizo A, Amano T, Momosaki S, Noguchi T
    • Journal Title

      The neuroradiology journal

      Volume: 35(6) Issue: 6 Pages: 777-9

    • DOI

      10.1177/19714009221096831

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preoperative Prediction of Intracranial Meningioma Grade Using Conventional CT and MRI2022

    • Author(s)
      Amano T, Nakamizo A, Murata H, Miyamatsu Y, Mugita F, Yamashita K, Noguchi T, Nagata S
    • Journal Title

      Cureus

      Volume: 14(1)

    • DOI

      10.7759/cureus.21610

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Validity of the gamma-Ray Evaluation with iodoamphetamine for Cerebral Blood Flow Assessment (REICA) method for quantification of cerebral blood flow including acetazolamide challenge test2022

    • Author(s)
      Miyazaki Y, Kameyama M, Nakamizo A, Noguchi T, Tabata N
    • Journal Title

      Ann Nucl Med

      Volume: 36(3) Issue: 3 Pages: 279-84

    • DOI

      10.1007/s12149-021-01700-w

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Accuracy of vertebral puncture in percutaneous vertebroplasty2022

    • Author(s)
      Noguchi T, Yamashita K, Shida Y, Okafuji T, Kamei R, Maehara J, Tajima T
    • Journal Title

      Jpn J Radiol

      Volume: 40(4) Issue: 4 Pages: 419-29

    • DOI

      10.1007/s11604-021-01216-3

    • NAID

      210000181385

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The usefulness of vertebral needle targeting simulation training system using ray-summation imaging: experimental study2022

    • Author(s)
      Uchiyama F, Noguchi T, Kamei S, Yamashita K, Shida Y, Okafuji T, Kamei R, Tajima T
    • Journal Title

      Jpn J Radiol

      Volume: 40(10) Issue: 10 Pages: 1096-103

    • DOI

      10.1007/s11604-022-01291-0

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interobserver Reliability on Intravoxel Incoherent Motion Imaging in Patients with Acute Ischemic Stroke2022

    • Author(s)
      Yamashita K, Kamei R, Sugimori H, Kuwashiro T, Tokunaga S, Kawamata K, Furuya K, Harada S, Maehara J, Okada Y, Noguchi T
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: 43(5) Issue: 5 Pages: 696-700

    • DOI

      10.3174/ajnr.a7486

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Right entorhinal cortical thickness is associated with Mini-Mental State Examination scores from multi-country datasets using MRI2022

    • Author(s)
      Yamashita K, Kuwashiro T, Ishikawa K, Furuya K, Harada S, Shin S, Wada N, Hirakawa C, Okada Y, Noguchi T
    • Journal Title

      Neuroradiology

      Volume: 64(2) Issue: 2 Pages: 279-88

    • DOI

      10.1007/s00234-021-02767-y

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Right adrenal vein identification using unenhanced magnetic resonance imaging2022

    • Author(s)
      Yamashita K, Wada N, Shin S, Watanabe T, Furuya K, Harada S, Noguchi T
    • Journal Title

      Polish journal of radiology / Polish Medical Society of Radiology

      Volume: 87( ) Pages: 592-596

    • DOI

      10.5114/pjr.2022.121236

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A practical system that enables physicians to respond expeditiously to significant unexpected findings (SUFs) in radiological reports2021

    • Author(s)
      Noguchi Tomoyuki、Tanaka Kumi、Okada Yasushi、Fukuizumi Kunitaka、Yokoda Sachiyo、Dairiki Motoko、Yamashita Koji、Shin Seitaro、Wada Noriaki、Harada Shino、Morita Shigeki
    • Journal Title

      Japanese Journal of Radiology

      Volume: 39 Issue: 5 Pages: 424-432

    • DOI

      10.1007/s11604-020-01077-2

    • NAID

      210000163235

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differentiating Dementia with Lewy Bodies and Alzheimer's Disease by Deep Learning to Structural MRI2021

    • Author(s)
      Nemoto Kiyotaka、Sakaguchi Hiromasa、Kasai Wataru、Hotta Masatoshi、Kamei Ryotaro、Noguchi Tomoyuki、Minamimoto Ryogo、Arai Tetsuaki、Asada Takashi
    • Journal Title

      Journal of Neuroimaging

      Volume: - Issue: 3 Pages: 579-587

    • DOI

      10.1111/jon.12835

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Safety and Efficacy of Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fractures: A Multicenter Retrospective Study in Japan2021

    • Author(s)
      Kobayashi Nobuo、Noguchi Tomoyuki、Kobayashi Daiki、Saito Hiroya、Shimoyama Keiji、Tajima Tsuyoshi、Sosogi Sho、Kobayashi Kiyokazu、Shida Yoshitaka、Hasebe Terumitsu、Numaguchi Yuji
    • Journal Title

      Interventional Radiology

      Volume: 6 Issue: 2 Pages: 21-28

    • DOI

      10.22575/interventionalradiology.2020-0032

    • NAID

      130008060947

    • ISSN
      2432-0935
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] MADGAN: unsupervised medical anomaly detection GAN using multiple adjacent brain MRI slice reconstruction2021

    • Author(s)
      Han Changhee、Rundo Leonardo、Murao Kohei、Noguchi Tomoyuki、Shimahara Yuki、Milacski Zolt?n ?d?m、Koshino Saori、Sala Evis、Nakayama Hideki、Satoh Shin’ichi
    • Journal Title

      BMC Bioinformatics

      Volume: 22 Issue: S2 Pages: 31-31

    • DOI

      10.1186/s12859-020-03936-1

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 画像診断報告書の予期せぬ重大所見の確認に関する多職種による医療安全対策2021

    • Author(s)
      田中久美、岡田靖、野口智幸、福泉公仁隆、与古田幸代、森田茂樹
    • Journal Title

      医療: 国立医療学会誌: Japanese journal of National Medical Services:

      Volume: 75 Pages: 199-206

    • NAID

      40022673809

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Proposal Of Regional Organ Classification (ROC) As Body Part Classification In Medical Imaging2023

    • Author(s)
      Noguchi, Tomoyuki; Matsuura, Shuji; Kamei, Ryotaro; Maehara, Junki; Furuya, Kiyomi; Harada, Shino; Adachi, Saki
    • Organizer
      第82回日本医学放射線学会総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 「Nothing about me without me」放射線科領域における患者中心医療2023

    • Author(s)
      野口智幸; 松浦秀司; 亀井僚太郎; 前原純樹; 古谷清美; 原田詩乃; 白石貴大; 高木美緒
    • Organizer
      第59回日本医学放射線学会秋季大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Proposal Of Regional Organ Classification (ROC) As Body Part Classification In Medical Imaging2023

    • Author(s)
      Noguchi T, Matsuura S, Kamei R, Maehara J, Furuya K, Harada S, Adachi S
    • Organizer
      第82回日本医学放射線学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 緊急内視鏡中に心停止を来した十二指腸潰瘍出血を経カテーテル塞栓術で止血しえた1例2023

    • Author(s)
      野口智幸, 松浦秀司, 亀井僚太郎, 前原純樹, 古谷清美, 原田詩乃, 智幸 野, 足達咲紀
    • Organizer
      第52回日本IVR学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] A fail-safe system for SUF Errors in Radiological Reports (SUFERR): Achievements and challenges2022

    • Author(s)
      Kamei R, Maehara J, Furuya K, Harada S, Yamashita K, Noguchi T
    • Organizer
      第81回日本医学放射線学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] Retrospective analysis of false-negative findings in Radiological reports放射線レポートにおける偽陰性所見の後方視的分析2022

    • Author(s)
      Noguchi T, Yamashita K, Kamei R, Maehara J, Furuya K, Harada S, Okada Y
    • Organizer
      第81回日本医学放射線学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 椎骨三分位穿刺(VETERAN)法による椎骨穿刺のシミュレーション分析A simulation analysis of vertebral puncture by the vertebral tertile area needling (VETERAN) method2022

    • Author(s)
      Noguchi T, Yamashita K, Kamei R, Maehara J, Furuya K, Harada S
    • Organizer
      第51回日本IVR学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 進行膵癌の仙骨転移に経皮的椎体形成術(PVP)を行った一例2022

    • Author(s)
      野口智幸, 亀井僚太郎, 前原純樹, 足達咲紀, 松浦秀司, 古谷清美, 原田詩乃, 加来豊馬
    • Organizer
      第53回福岡IVRカンファレンス(on the web,福岡市)
    • Related Report
      2022 Research-status Report
  • [Presentation] 既存療法に奏功しない有痛性仙骨転移に経皮的椎体形成術(PVP)を行った一例2022

    • Author(s)
      野口智幸, 亀井僚太郎, 前原純樹, 足達咲紀, 松浦秀司, 古谷清美, 原田詩乃, 加来豊馬
    • Organizer
      第58回日本医学放射線学会秋季大会
    • Related Report
      2022 Research-status Report
  • [Presentation] Management To Achieve Zero Non-action For SUFs.2021

    • Author(s)
      Noguchi T, Yamashita K, Kamei R, Maehara J, Furuya K, Harada S.
    • Organizer
      107th Scientific Assembly and Annual Meeting of Radiological Society of North America
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 学術賞:重大な画像所見(SUF)の見落とし防止システム(SUFERR防止システム):当センターの取り組み2021

    • Author(s)
      野口智幸
    • Organizer
      2021年度 九州医療センター臨床研究発表会
    • Related Report
      2021 Research-status Report
  • [Presentation] 放射線領域のAI画像診断2021

    • Author(s)
      野口智幸
    • Organizer
      2021年度 地域医師のための生涯研修セミナー第2回講演
    • Related Report
      2021 Research-status Report
  • [Presentation] 重大な画像所見(SUF)の見落とし防止システム(SUFERR防止システム)の実践2021

    • Author(s)
      野口智幸
    • Organizer
      第52回全国国立大学法人放射線診療部門会議
    • Related Report
      2021 Research-status Report
  • [Presentation] 「骨粗鬆症性椎体骨折に対する経皮的椎体形成術を安全に行うための指針」の概説と課題についてOutline and issues of the Guideline for safe percutaneous vertebroplasty for osteoporotic vertebral body fracturesin JAPAN2021

    • Author(s)
      野口智幸
    • Organizer
      第50回日本IVR学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] The efficacy and safety of percutaneous transhepatic portal vein embolization using coils alone2021

    • Author(s)
      Wada N, Yamashita K, Shin S, Harada S, Furuya K, Takami Y, Noguchi T
    • Organizer
      第50回日本IVR学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] CyPos賞銀賞:Data contamination and curation in training deep learning2021

    • Author(s)
      野口智幸, 山下孝二, 進政太郎, 和田憲明, 原田詩乃
    • Organizer
      第80回日本医学放射線学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] CyPos賞銅賞:An effective fail-safe alert system handling significant unexpected findings (SUFs) in radiological reports 画像診断レポートでの予期せぬ重大所見(SUF)に関する医療安全対策2021

    • Author(s)
      野口智幸, 山下孝二, 進政太郎, 和田憲明, 原田詩乃
    • Organizer
      第80回日本医学放射線学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Notice, Read, and Act on significant unexpected findings (SUF) in radiological reports2021

    • Author(s)
      野口智幸, 山下孝二, 進政太郎, 和田憲明, 原田詩乃
    • Organizer
      第80回日本医学放射線学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] An effective fail-safe alert system handling significant unexpected findings (SUFs) in radiological reports 画像診断レポートでの予期せぬ重大所見(SUF)に関する医療安全対策2021

    • Author(s)
      野口智幸, 山下孝二, 進政太郎, 和田憲明, 原田詩乃
    • Organizer
      第80回日本医学放射線学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Data contamination and curation in training deep learning2021

    • Author(s)
      野口智幸, 山下孝二, 進政太郎, 和田憲明, 原田詩乃
    • Organizer
      第80回日本医学放射線学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Current status and future challenges of percutaneous vertebroplasty (PVP)2021

    • Author(s)
      野口智幸
    • Organizer
      第80回日本医学放射線学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] A Comparative study of 3D Imaging Simulation for Virtual active self-training intervention regarding PVP procedure2021

    • Author(s)
      内山史也, 野口智幸, 志多由孝, 岡藤孝史, 亀井遼太郎, 亀井俊祐, 田嶋強
    • Organizer
      第80回日本医学放射線学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Correlation Between Right Entorhinal Cortical Thickness and MMSE Scores Using Multi-country Datasets2021

    • Author(s)
      山下孝二, 桑城貴弘, 石川謙介, 古谷清美, 原田詩乃, 進政太郎, 和田憲明, 平川千夏, 野口智幸
    • Organizer
      第80回日本医学放射線学会総会
    • Related Report
      2021 Research-status Report
  • [Book] 骨粗鬆症性脊椎骨折のための経皮的椎体形成術(PVP)マニュアル2023

    • Author(s)
      野口智幸
    • Total Pages
      120
    • Publisher
      株式会社メディカルアイ
    • ISBN
      9784862912633
    • Related Report
      2023 Annual Research Report
  • [Book] 骨粗鬆症性脊椎骨折のための経皮的椎体形成術(PVP)マニュアル2023

    • Author(s)
      野口智幸
    • Total Pages
      120
    • Publisher
      株式会社メディカルアイ
    • ISBN
      9784862912633
    • Related Report
      2022 Research-status Report

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Published: 2021-04-28   Modified: 2025-01-30  

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