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乳児期発症てんかんの遺伝学的解析に基づく精密医療の基盤構築

Research Project

Project/Area Number 21K07810
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52050:Embryonic medicine and pediatrics-related
Research InstitutionAichi Medical University

Principal Investigator

奥村 彰久  愛知医科大学, 医学部, 教授 (60303624)

Co-Investigator(Kenkyū-buntansha) 倉橋 宏和  愛知医科大学, 医学部, 講師 (30621817)
東 慶輝  愛知医科大学, 医学部, 講師 (60628593)
Project Period (FY) 2021-04-01 – 2025-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords乳児てんかん / 遺伝子解析 / 精密医療
Outline of Research at the Start

(1) 2歳未満に発症したてんかんのうち、周産期脳障害などの明らかな獲得性の病因を持たないものを広く対象とし、トリオ検体を用いた全エクソーム解析を行う。
(2) 全エクソーム解析で責任遺伝子を同定できなかった場合は、全ゲノム解析・ロングリードシークエンス・RNA-seq解析を行い、さらなる責任遺伝子の探索を行う。
(3) 発作症状や治療経過などの臨床情報に基づき、てんかんの表現型や薬剤の有効性を解析する。遺伝学的解析結果と臨床的解析結果を統合し、乳児期発症てんかんの遺伝学的情報に基づくprecision medicineの基盤を構築する。

Outline of Annual Research Achievements

2歳未満発症のてんかんのうち1)自然終息性乳児てんかんが疑われる症例、2)発熱感受性を示しDravet症候群およびその近縁疾患が疑われる症例、3)発達性およびてんかん性脳症(DEE)が疑われる症例について、解析を継続している。自然終息性乳児てんかんでは25例についてPRRT2遺伝子バリアントの有無を検討したところ、6例にPRRT2バリアントを認めた。PRRT2バリアントを認めない19例について全エクソーム解析を試行したところ、現在まで2つの遺伝子について新規のてんかん原性遺伝子の可能性があることが判明した。そのうち1つの遺伝子は複数の家系に関与しており、その病原性について解析を進めている。解析を行った症例では、PRRT2バリアントの有無によって発作予後には大きな相違はないが、PRRT2バリアントを認めない症例では年長児になっても発作が残存する例や知的能力症・神経発達症を認める症例が散見される点で、PRRT2バリアントを認める症例とは相違があった。Dravet症候群を疑う症例では、6例について様々な方法で遺伝子解析を試行した。6例中4例にはSCN1A遺伝子の病的なバリアントを認め、臨床症状と合わせてDravet症候群と診断した。これらの症例は全て顕著な発熱過敏性と多彩な発作を認め、抗発作薬による治療にもかかわらず発作が持続していた。1例はSTXBP1遺伝子に病的バリアントを認めた。この症例では家族の希望で抗発作薬を中止しケトン食による治療を行っているが、比較的発作コントロールは良好である。DEEを疑う症例では、全エクソーム解析によってKCNT1、TBCD1、SCN2A、CLTC、CHD2など様々な遺伝子バリアントを同定することができた。いずれの症例も著しい治療抵抗性の重篤なてんかん発作と重度の発達遅滞を呈した。このような重症症例における遺伝子解析の意義が確認された。

Current Status of Research Progress
Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

コロナウイルス感染症の流行により、研究のための時間の確保や情報の収集が困難になったこと、多施設との連携に困難が生じたこと、患者の受診控えなどの影響で、研究の進捗に遅滞を生じた。

Strategy for Future Research Activity

新たな症例の遺伝学的解析を進めるとともに、前年度に得られた症例についてさらに解析を進める。特に、PRRT2バリアントを認めない良性乳児てんかん、SCN1A遺伝子バリアントを認めない発熱感受性てんかんの新たな候補遺伝子については、その病的意義を解明することを試みる

Report

(3 results)
  • 2023 Research-status Report
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (44 results)

All 2023 2022 2021

All Journal Article (32 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 32 results,  Open Access: 15 results) Presentation (11 results) (of which Int'l Joint Research: 2 results,  Invited: 7 results) Book (1 results)

  • [Journal Article] Long-term efficacy of nusinersen and its evaluation in adolescent and adult patients with spinal muscular atrophy types 1 and 22023

    • Author(s)
      Iwayama Hideyuki、Kawahara Kohei、Takagi Mizuki、Numoto Shingo、Azuma Yoshiteru、Kurahashi Hirokazu、Yasue Yumiko、Kawajiri Hiroyuki、Yanase Atsushi、Ito Teruyoshi、Kimura Shinya、Kumagai Toshiyuki、Okumura Akihisa
    • Journal Title

      Brain and Development

      Volume: 45 Issue: 2 Pages: 110-116

    • DOI

      10.1016/j.braindev.2022.10.006

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] A nationwide survey of human metapneumovirus-associated encephalitis/encephalopathy in Japan2023

    • Author(s)
      Mori Ayumi、kawano Yoshihiko、Hara Shinya、Numoto Shingo、Kurahashi Hirokazu、okumura Akihisa
    • Journal Title

      Brain and Development

      Volume: 45 Issue: 4 Pages: 197-204

    • DOI

      10.1016/j.braindev.2023.01.001

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Severe pediatric acute encephalopathy syndromes related to SARS-CoV-2.2023

    • Author(s)
      Sakuma H, Takanashi JI, Okumura A, et al.
    • Journal Title

      Front Neurosci

      Volume: 17 Pages: 1085082-1085082

    • DOI

      10.3389/fnins.2023.1085082

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bacteremia Caused by Kalamiella piersonii Found in an Infant During the Course of Gastrointestinal Food Allergy.2023

    • Author(s)
      Sada J, Hirai J, Okumura A, et al.
    • Journal Title

      Infect Drug Resist.

      Volume: 16 Pages: 2647-2651

    • DOI

      10.2147/idr.s402364

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Radial nerve palsy caused by a rapidly growing intramuscular hematoma in an infant with biliary atresia: a case report2023

    • Author(s)
      Kawahara Kohei、Ota Koki、Numoto Shingo、Nakamura Nami、Miyamoto Ryosuke、Honma Hitoshi、Morishita Yusuke、Kawanami Katsuhisa、Matsushita Nozomi、Kato Shoko、Kaneko Kenitiro、Okumura Akihisa、Iwayama Hideyuki
    • Journal Title

      BMC Pediatrics

      Volume: 23 Issue: 1 Pages: 247-247

    • DOI

      10.1186/s12887-023-04071-5

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Current status of neonatal jaundice management in Japan.2023

    • Author(s)
      Honbe K, Hayakawa M, Okumura A, et al.
    • Journal Title

      Pediatr Int

      Volume: 65(1) Issue: 1

    • DOI

      10.1111/ped.15617

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Medical records as screening tools for child death review in Japan.2023

    • Author(s)
      Numaguchi A, Ishii A, Okumura A, et al.
    • Journal Title

      Pediatr Int

      Volume: 65(1) Issue: 1

    • DOI

      10.1111/ped.15692

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Burden of seizures and comorbidities in patients with epilepsy: a survey based on the tertiary hospital-based Epilepsy Syndrome Registry in Japan.2022

    • Author(s)
      Inoue Y, Hamano SI, Hayashi M, Sakuma H, Hirose S, Ishii A, Honda R, Ikeda A, Imai K, Jin K, Kada A, Kakita A, Kato M, Kawai K, Kawakami T, Kobayashi K, Matsuishi T, Matsuo T, Nabatame S, Okamoto N, Ito S, Okumura A, Saito A, Shiraishi H, Shirozu H, Saito T, Sugano H, Takahashi Y, Yamamoto H, Fukuyama T, Kuki I.
    • Journal Title

      Epileptic Disord

      Volume: 24 Issue: 1 Pages: 82-94

    • DOI

      10.1684/epd.2021.1361

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute encephalopathy with biphasic seizures and late reduced diffusion: Predictive EEG findings2022

    • Author(s)
      Ohno A, Okumura A, Fukasawa T, Nakata T, Suzuki M, Tanaka M, Okai Y, Ito Y, Yamamoto H, Tsuji T, Kidokoro H, Saitoh S, Natsume J.
    • Journal Title

      Brain Dev

      Volume: 44(3) Issue: 3 Pages: 221-228

    • DOI

      10.1016/j.braindev.2021.11.003

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of brain structures in childhood epilepsy with centrotemporal spikes2022

    • Author(s)
      Ito Y, Maki Y, Okai Y, Kidokoro H, Bagarinao E, Takeuchi T, Ohno A, Nakata T, Ishihara N, Okumura A, Yamamoto H, Maesawa S, Natsume J
    • Journal Title

      Pediatr Int

      Volume: 64(1)

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Death review of children receiving medical care at home2022

    • Author(s)
      Natsume J, Numaguchi A, Ohno A, Mizuno M, Takahashi Y, Okumura A, Yoshikawa T, Saitoh S, Miura K, Noda M
    • Journal Title

      Pediatr Res

      Volume: 91(5) Issue: 5 Pages: 1286-1289

    • DOI

      10.1038/s41390-021-01606-3

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Subcortical infarction in a young adult with Hunter syndrome2022

    • Author(s)
      Kimura M, Azuma Y, Taguchi S, Takagi M, Mori H, Shimomura Y, Niwa JI, Doyu M, Okumura A.
    • Journal Title

      Brain Dev

      Volume: 44(5) Issue: 5 Pages: 343-346

    • DOI

      10.1016/j.braindev.2022.01.003

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case report: Mild encephalitis with a reversible splenial lesion associated with SARS-CoV-2 infection in a patient with MYRF variant2022

    • Author(s)
      Saito Mizuho、Nakazawa Tomoyuki、Toriumi Shun、Takasu Michihiko、Yagisawa Hiromi、Murano Yayoi、Miyazaki Nao、Kurahashi Hirokazu、Okumura Akihisa、Shimizu Toshiaki
    • Journal Title

      Frontiers in Pediatrics

      Volume: 10 Pages: 971432-971432

    • DOI

      10.3389/fped.2022.971432

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Whole-exome analysis of 177 pediatric patients with undiagnosed diseases.2022

    • Author(s)
      Narita K, Muramatsu H, Narumi S, Nkawa T, Okumura A, et al.
    • Journal Title

      Sci Rep

      Volume: 12(1) Issue: 1 Pages: 14589-14589

    • DOI

      10.1038/s41598-022-14161-6

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Case report: Five patients with myocarditis after mRNA COVID-19 vaccination2022

    • Author(s)
      Murase Hiroki、Zhu Yiqing、Sakaida Keiya、Mizuno Hayato、Mori Hiromitsu、Iwayama Hideyuki、Suzuki Noriyuki、Nagai Noriko、Okumura Akihisa
    • Journal Title

      Frontiers in Pediatrics

      Volume: 10 Pages: 977476-977476

    • DOI

      10.3389/fped.2022.977476

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human herpesvirus 6 <scp>DNA</scp> was not detected in a brain specimen from a patient with mesial temporal sclerosis after status epilepticus due to human herpesvirus 6 infection2022

    • Author(s)
      Kawamura Yoshiki、Maesawa Satoshi、Numoto Shingo、Saito Ryuta、Yoshikawa Tetsushi、Okumura Akihisa
    • Journal Title

      Epilepsia Open

      Volume: 7 Issue: 4 Pages: 817-821

    • DOI

      10.1002/epi4.12634

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A pilot study of serum free carnitine levels in hospitalized febrile children.2021

    • Author(s)
      Okumura A, Muto T, Nakamura N, Masuda Y, Kodama S.
    • Journal Title

      Pediatr Int.

      Volume: 63 Issue: 1 Pages: 102-103

    • DOI

      10.1111/ped.14360

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Auditory brainstem response in preterm infants with bilirubin encephalopathy2021

    • Author(s)
      Okumura Akihisa、Kitai Yukihiro、Arai Hiroshi、Hayakawa Masahiro、Maruo Yoshihiro、Kusaka Takashi、Kunikata Tetsuya、Kumada Satoko、Morioka Ichiro
    • Journal Title

      Early Human Development

      Volume: 154 Pages: 105319-105319

    • DOI

      10.1016/j.earlhumdev.2021.105319

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnetic resonance imaging abnormalities during the neonatal period in preterm infants with bilirubin encephalopathy.2021

    • Author(s)
      Okumura A, Kitai Y, Arai H.
    • Journal Title

      Pediatr Neonatol.

      Volume: 62 Issue: 5 Pages: 567-568

    • DOI

      10.1016/j.pedneo.2021.03.013

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Carnitine supplementation prevents carnitine deficiency caused by pivalate-conjugated antibiotics in patients with epilepsy prescribed valproate.2021

    • Author(s)
      Okumura A, Numoto S, Iwayama H, Azuma Y, Kurahashi H.
    • Journal Title

      Epilepsy Behav.

      Volume: 117 Pages: 107883-107883

    • DOI

      10.1016/j.yebeh.2021.107883

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neonatal Jaundice in Preterm Infants with Bilirubin Encephalopathy2021

    • Author(s)
      Okumura Akihisa、Ichimura Shintaro、Hayakawa Masahiro、Arai Hiroshi、Maruo Yoshihiro、Kusaka Takashi、Kunikata Tetsuya、Kumada Satoko、Morioka Ichiro
    • Journal Title

      Neonatology

      Volume: 19 Issue: 3 Pages: 1-9

    • DOI

      10.1159/000513785

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnetic Resonance Imaging Findings in Preterm Infants With Bilirubin Encephalopathy Beyond Three Years Corrected Age.2021

    • Author(s)
      Okumura A, Kitai Y, Arai H, Hayakawa M, Maruo Y, Kusaka T, Kunikata T, Kumada S, Morioka I.
    • Journal Title

      Pediatr Neurol.

      Volume: 121 Pages: 56-58

    • DOI

      10.1016/j.pediatrneurol.2021.05.019

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of l-carnitine supplementation in patients with childhood-onset epilepsy prescribed valproate2021

    • Author(s)
      Okumura Akihisa、Takagi Mizuki、Numoto Shingo、Iwayama Hideyuki、Azuma Yoshiteru、Kurahashi Hirokazu
    • Journal Title

      Epilepsy &amp; Behavior

      Volume: 122 Pages: 108220-108220

    • DOI

      10.1016/j.yebeh.2021.108220

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Guidelines for the diagnosis and treatment of acute encephalopathy in childhood2021

    • Author(s)
      Mizuguchi Masashi、Ichiyama Takashi、Imataka George、Okumura Akihisa、Goto Tomohide、Sakuma Hiroshi、Takanashi Jun-ichi、Murayama Kei、Yamagata Takanori、Yamanouchi Hideo、Fukuda Tokiko、Maegaki Yoshihiro
    • Journal Title

      Brain and Development

      Volume: 43 Issue: 1 Pages: 2-31

    • DOI

      10.1016/j.braindev.2020.08.001

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Three-Year Longitudinal Motor Function and Disability Level of Acute Flaccid Myelitis2021

    • Author(s)
      Chong Pin Fee、Kira Ryutaro、Torisu Hiroyuki、Yasumoto Sawa、Okumura Akihisa、Mori Harushi、Tanaka-Taya Keiko.
    • Journal Title

      Pediatric Neurology

      Volume: 116 Pages: 14-19

    • DOI

      10.1016/j.pediatrneurol.2020.11.019

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute encephalopathy in children with tuberous sclerosis complex2021

    • Author(s)
      Numoto S, Kurahashi H, Sato A, Kubota M, Shiihara T, Okanishi T, Tanaka R, Kuki I, Fukuyama T, Kashiwagi M, Ikeno M, Kubota K, Akasaka M, Mimaki M, Okumura
    • Journal Title

      Orphanet J Rare Dis.

      Volume: 16 Issue: 1 Pages: 5-5

    • DOI

      10.1186/s13023-020-01646-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of the Diagnostic Criteria for Anti-NMDA Receptor Encephalitis in Japanese Children.2021

    • Author(s)
      Nishida H, Kohyama K, Kumada S, Takanashi JI, Okumura A, Horino A, Moriyama K, Sakuma H.
    • Journal Title

      Neurology.

      Volume: 96 Issue: 16

    • DOI

      10.1212/wnl.0000000000011789

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Repetitive sleep starts: An important differential diagnosis of infantile spasms.2021

    • Author(s)
      Maki Y, Kidokoro H, Okumura A, Yamamoto H, Nakata T, Fukasawa T, Kubota T, Kawaguchi M, Suzuki T, Tanaka M, Okai Y, Sakaguchi Y, Ohno A, Negoro T, Takahashi Y, Natsume J.
    • Journal Title

      Epilepsy Behav.

      Volume: 121 Pages: 108075-108075

    • DOI

      10.1016/j.yebeh.2021.108075

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical and electrophysiological features of acute flaccid myelitis: A national cohort study.2021

    • Author(s)
      Chong PF, Torisu H, Yasumoto S, Okumura A, Mori H, Sato T, Kimura J, Ohga S, Tanaka-Taya K, Kira R
    • Journal Title

      Clin Neurophysiol.

      Volume: 132 Issue: 10 Pages: 2456-2463

    • DOI

      10.1016/j.clinph.2021.07.013

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regional Difference in Myelination in Monocarboxylate Transporter 8 Deficiency: Case Reports and Literature Review of Cases in Japan2021

    • Author(s)
      Iwayama Hideyuki、Tanaka Tatsushi、Aoyama Kohei、Moroto Masaharu、Adachi Shinsuke、Fujisawa Yasuko、Matsuura Hiroki、Takano Kyoko、Mizuno Haruo、Okumura Akihisa
    • Journal Title

      Frontiers in Neurology

      Volume: 12 Pages: 657820-657820

    • DOI

      10.3389/fneur.2021.657820

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Measurement of Reverse Triiodothyronine Level and the Triiodothyronine to Reverse Triiodothyronine Ratio in Dried Blood Spot Samples at Birth May Facilitate Early Detection of Monocarboxylate Transporter 8 Deficiency2021

    • Author(s)
      Iwayama Hideyuki、Kakita Hiroki、Iwasa Masumi、Adachi Shinsuke、Takano Kyoko、Kikuchi Masahiro、Fujisawa Yasuko、Osaka Hitoshi、Yamada Yasumasa、Okumura Akihisa、Hirani Khemraj、Weiss Roy E.、Refetoff Samuel
    • Journal Title

      Thyroid

      Volume: 31 Issue: 9 Pages: 696-696

    • DOI

      10.1089/thy.2020.0696

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sodium channel blockers are effective for benign infantile epilepsy.2021

    • Author(s)
      Numoto S, Kurahashi H, Takagi M, Azuma Y, Iwayama H, Okumura A.
    • Journal Title

      Seizure

      Volume: 92 Pages: 207-210

    • DOI

      10.1016/j.seizure.2021.09.008

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] てんかん発作とてんかんでない「発作」:見分けるコツ2023

    • Author(s)
      奥村彰久
    • Organizer
      第126回日本小児科学会学術集会
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] Dravet症候群の診断と治療 New Chapter2023

    • Author(s)
      奥村彰久
    • Organizer
      第34回日本小児神経学会中国・四国地方会
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] 子どものてんかん診療における脳波の役割と抗発作薬2023

    • Author(s)
      奥村彰久、河村吉紀、前澤聡、沼本真吾、斎藤竜太、吉川哲史
    • Organizer
      第19回日本てんかん学会近畿地方会
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] 旧来の抗てんかん薬の出番は限られる2022

    • Author(s)
      奥村彰久
    • Organizer
      第55回日本てんかん学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 新分類って使いにくくないですか?2022

    • Author(s)
      奥村彰久
    • Organizer
      第55回日本てんかん学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] HHV-6によるけいれん性てんかん重積に続発した内側側頭葉硬化病変のウイルス学的解析2022

    • Author(s)
      奥村彰久、河村吉紀、前澤聡、沼本真吾、斎藤竜太、吉川哲史
    • Organizer
      第26回日本神経感染症学会学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] Amplitude-integrated EEG in Paediatric Patients: What is aEEG2021

    • Author(s)
      Akihisa Okumura.
    • Organizer
      The 13th Asian & Oceanian Epilepsy Congress
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Amplitude-integrated EEG in Paediatric Patients: aEEG in Children2021

    • Author(s)
      Akihisa Okumura.
    • Organizer
      The 13th Asian & Oceanian Epilepsy Congress
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 新生児発作の診断と治療2021

    • Author(s)
      奥村彰久
    • Organizer
      第54回日本てんかん学会学術集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 小児急性脳炎・脳症の変遷:全国調査から2021

    • Author(s)
      奥村彰久
    • Organizer
      第25回日本神経感染症学会学術大
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] バルプロ酸を内服中のてんかん患者におけるカルニチン補充の効果2021

    • Author(s)
      奥村彰久、沼本真吾、東慶輝、倉橋宏和
    • Organizer
      第54回日本てんかん学会学術集会
    • Related Report
      2021 Research-status Report
  • [Book] 初心者のための小児のてんかん・けいれん2022

    • Author(s)
      奥村彰久、白石秀明
    • Total Pages
      354
    • Publisher
      中外医学社
    • ISBN
      9784498328907
    • Related Report
      2022 Research-status Report

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Published: 2021-04-28   Modified: 2024-12-25  

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