Elucidation of the pathogenesis of pulmonary fibrosis and development of novel treatment based on cold-inducible RNA-binding protein

• Project/Area Number: 21K08176
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: 穗積 宏尚 浜松医科大学, 医学部, 助教 (40771457)
• Co-Investigator(Kenkyū-buntansha): 須田 隆文 浜松医科大学, 医学部, 教授 (30291397)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2023: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 肺線維症 / 低温誘導性RNA結合タンパク / ブレオマイシン / CIRBP / 線維芽細胞 / 特発性肺線維症

Outline of Research at the Start

肺線維症形成におけるCIRBPの役割を明らかにし，治療標的としての有用性を検討するため，次の研究を行う．
1.BLMモデルにおいて，野生型マウスとCIRBP欠損マウスの肺線維化の程度を比較する．
2.野生型マウスから単離した肺線維芽細胞とCIRBP欠損マウスから単離した肺線維芽細胞の増殖能や筋線維芽細胞への分化能，コラーゲン産生能を比較する．
3.肺線維芽細胞に対するCIRBP遺伝子ノックダウンの効果（増殖能，分化能，コラーゲン産生能）を評価する．
4.野生型マウスのBLM肺線維症モデルにおける，抗CIRBP中和抗体の治療効果を検討する．

Outline of Annual Research Achievements

特発性肺線維症（IPF）は、極めて予後不良な原因不明の間質性肺疾患である。我々はIPF患者の臨床検体からプロテオーム解析技術を駆使して低温誘導性RNA結合タンパク（CIRBP）を同定し、この分子がIPF患者の血液や肺組織で高発現し、呼吸機能の悪化や予後不良と有意に関連することを発見した。
本研究では，ブレオマイシン（BLM）肺線維症モデルマウスを用いて，CIRBPの肺線維症形成における役割を検討した．野生型マウスと比較して，CIRBPノックアウトマウスではBLMによる肺線維症が軽減した．野生型マウスに対するCIRBP阻害剤投与は，プラセボ投与と比較して，肺線維症を軽減させた．CIRBP阻害剤は肺線維症に対する有望な治療薬候補になりうることがわかった．今後，CIRBPの線維芽細胞におけるメカニズム解析をさらに進めていく予定である．

Research Products

• [Journal Article] Impact of preexisting interstitial lung disease on mortality in COVID-19 patients from the early pandemic to the delta variant epidemic: a nationwide population-based study (2024)
  • Author(s): Miyashita Koichi、Hozumi Hironao、Furuhashi Kazuki、Nakatani Eiji、Inoue Yusuke、Yasui Hideki、Suzuki Yuzo、Karayama Masato、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Ojima Toshiyuki、Suda Takafumi
  • Journal Title: Respiratory Research Volume: 25 Issue: 1 Pages: 95-95
  • DOI: 10.1186/s12931-024-02723-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CLEC10A expression defines functionally distinct subsets of conventional type 2 dendritic cells (cDC2) in the mouse lung (2024)
  • Author(s): Nihashi F, Furuhashi K, Horiguchi R, Kitahara Y, Inoue Y, Yasui H, Karayama M, Suzuki Y, Hozumi H, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Suda T.
  • Journal Title: Allergology International Volume: 73 Issue: 3 Pages: 481-484
  • DOI: 10.1016/j.alit.2024.01.011
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] CD109 Attenuates Bleomycin-induced Pulmonary Fibrosis by Inhibiting TGF-β Signaling (2024)
  • Author(s): Naoi Hyogo、Suzuki Yuzo、Miyagi Asuka、Horiguchi Ryo、Aono Yuya、Inoue Yusuke、Yasui Hideki、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Mii Shinji、Ichihara Masatoshi、Takahashi Masahide、Suda Takafumi
  • Journal Title: The Journal of Immunology Volume: 212 Issue: 7 Pages: 1221-1231
  • DOI: 10.4049/jimmunol.2300285
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Neutrophil-lymphocyte ratio being associated with mortality risk in patients receiving antifibrotic therapy (2024)
  • Author(s): Takuma Sho、Suzuki Yuzo、Kono Masato、Hasegawa Hirotsugu、Hashimoto Dai、Yokomura Koshi、Mori Kazutaka、Shimizu Mikihiro、Inoue Yusuke、Yasui Hideki、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Suda Takafumi
  • Journal Title: Respiratory Medicine Volume: 223 Pages: 107542-107542
  • DOI: 10.1016/j.rmed.2024.107542
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pan-cancer assessment of antineoplastic therapy-induced interstitial lung disease in patients receiving subsequent therapy immediately following immune checkpoint blockade therapy (2024)
  • Author(s): Kitahara Yoshihiro、Inoue Yusuke、Yasui Hideki、Karayama Masato、Suzuki Yuzo、Hozumi Hironao、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Funai Kazuhito、Honda Tetsuya、Misawa Kiyoshi、Miyake Hideaki、Takeuchi Hiroya、Inui Naoki、Suda Takafumi
  • Journal Title: Respiratory Research Volume: 25 Issue: 1
  • DOI: 10.1186/s12931-024-02683-8
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Role of Interferon-λ3 in Anti-Melanoma Differentiation-Associated Gene 5-Positive Dermatomyositis-Associated Interstitial Lung Disease (2024)
  • Author(s): Fukada Atsuki、Fujisawa Tomoyuki、Hozumi Hironao、et al
  • Journal Title: Arthritis & Rheumatology Volume: - Issue: 5 Pages: 796-805
  • DOI: 10.1002/art.42785
  • Peer Reviewed
• [Journal Article] Neutrophil?lymphocyte ratio in patients with idiopathic pleuroparenchymal fibroelastosis (2023)
  • Author(s): Suzuki Yuzo、Kono Masato、Hasegawa Hirotsugu、Hashimoto Dai、Yokomura Koshi、Imokawa Shiro、Inoue Yusuke、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Suda Takafumi
  • Journal Title: BMJ Open Respiratory Research Volume: 10 Issue: 1 Pages: e001763-e001763
  • DOI: 10.1136/bmjresp-2023-001763
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association of the lung immune prognostic index with the survival of patients with idiopathic interstitial pneumonias (2023)
  • Author(s): Suzuki Takahito、Karayama Masato、Aoshima Yoichiro、Mori Kazutaka、Yoshizawa Nobuko、Ichikawa Shintaro、Kato Shinpei、Yokomura Koshi、Kono Masato、Hashimoto Dai、Inoue Yusuke、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Fujisawa Tomoyuki、Enomoto Noriyuki、Goshima Satoshi、Inui Naoki、Suda Takafumi
  • Journal Title: Respirology Volume: 29 Issue: 2 Pages: 136-145
  • DOI: 10.1111/resp.14621
  • Peer Reviewed
• [Journal Article] Standardized 3D-CT lung volumes for patients with acute exacerbation of rheumatoid arthritis-associated interstitial lung disease (2023)
  • Author(s): Tanaka Yuko、Suzuki Yuzo、Saku Aiko、Kono Masato、Hashimoto Dai、Hasegawa Hirotsugu、Yokomura Koshi、Inoue Yusuke、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Suda Takafumi
  • Journal Title: Rheumatology Volume: 63 Issue: 4 Pages: 1162-1171
  • DOI: 10.1093/rheumatology/kead363
  • Peer Reviewed
• [Journal Article] Assessment of malnutrition-related risk in patients with idiopathic pleuroparenchymal fibroelastosis (2023)
  • Author(s): Suzuki Yuzo、Fukada Atsuki、Mori Kazutaka、Kono Masato、Hasegawa Hirotsugu、Hashimoto Dai、Yokomura Koshi、Imokawa Shiro、Inoue Yusuke、Yasui Hideki、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Nakamura Hidenori、Suda Takafumi
  • Journal Title: ERJ Open Research Volume: 9 Issue: 3 Pages: 00749-2022
  • DOI: 10.1183/23120541.00749-2022
  • Peer Reviewed / Open Access
• [Journal Article] Geriatric Nutritional Risk Index is a predictor of tolerability of antifibrotic therapy and mortality risk in patients with idiopathic pulmonary fibrosis (2023)
  • Author(s): Mochizuka Yasutaka、Suzuki Yuzo、Kono Masato、Hasegawa Hirotsugu、Hashimoto Dai、Yokomura Koshi、Inoue Yusuke、Yasui Hideki、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Nakamura Hidenori、Suda Takafumi
  • Journal Title: Respirology Volume: 28 Issue: 8 Pages: 775-783
  • DOI: 10.1111/resp.14523
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cytokine profiling identifies circulating IL-6 and IL-15 as prognostic stratifiers in patients with non-small cell lung cancer receiving anti-PD-1/PD-L1 blockade therapy (2023)
  • Author(s): Inoue Yusuke、Inui Naoki、Karayama Masato、Asada Kazuhiro、Fujii Masato、Matsuura Shun、Uto Tomohiro、Hashimoto Dai、Matsui Takashi、Ikeda Masaki、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Suda Takafumi
  • Journal Title: Cancer Immunology, Immunotherapy Volume: 72 Issue: 8 Pages: 2717-2728
  • DOI: 10.1007/s00262-023-03453-z
  • Peer Reviewed
• [Journal Article] Nationwide survey of adult patients with pulmonary alveolar proteinosis using the National Database of designated intractable diseases of Japan (2023)
  • Author(s): Miyashita Koichi、Hozumi Hironao、Inoue Yoshikazu、Suzuki Takuji、Suda Takafumi
  • Journal Title: Respiratory Investigation Volume: 61 Issue: 3 Pages: 364-370
  • DOI: 10.1016/j.resinv.2023.02.011
  • Peer Reviewed / Open Access
• [Journal Article] Enhanced immune complex formation in the lungs of patients with dermatomyositis (2023)
  • Author(s): Zaizen Yoshiaki、Okamoto Masaki、Azuma Koichi、Fukuoka Junya、Hozumi Hironao、Sakamoto Noriho、Suda Takafumi、Mukae Hiroshi、Hoshino Tomoaki
  • Journal Title: Respiratory Research Volume: 24 Issue: 1
  • DOI: 10.1186/s12931-023-02362-0
  • Peer Reviewed / Open Access
• [Journal Article] A predictive model for acute exacerbation of idiopathic interstitial pneumonias (2023)
  • Author(s): Karayama Masato、Aoshima Yoichiro、Suzuki Takahito、Mori Kazutaka、Yoshizawa Nobuko、Ichikawa Shintaro、Kato Shinpei、Yokomura Koshi、Kono Masato、Hashimoto Dai、Inoue Yusuke、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Fujisawa Tomoyuki、Enomoto Noriyuki、Goshima Satoshi、Inui Naoki、Suda Takafumi
  • Journal Title: European Respiratory Journal Volume: 61 Issue: 5 Pages: 2201634-2201634
  • DOI: 10.1183/13993003.01634-2022
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] CD109 on Dendritic Cells Regulates Airway Hyperreactivity and Eosinophilic Airway Inflammation (2023)
  • Author(s): Aono Yuya、Suzuki Yuzo、Horiguchi Ryo、Inoue Yusuke、Karayama Masato、Hozumi Hironao、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Mii Shinji、Takahashi Masahide、Suda Takafumi
  • Journal Title: American Journal of Respiratory Cell and Molecular Biology Volume: 68 Issue: 2 Pages: 201-212
  • DOI: 10.1165/rcmb.2022-0109oc
  • Peer Reviewed
• [Journal Article] Changes in the characteristics and outcomes of COVID-19 patients from the early pandemic to the delta variant epidemic: a nationwide population-based study (2022)
  • Author(s): Miyashita Koichi、Hozumi Hironao、Furuhashi Kazuki、Nakatani Eiji、Inoue Yusuke、Yasui Hideki、Karayama Masato、Suzuki Yuzo、Fujisawa Tomoyuki、Enomoto Noriyuki、Inui Naoki、Ojima Toshiyuki、Suda Takafumi
  • Journal Title: Emerging Microbes & Infections Volume: 12 Issue: 1
  • DOI: 10.1080/22221751.2022.2155250
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic significance of radiological pleuroparenchymal fibroelastosis in<i>Mycobacterium avium</i>complex lung disease: a multicentre retrospective cohort study (2022)
  • Author(s): Aono Yuya、Hozumi Hironao、Kono Masato、Hashimoto Dai、Nakamura Hidenori、Yokomura Koshi、Imokawa Shiro、Shirai Masahiro、Akahori Daisuke、Inoue Yusuke、Mori Kazutaka、Karayama Masato、Suzuki Yuzo、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: Thorax Volume: － Issue: 8 Pages: 825-834
  • DOI: 10.1136/thorax-2022-219116
  • Peer Reviewed
• [Journal Article] Frequency, proportion of PF-ILD, and prognostic factors in patients with acute exacerbation of ILD related to systemic autoimmune diseases (2022)
  • Author(s): Enomoto Noriyuki、Naoi Hyogo、Mochizuka Yasutaka、Isayama Takuya、Tanaka Yuko、Fukada Atsuki、Aono Yuya、Katsumata Mineo、Yasui Hideki、Mori Kazutaka、Karayama Masato、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Fujisawa Tomoyuki、Inui Naoki、Nakamura Yutaro、Suda Takafumi
  • Journal Title: BMC Pulmonary Medicine Volume: 22 Issue: 1
  • DOI: 10.1186/s12890-022-02197-3
  • Peer Reviewed / Open Access
• [Journal Article] Clinical practice of high-flow nasal cannula therapy in COVID-19 pandemic era: a cross-sectional survey of respiratory physicians (2022)
  • Author(s): Koyauchi Takafumi、Suzuki Yuzo、Inoue Yusuke、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Fujisawa Tomoyuki、Enomoto Noriyuki、Inui Naoki、Suda Takafumi
  • Journal Title: Respiratory Investigation Volume: 60 Issue: 6 Pages: 779-786
  • DOI: 10.1016/j.resinv.2022.08.007
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Hypoxia on Pulmonary Endothelial Cells from Bleomycin-Induced Pulmonary Fibrosis Model Mice (2022)
  • Author(s): Akahori Daisuke、Inui Naoki、Inoue Yusuke、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Suda Takafumi
  • Journal Title: International Journal of Molecular Sciences Volume: 23 Issue: 16 Pages: 8996-8996
  • DOI: 10.3390/ijms23168996
  • Peer Reviewed / Open Access
• [Journal Article] Associations of serum long-chain fatty acids with multiple organ involvement in patients with sarcoidosis (2022)
  • Author(s): Suzuki Takahito、Karayama Masato、Inoue Yusuke、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Fujisawa Tomoyuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: BMC Pulmonary Medicine Volume: 22 Issue: 1
  • DOI: 10.1186/s12890-022-02084-x
  • Peer Reviewed / Open Access
• [Journal Article] Serum immune modulators associated with immune-related toxicities and efficacy of atezolizumab in patients with non-small cell lung cancer (2022)
  • Author(s): Inoue Yusuke、Inui Naoki、Karayama Masato、Asada Kazuhiro、Matsuura Shun、Ikeda Masaki、Uto Tomohiro、Fujii Masato、Hashimoto Dai、Matsui Takashi、Matsuda Hiroyuki、Inami Nao、Toyoshima Mikio、Kaida Yusuke、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Suda Takafumi
  • Journal Title: Journal of Cancer Research and Clinical Oncology Volume: － Issue: 7 Pages: 2963-2974
  • DOI: 10.1007/s00432-022-04193-w
  • Peer Reviewed
• [Journal Article] Idiopathic pleuroparenchymal fibroelastosis: three-dimensional computed tomography assessment of upper-lobe lung volume (2022)
  • Author(s): Fukada Atsuki、Suzuki Yuzo、Mori Kazutaka、Kono Masato、Hasegawa Hirotsugu、Hashimoto Dai、Yokomura Koshi、Imokawa Shiro、Tanaka Yuko、Inoue Yusuke、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Fujino Yoshihisa、Nakamura Hidenori、Suda Takafumi
  • Journal Title: European Respiratory Journal Volume: 60 Issue: 6 Pages: 2200637-2200637
  • DOI: 10.1183/13993003.00637-2022
  • Peer Reviewed / Open Access
• [Journal Article] Standardised 3D-CT lung volumes for patients with idiopathic pulmonary fibrosis (2022)
  • Author(s): Tanaka Yuko、Suzuki Yuzo、Hasegawa Hirotsugu、Yokomura Koshi、Fukada Atsuki、Inoue Yusuke、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: Respiratory Research Volume: 23 Issue: 1
  • DOI: 10.1186/s12931-022-02062-1
  • Peer Reviewed / Open Access
• [Journal Article] Effects of long-acting muscarinic antagonists on promoting ciliary function in airway epithelium (2022)
  • Author(s): Katsumata Mineo、Fujisawa Tomoyuki、Kamiya Yosuke、Tanaka Yuko、Kamiya Chiaki、Inoue Yusuke、Hozumi Hironao、Karayama Masato、Suzuki Yuzo、Furuhashi Kazuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Maekawa Masato、Setou Mitsutoshi、Watanabe Hiroshi、Ikegami Koji、Suda Takafumi
  • Journal Title: BMC Pulmonary Medicine Volume: 22 Issue: 1 Pages: 186-186
  • DOI: 10.1186/s12890-022-01983-3
  • Peer Reviewed / Open Access
• [Journal Article] Impact of end-of-life respiratory modalities on quality of dying and death and symptom relief in patients with interstitial lung disease: a multicenter descriptive cross-sectional study (2022)
  • Author(s): Koyauchi Takafumi, Suzuki Yuzo, Sato Kazuki, Hozumi Hironao, Karayama Masato, Furuhashi Kazuki, Fujisawa Tomoyuki, Enomoto Noriyuki, Nakamura Yutaro, Inui Naoki, Yokomura Koshi, Imokawa Shiro, Nakamura Hidenori, Morita Tatsuya, Suda Takafumi
  • Journal Title: Respiratory Research Volume: in press Issue: 1 Pages: 79-79
  • DOI: 10.1186/s12931-022-02004-x
  • Peer Reviewed / Open Access
• [Journal Article] Impact of antifibrotic therapy on lung cancer development in idiopathic pulmonary fibrosis (2022)
  • Author(s): Naoi Hyogo、Suzuki Yuzo、Mori Kazutaka、Aono Yuya、Kono Masato、Hasegawa Hirotsugu、Yokomura Koshi、Inoue Yusuke、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Nakamura Hidenori、Suda Takafumi
  • Journal Title: Thorax Volume: in press Issue: 7 Pages: 1-1
  • DOI: 10.1136/thoraxjnl-2021-218281
  • Peer Reviewed / Open Access
• [Journal Article] Acute exacerbation of rheumatoid arthritis-associated interstitial lung disease: mortality and its prediction model (2022)
  • Author(s): Hozumi Hironao、Kono Masato、Hasegawa Hirotsugu、Kato Shinpei、Inoue Yusuke、Suzuki Yuzo、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Nakamura Yutaro、Yokomura Koshi、Nakamura Hidenori、Suda Takafumi
  • Journal Title: Respiratory Research Volume: 23 Issue: 1 Pages: 57-57
  • DOI: 10.1186/s12931-022-01978-y
  • Peer Reviewed / Open Access
• [Journal Article] Involvement of autophagy in exacerbation of eosinophilic airway inflammation in a murine model of obese asthma (2022)
  • Author(s): Suzuki Yuzo、Aono Yuya、Akiyama Norimichi、Horiike Yasuoki、Naoi Hyogo、Horiguchi Ryo、Shibata Kiyoshi、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: Autophagy Volume: － Issue: 9 Pages: 1-13
  • DOI: 10.1080/15548627.2022.2025571
  • Peer Reviewed / Open Access
• [Journal Article] Response to the editor (2021)
  • Author(s): Hozumi H, Kono M, Hasegawa H, Yasui H, Suzuki Y, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Nakamura Y, Yokomura K, Nakamura H, Suda T.
  • Journal Title: Chest Volume: 160 Issue: 6 Pages: e683-e685
  • DOI: 10.1016/j.chest.2021.07.044
  • Peer Reviewed
• [Journal Article] Radiological pleuroparenchymal fibroelastosis-like lesion in idiopathic interstitial pneumonias. (2021)
  • Author(s): Fujisawa T, Horiike Y, Egashira R, Sumikawa H, Iwasawa T, Matsushita S, Sugiura H, Kataoka K, Hashisako M, Yasui H, Hozumi H, Karayama M, Suzuki Y, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Suda T.
  • Journal Title: Respir Res. Volume: 22(1) Issue: 1 Pages: 290-290
  • DOI: 10.1186/s12931-021-01892-9
  • Peer Reviewed / Open Access
• [Journal Article] Combined assessment of the GAP index and body mass index at antifibrotic therapy initiation for prognosis of idiopathic pulmonary fibrosis (2021)
  • Author(s): Suzuki Yuzo、Mori Kazutaka、Aono Yuya、Kono Masato、Hasegawa Hirotsugu、Yokomura Koshi、Naoi Hyogo、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Nakamura Hidenori、Suda Takafumi
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 18579-18579
  • DOI: 10.1038/s41598-021-98161-y
  • Peer Reviewed / Open Access
• [Journal Article] Prospective nationwide multicentre cohort study of the clinical significance of autoimmune features in idiopathic interstitial pneumonias (2021)
  • Author(s): Enomoto Noriyuki、Homma Sakae、Inase Naohiko、Kondoh Yasuhiro、Saraya Takeshi et al.
  • Journal Title: Thorax Volume: 77 Issue: 2 Pages: 143-153
  • DOI: 10.1136/thoraxjnl-2020-216263
  • Peer Reviewed
• [Journal Article] Clinical Significance of Cold-Inducible RNA-Binding Protein in Idiopathic Pulmonary Fibrosis (2021)
  • Author(s): Hozumi Hironao、Kataoka Kensuke、Kondoh Yasuhiro、Isayama Takuya、Okada Jun、Sugiura Katsunori、Mori Kazutaka、Kono Masato、Suzuki Yuzo、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Nakamura Yutaro、Suda Takafumi
  • Journal Title: Chest Volume: 160 Issue: 6 Pages: 2149-2157
  • DOI: 10.1016/j.chest.2021.06.067
  • Peer Reviewed
• [Journal Article] Switching antifibrotics in patients with idiopathic pulmonary fibrosis: a multi-center retrospective cohort study (2021)
  • Author(s): Suzuki Yuzo、Mori Kazutaka、Aono Yuya、Kono Masato、Hasegawa Hirotsugu、Yokomura Koshi、Naoi Hyogo、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Nakamura Hidenori、Suda Takafumi
  • Journal Title: BMC Pulmonary Medicine Volume: 21 Issue: 1 Pages: 221-221
  • DOI: 10.1186/s12890-021-01587-3
  • Peer Reviewed / Open Access
• [Journal Article] Serum S100A8 and S100A9 as prognostic biomarkers in acute exacerbation of idiopathic pulmonary fibrosis. (2021)
  • Author(s): Tanaka K, Enomoto N, Hozumi H, Isayama T, Naoi H, Aono Y, Katsumata M, Yasui H, Karayama M, Suzuki Y, Furuhashi K, Fujisawa T, Inui N, Nakamura Y, Suda T.
  • Journal Title: Respir Investig. Volume: 59(6) Issue: 6 Pages: 827-836
  • DOI: 10.1016/j.resinv.2021.05.008
  • Peer Reviewed
• [Journal Article] Clinical Significance of Interstitial Lung Disease and Its Acute Exacerbation in Microscopic Polyangiitis (2021)
  • Author(s): Hozumi H, Kono M, Hasegawa H, Yasui H, Suzuki Y, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Nakamura Y, Yokomura K, Nakamura H, Suda T.
  • Journal Title: Chest . Volume: S0012-3692(21) Issue: 6 Pages: 00259-2
  • DOI: 10.1016/j.chest.2021.01.083
  • Peer Reviewed