Residual risk control in familial hypercholesterolemia: Basis for development of cholesterol efflux enhancers

• Project/Area Number: 21K08143
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Juntendo University (2023); Chiba University (2021-2022)
• Principal Investigator: 小倉 正恒 順天堂大学, 医療科学部, 教授 (30532486)
• Project Period (FY): 2021-04-01 – 2025-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: コレステロール引き抜き能 / 家族性高コレステロール血症 / HDL / HDL機能 / コレステロール搬出能 / 抗酸化能 / フォスフォリパーゼ / 動脈硬化 / リン脂質 / ホスフォリパーゼ

Outline of Research at the Start

脳梗塞や心筋梗塞などの動脈硬化性疾患は麻痺・寝たきり・認知症・心不全などの原因となり、健康寿命を短縮させるため、その予防は重要課題です。悪玉コレステロールと呼ばれるLDLコレステロールを低下させても動脈硬化性疾患のリスクはゼロにならないため、善玉コレステロールと考えられてきたHDL-Cを増加させる戦略が考えられてきました。しかし、HDLコレステロールを増やしても心血管イベントは減らないことが報告され、HDLの研究は量から質にシフトしています。本研究計画ではHDLの質の悪化と動脈硬化の重症化に共通する特定の物質を明らかにし、その阻害薬を開発するための基盤研究です。

Outline of Annual Research Achievements

心筋梗塞症例と非心筋梗塞症例においてHDLコレステロール(HDL-C)値とコレステロール引き抜き能（cholesterol efflux capacity: CEC）、全身の酸化ストレス指標となるマーカー(酸化アルブミン)との関連を検討する症例対照研究を開始し、①HDL-C値とCECの関連は正常対照群よりも心筋梗塞患者において低いこと、②心筋梗塞患者における全身の酸化ストレス指標はCECで予測できるが、HDL-C値では予測できないこと、という知見を得た（J Atheroscler Thromb. 2024 Feb 20. doi: 10.5551/jat.64691）。
また、CECがHDLの抗酸化作用の一部を担うparaoxonase 1 (PON1)の活性とPON1遺伝子多型の両方に関連することを明らかにした（J Atheroscler Thromb. 2024 Mar 19. doi: 10.5551/jat.64711）。
家族性高コレステロール血症患者におけるコレステロール取り込み能（cholesterol uptake capacity: CUC）の臨床的意義に関する金沢大学と神戸大学の共著論文に対し、Editorial Commentsを執筆した（Circ J. 2023 May 25;87(6):813-814）。
家族性高コレステロール血症患者のコレステロール引き抜き能を低下させる要因としてのLp(a)の関与を見出し、2024年度の国内および国外学会での発表に採択されたため、現在、論文化を進めている。
家族性高コレステロール血症関連では、日本循環器学会の「冠動脈疾患の一次予防に関するガイドライン（改訂版）」の班員として「家族性高コレステロール血症」の項を担当し執筆した（Circ J. 2024 Apr 25;88(5):763-842.）

Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

sPLA2-VのELISAキットの不具合により予備検討結果の検証が遅れている。一方でHDL-C値よりもCECが心筋梗塞急性期における酸化ストレス状態を反映していること、抗酸化能とCECの関連について新たな発見があった。

Strategy for Future Research Activity

引き続きPLA2活性とCECの関連を追究したいが、ELISAキットの不具合が改善されない場合は、新たに見出したLp(a)とCECの関連についてさらに検討を深め、論文化につなげたい。

Research Products

• [Journal Article] Do You Prescribe PCSK9 Inhibitors Properly? (2024)
  • Author(s): Ogura Masatsune
  • Journal Title: Circulation Journal Volume: 88 Issue: 10 Pages: 1637-1638
  • DOI: 10.1253/circj.CJ-24-0186
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2024-09-25
  • Peer Reviewed / Open Access
• [Journal Article] The Association of the Cholesterol Efflux Capacity with the <i>Paraoxonase 1</i> Q192R Genotype and the Paraoxonase Activity (2024)
  • Author(s): Oniki Kentaro、Ohura Kayoko、Endo Megumi、Akatwijuka Daniel、Matsumoto Erika、Nakamura Teruya、Ogata Yasuhiro、Yoshida Minoru、Harada-Shiba Mariko、Saruwatari Junji、Ogura Masatsune、Imai Teruko
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 31 Issue: 9 Pages: 1263-1276
  • DOI: 10.5551/jat.64711
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2024-09-01
  • Peer Reviewed / Open Access
• [Journal Article] Impaired Cholesterol Efflux Capacity rather than Low HDL-C Reflects Oxidative Stress under Acute Myocardial Infarction (2024)
  • Author(s): Oniki Kentaro、Ogura Masatsune、Matsumoto Erika、Watanabe Hiroshi、Imafuku Tadashi、Seguchi Yuri、Arima Yuichiro、Fujisue Koichiro、Yamanaga Kenshi、Yamamoto Eiichiro、Maeda Hitoshi、Ogata Yasuhiro、Yoshida Minoru、Harada-Shiba Mariko、Maruyama Toru、Tsujita Kenichi、Saruwatari Junji
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 31 Issue: 8 Pages: 1149-1161
  • DOI: 10.5551/jat.64691
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2024-08-01
  • Peer Reviewed / Open Access
• [Journal Article] Current Diagnosis and Management of Familial Hypobetalipoproteinemia 1 (2024)
  • Author(s): Wakabayashi Tetsuji、Takahashi Manabu、Okazaki Hiroaki、Okazaki Sachiko、Yokote Koutaro、Tada Hayato、Ogura Masatsune、et al
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 31 Issue: 7 Pages: 1005-1023
  • DOI: 10.5551/jat.RV22018
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2024-07-01
  • Peer Reviewed / Open Access
• [Journal Article] Transitional Medicine of Intractable Primary Dyslipidemias in Japan (2024)
  • Author(s): Ogura Masatsune、Okazaki Sachiko、Okazaki Hiroaki、Tada Hayato、Dobashi Kazushige、Nakamura Kimitoshi、Matsunaga Keiji、Miida Takashi、Minamino Tetsuo、Yokoyama Shinji、Harada-Shiba Mariko
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 31 Issue: 5 Pages: 501-519
  • DOI: 10.5551/jat.RV22016
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2024-05-01
  • Peer Reviewed / Open Access
• [Journal Article] JCS 2023 Guideline on the Primary Prevention of Coronary Artery Disease (2024)
  • Author(s): Fujiyoshi Akira、Kohsaka Shun、Hata Jun、Hara Mitsuhiko、Kai Hisashi、Masuda Daisaku、Miyamatsu Naomi、Nishio Yoshihiko、Ogura Masatsune、et al
  • Journal Title: Circulation Journal Volume: 88 Issue: 5 Pages: 763-842
  • DOI: 10.1253/circj.CJ-23-0285
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2024-04-25
  • Peer Reviewed / Open Access
• [Journal Article] Detectability of and interference by major and minor hemoglobin variants using a new-generation ion-exchange HPLC system with two switchable analysis modes (2024)
  • Author(s): Manita Daisuke、Ogino Shinji、Marivoet Stefaan、Ogura Masatsune
  • Journal Title: Practical Laboratory Medicine Volume: 38 Pages: e00346-e00346
  • DOI: 10.1016/j.plabm.2023.e00346
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between Familial Hypercholesterolemia and Serum Levels of Cholesterol Synthesis and Absorption Markers: The CACHE Study FH Analysis (2023)
  • Author(s): Matsuki Kota、Harada-Shiba Mariko、Hori Mika、Ogura Masatsune、Ishida Tatsuro、Ishigaki Yasushi、Kotani Kazuhiko、Masuda Daisaku、Matoba Tetsuya、Nakazato Masamitsu、Yamashita Shizuya、Shoji Tetsuo, et al
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 30 Issue: 9 Pages: 1152-1164
  • DOI: 10.5551/jat.63899
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2023-09-01
  • Peer Reviewed / Open Access
• [Journal Article] Is High-Density Lipoprotein Functionality Useful as a Residual Risk Marker for Familial Hypercholesterolemia? (2023)
  • Author(s): Ogura Masatsune
  • Journal Title: Circulation Journal Volume: 87 Issue: 6 Pages: 813-814
  • DOI: 10.1253/circj.CJ-22-0829
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2023-05-25
  • Peer Reviewed / Open Access
• [Journal Article] Gradual dose Titration of Lomitapide may Prevent Therapeutic Delays in Patients with Homozygous Familial Hypercholesterolemia (2023)
  • Author(s): Harada-Shiba Mariko、Koezuka Ryo、Makino Hisashi、Ogura Masatsune
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 30 Issue: 2 Pages: 203-205
  • DOI: 10.5551/jat.LE003
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2023-02-01
  • Peer Reviewed / Open Access
• [Journal Article] Additive Effects of Drinking Habits and a Susceptible Genetic Polymorphism on Cholesterol Efflux Capacity (2023)
  • Author(s): Matsumoto E, Oniki K, Ota-Kontani A, Seguchi Y, Sakamoto Y, Kaneko T, Imafuku T, Maeda H, Watanabe H, Maruyama T, Ogata Y, Yoshida M, Harada-Shiba M, Saruwatari J, Ogura M.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 30 Issue: 1 Pages: 23-38
  • DOI: 10.5551/jat.63277
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2023-01-01
  • Peer Reviewed / Open Access
• [Journal Article] The real-world data of lipid-lowering treatment in patients with peripheral artery disease and its association with severity of disease (2023)
  • Author(s): Komai Hiroyoshi、Ogura Masatsune、Sakashita Hideki、Miyama Noriyuki、Yamamoto Nobuko、Takai Kanako、Hatada Atsutoshi、Tanimura Nobuhiro、Nakamura Takashi、Yoshida Masato、Kawaura Takayuki、Kitawaki Tomomi
  • Journal Title: Journal of Cardiology Volume: 23 Issue: 1 Pages: 245-249
  • DOI: 10.1016/j.jjcc.2023.10.002
  • Peer Reviewed
• [Journal Article] Clinical Characteristics of Homozygous Familial Hypercholesterolemia in Japan (2023)
  • Author(s): Takeji Yasuaki、Tada Hayato et al.
  • Journal Title: JACC: Asia Volume: 3 Issue: 6 Pages: 881-891
  • DOI: 10.1016/j.jacasi.2023.07.011
  • Peer Reviewed / Open Access
• [Journal Article] Association between Achilles Tendon Softness and Atherosclerotic Cardiovascular Disease in Patients with Familial Hypercholesterolemia (2022)
  • Author(s): Michikura Masahito、Ogura Masatsune、Hori Mika、Matsuki Kota、Makino Hisashi、Hosoda Kiminori、Harada-Shiba Mariko
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 29 Issue: 11 Pages: 1603-1612
  • DOI: 10.5551/jat.63151
  • NAID: 130008140233
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2022-11-01
  • Peer Reviewed / Open Access
• [Journal Article] Achilles Tendon Thickness Assessed by X-ray Predicting a Pathogenic Mutation in Familial Hypercholesterolemia Gene (2022)
  • Author(s): Tada Hayato、Hori Mika、Matsuki Kota、Ogura Masatsune、Nohara Atsushi、Kawashiri Masa-aki、Harada-Shiba Mariko
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 29 Issue: 6 Pages: 816-824
  • DOI: 10.5551/jat.62869
  • NAID: 130008060205
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2022-06-01
  • Peer Reviewed / Open Access
• [Journal Article] Factors Associated with Carotid Atherosclerosis and Achilles Tendon Thickness in Japanese Patients with Familial Hypercholesterolemia: A Subanalysis of the Familial Hypercholesterolemia Expert Forum (FAME) Study (2022)
  • Author(s): Ogura Masatsune、Harada-Shiba Mariko、Masuda Daisaku、Arai Hidenori、Bujo Hideaki、Ishibashi Shun、Daida Hiroyuki、Koga Nobuhiko、Oikawa Shinichi、Yamashita Shizuya
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 29 Issue: 6 Pages: 906-922
  • DOI: 10.5551/jat.62925
  • NAID: 130008050731
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2022-06-01
  • Peer Reviewed / Open Access
• [Journal Article] Prospective Registry Study of Primary Dyslipidemia (PROLIPID): Rationale and Study Design (2022)
  • Author(s): Tada H, Kurashina T, Ogura M, Takegami M, Miyamoto Y, Arai H, Harada-Shiba M, Ishibashi S; Committee on Primary Dyslipidemia under the Research Program on Rare and Intractable Disease of the Ministry of Health, Labour and Welfare of Japan
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 29 Issue: 6 Pages: 953-969
  • DOI: 10.5551/jat.63222
  • NAID: 130008106840
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2022-06-01
  • Peer Reviewed / Open Access
• [Journal Article] A Resuscitated Case of Acute Myocardial Infarction with both Familial Hypercholesterolemia Phenotype Caused by Possibly Oligogenic Variants of the <i>PCSK9</i> and <i>ABCG5</i> Genes and Type I CD36 Deficiency (2022)
  • Author(s): Nishikawa Ryo、Furuhashi Masato、Hori Mika、Ogura Masatsune、Harada-Shiba Mariko、Okada Takeshi、Koseki Masahiro、Kujiraoka Takeshi、Hattori Hiroaki、Ito Ryosuke、Muranaka Atsuko、Kokubu Nobuaki、Miura Tetsuji
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 29 Issue: 4 Pages: 551-557
  • DOI: 10.5551/jat.58909
  • NAID: 130007992205
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2022-04-01
  • Peer Reviewed / Open Access
• [Journal Article] The Reason is Still Unclear (2022)
  • Author(s): Ogura Masatsune
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 29 Issue: 1 Pages: 3-4
  • DOI: 10.5551/jat.ED164
  • NAID: 130008138916
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2022-01-01
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of Polyvascular Disease in Heterozygous Familial Hypercholesterolemia: Its Association With Circulating Lipoprotein(a) Levels (2022)
  • Author(s): Funabashi Sayaka、Kataoka Yu、Hori Mika、Ogura Masatsune、Doi Takahito、Noguchi Teruo、Harada‐Shiba Mariko
  • Journal Title: Journal of the American Heart Association Volume: 11 Issue: 16
  • DOI: 10.1161/jaha.121.025232
  • Peer Reviewed / Open Access
• [Journal Article] HDL, cholesterol efflux, and ABCA1: Free from good and evil dualism (2022)
  • Author(s): Ogura Masatsune
  • Journal Title: Journal of Pharmacological Sciences Volume: 150 Issue: 2 Pages: 81-89
  • DOI: 10.1016/j.jphs.2022.07.004
  • Peer Reviewed / Open Access
• [Journal Article] The impact of gene variants on the thickness and softness of the Achilles tendon in familial hypercholesterolemia (2022)
  • Author(s): Michikura Masahito、Hori Mika、Ogura Masatsune、Hosoda Kiminori、Harada-Shiba Mariko
  • Journal Title: Atherosclerosis Volume: 358 Pages: 41-46
  • DOI: 10.1016/j.atherosclerosis.2022.08.014
  • Peer Reviewed
• [Journal Article] A Low-Frequency <i>APOB</i> p.(Pro955Ser) Variant Contributes to the Severity of/Variability in Familial Hypercholesterolemia (2022)
  • Author(s): Hori Mika、Takahashi Atsushi、Hosoda Kiminori、Ogura Masatsune、Harada-Shiba Mariko
  • Journal Title: The Journal of Clinical Endocrinology &amp; Metabolism Volume: 108 Issue: 2 Pages: 422-432
  • DOI: 10.1210/clinem/dgac572
  • Peer Reviewed
• [Journal Article] Current Diagnosis and Management of Abetalipoproteinemia (2021)
  • Author(s): Takahashi Manabu、Okazaki Hiroaki、Ohashi Ken、Ogura Masatsune、Ishibashi Shun、Okazaki Sachiko、Hirayama Satoshi、Hori Mika、Matsuki Kota、Yokoyama Shinji、Harada-Shiba Mariko
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 28 Issue: 10 Pages: 1009-1019
  • DOI: 10.5551/jat.RV17056
  • NAID: 130008095566
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2021-10-01
  • Peer Reviewed
• [Journal Article] Unresolved Issues Regarding Proper Intake of Omega-3 Fatty Acids (2021)
  • Author(s): Ogura Masatsune
  • Journal Title: Circulation Journal Volume: 85 Issue: 10 Pages: 1754-1755
  • DOI: 10.1253/circj.CJ-21-0356
  • NAID: 130008091442
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2021-09-24
  • Peer Reviewed
• [Journal Article] Cerebrotendinous Xanthomatosis: Molecular Pathogenesis, Clinical Spectrum, Diagnosis, and Disease-Modifying Treatments (2021)
  • Author(s): Koyama Shingo、Sekijima Yoshiki、Ogura Masatsune、Hori Mika、Matsuki Kota、Miida Takashi、Harada-Shiba Mariko
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 28 Issue: 9 Pages: 905-925
  • DOI: 10.5551/jat.RV17055
  • NAID: 130008036007
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2021-09-01
  • Peer Reviewed / Open Access
• [Journal Article] Current Diagnosis and Management of Primary Chylomicronemia (2021)
  • Author(s): Okazaki Hiroaki、Gotoda Takanari、Ogura Masatsune、Ishibashi Shun、Inagaki Kyoko、Daida Hiroyuki、Hayashi Toshio、Hori Mika、Masuda Daisaku、Matsuki Kota、Yokoyama Shinji、Harada-Shiba Mariko
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 28 Issue: 9 Pages: 883-904
  • DOI: 10.5551/jat.RV17054
  • NAID: 130008082103
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2021-09-01
  • Peer Reviewed / Open Access
• [Journal Article] Diagnosis and Management of Sitosterolemia 2021 (2021)
  • Author(s): Tada H, Nomura A, Ogura M, Ikewaki K, Ishigaki Y, Inagaki K, Tsukamoto K, Dobashi K, Nakamura K, Hori M, Matsuki K, Yamashita S, Yokoyama S, Kawashiri MA, Harada-Shiba M.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 28 Issue: 8 Pages: 791-801
  • DOI: 10.5551/jat.RV17052
  • NAID: 130008070338
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2021-08-01
  • Peer Reviewed / Open Access
• [Journal Article] Current Diagnosis and Management of Tangier Disease (2021)
  • Author(s): Koseki Masahiro、Yamashita Shizuya、Ogura Masatsune、Ishigaki Yasushi、Ono Koh、Tsukamoto Kazuhisa、Hori Mika、Matsuki Kota、Yokoyama Shinji、Harada-Shiba Mariko
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 28 Issue: 8 Pages: 802-810
  • DOI: 10.5551/jat.RV17053
  • NAID: 130008070332
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2021-08-01
  • Peer Reviewed / Open Access
• [Journal Article] Homozygous Familial Hypercholesterolemia (2021)
  • Author(s): Atsushi Nohara, Hayato Tada, Masatsune Ogura, Sachiko Okazaki, Koh Ono, Hitoshi Shimano, Hiroyuki Daida, Kazushige Dobashi, Toshio Hayashi, Mika Hori, Kota Matsuki, Tetsuo Minamino, Shinji Yokoyama, Mariko Harada-Shiba.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 28 Issue: 7 Pages: 665-678
  • DOI: 10.5551/jat.RV17050
  • NAID: 130008060156
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2021-07-01
  • Peer Reviewed / Open Access
• [Journal Article] Current Status of Familial LCAT Deficiency in Japan (2021)
  • Author(s): Kuroda Masayuki、Bujo Hideaki、Yokote Koutaro、Murano Takeyoshi、Yamaguchi Takashi、Ogura Masatsune、Ikewaki Katsunori、Koseki Masahiro、Takeuchi Yasuo、Nakatsuka Atsuko、Hori Mika、Matsuki Kota、Miida Takashi、Yokoyama Shinji、Wada Jun、Harada-Shiba Mariko.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 28 Issue: 7 Pages: 679-691
  • DOI: 10.5551/jat.RV17051
  • NAID: 130008060155
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2021-07-01
  • Peer Reviewed / Open Access
• [Journal Article] Achilles Tendon Softness as a New Tool for Diagnosing Familial Hypercholesterolemia (2021)
  • Author(s): Michikura Masahito、Ogura Masatsune、Hori Mika、Furuta Kenji、Hosoda Kiminori、Harada-Shiba Mariko
  • Journal Title: JACC: Cardiovascular Imaging Volume: - Issue: 7 Pages: 1483-1485
  • DOI: 10.1016/j.jcmg.2021.01.033
  • Peer Reviewed
• [Journal Article] Circulating Mature PCSK9 Level Predicts Diminished Response to Statin Therapy (2021)
  • Author(s): Kuyama Naoto、Kataoka Yu、Takegami Misa、Nishimura Kunihiro、Harada‐Shiba Mariko、Hori Mika、Ogura Masatsune、Otsuka Fumiyuki、Asaumi Yasuhide、Noguchi Teruo、Tsujita Kenichi、Yasuda Satoshi
  • Journal Title: Journal of the American Heart Association Volume: 10 Issue: 11
  • DOI: 10.1161/jaha.120.019525
  • Peer Reviewed
• [Journal Article] Switching from lipoprotein apheresis to evolocumab in FH siblings on hemodialysis: case reports and discussion (2021)
  • Author(s): Ishii Takeo、Ogura Masatsune、Nakamori Haruka、Hori Mika、Harada-Shiba Mariko、Tamura Kouichi、Oyama Kunio
  • Journal Title: CEN Case Reports Volume: 10 Issue: 4 Pages: 592-597
  • DOI: 10.1007/s13730-021-00605-x
  • Peer Reviewed
• [Journal Article] Increase of serum uric acid levels associated with APOE ε2 haplotype: a clinico-genetic investigation and in vivo approach (2021)
  • Author(s): Ogura Masatsune、Toyoda Yu、Sakiyama Masayuki、Kawamura Yusuke、Nakayama Akiyoshi、et al.
  • Journal Title: Human Cell Volume: 34 Issue: 6 Pages: 1727-1733
  • DOI: 10.1007/s13577-021-00609-w
  • Peer Reviewed / Open Access
• [Journal Article] Current concept and residual issues of lipoprotein(a) determination for a cardiovascular risk factor (2021)
  • Author(s): Yoshida Hiroshi、Hirowatari Yuji、Ogura Masatsune、Harada‐Shiba Mariko
  • Journal Title: European Journal of Clinical Investigation Volume: 52 Issue: 1
  • DOI: 10.1111/eci.13700
  • Peer Reviewed
• [Presentation] 内分泌代謝疾患のトランジション 若年発症脂質異常症のトランジション (2023)
  • Author(s): 小倉 正恒, 多田 隼人, 斯波 真理子
  • Organizer: 日本内分泌学会
  • Invited
• [Presentation] 家族性高コレステロール血症ヘテロ接合体におけるAPOB遺伝子の低頻度p.(Pro955Ser)バリアントの寄与 (2023)
  • Author(s): 堀 美香, 高橋 篤, 槇野 久士, 小倉 正恒, 斯波 真理子
  • Organizer: 日本動脈硬化学会
• [Presentation] FH診療ガイドライン(2022年版)の行間を読む (2023)
  • Author(s): 小倉 正恒
  • Organizer: 日本動脈硬化学会
  • Invited
• [Presentation] Interactive Session 症例から考える家族性高コレステロール血症ホモ接合体の診断と治療 (2023)
  • Author(s): 小倉 正恒
  • Organizer: 日本動脈硬化学会
  • Invited
• [Presentation] ライフステージと動脈硬化～シームレスな治療のために～ 原発性脂質異常症の移行期医療 小児慢性特定疾病制度と成人難病制度の現況と問題点、また取り組みについて (2023)
  • Author(s): 小倉 正恒
  • Organizer: 日本動脈硬化学会
  • Invited
• [Presentation] 診療ガイドラインupdate 原発性脂質異常症 (2023)
  • Author(s): 小倉 正恒
  • Organizer: 日本動脈硬化学会
  • Invited
• [Presentation] 脂質異常症難病ケーススタディ FHの鑑別疾患としてのコレステリルエステル蓄積病(ライソゾーム酸性リパーゼ欠損症) (2023)
  • Author(s): 小倉 正恒
  • Organizer: 日本動脈硬化学会
  • Invited
• [Presentation] Polyvascular diseaseを合併する家族性高コレステロール血症ヘテロ接合体の臨床像とLipoprotein(a)の関与についての解明研究 (2023)
  • Author(s): 舟橋 紗耶華, 片岡 有, 堀 美香, 小倉 正恒, 土井 貴仁, 野口 暉夫, 斯波 真理子
  • Organizer: 日本動脈硬化学会
• [Presentation] Cholesterol efflux capacity its clinical significance and unresolved issues (2023)
  • Author(s): Masatsune Ogura
  • Organizer: International Congress on Lipids and Atherosclerosis 2023
  • Int'l Joint Research / Invited
• [Presentation] Factors associated with coronary artery disease risk in familial hypercholesterolemia (2023)
  • Author(s): Masatsune Ogura
  • Organizer: International Congress on Lipids and Atherosclerosis 2023
  • Int'l Joint Research / Invited
• [Presentation] コレステロール引き抜き能の未解決課題とその克服 (2023)
  • Author(s): 小倉 正恒
  • Organizer: 日本臨床化学会
  • Invited
• [Presentation] Quantitative and Qualitative Assessment of Achilles Tendon Thickening and its Clinical Significance (2023)
  • Author(s): Masatsune Ogura
  • Organizer: KSoLA-JAS FH Joint Symposium
  • Invited
• [Presentation] 症状（と検査値）から診る原発性脂質異常症難病 (2023)
  • Author(s): 小倉正恒
  • Organizer: 日本動脈硬化学会セミナー
  • Invited
• [Presentation] 脂質異常症を合併するライソゾーム病に対する酵素補充療法 (2023)
  • Author(s): 小倉正恒
  • Organizer: 日本臨床化学会
  • Invited
• [Presentation] 残余リスクとしてのLp(a)高値を考える (2023)
  • Author(s): 小倉正恒
  • Organizer: 日本臨床化学会
  • Invited
• [Presentation] 動脈硬化性疾患予防ガイドライン（2022年版）改訂のポイント (2023)
  • Author(s): 小倉正恒
  • Organizer: 日本動脈硬化学会ガイドライン啓発講演会
  • Invited
• [Presentation] Low-density lipoprotein-triglycerides in familial hypercholesterolemia: its metabolism and clinical significance (2023)
  • Author(s): Ogura M, Harada-Shiba M
  • Organizer: 第87回日本循環器学会総会・学術集会
• [Presentation] Studies of rare disorders of lipid metabolism in Japan (2022)
  • Author(s): Ogura M
  • Organizer: 2022 JAS-KSoLA Joint Symposium on FH and Severe Dyslipidemia
  • Int'l Joint Research / Invited
• [Presentation] HDL Function and Lifestyle Modification (2022)
  • Author(s): Ogura M
  • Organizer: 22nd IUNS-ICN INTERNATIONAL CONGRESS OF NUTRITION IN TOKYO
  • Int'l Joint Research / Invited
• [Presentation] Clinical significance of low-density lipoprotein-triglycerides in patients with familial hypercholesterolemia (2022)
  • Author(s): Ogura M, Ito Y, Harada-Shiba M
  • Organizer: European Atherosclerosis Society Congress 2022
  • Int'l Joint Research
• [Presentation] 冠動脈疾患を有するFH ヘテロ接合体の妊娠、出産時の管理について (2022)
  • Author(s): 小倉正恒
  • Organizer: 第54回日本動脈硬化学会総会・学術集会 シンポジウム4
  • Invited
• [Presentation] 脂質異常症治療薬2022 and beyond (2022)
  • Author(s): 小倉正恒
  • Organizer: 第54回日本動脈硬化学会総会・学術集会 シンポジウム13
  • Invited
• [Presentation] 家族性高コレステロール血症ヘテロ接合体におけるLDLR、PCSK9 両遺伝子変異保有の 予後への影響に関する検討 (2022)
  • Author(s): 土井貴仁，堀美香，斯波真理子，片岡有，小野塚大介，西村邦宏，西川諒，津田 浩佑，小倉正恒，孫徹，宮本恵宏，野口暉夫，下川宏明，安田 聡.
  • Organizer: 第54回日本動脈硬化学会総会・学術集会，若手研究者奨励賞受賞講演
• [Presentation] HDL機能測定の臨床的意義とその課題克服 (2022)
  • Author(s): 小倉正恒
  • Organizer: 第62回日本臨床化学会年次学術集会 2022年度学会賞（学術賞）受賞記念講演
  • Invited
• [Presentation] FAME研究およびアキレス腱肥厚計測について (2022)
  • Author(s): 小倉正恒
  • Organizer: FH Awareness Day セミナー（日本動脈硬化学会 脂質代謝部会・厚生労働省 原発性脂質異常症に関する調査研究班共催）
  • Invited
• [Presentation] 2型糖尿病患者におけるHDLのcholesterol efflux capacityと動脈硬化の関連 (2022)
  • Author(s): 槇野久士、小倉正恒、肥塚諒、松原正樹、大畑洋子、玉那覇民子、野口倫生、斯波真理子、細田公則
  • Organizer: 第54回日本動脈硬化学会総会・学術集会
• [Presentation] 超音波検査にてアキレス腱に肥厚を認めたライソゾーム病（コレステロールエステル蓄積 症）の１症例 (2022)
  • Author(s): 道倉雅仁，斯波真理子，小倉正恒，山岡誠，南学，細田公則
  • Organizer: 第54回日本動脈硬化学会総会・学術集会
• [Presentation] 家族性高コレステロール血症におけるpolyvascular diseaseの臨床像と治療介入の可能性 (2022)
  • Author(s): 舟橋紗耶華，片岡有，堀美香，小倉正恒，野口暉夫，斯波真理子
  • Organizer: 第54回日本動脈硬化学会総会・学術集会
• [Presentation] FH診療アップデート (2022)
  • Author(s): 小倉正恒
  • Organizer: 日本動脈硬化学会 第22回動脈硬化教育フォーラム
  • Invited
• [Presentation] Lipid management for cardiovascular protection in 2022 and beyond（心血管イベント予防のための脂質管理2022） (2022)
  • Author(s): 小倉正恒
  • Organizer: 第86回日本循環器学会学術集会 モーニングセミナー5
  • Invited
• [Presentation] APOE ε2ハプロタイプは血清尿酸値を増加させる (2022)
  • Author(s): 小倉正恒、豊田優、河村優輔、中山昌喜、高田龍平、清水聖子、東野俊英、中嶌真由子、四ノ宮成祥、松尾洋孝
  • Organizer: 第55回日本痛風・尿酸核酸学会総会
• [Presentation] Latest Data on siRNA against PCSK9 (2021)
  • Author(s): Masatsune Ogura
  • Organizer: International Congress on Lipids and Atherosclerosis 2021
  • Int'l Joint Research / Invited
• [Presentation] Awareness of Familial Hypercholesterolemia in Japan (2021)
  • Author(s): Masatsune Ogura
  • Organizer: The 19th International Symposium on Atherosclerosis (ISA 2021)
  • Int'l Joint Research / Invited
• [Presentation] Characterization of High-density Lipoprotein Mediated Cholesterol Efflux Capacity in Diabetic and Non-diabetic Patients with Coronary Artery Disease: Comparison between Acute Coronary Syndrome and Stable Coronary Artery Disease. (2021)
  • Author(s): Funabashi S, Kataoka Y, Ogura M, Kuyama N, Ohtsuka F, Asaumi Y, Noguchi T, Harada-Shiba M.
  • Organizer: ESC Congress 2021 The Digital Experience
  • Int'l Joint Research
• [Presentation] Factors Associated with Carotid Atherosclerosis and Achilles Tendon Thickness in Japanese Patients with Familial Hypercholesterolemia: A Subanalysis of the Familial Hypercholesterolemia Expert Forum (FAME) Study (2021)
  • Author(s): Ogura M, Harada-Shiba M, Masuda D, Arai H, Bujo H, Ishibashi S, Daida H, Koga N, Oikawa S, Yamashita S
  • Organizer: The 19th International Symposium on Atherosclerosis (ISA 2021)
  • Int'l Joint Research
• [Presentation] MN-001(Tipelkast) Reduces Triglycerides Levels in Hepatocytes by down-regulating fatty acid translocase/CD36 expression (2021)
  • Author(s): Ogura M, Matsuda K, Harada-Shiba M
  • Organizer: The 19th International Symposium on Atherosclerosis (ISA 2021)
  • Int'l Joint Research
• [Presentation] IAS-defined Severe FH as a Very High-risk Subject Requiring More Intensive Lipid-Lowering Management for Their Primary Prevention of Atherosclerotic Cardiovascular Disease (2021)
  • Author(s): Kataoka Y, Funabashi S, Hori M, Ogura M, Doi T, Nishikawa R, Tsuda K, Noguchi T, Harada-Shiba M
  • Organizer: The 19th International Symposium on Atherosclerosis (ISA 2021)
  • Int'l Joint Research
• [Presentation] Characteristics of HDL Subfraction Separated by Anion-Exchange Liquid Chromatography and Comparison between Chromatographic Patterns and Cholesterol Efflux Capacity with Familial Hypercholesterolemia (2021)
  • Author(s): Hirowatari Y, Ogura M, Manita D, Horiuchi M, Harada-Shiba M
  • Organizer: The 19th International Symposium on Atherosclerosis (ISA 2021)
  • Int'l Joint Research
• [Presentation] Improvement of Intracellular Lipid Metabolism by Tipelukast in the Pathogenesis of NASH/NAFLD (2021)
  • Author(s): Ogura M, Matsuda K
  • Organizer: AASLD The Liver Meeting
  • Int'l Joint Research
• [Presentation] 高LDL-C血症患者に潜むコレステリルエステル蓄積病を見つける！治す！ (2021)
  • Author(s): 小倉正恒
  • Organizer: 第124回日本小児科学会学術集会 教育セミナー21
  • Invited
• [Presentation] なんちゃって研究医のすすめ (2021)
  • Author(s): 小倉正恒
  • Organizer: 第69回日本心臓病学会学術集会 総務/将来構想委員会セッション５ 循環器医のキャリアパス～仕事の流儀と人生の道標～
  • Invited
• [Presentation] 職場で高LDL-C血症の相談を受けたら～効率よくFHを見逃さないためのポイント～ (2021)
  • Author(s): 小倉正恒
  • Organizer: 第53回日本動脈硬化学会総会・学術集会 合同シンポジウム6
  • Invited
• [Presentation] 高トリグリセライド血症の成因 (2021)
  • Author(s): 小倉正恒
  • Organizer: 第53回日本動脈硬化学会総会・学術集会
  • Invited
• [Presentation] 家族性高コレステロール血症患者スクリーニングに用いるアキレス腱超音波検査の実際 (2021)
  • Author(s): 道倉雅仁、細田公則、山岡誠、小倉正恒、斯波真理子
  • Organizer: 第53回日本動脈硬化学会総会・学術集会 学会企画１
  • Invited
• [Presentation] 高LDLコレステロール血症に潜むライソゾーム酸性リパーゼ欠損症 (2021)
  • Author(s): 小倉正恒
  • Organizer: 第35回日本小児脂質研究会
  • Invited
• [Presentation] アクティブターゲティング能を付与した治療用ナノ粒子の作製と生物活性評価 (2021)
  • Author(s): 河上亮、福田亮介、河西文武、小倉正恒、村上達也
  • Organizer: 第37回日本DDS学会学術集会
• [Presentation] 急性冠症候群糖尿病症例におけるHDL粒子のコレステロール引き抜き能の検証：安定冠動脈疾患との比較 (2021)
  • Author(s): 舟橋紗耶華、片岡有、小倉正恒、九山直人、大塚文之、浅海泰栄、野口輝夫、斯波真理子
  • Organizer: 第53回日本動脈硬化学会総会・学術集会
• [Presentation] 家族性高コレステロール血症患者におけるlipoprotein (a) とアキレス腱厚との関連性 (2021)
  • Author(s): 山岡誠、道倉雅仁、小倉正恒、細田公則、斯波真理子
  • Organizer: 第53回日本動脈硬化学会総会・学術集会
• [Presentation] 家族性高コレステロール血症における頚動脈硬化とアキレス腱の厚さに関連する因子：Familial Hypercholesterolemia Expert Forum (FAME) 研究サブ解析 (2021)
  • Author(s): 小倉正恒、斯波真理子、増田大作、荒井秀典、武城英明、石橋俊、代田浩之、古賀伸彦、及川眞一、山下静也
  • Organizer: 第53回日本動脈硬化学会総会・学術集会
• [Book] 臨床工学技士標準テキスト 第4版 (2022)
  • Author(s): 小野 哲章、堀川 宗之、峰島 三千男、吉野 秀朗
  • Total Pages: 874
  • Publisher: 金原出版
  • ISBN: 9784307771849
• [Book] Q&Aでわかる！糖尿病×循環器疾患の治療 (2021)
  • Author(s): 伊藤 浩
  • Total Pages: 224
  • Publisher: 南江堂
  • ISBN: 9784524229581