心不全患者における基礎代謝と睡眠呼吸障害の関係と陽圧呼吸療法の効果に関する検討

• Project/Area Number: 21K08116
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Juntendo University
• Principal Investigator: 葛西 隆敏 順天堂大学, 大学院医学研究科, 准教授 (60465036)
• Co-Investigator(Kenkyū-buntansha): 須田 翔子 順天堂大学, 医学部, 非常勤助教 (40812722) ; 内藤 亮 順天堂大学, 医学部, 准教授 (70793032)
• Project Period (FY): 2021-04-01 – 2025-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2023: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2022: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2021: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 睡眠時無呼吸 / 基礎代謝 / 心不全 / 睡眠呼吸障害 / 陽圧呼吸療法

Outline of Research at the Start

心不全に高頻度に合併する睡眠呼吸障害では治療介入で心機能が改善するが、海外の大規模研究では治療によってむしろ予後が悪化すると報告された。また非心不全症例では陽圧呼吸療法にて呼吸が安定すると基礎代謝の亢進が是正され体重が増加することが最近の話題である。肥満が多い睡眠呼吸障害患者では陽圧呼吸療法導入後に肥満悪化の可能性があり注意が必要だが、心不全患者では、睡眠呼吸障害による基礎代謝亢進が低栄養を助長している可能性があり、睡眠呼吸障害に対する治療で栄養状態がむしろ改善する可能性がある。しかし、心不全の睡眠呼吸障害と基礎代謝を検討したデータはない。

Outline of Annual Research Achievements

本研究では、心不全患者の基礎代謝と睡眠呼吸障害の関係に関する横断調査と、睡眠呼吸障害に対する陽圧呼吸療法開始前後での基礎代謝と栄養状態の変化を調査することを目的とし、1年目より横断調査と陽圧呼吸療法導入症例の追跡を介予定であったが、COVID-19の関係で症例数の確保が困難であったことに加え、陽圧呼吸療法機器のリコールや世界的な半導体不足で機器の供給が極端に低下してしまったことなどから、計画が大幅に遅延した。当該年度においては、5例を被検者としてリクルートし、睡眠ポリグラフ検査に加え基礎代謝のデータ取得を行うことができた。

Current Status of Research Progress

4: Progress in research has been delayed.

Reason

引き続き睡眠ポリグラフ検査を行う心不全患者の数がCOVID-19流行前に比べ少なかったこととがあり昨年度に続き被験者の登録は限定的であった。しかし小型の基礎代謝測定装置によるデータ収集やその他のデータ収集に問題ないことが確認されており、今年度は被検者のリクルートのさらなる加速が期待できる。

Strategy for Future Research Activity

昨年同様に同じく遅延していた別研究において心不全患者における睡眠呼吸障害スクリーニングを行うため、睡眠ポリグラフを行う心不全患者数の大幅な増加が見込まれる状況となっており、横断調査の症例登録は加速させる予定である。また、陽圧呼吸療法に関しては、リコール問題がはまだ続いているものの、それと関係ない機種を用いてペースアップして登録を進める予定である。

Research Products

• [Journal Article] Prognostic Value of Cheyne-Stokes Respiration and Nutritional Status in Acute Decompensated Heart Failure (2023)
  • Author(s): Abulimiti Abidan、Naito Ryo、Kasai Takatoshi、Ishiwata Sayaki、Nishitani-Yokoyama Miho、Sato Akihiro、Suda Shoko、Matsumoto Hiroki、Shitara Jun、Yatsu Shoichiro、Murata Azusa、Shimizu Megumi、Kato Takao、Hiki Masaru、Daida Hiroyuki、Minamino Tohru
  • Journal Title: Nutrients Volume: 15 Issue: 4 Pages: 964-964
  • DOI: 10.3390/nu15040964
  • Peer Reviewed / Open Access
• [Journal Article] The interaction between physical frailty and prognostic impact of heart failure medication in elderly patients (2023)
  • Author(s): Abe Takuro、Jujo Kentaro、Maeda Daichi、Saito Katsumi、Ogasahara Yuki、Saito Kazuya、Saito Hiroshi、Iwata Kentaro、Konishi Masaaki、Kitai Takeshi、Kasai Takatoshi、Wada Hiroshi、Momomura Shin‐ichi、Kagiyama Nobuyuki、Kamiya Kentaro、Yamashita Masashi、Hamazaki Nobuaki、Nozaki Kohei、Maekawa Emi、Ako Junya、Matsue Yuya
  • Journal Title: ESC Heart Failure Volume: 10 Issue: 3 Pages: 1698-1705
  • DOI: 10.1002/ehf2.14114
  • Peer Reviewed / Open Access
• [Journal Article] Impact of antiallergy agents on CPAP therapy and sleep quality with spring pollinosis in Japanese (2023)
  • Author(s): Yoshikawa Akihisa、Inoshita Ayako、Sata Naoko、Nakamura Masahiro、Suzuki Yo、Ishimizu Erina、Suda Shoko、Naito Ryo、Kasai Takatoshi、Matsumoto Fumihiko
  • Journal Title: Sleep and Breathing Volume: - Issue: 5 Pages: 1795-1803
  • DOI: 10.1007/s11325-023-02788-2
  • Peer Reviewed / Open Access
• [Journal Article] External validation of the ACUTE HF score for risk stratification in acute heart failure (2023)
  • Author(s): Kaneko Tomohiro、Kagiyama Nobuyuki、Nakamura Yutaka、Dotare Taishi、Sunayama Tsutomu、Ishiwata Sayaki、Maeda Daichi、Iso Takashi、Kato Takao、Suda Shoko、Hiki Masaru、Matsue Yuya、Kasai Takatoshi、Minamino Tohru
  • Journal Title: International Journal of Cardiology Volume: 370 Pages: 396-401
  • DOI: 10.1016/j.ijcard.2022.10.130
  • Peer Reviewed
• [Journal Article] Obstructive coronary artery disease, a common and curable but critical comorbidity in acute decompensated heart failure (2022)
  • Author(s): Naito Ryo、Kasai Takatoshi
  • Journal Title: European Journal of Heart Failure Volume: 24 Issue: 11 Pages: 2150-2151
  • DOI: 10.1002/ejhf.2665
  • Peer Reviewed
• [Journal Article] Multimodal Telemonitoring for Weight Reduction in Patients With Sleep Apnea (2022)
  • Author(s): Murase Kimihiko、Gozal David、Kasai Takatoshi、et al.
  • Journal Title: Chest Volume: 162 Issue: 6 Pages: 1373-1383
  • DOI: 10.1016/j.chest.2022.07.032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of radiotherapy for head and neck cancer on obstructive sleep apnea: a prospective study (2022)
  • Author(s): Inoshita Ayako、Sata Naoko、Ohba Shinichi、Suzuki Yo、Ito Shin、Shiroshita Nanako、Kawana Fusae、Kasai Takatoshi、Higo Ryuzaburo、Ikeda Katsuhisa、Matsumoto Fumihiko
  • Journal Title: Annals of Palliative Medicine Volume: 11 Issue: 8 Pages: 2631-2640
  • DOI: 10.21037/apm-22-267
  • Peer Reviewed / Open Access
• [Journal Article] Low apolipoprotein <scp>A1</scp> was associated with increased risk of cancer mortality in patients following percutaneous coronary intervention: A 10‐year follow‐up study (2022)
  • Author(s): Nishiyama Hiroki、Funamizu Takehiro、Iwata Hiroshi、Endo Hirohisa、Chikata Yuichi、Doi Shinichiro、Wada Hideki、Naito Ryo、Ogita Manabu、Kato Yoshiteru、Okai Iwao、Dohi Tomotaka、Kasai Takatoshi、Isoda Kikuo、Okazaki Shinya、Miyauchi Katsumi、Minamino Tohru
  • Journal Title: International Journal of Cancer Volume: 151 Issue: 9 Pages: 1482-1490
  • DOI: 10.1002/ijc.34164
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Asian Pacific Society of Cardiology Consensus Statements on the Diagnosis and Management of Obstructive Sleep Apnoea in Patients with Cardiovascular Disease (2022)
  • Author(s): Tan Jack Wei Chieh、Leow Leong Chai、Wong Serene、Khoo See Meng、Kasai Takatoshi、Kojodjojo Pipin、Sy Duong-Quy、Lee Chuen Peng、Chirakalwasan Naricha、Li Hsueh-Yu、Koh Natalie、Tan Adeline、Ong Thun How、Aung Aye Thandar、Toh Song Tar、Lee Chi-Hang
  • Journal Title: European Cardiology Review Volume: 17
  • DOI: 10.15420/ecr.2021.59
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sarcopenic obesity is associated with impaired physical function and mortality in older patients with heart failure: insight from FRAGILE-HF (2022)
  • Author(s): Saito Hiroshi、Matsue Yuya、Kamiya Kentaro、Kagiyama Nobuyuki、Kasai Takatoshi、et al.
  • Journal Title: BMC Geriatrics Volume: 22 Issue: 1 Pages: 556-556
  • DOI: 10.1186/s12877-022-03168-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of a telemedicine system on work burden and mental health of healthcare providers working with COVID-19: a multicenter pre-post prospective study (2022)
  • Author(s): Kagiyama Nobuyuki、Komatsu Takayuki、Nishikawa Masanori、Hiki Makoto、Kobayashi Mariko、Matsuzawa Wataru、Daida Hiroyuki、Minamino Tohru、Naito Toshio、Sugita Manabu、Miyazaki Kunihisa、Anan Hideaki、Kasai Takatoshi
  • Journal Title: JAMIA Open Volume: 5 Issue: 2
  • DOI: 10.1093/jamiaopen/ooac037
  • Peer Reviewed / Open Access
• [Journal Article] Association between Frequency of Central Respiratory Events and Clinical Outcomes in Heart Failure Patients with Sleep Apnea (2022)
  • Author(s): Naito Ryo、Kasai Takatoshi、Narui Koji、Momomura Shin-Ichi
  • Journal Title: Journal of Clinical Medicine Volume: 11 Issue: 9 Pages: 2403-2403
  • DOI: 10.3390/jcm11092403
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of Sleep Parameters and Sleep Staging (Slow Wave Sleep) in Athletes by Fitbit Alta HR, a Consumer Sleep Tracking Device (2022)
  • Author(s): Kawasaki Yu、Kasai Takatoshi、Sakurama Yuko、Sekiguchi Akiko、Kitamura Eri、Midorikawa Itsuki、Shiroshita Nanako、Kawana Fusae、Ogasawara Etsuko、Kitade Mari、Koikawa Natsue、Matsuda Takao
  • Journal Title: Nature and Science of Sleep Volume: Volume 14 Pages: 819-827
  • DOI: 10.2147/nss.s351274
  • Peer Reviewed / Open Access
• [Journal Article] Pulse transit time-estimated blood pressure: a comparison of beat-to-beat and intermittent measurement (2022)
  • Author(s): Hoshide Satoshi、Yoshihisa Akiomi、Tsuchida Fumihiro、Mizuno Hiroyuki、Teragawa Hiroki、Kasai Takatoshi、Koito Hitoshi、Ando Shin-ichi、Watanabe Yoshihiko、Takeishi Yasuchika、Kario Kazuomi
  • Journal Title: Hypertension Research Volume: 45 Issue: 6 Pages: 1001-1007
  • DOI: 10.1038/s41440-022-00899-z
  • Peer Reviewed
• [Journal Article] Clinical significance of 123I-BMIPP washout rate in patients with uncertain chronic heart failure (2022)
  • Author(s): Aoshima C、Fujimoto S、Kudo A、Kawaguchi Y O.、Takamura K、Matsue Y、Kato T、Kawamura Y、Kimura S、Kamo Y、Nozaki Y O.、Takahashi D、Tomizawa N、Hiki M、Kasai T、Nojiri S、Miyauchi H、Hirano Ki、Shimada K、Murakami K、Minamino T
  • Journal Title: European Journal of Nuclear Medicine and Molecular Imaging Volume: 49 Issue: 9 Pages: 3129-3139
  • DOI: 10.1007/s00259-022-05749-1
  • Peer Reviewed / Open Access
• [Journal Article] Prevalence and prognostic impact of cognitive frailty in elderly patients with heart failure: sub‐analysis of FRAGILE‐HF (2022)
  • Author(s): Yamamoto Shuhei、Yamasaki Saeko、Kasai Takatoshi、et al.
  • Journal Title: ESC Heart Failure Volume: 9 Issue: 3 Pages: 1574-1583
  • DOI: 10.1002/ehf2.13844
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inaccurate recognition of own comorbidities is associated with poor prognosis in elderly patients with heart failure (2022)
  • Author(s): Maeda Daichi、Matsue Yuya、et al.
  • Journal Title: ESC Heart Failure Volume: 9 Issue: 2 Pages: 1351-1359
  • DOI: 10.1002/ehf2.13824
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sex differences in the prevalence and prognostic impact of physical frailty and sarcopenia among older patients with heart failure (2022)
  • Author(s): Maeda Daichi、Matsue Yuya、Kagiyama Nobuyuki、Jujo Kentaro、Saito Kazuya、Kamiya Kentaro、Saito Hiroshi、Ogasahara Yuki、Maekawa Emi、Konishi Masaaki、Kitai Takeshi、Iwata Kentaro、Wada Hiroshi、Hiki Masaru、Dotare Taishi、Sunayama Tsutomu、Kasai Takatoshi、Nagamatsu Hirofumi、Ozawa Tetsuya、Izawa Katsuya、et al.
  • Journal Title: Nutrition, Metabolism and Cardiovascular Diseases Volume: 32 Issue: 2 Pages: 365-372
  • DOI: 10.1016/j.numecd.2021.10.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Sleep Apnea Syndrome (SAS) Clinical Practice Guidelines 2020 (2022)
  • Author(s): Akashiba Tsuneto、Inoue Yuichi、Uchimura Naohisa、Ohi Motoharu、Kasai Takatoshi、Kawana Fusae、Sakurai Shigeru、Takegami Misa、Tachikawa Rho、Tanigawa Takeshi、Chiba Shintaro、Chin Kazuo、Tsuiki Satoru、Tonogi Morio、Nakamura Hiroshi、Nakayama Takeo、Narui Koji、Yagi Tomoko、Yamauchi Motoo、et al.
  • Journal Title: Respiratory Investigation Volume: 60 Issue: 1 Pages: 3-32
  • DOI: 10.1016/j.resinv.2021.08.010
  • NAID: 40022810958
  • Peer Reviewed / Open Access
• [Journal Article] Factors Associated With the Improvement of Left Ventricular Systolic Function by Continuous Positive Airway Pressure Therapy in Patients With Heart Failure With Reduced Ejection Fraction and Obstructive Sleep Apnea (2022)
  • Author(s): Naito Ryo、Kasai Takatoshi、Dohi Tomotaka、Takaya Hisashi、Narui Koji、Momomura Shin-ichi
  • Journal Title: Frontiers in Neurology Volume: 13
  • DOI: 10.3389/fneur.2022.781054
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic effect of sleep-disordered breathing on hospitalized patients following acute heart failure (2021)
  • Author(s): Ishiwata Sayaki、Kasai Takatoshi、Sato Akihiro、Suda Shoko、Matsumoto Hiroki、Shitara Jun、Yatsu Shoichiro、Murata Azusa、Shimizu Megumi、Kato Takao、Hiki Masaru、Matsue Yuya、Naito Ryo、Daida Hiroyuki、Minamino Tohru
  • Journal Title: Clinical Research in Cardiology Volume: - Issue: 6 Pages: 663-672
  • DOI: 10.1007/s00392-021-01969-x
  • Peer Reviewed
• [Journal Article] Effects of Telerehabilitation Interventions on Heart Failure Management (2015-2020): Scoping Review (2021)
  • Author(s): Skov Schacksen Cathrine、Henneberg Nanna Celina、Muthulingam Janusiya Anajan、Morimoto Yuh、Sawa Ryuichi、Saitoh Masakazu、Morisawa Tomoyuki、Kagiyama Nobuyuki、Takahashi Tetsuya、Kasai Takatoshi、Daida Hiroyuki、Refsgaard Jens、Hollingdal Malene、Dinesen Birthe
  • Journal Title: JMIR Rehabilitation and Assistive Technologies Volume: 8 Issue: 4 Pages: e29714-e29714
  • DOI: 10.2196/29714
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of physical performance on exercise capacity in older patients with heart failure with reduced and preserved ejection fraction (2021)
  • Author(s): Saka Kenichiro、Konishi Masaaki、Kagiyama Nobuyuki、Kamiya Kentaro、Saito Hiroshi、Saito Kazuya、Ogasahara Yuki、Maekawa Emi、Misumi Toshihiro、Kitai Takeshi、Iwata Kentaro、Jujo Kentaro、Wada Hiroshi、Kasai Takatoshi、Nagamatsu Hirofumi、Ozawa Tetsuya、Izawa Katsuya、Yamamoto Shuhei、Aizawa Naoki、et al.
  • Journal Title: Experimental Gerontology Volume: 156 Pages: 111626-111626
  • DOI: 10.1016/j.exger.2021.111626
  • Peer Reviewed
• [Presentation] Impact of sleep disordered breathing on overnight changes of atrial stiffness in patients with heart failure (2022)
  • Author(s): Shoichiro Yatsu、Takatoshi Kasai、Hiroki Matsumoto、et al.
  • Organizer: American College of Cardiology 2022: 71st Annual Scientific Session & Expo
  • Int'l Joint Research
• [Presentation] Diagnosis, treatment and clinical imlications of sleep apnea in patients with hypertension (2022)
  • Author(s): Takatoshi Kasai
  • Organizer: 29th International Society of Hypertension
  • Int'l Joint Research / Invited
• [Presentation] Prognostic Value of Cheyne-Stokes Respiration and Nutritional Status in Acute Heart Failure Patients (2022)
  • Author(s): Abidan Abulimiti, Ryo Naito, Takatoshi Kasai, Sayaki Ishiwata, Miho-Nishitani Yokoyama, Akihiro Sato, Shoko Suda, Hiroki Matsumoto, Jun Shitara, Shoichiro Yatsu, Azusa Murata, Megumi Shimizu, Takao Kato, Masaru Hiki, Hiroyuki Daida, Tohru Minamino
  • Organizer: European Society of Cardiology Heart Failure 2022
  • Int'l Joint Research