多施設レジストリデータベースを用いた心不全患者の多面的評価
Project/Area Number |
21K08142
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 53020:Cardiology-related
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Research Institution | Sakakibara Heart Foundation |
Principal Investigator |
吉川 勉 公益財団法人榊原記念財団(臨床研究施設・研究部門), 顧問室, 常勤顧問 (20174906)
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Co-Investigator(Kenkyū-buntansha) |
香坂 俊 慶應義塾大学, 医学部(信濃町), 講師 (30528659)
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Project Period (FY) |
2021-04-01 – 2024-03-31
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Project Status |
Granted (Fiscal Year 2022)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 心不全 / ガイドライン / 高齢者 / 薬物治療 / 合併症 / 低栄養 / 血糖値 / 利尿薬 / 突然死 / 尿酸 / フレイル |
Outline of Research at the Start |
心不全患者は極めて非均一な集団であり、ゆえに治療戦略は複雑化し、効果的な介入につなげることが難しくなっている。こうした現状を打破するには、従来からの臨床評価項目に加えて、多職種からの視点を含んだ医療チームによる多面的な患者評価が必要である。また近年、Shared Decision Makingの機運が高まっており、医師患者間の情報共有が重要となっている。本研究では質問紙票を用いて、患者と医師双方の理解を評価し、効果的な介入方法を探索する。
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Outline of Annual Research Achievements |
症例登録は順調に進んでいる。 収縮不全における低栄養状態が薬物治療の実践に及ぼす影響、国際的大規模臨床試験であるPARDIGM-HF試験、DAPA-HF試験、SHIFT試験のエントリー基準に該当する心不全患者において本邦でどの程度ガイドラインに基づく治療がなされているかの調査、他臓器合併症を有する場合の治療内容と予後に及ぼす影響、短時間作用型と長時間作用型利尿薬の臨床転帰に及ぼす影響などについて論文を公表した。 心不全増悪による入院中の治療薬の増減がその後の臨床転帰に及ぼす影響、低血圧症例におけるガイドライン推奨心不全治療薬使用の意義、心不全入院の契機となる増悪因子の検討、入院中の心不全治療薬の増量が予後に及ぼす影響、至適心拍数の個別化の試み、入院中の血糖値の変動が予後に及ぼす影響などについて学会発表した。
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Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
症例数蓄積は順調に進んでいる。解析項目の修正に伴い、さらに多面的な解析が可能となった。
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Strategy for Future Research Activity |
収縮機能の保たれた心不全例における慢性腎臓病を合併した場合のレニン・アンジオテンシン系阻害薬の意義、心不全薬物治療の性差、低栄養合併例におけるSGLT2阻害薬の効果、三尖弁閉鎖不全への介入、肺高血圧の残存が予後に及ぼす影響、高齢者心不全のフェノタイピング、身体所見による予後予測などについて検討予定である。
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Report
(2 results)
Research Products
(43 results)
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[Journal Article] Cardiovascular vs. Non-Cardiovascular deaths after Heart Failure Hospitalization in Young, Older, and Very Old Patients.2023
Author(s)
Nakamaru R, Shiraishi Y, Sandhu AT, Heidenreich PA, Shoji S, Kohno T, Takei M, Nagatomo Y, Nakano S, Kohsaka S, Yoshikawa T
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Journal Title
ESC Heart Fail.
Volume: 10
Issue: 1
Pages: 673-684
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Improved prediction of sudden cardiac death in patients with heart failure through digital processing of electrocardiography.2023
Author(s)
Shiraishi Y, Goto S, Niimi N, Katsumata Y, Goda A, Takei M, Saji M, Sano M, Fukuda K, Kohno T, Yoshikawa T, Kohsaka S.
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Journal Title
Europace.
Volume: 25(3)
Issue: 3
Pages: 922-930
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association of potassium level at discharge with long-term mortality in hospitalized patients with heart failure.2023
Author(s)
Miura Y, Higuchi S, Kohn T, Shiraishi Y, Kitamura M, Nagatomo Y, Takei M, Nakano S, Goda A, Soejima K, Kohsaka S, Yoshikawa T
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Journal Title
J Clin Med
Volume: 999
Pages: 999-999
Related Report
Peer Reviewed / Open Access
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[Journal Article] otential association with malnutrition and allocation of combination medical therapies in hospitalized heart failure patients with reduced ejection fraction.2022
Author(s)
Kawakubo Y, Shiraishi Y, Kohsaka S, Kohno T, Goda A, Nagatomo Y, Nishihata Y, Saji M, Takei M, Ikegami Y, Niimi N, Sandhu ATS, Nakano S, Yoshikawa T, Fukuda K; West Tokyo Heart Failure Registry.
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Journal Title
Sci Rep.
Volume: 12(1)
Issue: 1
Pages: 8318-8318
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Conventional medical therapy in heart failure patients eligible for the PARADIGM-HF, DAPA-HF, and SHIFT trials2022
Author(s)
Satoshi Shoji, Shun Kohsaka, Yasuyuki Shiraishi, Takashi Kohno, Mitsuaki Sawano, Nobuhiro Ikemura, Nozomi Niimi, Yuji Nagatomo, Toshikazu D Tanaka, Makoto Takei, Tomohiko Ono, Munehisa Sakamoto, Shintaro Nakano, Iwao Nakamura, Soushin Inoue, Keiichi Fukuda, Tsutomu Yoshikawa
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Journal Title
Int J Cardiol
Volume: S0167-5273
Pages: 76-83
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Use of short-acting vs. long-acting loop diuretics after heart failure hospitalization.2022
Author(s)
Imaeda S, Shiraishi Y, Kohsaka S, Niimi N, Goda A, Nagatomo Y, Takei M, Saji M, Nakano S, Kohno T, Fukuda K, Yoshikawa T.
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Journal Title
ESC Heart Fail.
Volume: 9(5)
Issue: 5
Pages: 2967-2977
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association between class of foundational medication for heart failure and prognosis in heart failure with reduced/mildly reduced ejection fraction.2022
Author(s)
Ito M, Maeda D, Matsue Y, Shiraishi Y, Dotare T, Sunayama T, Nogi K, Takei M, Ueda T, Nogi M, Ishihara S, Nakada Y, Kawakami R, Kagiyama N, Kitai T, Oishi S, Akiyama E, Suzuki S, Yamamoto M, Kida K, Okumura T, Nagatomo Y, Kohno T, Nakano S, Kohsaka S, Yoshikawa T, Saito Y, Minamino T
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Journal Title
Sci Rep
Volume: 12
Issue: 1
Pages: 16611-16611
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Left ventricular mass index-to-QRS-voltage ratio predicts outcomes in heart failure with preserved ejection fraction.2022
Author(s)
Kinugasa Y, Nakamura K, Kamitani H, Hirai M, Yanagihara K, Kato M, Nagai T, Yoshikawa T, Saito Y, Takeishi Y, Yamamoto K, Anzai T
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Journal Title
ESC Heart Fail
Volume: 9
Issue: 2
Pages: 1098-1106
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Precipitating factors and short- and long-term outcomes of acute heart failure: A report from WET-HF2 Registry.2023
Author(s)
Kawakubo Y, Shiraishi Y, Nakamaru R, Kohno T, Nagatomo Y, Saji M, Takei M, Sakamoto M, Nakano S, Fukuda K, Kohsaka S, Yoshikawa T
Organizer
Japanese Ciculation Society Meeting
Related Report
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[Presentation] Impact of Barthel Index on home discharge and long-term outcomes in patients hospitalized with heart failure.2023
Author(s)
Izumi K, Kohno T, Goda A, Takeuchi S, Shiraishi Y, Nagatomo Y, Kitamura M, Takei M, Sakamot M, Mizuno A, Nakano S, Soejima K, Kohsaka S, Yoshikawa T
Organizer
Japanese Ciculation Society Meeting
Related Report
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[Presentation] Sex-related differences in long-term outcome across the spectrum of left ventricular ejection fraction in patients with heart failure.2023
Author(s)
Kawai A, Nagatomo Y, Saji M, Takei M, Goda A, Kohno T, Nakano S, Nishihata Y, Ikegami Y, Shoji S, Shiraishi Y, Kohsaka S, Yoshikawa T
Organizer
Japanese Ciculation Society Meeting
Related Report
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[Presentation] Association of blood glucose dysregulation with long-term prognosis in acute decompensated heart failure.2022
Author(s)
Chishiki T, Nagatomo Y, Saji M, Takei M, Goda A, Kohno T, Nakano S, Nishihata Y, Ikegami Y, Shoji S, Shiraishi Y, Kohsaka S, Adachi K, Yoshikawa T
Organizer
26th Japanese Heart Failure Society Meeting, YIA Clinical 1
Related Report
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[Presentation] In-hospital up-titration of guideline-based medications and outcome in acute heart failure patients: An analysis from WET-HF Registry in Japan.2022
Author(s)
Ohata T, Niimi N, Shiraishi Y, Nakatsu F, Iekushi K, Kohno T, Nagatomo Y, Takei M, Ono T, Sakamoto M, Nakano S, Fukuda K, Kohsaka S, Yoshikawa T
Organizer
26th Japanese Heart Failure Society Meeting
Related Report
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[Presentation] Prevalence and Prognostic Impact of Malnutrition among Heart Failure Patients Eligible for EMPEROR-Preserved Trial.2022
Author(s)
Takeuchi S, Kohno T, Goda A, Shiraishi Y, Saji M, YNagatomo Y, Tanaka T, Takei M, Nakano S, Soejima K, Kohsaka S, Yoshikawa T
Organizer
Japanese Circulation Society Meeting
Related Report
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[Presentation] Clinical Significance of Guideline-Directed Medical Therapy in Heart Failure Patients with Low Blood Pressure.2022
Author(s)
Izumi K, Kohno T, Goda A, Takeuchi S, Shiraishi Y, Saji M, Nagatomo Y, Tanaka T, Takei M, Nakano S, Soejima K, Kohsaka S, Yoshikawa T
Organizer
Japanese Circulation Society Meeting, Featured Research Session
Related Report
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[Presentation] Electrocardiography-Based Prediction of Sudden Cardiac Death in Heart Failure Patients: Application of Artificial Intelligence.2022
Author(s)
Shiraishi Y, Goto S, Niimi N, Katsumata Y, Goda A, Takei M, Saji M, Nishihata Y, Sano M, Fukuda K, Kohno T, Yoshikawa T, Shun Kohsaka S
Organizer
Japanese Circulation Society Meeting, YIA Clinical Research
Related Report
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[Presentation] “Target Heart Rate” calculated aiming at zero overlap of mitral E and A waves is useful for prediction of long-term outcome for patients with heart failure and reduced ejection fraction.2021
Author(s)
Yumita Y, Nagatomo Y, Takei M, Goda A, Kohno T, Nakano S, Nishihata Y, Ikegami Y, Shiraishi Y, Kohsaka S, Yoshikawa T
Organizer
Eur Congress Cardiology Meeting
Related Report
Int'l Joint Research
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[Presentation] Validation of the HFA-PEFF and the H2FPEF scores for the diagnosis of heart failure with preserved ejection fraction in Japanese patients: a report from the Japanese muticentre registry.2021
Author(s)
Tada A, Nagai T, Tsujinaga S, Kamiya K, Konishi T, Saito T, Komoriyama H, Kobayashi Y, Takenaka S, Mizoguchi Y, Yamamoto K, Yoshikawa T, Saito Y, Anzai T
Organizer
Eur Congress Cardiology Meeting
Related Report
Int'l Joint Research
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[Presentation] Under-utilization of conventional guideline-directed medical therapy among patients eligible for the recent large-scale clinical trials of heart failure with reduced ejection fraction.2021
Author(s)
Shoji S, Kohsaka S, Shiraishi Y, Sawano M, Ikemura N, Niimi N, Kohno T, Goda A, Nagatomo Y, Saji M, Takei M, Nakano S, Fukuda K, Yoshikawa T
Organizer
American Heart Association Scientific Meeting
Related Report
Int'l Joint Research
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[Presentation] Outcomes in Elderly Patients with Hospitalized Heart Failure Stratified by Left Ventricular Ejection Fraction.2021
Author(s)
Nakamaru R, Shiraishi Y, Kohsaka S, Kohno T, Goda A, Takei M, Nagatomo Y, Tanaka TD, Nakano S, Fukuda K, Tsutomu Yoshikawa T
Organizer
American Heart Association Scientific Meeting
Related Report
Int'l Joint Research
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[Presentation] Mode of Death After Heart Failure Hospitalization in Elderly Patients.2021
Author(s)
Nakamaru R, Shiraishi Y, Kohsaka S, Kohno T, Goda A, Takei M, Nagatomo Y, Tanaka TD, Nakano S, Fukuda K, Yoshikawa T
Organizer
American Heart Association Scientific Meeting
Related Report
Int'l Joint Research