Research Project
Grant-in-Aid for Scientific Research (C)
COPDの肺では、喫煙刺激により細胞老化がおきている。また、ウイルスや細菌感染により急性増悪の病態を示す。COPD急性増悪では、制御されたネクローシス(細胞膜の破壊により内容が外に漏出し強い炎症をおこす)がおきていることが考えられる。これらの細胞の運命(細胞老化、制御されたネクローシス)の機序をヒト検体やマウスモデルを用いて解明し、COPDの発症と憎悪に対するリスク診断・治療戦略の確立を目指す。
We focused on thrombospondin-1 (TS-1) as a key molecule in smoking-induced inflammatory signals in COPD and revealed that TS-1 expression was increased in the airway epithelium of COPD. We also investigated the effects of IL-1beta, IL-8, and IL-13 on smoking-induced cellular senescence, and confirmed that IL-1beta promoted cellular senescence, but the effects of IL-8 and IL-13 were unclear. During the study period, the COVID-19 pandemic caused great difficulties in sample collection, so we investigated the state of suppression of lung cancer screening in Akita Prefecture during the pandemic. It was suggested that participation in lung cancer screening decreased, especially among the elderly, and that this may have led to a decrease in lung cancer diagnoses, resulting in a decrease in the number of early lung cancer registrations.
COPD病態成立におけるTS-1の重要性が明らかになりつつあり、TS-1によるIL-8の誘導性や肺機能との関連も検討中である。新型コロナ禍における、肺がん検診の受診状態の検討では、高齢者が感染に対するSocial Stigmaにより集団肺がん検診を避け、早期肺がん診断の妨げになった事が示唆された。感染症罹患に対するSocial Stigmaの解消と肺がん検診の重要性の啓蒙が大切であると考えられた。
All 2023 2022 2021
All Journal Article (20 results) (of which Peer Reviewed: 10 results, Open Access: 5 results) Presentation (14 results) (of which Int'l Joint Research: 1 results, Invited: 4 results) Book (3 results)
Geriatr Gerontol Int
Volume: 8 Issue: 8 Pages: 622-627
10.1111/ggi.14637
Interdisciplinary CardioVascular and Thoracic Surgery
Volume: - Issue: 5
10.1093/icvts/ivad035
Cancer Chemother Pharmacol
Volume: 92 Issue: 4 Pages: 315-324
10.1007/s00280-023-04569-w
Current Problems in Cancer: Case Reports
Volume: 10 Pages: 100245-100245
Medical Practice
Volume: 40 Pages: 439-446
秋田県医師会雑誌
Volume: 73 Pages: 21-30
Volume: -
呼吸器内科
Volume: 40（3） Pages: 439-446
Volume: 73（1） Pages: 21-30
Japan Journal of Nursing Science
Volume: 20 Issue: 2
10.1111/jjns.12519
Investigational New Drugs
Volume: 40 Issue: 6 Pages: 1254-1262
10.1007/s10637-022-01304-9
日本臨牀
Volume: 80（6）増刊号 Pages: 97-103
Volume: 80（6）増刊号 Pages: 108-119
JOHNS
Volume: 38（5） Pages: 519-522
Asia Pac Allergy
Volume: 11 Issue: 3 Pages: e24-e24
10.5415/apallergy.2021.11.e24
The Journal of Immunology
Volume: 207 Issue: 1 Pages: 65-76
10.4049/jimmunol.2001364
Biology
Volume: 10 Issue: 10 Pages: 1054-1054
10.3390/biology10101054
120007172095
日本医師会雑誌
Volume: 149 Pages: 2130-2134
Aging＆Health
Volume: 30 Pages: 18-22
