• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The role of extracellular matrix in immune escape and progression in the skin cancer microenvironment

Research Project

Project/Area Number 21K08321
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53050:Dermatology-related
Research InstitutionUniversity of Fukui

Principal Investigator

Oyama Noritaka  福井大学, 学術研究院医学系部門, 准教授 (30332927)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords細胞外基質 / 皮膚癌微小環境 / 黒色腫 / 有棘細胞癌 / ECM1 / 腫瘍浸潤 / 腫瘍転移 / マウスモデル / 間葉転換 / 癌微小環境 / 皮膚がん
Outline of Research at the Start

本研究では、細胞外基質の1つであるECM1が皮膚癌の周辺微小環境を整え、癌の多彩な間葉転換と免疫回避能の制御に及ぼす役割を解析する.さらに細胞外基質の機能変化を発端とする新たな癌寛容機構の解明を目指す.ECM1欠損マウスの皮膚に種々の担癌状態を誘導し、癌の生着能と進展様式を評価する.癌微小環境の細胞外基質と免疫担当細胞の変化を網羅的に解析し、特定の細胞外基質に依存する癌の免疫応答と進展の機序を理解する.これらをヒト皮膚癌と比較し、ECM1が皮膚の老化発癌を制御する癌間質マスター分子である可能性を追求し、周辺間質分子の標的治療を視野にいれた臨床応用の基盤の構築を目指す.

Outline of Final Research Achievements

ECM1-deficient mice were transplanted with skin-derived cancer cell lines (spinous cell carcinoma and melanoma) to analyze the mechanisms of their local maintenance and progression. Conventional methods were used to generate ECM1 gene-deficient mice, but all of them died during the embryonic period. This result suggests that ECM1 is not only a disease susceptibility gene but also a developmentally important molecule. We next created an organ-specific ECM1-deficient state by a conditioned KO method, and further analyzed cultured dermal fibroblasts treated by the siRNA method targeting ECM1 gene alone.

The KO human model for ECM1 gene, mucocutaneous hyalinosis, is a genetic disease without fetal lethality or prognostic value for life. The present results indicate a differential, unidentified ECM1 function between human and mice.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果が癌間質分子を標的とする創薬に結び付いた際には、癌自体を標的とする既存の抗癌剤との併用も可能な作用機序である点からも、相乗効果や耐性の獲得を一層回避できる治療戦略を構築できる可能性が高く、学術的にも社会的にも貢献度の高い研究テーマであると考えている.

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (18 results)

All 2023 2022 2021

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 4 results) Presentation (9 results) (of which Int'l Joint Research: 8 results)

  • [Journal Article] Non-episodic angioedema with eosinophilia developing after influenza vaccination: A case report.2023

    • Author(s)
      Uesugi-Uchida S, Fujisaki M, Sekine S, Takenao C, Oyama N, Hasegawa M.
    • Journal Title

      J Dermatol

      Volume: 50 Issue: 3

    • DOI

      10.1111/1346-8138.16626

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lichen Sclerosus: A Current Landscape of Autoimmune and Genetic Interplay.2022

    • Author(s)
      Oyama N, Hasegawa M.
    • Journal Title

      Diagnostics

      Volume: 6 Issue: 12 Pages: 3070-3070

    • DOI

      10.3390/diagnostics12123070

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intertriginous erythema associated with enfortumab vedotin, a nectin-4-targeting antibody-drug conjugate, in a case with metastatic urothelial cancer: Immunohistochemical evidence for molecular-targeted eruption.2022

    • Author(s)
      Hasegawa T, Oyama N, Kasamatsu H, Chino T, Taga M, Hasegawa M.
    • Journal Title

      J Dermatol

      Volume: 49 Issue: 12

    • DOI

      10.1111/1346-8138.16567

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Retrospective evaluation of the utility of two-step surgery for facial basal cell carcinoma and squamous cell carcinoma.2022

    • Author(s)
      Iino S, Baba N, Hasegawa T, Kasamatsu H, Oyama N, Tokunaga T, Hasegawa M.
    • Journal Title

      Front Surg

      Volume: 9 Pages: 915731-915731

    • DOI

      10.3389/fsurg.2022.915731

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The compound LG283 inhibits bleomycin-induced skin fibrosis via antagonizing TGF-β signaling2022

    • Author(s)
      Utsunomiya A, Hasegawa M, et al.
    • Journal Title

      Arthritis Research and Therapy

      Volume: 24 Issue: 1 Pages: 94-94

    • DOI

      10.1186/s13075-022-02773-2

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical course of Japanese patients with early systemic sclerosis: A multicenter, prospective, observational study.2021

    • Author(s)
      Utsunomiya A, Hasegawa M, Oyama N, Asano Y, Endo H, Fujimoto M, Goto D, Ishikawa O, Kawaguchi Y, Kuwana M, Ogawa F, Takahashi H, Tanaka S, Sato S, Takehara K, Ihn H.
    • Journal Title

      Mod Rheumatol

      Volume: 31 Issue: 1 Pages: 162-170

    • DOI

      10.1080/14397595.2020.1751408

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Repigmentation of aging gray hair associated with unrecognized development and progression of amelanotic melanoma of the scalp: A physiological alert underlying hair rejuvenation2021

    • Author(s)
      Hasegawa T, Iino S, Kitakaze K, Kato T, Kabata D, Oyama N, Hasegawa M
    • Journal Title

      J Dermatol

      Volume: 48 Issue: 6 Pages: 281-283

    • DOI

      10.1111/1346-8138.15881

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Long-standing refractory hidradenitis suppurativa responded to a brodalumab monotherapy in a patient with psoriasis: A possible involvement of Th17 across the spectrum of both diseases2021

    • Author(s)
      Yoshida Y, Oyama N, Iino S, Shimizu C, Hasegawa M
    • Journal Title

      J Dermatol

      Volume: 48 Issue: 6 Pages: 916-920

    • DOI

      10.1111/1346-8138.15807

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bullous pemphigoid receiving a novel long-acting dipeptidyl-peptidase-4 (DPP-4) inhibitor omarigliptin in a patient with type 2 diabetes: A case report2021

    • Author(s)
      Kasamatsu H, Chino T, Oyama N, Nakaya T, Hasegawa M
    • Journal Title

      J Cutan Allergy Immunol

      Volume: 4 Issue: 4 Pages: 89-91

    • DOI

      10.1002/cia2.12162

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] A serum N-glycan profile: a new candidate biomarker for clinical practice of psoriasis2022

    • Author(s)
      Kentarou NISHIMURA, Noritaka OYAMA, Takumi HASEGAWA, Hiroshi KASAMATSU, Takenao CHINO, Minoru HASEGAWA
    • Organizer
      12th Asian Dermatological Congress
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Antifibrotic effects of a calpain inhibitor ALLN on bleomycin-induced systemic sclerosis model via antagonizing TGF-β/Smad signaling pathway.2022

    • Author(s)
      Hiroshi Kasamatsu, Takenao Chino, Takumi Hasegawa, Natsuko Utsunomiya, Akira Utsunomiya, Noritaka Oyama, Masami Yamada, Minoru Hasegawa
    • Organizer
      51st European Society for Dermatological Research
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Blockade of calpain enzymatic activity exerts anti-fibrotic effects in bleomycin-induced systemic sclerosis model mice.2022

    • Author(s)
      Hiroshi Kasamatsu, Takenao Chino, Takumi Hasegawa, Natsuko Utsunomiya, Akira Utsunomiya, Noritaka Oyama, Masami Yamada, Minoru Hasegawa
    • Organizer
      47th Japanese Society for Investigative Dermatology
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 血清中N結合型糖鎖プロファイル分析による 乾癬の新規バイオマーカーの探索2022

    • Author(s)
      西村健太郎、尾山徳孝、長谷川 巧、笠松宏至、知野剛直、長谷川 稔、徳永貴広、東 清史、斎藤幸一、山田佳太
    • Organizer
      第50回日本臨床免疫学会総会
    • Related Report
      2022 Research-status Report
  • [Presentation] A rare case of clinically aggressive pancreatic panniculitis caused by an occult neuroendocrine tumor in the corresponding organ2022

    • Author(s)
      Hiroshi Kasamatsu, Noritaka Oyama, Minoru Hasegawa, Youhei Oku, Genki Inoue, Makiko Kimura, Masataka Kanno, Takumi Kawakami, Hajime Ohta, Manabu Yoneshima
    • Organizer
      6th Eastern Asia Dermatological Congress
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] A calpain inhibitor ALLN attenuates bleomycin-induced skin fibrosis in a mice model2021

    • Author(s)
      Kasamatsu H, Chino T, Hasegawa T, Utsunomiya N, Utsunomiya A, Oyama N, Yamada M, Hasegawa M
    • Organizer
      46th Annual Meeting, Japanese Society for Investigative Deramtology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] A calpain inhibitor ALLN alleviates bleomycin-induced skin fibrosis via antagonizing TGF-β/Smad signaling pathway2021

    • Author(s)
      Kasamatsu H, Chino T, Hasegawa T, Utsunomiya N, Utsunomiya A, Oyama N, Yamada M, Hasegawa M
    • Organizer
      79th Annual Meeting, Society for Investigative Dermatology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Blockade of CX3CL1-CX3CR1 pathway inhibits mouse sclerodermatous chronic graft-versus-host disease model2021

    • Author(s)
      Utsunomiya A, Luong VH, Chino T, Oyama N, Matsushita T, Ishii N, Imai T, Hasegawa M
    • Organizer
      46th Annual Meeting, Japanese Society for Investigative Deramtology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Anti-fractalkine monoclonal antibody therapy ameliorates murine sclerodermatous chronic graft-versus-host disease2021

    • Author(s)
      Utsunomiya A, Luong VH, Chino T, Oyama N, Matsushita T, Ishii N, Imai T, Hasegawa M
    • Organizer
      50th Annual Meeting, European Society for Dermatological Research
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2021-04-28   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi