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New strategy of prevention of transition from AKI to CKD

Research Project

Project/Area Number 21K08231
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53040:Nephrology-related
Research InstitutionKochi University

Principal Investigator

Terada Yoshio  高知大学, 教育研究部医療学系臨床医学部門, 教授 (30251531)

Co-Investigator(Kenkyū-buntansha) 谷口 義典  高知大学, 教育研究部医療学系臨床医学部門, 講師 (70584431)
堀野 太郎  高知大学, 教育研究部医療学系臨床医学部門, 准教授 (90448382)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords急性腎障害 / 尿細管 / 慢性腎臓病 / 線維化 / Zeb2 / 慢性腎不全 / 透析 / PNUTS / 腎臓 / IkBζ / 虚血 / 繊維化 / アポトーシス / ZEB2
Outline of Research at the Start

透析患者数は急増しており、その原疾患の一つである急性腎障害(AKI)の病態は繊維化により慢性腎臓病(CKD)に移行する事が報告されている。本申請課題では、AKIからCKDに移行するメカニズムの一つの繊維化に着目し、特にZeb2とPhosphatase関連遺伝子である(PNUTS)がAKI後の腎繊維化にどのように関与するかを基礎的・臨床的手法を総合的に駆使して解明するとともに、AKIからCKDに移行した患者の腎生検検体を用いてZeb2発現がCKD移行の新規のバイオマーカーになり得るかを検討する。腎繊維化の早期診断法の開発と、新規の治療法開発につなげる事を目標にする。

Outline of Final Research Achievements

Currently, the number of patients undergoing dialysis therapy exceeds 340,000 nationwide, and acute kidney injury (AKI), in particular, is becoming more frequent due to the aging of patients, and it occurs in about 10% of all hospitalized patients and is chronic. It has been reported that the disease progresses to kidney disease (CKD) at a high rate and deteriorates the kidneys and life prognosis, and countermeasures are urgently needed. In this application, we will focus on fibrosis, which is one of the mechanisms involved in the transition from AKI to CKD, and will conduct a basic research on how Zeb2 and the Phosphatase-related gene (PNUTS) are involved in renal fibrosis after AKI. We will elucidate this by comprehensively using clinical methods, and examine whether Zeb2 expression can be a new biomarker for CKD transition using renal biopsy specimens from patients who have transitioned from AKI to CKD.

Academic Significance and Societal Importance of the Research Achievements

透析患者数は34万人を超え、その原疾患の一つである急性腎障害(AKI)の患者数と透析導入が著増している。AKIは線維化により慢性腎臓病(CKD)に移行する事が報告されており、透析患者数の減少のためには、病態の解明が急務である。本申請課題では、AKIの病態とCKDに移行するメカニズムの一つの繊維化に着目し、特にZeb2とPhosphatase関連遺伝子である(PNUTS)がAKI後の腎繊維化にどのように関与するかを基礎的・臨床的手法を総合的に駆使して解明するとともに、AKIからCKDに移行した患者の腎生検検体を用いてZeb2発現がCKD移行の新規のバイオマーカーになり得るかを検討した。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (19 results)

All 2023 2022 2021

All Journal Article (9 results) (of which Peer Reviewed: 8 results,  Open Access: 2 results) Presentation (7 results) (of which Invited: 2 results) Book (3 results)

  • [Journal Article] Hypereosinophilic syndrome presenting as eosinophilic gastroenteritis exacerbated by clopidogrel bisulphate.2023

    • Author(s)
      Horino T, Ohnishi H, Komori M, Terada Y
    • Journal Title

      Rom J Intern Med

      Volume: 61 Issue: 4 Pages: 216-221

    • DOI

      10.2478/rjim-2023-0022

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Patellar tendon ectopic calcification in a patient with undiagnosed limited cutaneous systemic sclerosis.2023

    • Author(s)
      Horino T, Inotani S, Terada Y.
    • Journal Title

      Clin Exp Rheumatol

      Volume: 135 Pages: 24-25

    • DOI

      10.55563/clinexprheumatol/j2e1n7

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-episodic angioedema with eosinophilia in a patient who received frequent COVID-19 and influenza vaccinations.2023

    • Author(s)
      Horino T, Nakajima K, Terada Y.
    • Journal Title

      Intern Med J

      Volume: 53 Issue: 5 Pages: 871-872

    • DOI

      10.1111/imj.16095

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gemcitabine-induced renal thrombotic microangiopathy2022

    • Author(s)
      Horino T, Inotani S, Ishihara M, Terada Y
    • Journal Title

      Nephrology (Carlton).

      Volume: 27 Issue: 8 Pages: 724-725

    • DOI

      10.1111/nep.14043

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Jaccoud's arthropathy in the elderly2022

    • Author(s)
      Horino T, Ueba H, Inotani S, Izumi M, Ichii O, Terada Y
    • Journal Title

      Rheumatology

      Volume: 61 Issue: 7 Pages: e212-e212

    • DOI

      10.1093/rheumatology/keab770

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Haematologic malignancy-associated mucocutaneous paraneoplastic syndrome2022

    • Author(s)
      Horino T, Ohmi S, Inotani S, Nakajima H, Ohnishi H, Komori M, Ichii O, Terada Y.
    • Journal Title

      Rheumatology

      Volume: 61 Issue: 7 Pages: e207-e208

    • DOI

      10.1093/rheumatology/keab789

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Calcinosis and acro-osteolysis in systemic sclerosis2022

    • Author(s)
      Horino T, Inotani S, Nakajima H, Ohnishi H, Komori M, Terada Y.
    • Journal Title

      QJM

      Volume: 115 Issue: 2 Pages: 113-114

    • DOI

      10.1093/qjmed/hcab331

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Necrotizing granulomatous vasculitis without crescentic glomerulonephritis in granulomatosis with polyangiitis2022

    • Author(s)
      Horino T, Inotani S, Ichii O, Terada Y
    • Journal Title

      QJM

      Volume: 115 Issue: 2 Pages: 98-99

    • DOI

      10.1093/qjmed/hcab267

    • Related Report
      2021 Research-status Report
  • [Journal Article] Knockout of Zeb2 ameliorates progression of renal tubulointerstitial fibrosis in a mouse model of renal ischemia?reperfusion injury2021

    • Author(s)
      Inotani Satoshi、Taniguchi Yoshinori、Nakamura Keisyun、Nishikawa Hirofumi、Matsumoto Tatsuki、Horino Taro、Fujimoto Shimpei、Sano Shigetoshi、Yanagita Motoko、Terada Yoshio
    • Journal Title

      Nephrology Dialysis Transplantation

      Volume: 37 Issue: 3 Pages: 454-468

    • DOI

      10.1093/ndt/gfab311

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed
  • [Presentation] IkBz(NFKBIZ)はAKIの病態と腎繊維化に関与しCKDへの移行を進行させる2023

    • Author(s)
      市川(増本)陽菜、猪谷哲司、西川浩文, 松本竜季、谷口義典、堀野太郎、藤本新平、佐野栄紀、寺田典生
    • Organizer
      第66回日本腎臓学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ANCA関連血管炎患者の腎病理分類と臨床所見の相関の検討2023

    • Author(s)
      橿尾岳、猪谷哲司, 松本竜季、谷口義典、堀野太郎、藤本新平、寺田典生
    • Organizer
      第66回日本腎臓学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] CKD患者におけるAmphiregulin(AREG)の臨床的意義について2022

    • Author(s)
      刑部有紀、猪谷哲司、西川浩文、松本竜季、大出佳寿、島村芳子、谷口義典、堀野太郎、藤本新平、寺田典生
    • Organizer
      第65回日本腎臓学会学術総会
    • Related Report
      2022 Research-status Report
  • [Presentation] Zeb2は腎繊維化を促進しAKIからCKDへの移行を進行させる2022

    • Author(s)
      猪谷哲司、市川陽菜、西川浩文, 松本竜季、谷口義典、堀野太郎、藤本新平、佐野栄紀、柳田素子、寺田典生
    • Organizer
      第65回日本腎臓学会学術総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 癌罹患部位による急性腎障害および慢性腎臓病の発生率の違いに関する検討2022

    • Author(s)
      堀野太郎,畠山豊,安井繁宏,奥原義保,寺田典生
    • Organizer
      第65回日本腎臓学会学術総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 尿細管障害の診断と治療2021

    • Author(s)
      寺田典生
    • Organizer
      第118回日本内科学会学術総会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 急性腎障害の基礎と臨床2021

    • Author(s)
      寺田典生
    • Organizer
      第51回日本腎臓西部学術大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Book] 専門医のための腎臓病学2023

    • Author(s)
      堀野太郎 寺田典生
    • Total Pages
      250
    • Publisher
      医学書院
    • ISBN
      9784260051002
    • Related Report
      2023 Annual Research Report
  • [Book] 今日の治療指針2023

    • Author(s)
      寺田典生
    • Total Pages
      397
    • Publisher
      医学書院
    • ISBN
      9784260050340
    • Related Report
      2023 Annual Research Report 2022 Research-status Report
  • [Book] 腎臓の細胞死(necrosis, apoptosis)とautophagy、腎臓論文ベストセレクション2022

    • Author(s)
      寺田典生
    • Total Pages
      289
    • Publisher
      中外医学社
    • ISBN
      9784498148086
    • Related Report
      2021 Research-status Report

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Published: 2021-04-28   Modified: 2025-01-30  

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