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A novel stereotactic radiotherapy treatment planning using artificial intelligence for patients with brain metastases

Research Project

Project/Area Number 21K07742
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionThe University of Tokyo (2023)
Osaka International Cancer Institute (2021-2022)

Principal Investigator

Ohira Shingo  東京大学, 医学部附属病院, 学術専門職員 (50792694)

Co-Investigator(Kenkyū-buntansha) 小池 優平  関西医科大学, 医学部, 助教 (90866154)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2023: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2022: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2021: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords転移性脳腫瘍 / 放射線治療 / MRI / 人工知能 / 定位放射線治療 / 医学物理 / 迅速
Outline of Research at the Start

有害事象低減を目的とする定位放射線治療(治療一回あたりに大線量を投与する技法、治療準備期間7-14日)において、急速に増大する転移性脳腫瘍に対して迅速に治療を施行しなければ、投与線量が不十分となり、期待する治療効果を得られない可能性がある。本研究では、人工知能を活用することで、迅速に治療を提供する革新的迅速放射線治療計画法の構築を行う。

Outline of Final Research Achievements

Metastatic brain tumors can seriously impair a patient's quality of life and can be a direct cause of death. Stereotactic radiotherapy (a high-dose-per-treatment technique with a 7-14 day preparation period) must be administered immediately to rapidly growing tumors or the dose may be inadequate and the expected therapeutic effect may not be achieved. In this study, we developed an innovative radiotherapy planning method for rapid stereotactic radiotherapy for metastatic brain tumors by utilizing artificial intelligence (deep/machine learning). It is expected to improve treatment outcomes and reduce adverse events.

Academic Significance and Societal Importance of the Research Achievements

本研究では経験豊富な医学物理士または診療放射線技師が作成した転移性脳腫瘍に対する治療計画の線量分布を機械学習させることによって、優れた治療計画を自動で生成する学術的価値・創造性の高い研究である。さらに、転移性脳腫瘍の描出に優れるMR画像からCT画像を生成することによって、放射線治療のシミュレーションから治療開始までの期間を短縮することが期待される。急速に増大する転移性脳腫瘍に対して迅速な治療の提供は治療成績の改善につながる可能性があり、社会的意義は大きい。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (10 results)

All 2024 2023 2022 2021

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 5 results) Book (1 results)

  • [Journal Article] Long-term geometric quality assurance of radiation focal point and cone-beam computed tomography for Gamma Knife radiosurgery system2024

    • Author(s)
      Ohira Shingo、Imae Toshikazu、Minamitani Masanari、Katano Atsuto、Aoki Atsushi、Ohta Takeshi、Umekawa Motoyuki、Shinya Yuki、Hasegawa Hirotaka、Nishio Teiji、Koizumi Masahiko、Yamashita Hideomi、Saito Nobuhito、Nakagawa Keiichi
    • Journal Title

      Radiological Physics and Technology

      Volume: 11 Issue: 2 Pages: 389-395

    • DOI

      10.1007/s12194-024-00788-9

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effects of distance between the imaging isocenter and brain center on the image quality of cone-beam computed tomography for brain stereotactic irradiation2024

    • Author(s)
      Kihara Sayaka、Ohira Shingo、Kanayama Naoyuki、Ikawa Toshiki、Ueda Yoshihiro、Inui Shoki、Minami Hikari、Sagawa Tomohiro、Miyazaki Masayoshi、Koizumi Masahiko、Konishi Koji
    • Journal Title

      Physical and Engineering Sciences in Medicine

      Volume: - Issue: 2 Pages: 597-609

    • DOI

      10.1007/s13246-024-01389-x

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of magnetic resonance imaging-related geometric distortion of dose distribution in fractionated stereotactic radiotherapy in patients with brain metastases2023

    • Author(s)
      Ohira Shingo、Suzuki Yuta、Washio Hayate、Yamamoto Yuki、Tateishi Soichiro、Inui Shoki、Kanayama Naoyuki、Kawamata Minoru、Miyazaki Masayoshi、Nishio Teiji、Koizumi Masahiko、Nakanishi Katsuyuki、Konishi Koji
    • Journal Title

      Strahlentherapie und Onkologie

      Volume: 200 Issue: 1 Pages: 39-48

    • DOI

      10.1007/s00066-023-02120-7

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of target coverage using automated non-coplanar volumetric modulated arc therapy planning in stereotactic radiotherapy for cervical metastatic spinal tumors2023

    • Author(s)
      Ohira Shingo、Ikawa Toshiki、Inui Shoki、Kanayama Naoyuki、Ueda Yoshihiro、Miyazaki Masayoshi、Nishio Teiji、Koizumi Masahiko、Konishi Koji
    • Journal Title

      Medical Dosimetry

      Volume: 48 Issue: 3 Pages: 197-201

    • DOI

      10.1016/j.meddos.2023.04.001

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Linear accelerator-based stereotactic radiotherapy for brain metastases, including multiple and large lesions, carries a low incidence of acute toxicities: a retrospective analysis2023

    • Author(s)
      Ikawa Toshiki、Kanayama Naoyuki、Arita Hideyuki、Ohira Shingo、Takano Koji、Hirata Takero、Morimoto Masahiro、Teshima Teruki、Konishi Koji
    • Journal Title

      Radiation Oncology

      Volume: 18 Issue: 1 Pages: 1-9

    • DOI

      10.1186/s13014-023-02262-z

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of dosimetric parameters and robustness for rotational errors in fractionated stereotactic irradiation using automated noncoplanar volumetric modulated arc therapy for patients with brain metastases: single- versus multi-isocentric technique2023

    • Author(s)
      Yamamoto Yuki、Ohira Shingo、Kanayama Naoyuki、Inui Shoki、Ueda Yoshihiro、Koike Yuhei、Miyazaki Masayoshi、Nishio Teiji、Koizumi Masahiko、Konishi Koji
    • Journal Title

      Radiological Physics and Technology

      Volume: 16 Issue: 2 Pages: 310-318

    • DOI

      10.1007/s12194-023-00720-7

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dosimetric potential of knowledge‐based planning model trained with HyperArc plans for brain metastases2022

    • Author(s)
      Sagawa Tomohiro、Ueda Yoshihiro、Tsuru Haruhi、Kamima Tatsuya、Ohira Shingo、Tamura Mikoto、Miyazaki Masayoshi、Monzen Hajime、Konishi Koji
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 24 Issue: 2

    • DOI

      10.1002/acm2.13836

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intra‐fractional motion error during HyperArc stereotactic radiosurgery on patients with brain metastases: Comparison of open and full‐face clamshell‐style immobilization devices2022

    • Author(s)
      Ohira Shingo、Komiyama Riho、Kanayama Naoyuki、Ueda Yoshihiro、Inui Shoki、Miyazaki Masayoshi、Koizumi Masahiko、Konishi Koji
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 23 Issue: 4 Pages: 1-8

    • DOI

      10.1002/acm2.13536

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Multileaf Collimator Width on Dose Distribution in HyperArc Fractionated Stereotactic Irradiation for Multiple (-) Brain Metastases2021

    • Author(s)
      OHIRA SHINGO、UEDA YOSHIHIRO、KANAYAMA NAOYUKI、ISONO MASARU、INUI SHOKI、KOMIYAMA RIHO、WASHIO HAYATE、MIYAZAKI MASAYOSHI、KOIZUMI MASAHIKO、TESHIMA TERUKI、KONISHI KOJI
    • Journal Title

      Anticancer Research

      Volume: 41 Issue: 6 Pages: 3153-3159

    • DOI

      10.21873/anticanres.15101

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Book] 放射線治療学2023

    • Author(s)
      井上 俊彦、小川 和彦、小泉 雅彦
    • Total Pages
      481
    • Publisher
      南山堂
    • ISBN
      9784525270971
    • Related Report
      2023 Annual Research Report

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Published: 2021-04-28   Modified: 2025-01-30  

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