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Research for the pathogenesis of kaposiform lymphangiomatosis in PIK3CA/RAS signal pathway

Research Project

Project/Area Number 21K07838
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52050:Embryonic medicine and pediatrics-related
Research InstitutionGifu University

Principal Investigator

Ozeki Michio  岐阜大学, 医学部附属病院, 講師 (60444303)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsリンパ管腫症 / 小児 / PIK3CA
Outline of Research at the Start

カポジ型リンパ管腫症(Kaposiform lymphangiomatosis: KLA)は全身にリンパ管組織が増殖する進行性の希少難治性疾患であるリンパ管腫症の中で、特に予後の不良なタイプを指し、原因が不明であるだけでなく、有効な治療法も確立されていない。近年、KLAの病変部位より、血管・リンパ管新生に重要な経路である「PIK3/RASシグナル」の遺伝子変異が検出されたが、その遺伝子異常がどのようにKLAの臨床像を引き起こすかどうかは不明である。本研究課題では、これらのシグナル伝達経路に着目し、KLAの病態を解明し、その経路に対する分子標的薬の治療効果を検証する。

Outline of Final Research Achievements

Kaposiform lymphangiomatosis is a progressive, rare, and difficult-to-treat type of lymphangiomatosis that involves the proliferation of lymphatic tissue throughout the body. Recently, genetic mutations in the 'PIK3/RAS signaling' pathway, which is important for angiogenesis and lymphangiogenesis, have been detected in the affected areas, but it is unclear how these genetic abnormalities lead to clinical symptoms. In this study, the NRAS (Q61R) gene mutation was introduced into human lymphatic endothelial cells, and cell proliferation ability was measured using the MTT assay, as well as Real-time PCR and Western blot analysis, and the effects of inhibitors were tested. Additionally, a transgenic mouse expressing the NRAS Q61R mutation in lymphatic endothelial cells was created.

Academic Significance and Societal Importance of the Research Achievements

リンパ管腫症の中でも非常に予後が悪く、治療抵抗性であるカポジ型リンパ管腫症の病態マ解明に繋がる研究を行った。最近では、mTOR阻害剤がリンパ管腫症に対する新規治療薬として薬事承認されたが、いまだ治療抵抗性で亡くなる症例も多い。今回の病態解明によって、NRAS変異が病態に関与すること、および新規治療薬に繋がる研究結果を得た。今後はその候補となる薬剤の臨床応用を検討している。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (66 results)

All 2024 2023 2022 2021

All Journal Article (29 results) (of which Peer Reviewed: 28 results,  Open Access: 2 results) Presentation (37 results) (of which Int'l Joint Research: 3 results,  Invited: 25 results)

  • [Journal Article] Changes in cell morphology and function induced by the NRAS Q61R mutation in lymphatic endothelial cells2024

    • Author(s)
      Yasue S, Ozeki M, Nozawa A, Endo S, Ohnishi H
    • Journal Title

      PLOS ONE

      Volume: -

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lymphatic endothelial cell-specific NRAS p.Q61R mutant embryos show abnormal lymphatic vessel morphogenesis2024

    • Author(s)
      Nozawa A, Abe T, Niihori T, Ozeki M, Aoki Y, Ohnishi H
    • Journal Title

      Human Molecular Genetics

      Volume: -

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] doi: 10.1089/lrb.2023.0023. Epub 2023 Dec 19. The Prospective Natural History Study of Patients with Intractable Venous Malformation and Klippel-Trenaunay Syndrome to Guide Designing a Proof-of-Concept Clinical Trial for Novel Therapeutic Intervention2024

    • Author(s)
      Akihiro Fujino, Kanako Kuniyeda, Taiki Nozaki, Michio Ozeki, Junko Ochi, Saya Horiuchi, Hiroshi Nagabukuro, et al.
    • Journal Title

      Lymphatic Research and Biology

      Volume: 22 Issue: 1 Pages: 27-36

    • DOI

      10.1089/lrb.2023.0023

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eculizumab treatment in paediatric patients diagnosed with aHUS after haematopoietic stem cell transplantation: a HSCT-TMA case series from Japanese aHUS post-marketing surveillance2024

    • Author(s)
      Ito S, Saito A, Sakurai A, Watanabe K, Karakawa S, Miyamura T, Yokosuka T, Ueki H, Goto H, Yagasaki H, Kinoshita M, Ozeki M, Yokoyama N, Teranishi H
    • Journal Title

      Bone Marrow Transplant

      Volume: 59 Issue: 3 Pages: 315-324

    • DOI

      10.1038/s41409-023-02161-7

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sirolimus treatment for intractable lymphatic anomalies: an open-label, single-arm, multicenter, prospective trial2024

    • Author(s)
      Ozeki M, Asada R, Saito AM, Hashimoto H, Fujimura T, Kuroda T, Ueno S, Watanabe S, Nosaka S, Miyasaka M, Umezawa A, Matsuoka K, Maekawa T, Yamada Y, Hirakawa S, Furukawa T, Tajiri T, Kinoshita Y, Souzaki R, Fujino A
    • Journal Title

      Front. Med

      Volume: 11 Pages: 1-10

    • DOI

      10.3389/fmed.2024.1335469

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive phenotypic and genomic characterization of venous malformations2024

    • Author(s)
      Hirose Katsutoshi、Hori Yumiko、Ozeki Michio、Motooka Daisuke、Hata Kenji、Tahara Shinichiro、Matsui Takahiro、Kohara Masaharu、Maruyama Kazuaki、Imanaka-Yoshida Kyoko、Toyosawa Satoru、Morii Eiichi
    • Journal Title

      Human Pathology

      Volume: 145 Pages: 48-55

    • DOI

      10.1016/j.humpath.2024.02.004

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of transient abnormal myelopoiesis blasts in a liver biopsy specimen by double-immunostaining for full-length GATA1 and CD42b2023

    • Author(s)
      Haba Azusa、Imaizumi Yuko、Hayashi Daichi、Yasue Shiho、Otsuka Hiroki、Endo Saori、Ozeki Michio、Kobayashi Kazuhiro、Miyazaki Tatsuhiko、Hara Akira、Ohnishi Hidenori
    • Journal Title

      Hematology

      Volume: 28 Issue: 1

    • DOI

      10.1080/16078454.2023.2240135

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two Pediatric Patients with Acute Acquired Comitant Esotropia as the First Symptom of Brainstem Tumor: A Case Report2023

    • Author(s)
      Yagasaki Ayaka、Miyase Taishi、Sakai Shota、Mochizuki Kiyofumi、Sakaguchi Hirokazu、Yagasaki Teiji、Ohe Naoyuki、Yasue Shiho、Endo Saori、Ozeki Michio
    • Journal Title

      Case Reports in Ophthalmology

      Volume: - Pages: 613-619

    • DOI

      10.1159/000534709

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pediatric case of acquired progressive lymphatic anomaly treated with sirolimus2023

    • Author(s)
      Komamizu Sayano、Ozeki Michio、Hayashi Daichi、Endo Saori、Hori‐Hirose Yumiko、Sasaki Satoru、Ohnishi Hidenori
    • Journal Title

      Pediatrics International

      Volume: 65 Issue: 1

    • DOI

      10.1111/ped.15497

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Case of Multifocal Lymphangioendotheliomatosis With Thrombocytopenia and Changes in Coagulopathy2023

    • Author(s)
      Nagao Daiki、Ozeki Michio、Nozawa Akifumi、Yasue Shiho、Sasai Hideo、Endo Saori、Kato Takazumi、Hori Yumiko、Ohnishi Hidenori
    • Journal Title

      Journal of Pediatric Hematology/Oncology

      Volume: 45 Issue: 3 Pages: e384-e388

    • DOI

      10.1097/mph.0000000000002597

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] 血管腫・血管奇形(脈管異常).小児疾患診療のための病態生理32022

    • Author(s)
      小関道夫
    • Journal Title

      小児内科増刊号

      Volume: 54 Pages: 1105-1110

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] 頭頸部リンパ管腫の診断と治療 難治性リンパ管疾患に対するシロリムス療法2022

    • Author(s)
      小関道夫
    • Journal Title

      小児耳

      Volume: 43

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【母斑・母斑症の診療update-基礎から実践まで-】青色ゴムまり様母斑症候群・Klippel-Trenaunay症候群・その他の脈管腫瘍・脈管奇形2022

    • Author(s)
      小関 道夫
    • Journal Title

      Derma

      Volume: 317 Pages: 25-34

    • Related Report
      2022 Research-status Report
  • [Journal Article] Comprehensive targeted next-generation sequencing in patients with slow-flow vascular malformations2022

    • Author(s)
      Nozawa Akifumi、Fujino Akihiro、Yuzuriha Shunsuke、Suenobu Souichi、Kato Aiko、Shimizu Fumiaki、Aramaki-Hattori Noriko、Kuniyeda Kanako、Sakaguchi Kazuya、Ohnishi Hidenori、Aoki Yoko、Ozeki Michio
    • Journal Title

      Journal of Human Genetics

      Volume: 67 Issue: 12 Pages: 721-728

    • DOI

      10.1038/s10038-022-01081-6

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Severe hypoglycemia in propranolol treatment for infantile hemangiomas2022

    • Author(s)
      Morimoto Akira、Ozeki Michio、Sasaki Satoru、Baba Naoko、Kuwano Yoshihiro、Kaneko Tsuyoshi
    • Journal Title

      Pediatrics International

      Volume: 64 Issue: 1

    • DOI

      10.1111/ped.15278

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Poorly Differentiated Chordoma of the Clivus With Loss of SMARCB1 Expression in a Pediatric Patient: A Case Report2022

    • Author(s)
      Yasue Shiho、Ozeki Michio、Endo Saori、Kanayama Tomohiro、Suzui Natsuko、Nakamura Sayaka、Kishimoto Kenji、Kosaka Yoshiyuki、Miyazaki Tatsuhiko、Demizu Yusuke、Soejima Toshinori、Kawamura Atsufumi、Ohnishi Hidenori
    • Journal Title

      Journal of Pediatric Hematology/Oncology

      Volume: 44 Issue: 8 Pages: 465-470

    • DOI

      10.1097/mph.0000000000002402

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Correction: PIK3CA mutation correlates with mTOR pathway expression but not clinical and pathological features in Fibro-adipose vascular anomaly (FAVA)2022

    • Author(s)
      Hori Yumiko、Hirose Katsutoshi、Ozeki Michio、Hata Kenji、Motooka Daisuke、Tahara Shinichiro、Matsui Takahiro、Kohara Masaharu、Higashihara Hiroki、Ono Yusuke、Tanaka Kaishu、Toyosawa Satoru、Morii Eiichi
    • Journal Title

      Diagnostic Pathology

      Volume: 17 Issue: 1

    • DOI

      10.1186/s13000-022-01224-5

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] A rare pediatric case of McCune?Albright syndrome with acute visual disturbance2022

    • Author(s)
      Ninomiya Hiroshi、Ozeki Michio、Nozawa Akifumi、Yasue Shiho、Endo Saori、Inuzuka Masayuki、Obara Natsuko、Mochizuki Kiyofumi、Kawaguchi Masaya、Kaneko Yo、Ohe Naoyuki、Aoki Yoko、Matsuo Masayuki、Iwama Toru、Ohnishi Hidenori
    • Journal Title

      Medicine

      Volume: 101 Issue: 6 Pages: e28815-e28815

    • DOI

      10.1097/md.0000000000028815

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] PIK3CA mutation correlates with mTOR pathway expression but not clinical and pathological features in Fibfibroipose vascular anomaly (FAVA)2022

    • Author(s)
      Yumiko Hori, Katsutoshi Hirose, Michio Ozeki, Kenji Hata, Daisuke Motooka, Shinichiro Tahara, Takahiro Matsui, Masaharu Kohara, Hiroki Higashihara, Yusuke Ono, Kaishu Tanaka, Satoru Toyosawa & Eiichi Morii
    • Journal Title

      Diagnostic Pathology

      Volume: 17 Issue: 1 Pages: 19-19

    • DOI

      10.1186/s13000-022-01199-3

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of sirolimus treatment of kaposiform hemangioendothelioma in the neck2022

    • Author(s)
      Kuwabara Yuya、Ozeki Michio、Hira Kota、Fujisaki Hiroyuki、Ohnishi Hidenori
    • Journal Title

      Pediatrics International

      Volume: 64 Issue: 1

    • DOI

      10.1111/ped.15000

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 岐阜県における小児AYA世代に対する取り組み ~AYA WEEKを通じて~2021

    • Author(s)
      小関道夫,安江志保, 遠渡沙緒理,山本崇裕,兼村信宏,古井辰郎,大西秀典
    • Journal Title

      AYAがんの医療と支援

      Volume: 1 Pages: 77-81

    • NAID

      130008089322

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【脈管異常のアップデート-新ISSVA分類で深める病態の理解-】脈管異常に対する薬物療法の動向と展望2021

    • Author(s)
      小関道夫
    • Journal Title

      画像診断

      Volume: 41 Pages: 1261-1271

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 青色ゴムまり様母斑症候群・Klippel-Trenaunay症候群・その他の脈管腫瘍・脈管奇形2021

    • Author(s)
      小関道夫
    • Journal Title

      Derma

      Volume: 317 Pages: 25-34

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] PIK3CA(関連疾患:Klippel-Trenaunay症候群)小児遺伝子疾患辞典2021

    • Author(s)
      野澤明史,小関道夫
    • Journal Title

      小児科診療

      Volume: 84 Pages: 1459-1460

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] 乳児血管腫(いちご状血管腫)治療の実際2021

    • Author(s)
      小関道夫
    • Journal Title

      小児科

      Volume: 62 Pages: 1695-1705

    • NAID

      40022779868

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] CT and MRI Findings of Focal Splenic Lesions and Ascites in Generalized Lymphatic Anomaly, Kaposiform Lymphangiomatosis, and Gorham-Stout Disease2021

    • Author(s)
      Nakamura Fumihiko、Kato Hiroki、Ozeki Michio、Matsuo Masayuki
    • Journal Title

      Journal of Clinical Imaging Science

      Volume: 11 Pages: 44-44

    • DOI

      10.25259/jcis_101_2021

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of kaposiform lymphangiomatosis tissue‐derived cells2021

    • Author(s)
      Nozawa Akifumi、Ozeki Michio、Yasue Shiho、Endo Saori、Noguchi Kei、Kanayama Tomohiro、Tomita Hiroyuki、Aoki Yoko、Ohnishi Hidenori
    • Journal Title

      Pediatric Blood & Cancer

      Volume: 68 Issue: 10

    • DOI

      10.1002/pbc.29086

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Validation of measurement scores for evaluating vascular anomaly skin lesions2021

    • Author(s)
      Yasue Shiho、Ozeki Michio、Endo Saori、Ishihara Takuma、Nishiguchi‐Kurimoto Mana、Jinnin Masatoshi、Kawamura Miho、Seishima Mariko、Ohnishi Hidenori
    • Journal Title

      The Journal of Dermatology

      Volume: 48 Issue: 7 Pages: 993-998

    • DOI

      10.1111/1346-8138.15839

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Propranolol for infantile hemangiomas with hyperinsulinemic hypoglycemia2021

    • Author(s)
      Miyazaki Taichi、Ozeki Michio、Sasai Hideo、Ohnishi Hidenori
    • Journal Title

      Pediatrics International

      Volume: 63 Issue: 6 Pages: 724-725

    • DOI

      10.1111/ped.14471

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] Development of Sirolimus for Complex Vascular Anomalies in Japan2023

    • Author(s)
      Michio Ozeki
    • Organizer
      International Society for the Study of Vascular Anomalies
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Progressive tumor of the left thigh2023

    • Author(s)
      Michio Ozeki
    • Organizer
      International Society for the Study of Vascular Anomalies
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 難治性の脈管腫瘍・脈管奇形に対するNPC-12T(顆粒剤・錠剤)の有効性及び安全性を検討する多施設共同第III相医師主導治験2023

    • Author(s)
      小関道夫, 文野誠久, 古川泰三, 藤野明浩, 川久保尚徳, 田尻達郎, 加藤源俊, 黒田達夫
    • Organizer
      日本小児外科学会学術集会(第60回)
    • Related Report
      2023 Annual Research Report
  • [Presentation] 難治性リンパ管疾患の病態と新規治療薬2023

    • Author(s)
      小関道夫
    • Organizer
      日本小児放射線学会学術集会(第59回)
    • Related Report
      2023 Annual Research Report
  • [Presentation] 難治性リンパ管疾患に対する新たな治療戦略~ラパリムス錠の位置づけ~2023

    • Author(s)
      小関道夫
    • Organizer
      日本リンパ学会総会(第47回)
    • Related Report
      2023 Annual Research Report
  • [Presentation] カサバッハ・メリット現象に対するシロリムス療法2023

    • Author(s)
      小関道夫, 林大地, 遠渡沙緒理, 文野誠久, 古川泰三, 武本淳吉, 川久保尚徳, 前川貴伸, 藤野明浩, 加藤源俊, 黒田達夫, 田尻達郎, 大西秀典
    • Organizer
      第45回日本血栓止血学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 難治性リンパ管疾患への薬物療法~ガイドライン2022をふまえて~ 小児科の立場からの経験例について2023

    • Author(s)
      小関道夫
    • Organizer
      日本血管腫血管奇形学会学術集会(第19回)
    • Related Report
      2023 Annual Research Report
  • [Presentation] 血管腫・血管奇形に対するシロリムス療法2023

    • Author(s)
      小関道夫
    • Organizer
      小児血液・がん学会学術集会(第65回)
    • Related Report
      2023 Annual Research Report
  • [Presentation] 脈管異常に伴う血液凝固異常.2022

    • Author(s)
      小関道夫
    • Organizer
      第2回神奈川小児血液疾患WEBセミナー
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 専門医のための血管腫・血管奇形の基礎知識.2022

    • Author(s)
      小関道夫
    • Organizer
      東京小児がん研究グループ(TCCSG)セミナー
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] Effects of sirolimus for localized intravascular coagulopathy of slow-flow vascular malformations2022

    • Author(s)
      Ozeki M, Yasue S, Endo S, Maekawa T, Fujino A, Fumino S, Furukawa T, Takemoto J, Tajiri T, Ohnishi H.
    • Organizer
      International Society for the Study of Vascular Anomalies
    • Related Report
      2022 Research-status Report
  • [Presentation] 脈管異常に伴う血液凝固異常2022

    • Author(s)
      小関道夫
    • Organizer
      静岡県血液疾患セミナー
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 難治性脈管異常に対するシロリムス療法2022

    • Author(s)
      小関道夫
    • Organizer
      第8回日本HHT研究会 HHT JAPAN
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 症例から学ぶ!小児科医のためのリンパ管疾患の最新治療2022

    • Author(s)
      小関道夫
    • Organizer
      日本小児科学会学術集会(第125回)
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 治療すべき乳児血管腫とそのタイミングとは?2022

    • Author(s)
      小関道夫
    • Organizer
      おおさか小児皮膚疾患治療フォーラム
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 難治性リンパ管疾患に対するシロリムス療法. シンポジウム1:難治性リンパ管疾患への薬物療法.2022

    • Author(s)
      小関道夫
    • Organizer
      日本血管腫血管奇形学会学術集会(第18回)
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 難治性脈管異常に対するシロリムス療法研究の進捗2022

    • Author(s)
      小関道夫
    • Organizer
      第3回シロリムス新作用研究会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 血管腫血管奇形診療の最新の知見 難治性血管腫血管奇形に対する最新の薬物療法.2022

    • Author(s)
      小関 道夫
    • Organizer
      日本脈管学会学術総会(第64回)
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 難治性脈管異常に対する新たな治療戦略~ラパリムスの位置づけ~2022

    • Author(s)
      小関 道夫
    • Organizer
      Hokkaido LM Expert Seminar
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 脈管異常のシロリムス療法に関連したバイオマーカー検索2022

    • Author(s)
      小関 道夫, 林 大地, 安江 志保, 遠渡 沙緒理, 文野 誠久, 古川 泰三, 武本 淳吉, 田尻 達郎, 大西 秀典:
    • Organizer
      日本小児血液・がん学会学術集会(第64回)
    • Related Report
      2022 Research-status Report
  • [Presentation] 難治性血管腫・血管奇形に対する新たな治療選択2022

    • Author(s)
      小関 道夫
    • Organizer
      信州形成外科学会(第85回)
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] プロプラノロール塩酸塩シロップの服薬指導ポイント2022

    • Author(s)
      小関 道夫
    • Organizer
      第27回滋賀県薬薬連携研修会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 小児・AYA世代がんと患者支援について2022

    • Author(s)
      小関 道夫
    • Organizer
      岐阜県相談支援実務者研修会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 乳児血管腫治療におけるChildren Firstの実践2021

    • Author(s)
      小関道夫
    • Organizer
      第124回日本小児科学会学術集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] リンパ管腫、血管腫2021

    • Author(s)
      小関道夫
    • Organizer
      第36回日本小児外科学会卒後教育セミナー
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 乳児血管腫患者家族のQOL調査の妥当性検討および前方視的解析2021

    • Author(s)
      小関道夫, 安江志保, 遠渡沙緒理, 清島真理子, 大西秀典
    • Organizer
      第45回日本小児皮膚科学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 難治性リンパ管疾患に対するシロリムスの有効性及び安全性を検討する多施設共同医師主導治験(SILA study)2021

    • Author(s)
      小関道夫、安江志保、遠渡沙緒理、浅田隆太、橋本大哉、 前川貴伸、藤野明浩、藤村匠、黒田達夫、宗崎良太、 武本淳吉、文野誠久、古川泰三、田尻達郎
    • Organizer
      第12回血管腫血管奇形講習会
    • Related Report
      2021 Research-status Report
  • [Presentation] The research for complex lymphatic anomalies in Japan (LGDA Founder’s Awards)2021

    • Author(s)
      Michio Ozeki
    • Organizer
      LGDA/LMI International Conference on Complex Lymphatic Anomalies
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 岐阜県における小児・AYA世代への取り組み2021

    • Author(s)
      小関道夫
    • Organizer
      第9回岐阜県がん情報センター県民公開講座
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 新しい治療薬・シロリムス療法について2021

    • Author(s)
      小関道夫
    • Organizer
      第4回小児リンパ管疾患シンポジウム
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 難治性リンパ管疾患に対するシロリムス療法2021

    • Author(s)
      小関道夫
    • Organizer
      第2回JASMIN研究会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 難治性リンパ管疾患の病態と最新治療2021

    • Author(s)
      小関道夫
    • Organizer
      第83回日本臨床外科学会総会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 小児難治性リンパ管疾患に対するシロリムスへの期待2021

    • Author(s)
      小関道夫
    • Organizer
      第63回日本小児血液がん学術集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Effects of sirolimus for localized intravascular coagulopathy of slow-flow vascular malformations2021

    • Author(s)
      小関道夫
    • Organizer
      第63回日本小児血液がん学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 難治性リンパ管疾患に対するシロリムス療法2021

    • Author(s)
      小関道夫
    • Organizer
      第3回小児リンパ勉強会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 脈管異常に伴う血液凝固異常2021

    • Author(s)
      小関道夫
    • Organizer
      第2回神奈川小児血液疾患WEBセミナー
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 専門医のための血管腫・血管奇形の基礎知識2021

    • Author(s)
      小関道夫
    • Organizer
      日本小児血液・がん学会、東京都小児・AYA世代がん診療連携協議会、東京小児がん研究グループ(TCCSG)共同開催研修会
    • Related Report
      2021 Research-status Report
    • Invited

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Published: 2021-04-28   Modified: 2025-01-30  

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