乳児期発症てんかんの遺伝学的解析に基づく精密医療の基盤構築

• Project/Area Number: 21K07810
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52050:Embryonic medicine and pediatrics-related
• Research Institution: Aichi Medical University
• Principal Investigator: 奥村 彰久 愛知医科大学, 医学部, 教授 (60303624)
• Co-Investigator(Kenkyū-buntansha): 倉橋 宏和 愛知医科大学, 医学部, 講師 (30621817) ; 東 慶輝 愛知医科大学, 医学部, 講師 (60628593)
• Project Period (FY): 2021-04-01 – 2025-03-31
• Project Status: Completed (Fiscal Year 2024)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 乳児てんかん / 遺伝子解析 / 精密医療

Outline of Research at the Start

(1) 2歳未満に発症したてんかんのうち、周産期脳障害などの明らかな獲得性の病因を持たないものを広く対象とし、トリオ検体を用いた全エクソーム解析を行う。
(2) 全エクソーム解析で責任遺伝子を同定できなかった場合は、全ゲノム解析・ロングリードシークエンス・RNA-seq解析を行い、さらなる責任遺伝子の探索を行う。
(3) 発作症状や治療経過などの臨床情報に基づき、てんかんの表現型や薬剤の有効性を解析する。遺伝学的解析結果と臨床的解析結果を統合し、乳児期発症てんかんの遺伝学的情報に基づくprecision medicineの基盤を構築する。

Outline of Annual Research Achievements

2歳未満で発症するてんかんについて、以下の3つに対して遺伝学的解析を施行した。1）自然終息性乳児てんかん（SeLIE）が疑われる症例、2）Dravet症候群およびその近縁疾患が疑われる症例、3）発達性およびてんかん性脳症（DEE）。SeLIEでは、39例にPRRT2遺伝子バリアントの有無を検討し、11例にバリアントを認めた。PRRT2バリアントを認めない症例に対して全エクソーム解析を試行したところ、2例にTMEM151A遺伝子のバリアントを認めた。PRRT2バリアントの有無によって発作予後には大きな相違はないが、バリアントを認めない症例では発作が残存する例や知的能力症・神経発達症を認める症例が散見された。Dravet症候群を疑う症例では、10例について遺伝子解析を試行した。10例中5例にSCN1A遺伝子バリアントを認め、4例をDravet症候群、1例をGEFS+と診断した。Dravet症候群ではフェンフルラミンが著効し、遺伝子解析に基づく治療の可能性が示唆された。GEFS+の症例は発熱時の抗発作薬の頓用で経過を追跡している。DEEを疑う症例では、全エクソーム解析によってKCNT1、STXBP1、TBCD1、SCN2A、CLTC、CHD2、TRIM8など様々な遺伝子バリアントを同定することができた。ほとんどの症例が著しく治療抵抗性の重篤なてんかん発作と重度の発達遅滞を呈したが、STXBP1バリアントの1例はDravet症候群に類似した表現型を呈したにもかかわらず、家族の希望で抗発作薬を中止し、ケトン食による治療によって比較的発作コントロールは良好であった。この結果は、DEEにおいても遺伝子解析の結果に基づく精密医療が提供できる可能性を示唆するものであった。一方、KCNT1やSCN2Aバリアントには既知の精密医療のいずれもが効果を認めず、既存の治療法には限界があった。

Research Products

• [Journal Article] Clinical factors related to bilirubin encephalopathy in preterm infants: A case-control study (2025)
  • Author(s): Okumura Akihisa、Hayakawa Masahiro、Arai Hiroshi、Maruo Yoshihiro、Kusaka Takashi、Kunikata Tetsuya、Iwatani Sota、Sato Yoshiaki、Morioka Ichiro
  • Journal Title: Brain and Development Volume: 47 Pages: 104342～104342
  • DOI: 10.1016/j.braindev.2025.104342
  • Peer Reviewed / Open Access
• [Journal Article] A 7-year delayed diagnosis in a case of spinal muscular atrophy (2025)
  • Author(s): Iwayama Hideyuki、Fukasawa Tatsuya、Azuma Yoshiteru、Kurahashi Hirokazu、Ito Yoshinori、Okumura Akihisa
  • Journal Title: Brain and Development Volume: 47 Pages: 104320～104320
  • DOI: 10.1016/j.braindev.2025.104320
  • Peer Reviewed
• [Journal Article] Characteristics of neonatal-onset and presumed neonatal arterial ischemic stroke (2025)
  • Author(s): Ueda Kazuto、Kataoka Erina、Natsume Jun、Hori Ikumi、Tsuji Takeshi、Miyake Misa、Suzuki Michio、Kobayashi Satoru、Kurahashi Hirokazu、Sato Yoshiaki、Okumura Akihisa、Yoshikawa Tetsushi、Saitoh Shinji、Takahashi Yoshiyuki
  • Journal Title: Brain and Development Volume: 47 Pages: 104343～104343
  • DOI: 10.1016/j.braindev.2025.104343
  • Peer Reviewed
• [Journal Article] Paroxysmal Kinesigenic Dyskinesia in Two Siblings With Novel Heterozygous <scp><i>TMEM151A</i></scp> Frameshift Variant: The First Case Report in Japan (2025)
  • Author(s): Kurahashi Hirokazu、Azuma Yoshiteru、Takeuchi Tomoya、Shimada Mayuko、Numoto Shingo、Nishida Mizuki、Ito Yoshinori、Ogi Tomoo、Okumura Akihisa
  • Journal Title: American Journal of Medical Genetics Part A Volume: Apr 1 Pages: e64079
  • DOI: 10.1002/ajmg.a.64079
  • Peer Reviewed / Open Access
• [Journal Article] Second nationwide survey of bilirubin encephalopathy in preterm infants in Japan (2024)
  • Author(s): Okumura Akihisa、Morioka Ichiro、Arai Hiroshi、Hayakawa Masahiro、Maruo Yoshihiro、Kusaka Takashi、Kunikata Tetsuya、Iwatani Sota
  • Journal Title: Brain and Development Volume: 46 Pages: 2～9
  • DOI: 10.1016/j.braindev.2023.08.009
  • Peer Reviewed
• [Journal Article] Underlying Disorders in Children With Infection-Related Acute Encephalopathy (2024)
  • Author(s): Nakata Tomohiko、Natsume Jun、Yamamoto Hiroyuki、Ito Yuji、Suzuki Takeshi、Kawaguchi Masahiro、Shiraki Anna、Kumai Sumire、Sawamura Fumi、Suzui Ryosuke、Mitsumatsu Takamasa、Narita Hajime、Tsuji Takeshi、Kubota Tetsuo、Saitoh Shinji、Okumura Akihisa、Kidokoro Hiroyuki
  • Journal Title: Pediatric Neurology Volume: 155 Pages: 126～132
  • DOI: 10.1016/j.pediatrneurol.2024.03.017
  • Peer Reviewed
• [Journal Article] Acute Magnetic Resonance Imaging Findings in Young Children With Moyamoya Disease (2024)
  • Author(s): Numoto Shingo、Takasu Syuntaro、Nakamura Tomomi、Takagi Mizuki、Kurahashi Hirokazu、Azuma Yoshiteru、Okumura Akihisa
  • Journal Title: Pediatric Neurology Volume: 156 Pages: 106～112
  • DOI: 10.1016/j.pediatrneurol.2024.03.025
  • Peer Reviewed
• [Journal Article] Long-term efficacy of nusinersen and its evaluation in adolescent and adult patients with spinal muscular atrophy types 1 and 2. (2023)
  • Author(s): Iwayama H, Kawahara K, Okumura A, et al
  • Journal Title: Brain Dev Volume: 45(2) Pages: 110-116
  • DOI: 10.1016/j.braindev.2022.10.006
  • Peer Reviewed
• [Journal Article] A nationwide survey of human metapneumovirus-associated encephalitis/encephalopathy in Japan. (2023)
  • Author(s): Mori A, Kawano Y, Okumura A, et al.
  • Journal Title: Brain Dev Volume: 45(4) Pages: 197-204
  • DOI: 10.1016/j.braindev.2023.01.001.
  • Peer Reviewed
• [Journal Article] Severe pediatric acute encephalopathy syndromes related to SARS-CoV-2. (2023)
  • Author(s): Sakuma H, Takanashi JI, Okumura A, et al.
  • Journal Title: Front Neurosci Volume: 17 Pages: 1085082
  • DOI: 10.3389/fnins.2023.1085082
  • Peer Reviewed / Open Access
• [Journal Article] Bacteremia Caused by Kalamiella piersonii Found in an Infant During the Course of Gastrointestinal Food Allergy. (2023)
  • Author(s): Sada J, Hirai J, Okumura A, et al.
  • Journal Title: Infect Drug Resist. Volume: 16 Pages: 2647-2651
  • DOI: 10.2147/IDR.S402364
  • Peer Reviewed / Open Access
• [Journal Article] Radial nerve palsy caused by a rapidly growing intramuscular hematoma in an infant with biliary atresia: a case report. (2023)
  • Author(s): Kawahara K, Ota K, Okumura A, et al.
  • Journal Title: BMC Pediatr. Volume: 3(1) Pages: 247
  • DOI: 10.1186/s12887-023-04071-5
  • Peer Reviewed / Open Access
• [Journal Article] Current status of neonatal jaundice management in Japan. (2023)
  • Author(s): Honbe K, Hayakawa M, Okumura A, et al.
  • Journal Title: Pediatr Int Volume: 65(1) Pages: e15617
  • DOI: 10.1111/ped.15617
  • Peer Reviewed
• [Journal Article] Medical records as screening tools for child death review in Japan. (2023)
  • Author(s): Numaguchi A, Ishii A, Okumura A, et al.
  • Journal Title: Pediatr Int Volume: 65(1) Pages: e15692
  • DOI: 10.1111/ped.15692
  • Peer Reviewed
• [Journal Article] Burden of seizures and comorbidities in patients with epilepsy: a survey based on the tertiary hospital-based Epilepsy Syndrome Registry in Japan. (2022)
  • Author(s): Inoue Y, Hamano SI, Hayashi M, Okumura A, et al.
  • Journal Title: Epileptic Disord Volume: 24(1) Pages: 82-94
  • DOI: 10.1684/epd.2021.1361
  • Peer Reviewed / Open Access
• [Journal Article] Acute encephalopathy with biphasic seizures and late reduced diffusion: Predictive EEG findings (2022)
  • Author(s): Ohno A, Okumura A, Fukasawa T, Nakata T, Suzuki M, Tanaka M, Okai Y, Ito Y, Yamamoto H, Tsuji T, Kidokoro H, Saitoh S, Natsume J.
  • Journal Title: Brain Dev Volume: 44(3) Pages: 221-228
  • DOI: 10.1016/j.braindev.2021.11.003
  • Peer Reviewed
• [Journal Article] Involvement of brain structures in childhood epilepsy with centrotemporal spikes (2022)
  • Author(s): Ito Y, Maki Y, Okai Y, Kidokoro H, Bagarinao E, Takeuchi T, Ohno A, Nakata T, Ishihara N, Okumura A, Yamamoto H, Maesawa S, Natsume J
  • Journal Title: Pediatr Int Volume: 64(1) Pages: e15001
  • DOI: 10.1111/ped.1500
  • Peer Reviewed
• [Journal Article] Death review of children receiving medical care at home (2022)
  • Author(s): Natsume J, Numaguchi A, Ohno A, Mizuno M, Takahashi Y, Okumura A, Yoshikawa T, Saitoh S, Miura K, Noda M
  • Journal Title: Pediatr Res Volume: 91(5) Pages: 1286-1289
  • DOI: 10.1038/s41390-021-01606-3
  • Peer Reviewed
• [Journal Article] Subcortical infarction in a young adult with Hunter syndrome (2022)
  • Author(s): Kimura M, Azuma Y, Taguchi S, Takagi M, Mori H, Shimomura Y, Niwa JI, Doyu M, Okumura A.
  • Journal Title: Brain Dev Volume: 44(5) Pages: 343-346
  • DOI: 10.1016/j.braindev.2022.01.003.
  • Peer Reviewed
• [Journal Article] Mild encephalitis with a reversible splenial lesion associated with SARS-CoV-2 infection in a patient with MYRF variant. (2022)
  • Author(s): Saito M, Nakazawa T, Toriumi S, Takasu M, Yagisawa H, Murano Y, Miyazaki N, Kurahashi H, Okumura A, Shimizu T.
  • Journal Title: Front Pediatr Volume: 10 Pages: 971432
  • DOI: 10.3389/fped.2022.971432
  • Peer Reviewed / Open Access
• [Journal Article] Whole-exome analysis of 177 pediatric patients with undiagnosed diseases. (2022)
  • Author(s): Narita K, Muramatsu H, Narumi S, Nkawa T, Okumura A, et al.
  • Journal Title: Sci Rep Volume: 12(1) Pages: 14589
  • DOI: 10.1038/s41598-022-14161-6
  • Peer Reviewed / Open Access
• [Journal Article] Five patients with myocarditis after mRNA COVID-19 vaccination (2022)
  • Author(s): Murase H, Zhu Y, Sakaida K, Mizuno H, Mori H, Iwayama H, Suzuki N, Nagai N, Okumura A
  • Journal Title: Front Pediatr Volume: 10 Pages: 977476
  • DOI: 10.3389/fped.2022.977476
  • Peer Reviewed / Open Access
• [Journal Article] Human herpesvirus 6 DNA was not detected in a brain specimen from a patient with mesial temporal sclerosis after status epilepticus due to human herpesvirus 6 infection (2022)
  • Author(s): Kawamura Y, Maesawa S, Numoto S, Saito R, Yoshikawa T, Okumura A
  • Journal Title: Epilepsia Open Volume: 7(4) Pages: 817-821
  • DOI: 10.1002/epi4.12634
  • Peer Reviewed / Open Access
• [Journal Article] A pilot study of serum free carnitine levels in hospitalized febrile children. (2021)
  • Author(s): Okumura A, Muto T, Nakamura N, Masuda Y, Kodama S.
  • Journal Title: Pediatr Int. Volume: 63 Pages: 102-103
  • DOI: 10.1111/ped.14360.
  • Peer Reviewed
• [Journal Article] Auditory brainstem response in preterm infants with bilirubin encephalopathy. (2021)
  • Author(s): Okumura A, Kitai Y, Arai H, Hayakawa M, Maruo Y, Kusaka T, Kunikata T, Kumada S, Morioka I.
  • Journal Title: Early Hum Dev. Volume: 154 Pages: 105319
  • DOI: 10.1016/j.earlhumdev.2021.105319.
  • Peer Reviewed
• [Journal Article] Magnetic resonance imaging abnormalities during the neonatal period in preterm infants with bilirubin encephalopathy. (2021)
  • Author(s): Okumura A, Kitai Y, Arai H.
  • Journal Title: Pediatr Neonatol. Volume: 62 Pages: 567-568
  • DOI: 10.1016/j.pedneo.2021.03.013.
  • Peer Reviewed
• [Journal Article] Carnitine supplementation prevents carnitine deficiency caused by pivalate-conjugated antibiotics in patients with epilepsy prescribed valproate. (2021)
  • Author(s): Okumura A, Numoto S, Iwayama H, Azuma Y, Kurahashi H.
  • Journal Title: Epilepsy Behav. Volume: 117 Pages: 107883
  • DOI: 10.1016/j.yebeh.2021.107883.
  • Peer Reviewed
• [Journal Article] Neonatal Jaundice in Preterm Infants with Bilirubin Encephalopathy. (2021)
  • Author(s): Okumura A, Ichimura S, Hayakawa M, Arai H, Maruo Y, Kusaka T, Kunikata T, Kumada S, Morioka I.
  • Journal Title: Neonatology. Volume: 118 Pages: 301-309
  • DOI: 10.1159/000513785.
  • Peer Reviewed / Open Access
• [Journal Article] Magnetic Resonance Imaging Findings in Preterm Infants With Bilirubin Encephalopathy Beyond Three Years Corrected Age. (2021)
  • Author(s): Okumura A, Kitai Y, Arai H, Hayakawa M, Maruo Y, Kusaka T, Kunikata T, Kumada S, Morioka I.
  • Journal Title: Pediatr Neurol. Volume: 121 Pages: 56-58
  • DOI: 10.1016/j.pediatrneurol.2021.05.019.
  • Peer Reviewed
• [Journal Article] Effects of l-carnitine supplementation in patients with childhood-onset epilepsy prescribed valproate. (2021)
  • Author(s): Okumura A, Takagi M, Numoto S, Iwayama H, Azuma Y, Kurahashi H.
  • Journal Title: Epilepsy Behav. Volume: 122 Pages: 108220
  • DOI: 10.1016/j.yebeh.2021.108220.
  • Peer Reviewed
• [Journal Article] Guidelines for the diagnosis and treatment of acute encephalopathy in childhood. (2021)
  • Author(s): Mizuguchi M, Ichiyama T, Imataka G, Okumura A, Goto T, Sakuma H, Takanashi JI, Murayama K, Yamagata T, Yamanouchi H, Fukuda T, Maegaki Y.
  • Journal Title: Brain Dev Volume: 43 Pages: 2-31
  • DOI: 10.1016/j.braindev.2020.08.001.
  • Peer Reviewed
• [Journal Article] Three-Year Longitudinal Motor Function and Disability Level of Acute Flaccid Myelitis. (2021)
  • Author(s): Chong PF, Kira R, Torisu H, Yasumoto S, Okumura A, Mori H, Tanaka-Taya K
  • Journal Title: Pediatr Neurol Volume: 116 Pages: 14-19
  • DOI: 10.1016/j.pediatrneurol.2020.11.019
  • Peer Reviewed
• [Journal Article] Acute encephalopathy in children with tuberous sclerosis complex. (2021)
  • Author(s): Numoto S, Kurahashi H, Sato A, Kubota M, Shiihara T, Okanishi T, Tanaka R, Kuki I, Fukuyama T, Kashiwagi M, Ikeno M, Kubota K, Akasaka M, Mimaki M, Okumura A.
  • Journal Title: Orphanet J Rare Dis. Volume: 16 Pages: 1-5
  • DOI: 10.1186/s13023-020-01646-8.
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of the Diagnostic Criteria for Anti-NMDA Receptor Encephalitis in Japanese Children. (2021)
  • Author(s): Nishida H, Kohyama K, Kumada S, Takanashi JI, Okumura A, Horino A, Moriyama K, Sakuma H.
  • Journal Title: Neurology. Volume: 96 Pages: e2070-e2077
  • DOI: 10.1212/WNL.0000000000011789.
  • Peer Reviewed
• [Journal Article] Repetitive sleep starts: An important differential diagnosis of infantile spasms. (2021)
  • Author(s): Maki Y, Kidokoro H, Okumura A, Yamamoto H, Nakata T, Fukasawa T, Kubota T, Kawaguchi M, Suzuki T, Tanaka M, Okai Y, Sakaguchi Y, Ohno A, Negoro T, Takahashi Y, Natsume J.
  • Journal Title: Epilepsy Behav. Volume: 121 Pages: 108075
  • DOI: 10.1016/j.yebeh.2021.108075.
  • Peer Reviewed
• [Journal Article] Clinical and electrophysiological features of acute flaccid myelitis: A national cohort study. (2021)
  • Author(s): Chong PF, Torisu H, Yasumoto S, Okumura A, Mori H, Sato T, Kimura J, Ohga S, Tanaka-Taya K, Kira R
  • Journal Title: Clin Neurophysiol. Volume: 132 Pages: 2456-2463
  • DOI: 10.1016/j.clinph.2021.07.013.
  • Peer Reviewed
• [Journal Article] Regional Difference in Myelination in Monocarboxylate Transporter 8 Deficiency: Case Reports and Literature Review of Cases in Japan.Insulin-like growth factor-1 level is a poor diagnostic indicator of growth hormone deficiency. (2021)
  • Author(s): IwIwayama H, Tanaka T, Aoyama K, Moroto M, Adachi S, Fujisawa Y, Matsuura H, Takano K, Mizuno H, Okumura A.ayama H, Kitagawa S, Sada J, Miyamoto R, Hayakawa T, Kuroyanagi Y, Muto T, Kurahashi H, Ohashi W, Takagi J, Okumura A.
  • Journal Title: Front Neurol. Volume: 12 Pages: 657820
  • DOI: 10.3389/fneur.2021.657820
  • Peer Reviewed / Open Access
• [Journal Article] Measurement of Reverse Triiodothyronine Level and the Triiodothyronine to Reverse Triiodothyronine Ratio in Dried Blood Spot Samples at Birth May Facilitate Early Detection of Monocarboxylate Transporter 8 Deficiency. (2021)
  • Author(s): Iwayama H, Kakita H, Iwasa M, Adachi S, Takano K, Kikuchi M, Fujisawa Y, Osaka H, Yamada Y, Okumura A, Hirani K, Weiss RE, Refetoff S.
  • Journal Title: Thyroid. Volume: 31 Pages: 1316-1321
  • DOI: 10.1089/thy.2020.0696.
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sodium channel blockers are effective for benign infantile epilepsy. (2021)
  • Author(s): Numoto S, Kurahashi H, Takagi M, Azuma Y, Iwayama H, Okumura A.
  • Journal Title: Seizure Volume: 92 Pages: 207-210
  • DOI: 10.1016/j.seizure.2021.09.008.
  • Peer Reviewed
• [Presentation] 新生児発作の脳波 (2024)
  • Author(s): 奥村彰久
  • Organizer: 第57回日本てんかん学会学術集会
  • Invited
• [Presentation] Neonatal EEG in perinatal brain injuries in term and preterm infants (2024)
  • Author(s): Akihisa Okumura
  • Organizer: 2024 Annual Meeting of the Children’s Epilepsy Association of Taiwan
  • Int'l Joint Research / Invited
• [Presentation] 学校におけるてんかん発作への対応 (2024)
  • Author(s): 奥村彰久
  • Organizer: 日本養護教諭教育学会 第32回学術集会
  • Invited
• [Presentation] SPTBN2 遺伝子変異による乳児期発症脊髄小脳変性症の1 例 (2024)
  • Author(s): 倉橋宏和、丸山幸一、山下大記、村松秀城、奥野友介、水野誠司、奥村彰久
  • Organizer: 第59 回日本小児神経学会東海地方会
• [Presentation] てんかん発作とてんかんでない「発作」：見分けるコツ (2023)
  • Author(s): 奥村彰久
  • Organizer: 第126回日本小児科学会学術集会
  • Invited
• [Presentation] Dravet症候群の診断と治療 New Chapter (2023)
  • Author(s): 奥村彰久
  • Organizer: 第34回日本小児神経学会中国・四国地方会
  • Invited
• [Presentation] 子どものてんかん診療における脳波の役割と抗発作薬 (2023)
  • Author(s): 奥村彰久、河村吉紀、前澤聡、沼本真吾、斎藤竜太、吉川哲史
  • Organizer: 第19回日本てんかん学会近畿地方会
  • Invited
• [Presentation] 旧来の抗てんかん薬の出番は限られる (2022)
  • Author(s): 奥村彰久
  • Organizer: 第55回日本てんかん学会学術集会
• [Presentation] 新分類って使いにくくないですか？ (2022)
  • Author(s): 奥村彰久
  • Organizer: 第55回日本てんかん学会学術集会
• [Presentation] HHV-6によるけいれん性てんかん重積に続発した内側側頭葉硬化病変のウイルス学的解析 (2022)
  • Author(s): 奥村彰久、河村吉紀、前澤聡、沼本真吾、斎藤竜太、吉川哲史
  • Organizer: 第26回日本神経感染症学会学術大会
• [Presentation] Amplitude-integrated EEG in Paediatric Patients: What is aEEG (2021)
  • Author(s): Akihisa Okumura.
  • Organizer: The 13th Asian & Oceanian Epilepsy Congress
  • Int'l Joint Research / Invited
• [Presentation] Amplitude-integrated EEG in Paediatric Patients: aEEG in Children (2021)
  • Author(s): Akihisa Okumura.
  • Organizer: The 13th Asian & Oceanian Epilepsy Congress
  • Int'l Joint Research / Invited
• [Presentation] 新生児発作の診断と治療 (2021)
  • Author(s): 奥村彰久
  • Organizer: 第54回日本てんかん学会学術集会
  • Invited
• [Presentation] 小児急性脳炎・脳症の変遷：全国調査から (2021)
  • Author(s): 奥村彰久
  • Organizer: 第25回日本神経感染症学会学術大
  • Invited
• [Presentation] バルプロ酸を内服中のてんかん患者におけるカルニチン補充の効果 (2021)
  • Author(s): 奥村彰久、沼本真吾、東慶輝、倉橋宏和
  • Organizer: 第54回日本てんかん学会学術集会
• [Book] 初心者のための小児のてんかん・けいれん (2022)
  • Author(s): 奥村彰久、白石秀明
  • Total Pages: 354
  • Publisher: 中外医学社
  • ISBN: 978-4-498-32890-7