iPS cell-derived macrophage therapy regulating tumor micro environment

• Project/Area Number: 21K08351
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Kumamoto University
• Principal Investigator: FUKUSHIMA SATOSHI 熊本大学, 大学院生命科学研究部(医), 教授 (50398210)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2023: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: メラノーマ / がん免疫 / マクロファージ / 腫瘍微小環境 / iPS細胞 / 免疫チェックポイント阻害薬 / 免疫療法 / 細胞医薬 / マウスモデル / インターフェロン / がん免疫療法

Outline of Research at the Start

免疫チェックポイント阻害薬（ICI）はがん診療に革新的な進歩をもたらした。しか
しその奏効率は未だ十分ではない。我々は腫瘍微小環境を変えることがその解決策と考えており、遺伝子改変iPS細胞由来マクロファージ療法（iPS-MP）の開発を行う。治療細胞のソースとしてiPS細胞を用いることで、遺伝子改変し免疫調整機能を持たせた細胞を無限に得ることができる。本研究では臨床応用にむけた研究を行う。

Outline of Final Research Achievements

In cases where immune checkpoint inhibitors (ICIs) are ineffective, controlling the tumour microenvironment is considered a solution. The use of iPS cells as a source of therapeutic cells allows an unlimited number of cells to be obtained and genetically modified to have an immunomodulatory function. In a mouse melanoma model, we have confirmed that mouse iPS cell-derived macrophages genetically modified to produce interferon-β show an add-on effect when PD-1 inhibitions are inadequately effective. The mechanism of their efficacy was also analysed. It was suggested that genetically modified iPS cell-derived macrophages could be a promising treatment for ICI failure.

Academic Significance and Societal Importance of the Research Achievements

ICIが無効な腫瘍微小環境を変えようという試みは、全世界で競合している分野であるが、未だ臨床的成果を挙げるに至った例はない。本研究により種々の遺伝子改変iPS細胞由来マクロファージが、ICIの無効な腫瘍微小環境を変え、腫瘍抑制効果をマウスモデルで示したことは、今後のヒトへの臨床開発に向けて大きく弾みをつけるものである。今後、本研究結果を元にヒトiPS細胞を用いて研究に進めていく。その成果がさらにヒトの臨床試験まで到達し、有効性を示すことができれば、iPS細胞という日本が世界にさきがけた発明を生かし、機能をもった免疫細胞を誘導し、がん治療に応用するという大きな意義を持つ。

Research Products

• [Journal Article] DNA repair ability in a patient with voriconazole-related squamous cell carcinoma that required differential diagnosis from xeroderma pigmentosum (2024)
  • Author(s): Fukumoto Takeshi、Harada Tomoka、Ito Takamichi、Fukushima Satoshi、Ono Ryusuke、Furue Masutaka、Nishigori Chikako
  • Journal Title: Journal of Dermatological Science Volume: - Issue: 2 Pages: 00028-8
  • DOI: 10.1016/j.jdermsci.2024.02.005
  • Peer Reviewed
• [Journal Article] Deciphering the role of adjuvant therapy in melanoma and its actual benefits (2024)
  • Author(s): Fukushima Satoshi、Miyashita Azusa、Kimura Toshihiro、Kuriyama Haruka、Mizuhashi Satoru、Ichigozaki Yuki、Masuguchi Shinichi
  • Journal Title: The Journal of Dermatology Volume: 51 Issue: 3 Pages: 335-342
  • DOI: 10.1111/1346-8138.17093
  • Peer Reviewed / Open Access
• [Journal Article] <i>PIK3CA</i> mutations in cutaneous squamous cell carcinoma (2023)
  • Author(s): Kusaba Yudo、Kajihara Ikko、Sakamoto Ryoko、Maeda-Otsuka Saki、Yamada-Kanazawa Saori、Sawamura Soichiro、Makino Katsunari、Aoi Jun、Masuguchi Shinichi、Fukushima Satoshi
  • Journal Title: Intractable & Rare Diseases Research Volume: 12 Issue: 3 Pages: 206-207
  • DOI: 10.5582/irdr.2023.01069
  • ISSN: 2186-361X, 2186-3644
  • Year and Date: 2023-08-31
  • Peer Reviewed / Open Access
• [Journal Article] A case of melanoma complicated with uveitis induced by two types of BRAF/MEK inhibitors and nivolumab treatment (2023)
  • Author(s): Obaru Chiaki、Kimura Toshihiro、Yamamura Manami、Kuriyama Haruka、Kashiwada‐Nakamura Kayo、Mizuhashi Satoru、Matsumura Tomoyo、Watanabe Takahiro、Inoue Toshihiro、Fukushima Satoshi
  • Journal Title: The Journal of Dermatology Volume: 51 Issue: 4
  • DOI: 10.1111/1346-8138.17015
  • Peer Reviewed
• [Journal Article] Thymus alterations and susceptibility to immune checkpoint inhibitor myocarditis (2023)
  • Author(s): Fenioux Charlotte、Abbar Baptiste、Boussouar Samia、et al.
  • Journal Title: Nature Medicine Volume: 29 Issue: 12 Pages: 3100
  • DOI: 10.1038/s41591-023-02591-2
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Efficacy of salvage therapies for advanced acral melanoma after anti-PD-1 monotherapy failure: a multicenter retrospective study of 108 Japanese patients (2023)
  • Author(s): Mori T, Namikawa K, Yamazaki N, Kiniwa Y, Yamasaki O, et al
  • Journal Title: Frontiers in Medicine Volume: 10
  • DOI: 10.3389/fmed.2023.1229937
  • Peer Reviewed / Open Access
• [Journal Article] Systemic therapy for Asian patients with advanced BRAF V600‐mutant melanoma in a real‐world setting: A multi‐center retrospective study in Japan (B‐CHECK‐RWD study) (2023)
  • Author(s): Namikawa Kenjiro、Ito Takamichi、Yoshikawa Shusuke、Yoshino Koji、Kiniwa Yukiko、Ohe Shuichi、Isei Taiki、Takenouchi Tatsuya、Kato Hiroshi、Mizuhashi Satoru、Fukushima Satoshi、Yamamoto Yosuke、Inozume Takashi、Fujisawa Yasuhiro、Yamasaki Osamu、Nakamura Yasuhiro、Asai Jun、Maekawa Takeo、Funakoshi Takeru、et al
  • Journal Title: Cancer Medicine Volume: 12 Issue: 17 Pages: 17967-17980
  • DOI: 10.1002/cam4.6438
  • Peer Reviewed / Open Access
• [Journal Article] Adverse events associated with postoperative outcomes of adjuvant <scp>anti‐PD</scp>‐1 antibody therapy in both acral and non‐acral cutaneous melanomas: A multicenter, observational, post hoc analysis study (2023)
  • Author(s): Muto Yusuke、Kambayashi Yumi、Kato Hiroshi、Fukushima Satoshi、Ito Takamichi、Maekawa Takeo、Fujisawa Yasuhiro、Yoshino Koji、Uchi Hiroshi、Matsushita Shigeto、Yamamoto Yuki、Amagai Ryo、Ohuchi Kentaro、Hashimoto Akira、Asano Yoshihide、Fujimura Taku
  • Journal Title: The Journal of Dermatology Volume: 51 Issue: 3 Pages: 458-462
  • DOI: 10.1111/1346-8138.16912
  • Peer Reviewed / Open Access
• [Journal Article] ANGPTL2‐mediated epigenetic repression of MHC‐I in tumor cells accelerates tumor immune evasion (2023)
  • Author(s): Kadomatsu Tsuyoshi、Hara Chiaki、Kurahashi Ryoma、Horiguchi Haruki、Morinaga Jun、Miyata Keishi、Kurano Sohtaro、Kanemaru Hisashi、Fukushima Satoshi、Araki Kimi、Baba Masaya、Linehan W. Marston、Kamba Tomomi、Oike Yuichi
  • Journal Title: Molecular Oncology Volume: 17 Issue: 12 Pages: 2637-2658
  • DOI: 10.1002/1878-0261.13490
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Deep intronic founder mutations identified in the ERCC4/XPF gene are potential therapeutic targets for a high-frequency form of xeroderma pigmentosum (2023)
  • Author(s): Senju Chikako、Nakazawa Yuka、Oso Taichi、Shimada Mayuko、Kato Kana、Matsuse Michiko、Tsujimoto Mariko、Masaki Taro、Miyazaki Yasushi、Fukushima Satoshi、Tateishi Satoshi、Utani Atsushi、Murota Hiroyuki、Tanaka Katsumi、Mitsutake Norisato、Moriwaki Shinichi、Nishigori Chikako、Ogi Tomoo
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 120 Issue: 27
  • DOI: 10.1073/pnas.2217423120
  • Peer Reviewed / Open Access
• [Journal Article] Postoperative adjuvant therapy for 120?patients with melanoma, including acral and mucosal subtypes: a multicentre, observational study of 2-year follow-up results (2023)
  • Author(s): Muto Yusuke、Kambayashi Yumi、Kato Hiroshi、Fukushima Satoshi、Ito Takamichi、Maekawa Takeo、Shoichiro Ishizuki、Uchi Hiroshi、Matsushita Shigeto、Yamamoto Yuki?、Yoshino Koji、Fujisawa Yasuhiro?、Amagai Ryo、Ohuchi Kentaro?、Hashimoto Akira、Asano Yoshihide?、Fujimura Taku
  • Journal Title: British Journal of Dermatology Volume: 189 Issue: 4 Pages: 476-478
  • DOI: 10.1093/bjd/ljad183
  • Peer Reviewed / Open Access
• [Journal Article] Overexpression of heat shock protein 90 through the downregulation of miR‐9‐5p in extramammary Paget's disease (2023)
  • Author(s): Ohnuma Takehiro、Mijiddorj Myangat Tselmeg、Kajihara Ikko、Sawamura Soichiro、Sakamoto Ryoko、Maeda‐Otsuka Saki、Yamada‐Kanazawa Saori、Makino Katsunari、Aoi Jun、Masuguchi Shinichi、Fukushima Satoshi
  • Journal Title: The Journal of Dermatology Volume: 50 Issue: 9 Pages: 1216-1221
  • DOI: 10.1111/1346-8138.16825
  • Peer Reviewed
• [Journal Article] A case of unknown primary melanoma detected with a BRAF gene mutation from a pleural fluid cell block (2023)
  • Author(s): Yamamoto Sotaro、Kuriyama Haruka、Kashiwada‐Nakamura Kayo、Kajihara Ikko、Makino Katsunari、Aoi Jun、Miyashita Azusa、Yoshida Chieko、Kubo Yosuke、Fukushima Satoshi
  • Journal Title: The Journal of Dermatology Volume: 50 Issue: 9
  • DOI: 10.1111/1346-8138.16812
  • Peer Reviewed
• [Journal Article] Combined use of nivolumab and ipilimumab in Japanese patients with melanoma: a multicentre retrospective study of 111 cases (2023)
  • Author(s): Fujisawa Yasuhiro、Namikawa Kenjiro、Yoshino Koji、et al.
  • Journal Title: British Journal of Dermatology Volume: 189 Issue: 2 Pages: 223-250
  • DOI: 10.1093/bjd/ljad114
  • Peer Reviewed
• [Journal Article] Ipilimumab-related uveitis and refractory hypotony with a flat chamber in a trabeculectomized eye with exfoliation glaucoma: A case report (2023)
  • Author(s): Funagura Naofumi、Fukushima Satoshi、Inoue Toshihiro
  • Journal Title: American Journal of Ophthalmology Case Reports Volume: 29 Pages: 101807-101807
  • DOI: 10.1016/j.ajoc.2023.101807
  • Peer Reviewed / Open Access
• [Journal Article] Clues for developing next‐generation cancer immunotherapy (2023)
  • Author(s): Inozume Takashi、Fukushima Satoshi
  • Journal Title: Experimental Dermatology Volume: 32 Issue: 3 Pages: 238-239
  • DOI: 10.1111/exd.14751
  • Peer Reviewed
• [Journal Article] Clinical significance of circulating exosomal interleukin‐23 and tumour necrosis factor‐α messenger RNA in psoriasis (2023)
  • Author(s): Sawamura Soichiroa、Tselmeg Mijiddorj Myangat、Kajihara Ikko、Shimada Shuichi、Kanemaru Hisashi、Yamada‐Kanazawa Saori、Makino Katsunari、Aoi Jun、Masuguchi Shinichi、Fukushima Satoshi
  • Journal Title: Journal of the European Academy of Dermatology and Venereology Volume: - Issue: 6
  • DOI: 10.1111/jdv.18945
  • Peer Reviewed
• [Journal Article] Elevation of cell‐free DNA in patients with clinically amyopathic dermatomyositis (2023)
  • Author(s): Ishino Tomohiro、Myangat Tselmeg Mijiddorj、Sawamura Soichiro、Kajihara Ikko、Shimada Shuichi、Kanemaru Hisashi、Kashiwada‐Nakamura Kayo、Makino Katsunari、Masuguchi Shinichi、Fukushima Satoshi
  • Journal Title: The Journal of Dermatology Volume: - Issue: 6
  • DOI: 10.1111/1346-8138.16714
  • Peer Reviewed
• [Journal Article] A Japanese case of melanoma of unknown origin with a rare <i>BRAF</i>^V600R mutation was successfully treated with BRAF/MEK inhibitors (2022)
  • Author(s): Kuriyama Haruka、Kimura Toshihiro、Mizuhashi Satoru、Nishimura Yuki、Kanemaru Hisashi、Kajihara Ikko、Makino Katsunari、Aoi Jun、Matsui Hirotaka、Fukushima Satoshi
  • Journal Title: Drug Discoveries & Therapeutics Volume: 16 Issue: 5 Pages: 256-257
  • DOI: 10.5582/ddt.2022.01072
  • ISSN: 1881-7831, 1881-784X
  • Year and Date: 2022-10-31
  • Peer Reviewed / Open Access
• [Journal Article] Nevus of Ota on the auricle successfully treated with Q-switched ruby laser (2022)
  • Author(s): Yamada-Kanazawa Saori、Jinnin Masatoshi、Fukushima Satoshi
  • Journal Title: Drug Discoveries & Therapeutics Volume: 16 Issue: 5 Pages: 254-255
  • DOI: 10.5582/ddt.2022.01062
  • ISSN: 1881-7831, 1881-784X
  • Year and Date: 2022-10-31
  • Peer Reviewed
• [Journal Article] Extracardiac Biopsy Sensitivity in Transthyretin Amyloidosis Cardiomyopathy Patients With Positive ^{99 m}Tc-Labeled Pyrophosphate Scintigraphy Findings (2022)
  • Author(s): Nishi Masato、Takashio Seiji、Morioka Mami、Fujiyama Akira、Nakashima Naoya、Hirakawa Kyoko、Hanatani Shinsuke、Usuku Hiroki、Yamamoto Eiichiro、Kidoh Masafumi、Oda Seitaro、Gushima Ryosuke、Matsushita Kenichi、Fukushima Satoshi、Ueda Mitsuharu、Tsujita Kenichi
  • Journal Title: Circulation Journal Volume: 86 Issue: 7 Pages: 1113-1120
  • DOI: 10.1253/circj.CJ-22-0118
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2022-06-24
  • Peer Reviewed
• [Journal Article] Analysis of microsatellite instability using Promega panel in dermatofibrosarcoma protuberans (2022)
  • Author(s): Maeda-Otsuka Saki、Mijiddorj Myangat Tselmeg、Kajihara Ikko、Nishimura Yuki、Kanemaru Hisashi、Sawamura Soichiro、Makino Katsunari、Aoi Jun、Masuguchi Shinichi、Fukushima Satoshi
  • Journal Title: BioScience Trends Volume: 16 Issue: 2 Pages: 176-177
  • DOI: 10.5582/bst.2022.01048
  • NAID: 130008161566
  • ISSN: 1881-7815, 1881-7823
  • Year and Date: 2022-04-30
  • Peer Reviewed
• [Journal Article] Future prospects for cancer immunotherapy using induced pluripotent stem cell‐derived dendritic cells or macrophages (2022)
  • Author(s): Fukushima Satoshi、Miyashita Azusa、Kuriyama Haruka、Kimura Toshihiro、Mizuhashi Satoru、Kubo Yosuke、Nakahara Satoshi、Kanemaru Hisashi、Tsuchiya Nobuhiro、Mashima Hiroaki、Zhang Rong、Uemura Yasushi
  • Journal Title: Experimental Dermatology Volume: 32 Issue: 3 Pages: 290-296
  • DOI: 10.1111/exd.14729
  • Peer Reviewed
• [Journal Article] Dermatophyte antigen kit in diagnosis of onychomycosis caused by Fusarium solani (2022)
  • Author(s): Higuchi Sara、Noguchi Hiromitsu、Matsumoto Tadahiko、Kashiwada‐Nakamura Kayo、Kubo Masahide、Kano Rui、Yaguchi Takashi、Satoh Takahiro、Fukushima Satoshi
  • Journal Title: The Journal of Dermatology Volume: 50 Issue: 5
  • DOI: 10.1111/1346-8138.16693
  • Peer Reviewed
• [Journal Article] Majocchi Granuloma in a Patient with Adult T-cell Leukemia (2022)
  • Author(s): Ishibashi Takayuki、Ichimura Chika、Kubo Masahide、Noguchi Hiromitsu、Matsumoto Tadahiko、Kano Rui、Yaguchi Takashi、Fukushima Satoshi
  • Journal Title: Mycopathologia Volume: 188 Issue: 3 Pages: 259
  • DOI: 10.1007/s11046-022-00690-1
  • Peer Reviewed
• [Journal Article] Efficacy comparison between anti-PD-1 antibody monotherapy and anti-PD-1 plus anti-CTLA-4 combination therapy as first-line immunotherapy for advanced acral melanoma: A retrospective, multicenter study of 254 Japanese patients (2022)
  • Author(s): Nakamura Yasuhiro、Namikawa Kenjiro、Kiniwa Yukiko、Kato Hiroshi、Yamasaki Osamu、Yoshikawa Shusuke、Maekawa Takeo、Matsushita Shigeto、Takenouchi Tatsuya、Inozume Takashi、Nakai Yasuo、Fukushima Satoshi、et al.
  • Journal Title: European Journal of Cancer Volume: 176 Pages: 78-87
  • DOI: 10.1016/j.ejca.2022.08.030
  • Peer Reviewed
• [Journal Article] Dermoscopic findings of sporotrichosis manifesting as a punched‐out ulcer (2022)
  • Author(s): Kashiwada‐Nakamura Kayo、Noguchi Hiromitsu、Hiruma Masataro、Tanaka Masaru、Yaguchi Takashi、Kusaba Yudo、Miyashita Azusa、Hayashi Hideyuki、Fukushima Satoshi
  • Journal Title: The Journal of Dermatology Volume: 49 Issue: 12 Pages: 449-450
  • DOI: 10.1111/1346-8138.16557
  • Peer Reviewed
• [Journal Article] Elevated Alpha 1(I) to Alpha 2(I) Collagen Ratio in Dermal Fibroblasts Possibly Contributes to Fibrosis in Systemic Sclerosis (2022)
  • Author(s): Sawamura Soichiro、Makino Katsunari、Ide Maho、Shimada Shuichi、Kajihara Ikko、Makino Takamitsu、Jinnin Masatoshi、Fukushima Satoshi
  • Journal Title: International Journal of Molecular Sciences Volume: 23 Issue: 12 Pages: 6811-6811
  • DOI: 10.3390/ijms23126811
  • Peer Reviewed
• [Journal Article] Adjuvant Anti-PD-1 Antibody Therapy for Advanced Melanoma: A Multicentre Study of 78 Japanese Cases. (2022)
  • Author(s): Muto Y, Kambayashi Y, Kato H, Fukushima S, Ito T, Maekawa T, Fujisawa Y, Yoshino K, Uchi H, Matsushita S, Yamamoto Y, Amagai R, Ohuchi K, Hashimoto A, Fujimura T.
  • Journal Title: Acta DermatoVenereologica Volume: in press Pages: 00756-00756
  • DOI: 10.2340/actadv.v102.678
  • Peer Reviewed / Open Access
• [Journal Article] A phase I study of the safety and efficacy of talimogene laherparepvec in Japanese patients with advanced melanoma (2022)
  • Author(s): Yamazaki Naoya、Isei Taiki、Kiyohara Yoshio、Koga Hiroshi、Kojima Takashi、Takenouchi Tatsuya、Yokota Kenji、Namikawa Kenjiro、Yi Min、Keegan Alissa、Fukushima Satoshi
  • Journal Title: Cancer Science Volume: 113 Issue: 8 Pages: 2798-2806
  • DOI: 10.1111/cas.15450
  • Peer Reviewed
• [Journal Article] Clinical significance of ERBB2 S310F mutation in extramammary Paget's disease (2022)
  • Author(s): Kusaba Yudo、Kajihara Ikko、Myangat Tselmeg Mijiddorj、Tanaka Kenichiro、Kanemaru Hisashi、Sawamura Soichiro、Makino Katsunari、Aoi Jun、Masuguchi Shinichi、Fukushima Satoshi
  • Journal Title: The Journal of Dermatology Volume: 49 Issue: 9 Pages: 305-306
  • DOI: 10.1111/1346-8138.16439
  • Peer Reviewed
• [Journal Article] Concordance in judgment of clinical borders of basal cell carcinomas in Japanese patients: A preliminary study of JCOG2005 (J‐BASE‐MARGIN) (2022)
  • Author(s): Kamimura Anna、Nakamura Yasuhiro、Fukushima Satoshi、Yamazaki Naoya et al.
  • Journal Title: The Journal of Dermatology Volume: 49 Issue: 9 Pages: 837-844
  • DOI: 10.1111/1346-8138.16422
  • Peer Reviewed
• [Journal Article] Elevation of circulating interleukin‐23 DNA levels in patients with psoriasis (2022)
  • Author(s): Sawamura Soichiro、Kajihara Ikko、Sakamoto Ryoko、Otsuka‐Maeda Saki、Kanemaru Hisashi、Kanazawa‐Yamada Saori、Makino Katsunari、Aoi Jun、Masuguchi Shinichi、Fukushima Satoshi
  • Journal Title: The Journal of Dermatology Volume: 49 Issue: 9 Pages: 295-296
  • DOI: 10.1111/1346-8138.16418
  • Peer Reviewed
• [Journal Article] Cas9‐guided haplotyping of three truncation variants in autosomal recessive disease (2022)
  • Author(s): Natsuga Ken、Furuta Yoshikazu、Takashima Shota、Nohara Takuma、Huang Hsin‐Yu、Shinkuma Satoru、Nakamura Hideki、Katsuda Yousuke、Higashi Hideaki、Hsu Chao‐Kai、Fukushima Satoshi、Ujiie Hideyuki
  • Journal Title: Human Mutation Volume: - Issue: 7 Pages: 877-881
  • DOI: 10.1002/humu.24385
  • Peer Reviewed
• [Journal Article] Prognoses of melanoma patients who continue/discontinue anti‐programmed death‐1 therapy after achieving a complete response in a real‐world setting: A multicenter retrospective study (2022)
  • Author(s): Kato Junji、Namikawa Kenjiro、Uehara Jiro、Nomura Motoo、Nakamura Yasuhiro、Uhara Hisashi、Uchi Hiroshi、Yoshikawa Shusuke、Kiniwa Yukiko、Nakamura Yoshiyuki、Miyagawa Takuya、Matsushita Shigeto、Takenouchi Tatsuya、Hatta Naohito、Ohno Fumitaka、Maeda Taku、Fukushima Satoshi、Yamazaki Naoya
  • Journal Title: British Journal of Dermatology Volume: - Issue: 4 Pages: 594-596
  • DOI: 10.1111/bjd.21276
  • Peer Reviewed
• [Journal Article] Relationship between Type 2 diabetes mellitus and aggressiveness of melanoma (2022)
  • Author(s): Kaneko Akira、Kanemaru Hisashi、Mizuhashi Satoru、Kimura Toshihiro、Kuriyama Haruka、Sawamura Soichiro、Kajihara Ikko、Makino Katsunari、Miyashita Azusa、Aoi Jun、Masuguchi Shinichi、Fukushima Satoshi
  • Journal Title: Journal of Dermatological Science Volume: 106 Issue: 1 Pages: 65-67
  • DOI: 10.1016/j.jdermsci.2022.03.006
  • Peer Reviewed
• [Journal Article] Genomic mutation analysis of circulating tumor DNA in metastatic cutaneous squamous cell carcinoma (2022)
  • Author(s): Sawamura Soichiro、Myangat Tselmeg Mijiddorj、Kajihara Ikko、Tanaka Kenichiro、Kanemaru Hisashi、Nishimura Yuki、Kashiwada-Nakamura Kayo、Makino Kastunari、Aoi Jun、Masuguchi Shinichi、Fukushima Satoshi
  • Journal Title: Journal of Dermatological Science Volume: 106 Issue: 1 Pages: 61-64
  • DOI: 10.1016/j.jdermsci.2022.03.004
  • Peer Reviewed
• [Journal Article] Promising Blood-Based Biomarkers for Melanoma: Recent Progress of Liquid Biopsy and Its Future Perspectives (2022)
  • Author(s): Kanemaru Hisashi、Mizukami Yukari、Kaneko Akira、Kajihara Ikko、Fukushima Satoshi
  • Journal Title: Current Treatment Options in Oncology Volume: 23 Issue: 4 Pages: 562-577
  • DOI: 10.1007/s11864-022-00948-2
  • Peer Reviewed
• [Journal Article] Empiric antifungal therapy in patients with cutaneous and subcutaneous phaeohyphomycosis (2022)
  • Author(s): Noguchi Hiromitsu、Matsumoto Tadahiko、Kimura Utako、Hiruma Masataro、Kano Rui、Yaguchi Takashi、Kubo Masahide、Kashiwada‐Nakamura Kayo、Fukushima Satoshi
  • Journal Title: The Journal of Dermatology Volume: 49 Issue: 5 Pages: 564
  • DOI: 10.1111/1346-8138.16312
  • Peer Reviewed
• [Journal Article] Clinical significance of maximum standardized uptake value of positron emission tomography/computed tomography as prognostic factor in extramammary Paget’s disease (2022)
  • Author(s): Kusaba Yudo、Kajihara Ikko、Sawamura Soichiro、Kanemaru Hisashi、Makino Katsunari、Aoi Jun、Masuguchi Shinichi、Morinaga Jun、Fukushima Satoshi
  • Journal Title: The Journal of Dermatology Volume: 49 Issue: 6 Pages: 508-514
  • DOI: 10.1111/1346-8138.16328
  • Peer Reviewed
• [Journal Article] Bioactive substances in the stratum corneum of the epidermis found as indicators of skin damage due to sun exposure (2022)
  • Author(s): Fukunaga Atsushi、Fukushima Satoshi、Iwata Hiroaki、Nakahara Makiko、Sasaki Rikako、Baba Naoko、Matsunaka Hiroshi、Murakami Yumi、Furue Masutaka、Nishigori Chikako
  • Journal Title: Photodermatology, Photoimmunology & Photomedicine Volume: 38 Issue: 3 Pages: 241-249
  • DOI: 10.1111/phpp.12743
  • Peer Reviewed
• [Journal Article] iPS細胞由来の樹状細胞やマクロファージによるがん免疫療法 (2022)
  • Author(s): 福島聡
  • Journal Title: 西日本皮膚科 Volume: 84 Pages: 93-99
• [Journal Article] Current Organ Topics メラノーマ、皮膚癌 II. 皮膚がんに対する免疫療法の現在と未来 (2022)
  • Author(s): 福島聡
  • Journal Title: 癌と化学療法 Volume: 49 Pages: 413-416
• [Journal Article] 特集・悪性黒色腫の最前線 １.基礎 １）遺伝子変異からみた発症メカニズム (2022)
  • Author(s): 福島聡
  • Journal Title: 月刊「皮膚科」 Volume: 1 Pages: 1-8
• [Journal Article] Intertumor and intratumor heterogeneity of PIK3CA mutations in extramammary Paget’s disease (2022)
  • Author(s): Kusaba Yudo、Kajihara Ikko、Myangat Tselmeg Mijiddorj、Tanaka Kenichiro、Sakamoto Ryoko、Maeda‐Otsuka Saki、Yamada‐Kanazawa Saori、Sawamura Soichiro、Kanemaru Hisashi、Nishimura Yuki、Nakamura‐Kashiwada Kayo、Makino Katsunari、Miyashita Azusa、Aoi Jun、Masuguchi Shinichi、Fukushima Satoshi
  • Journal Title: The Journal of Dermatology Volume: - Issue: 5 Pages: 508-514
  • DOI: 10.1111/1346-8138.16343
  • Peer Reviewed
• [Journal Article] Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccination. (2022)
  • Author(s): Miyashita Y, Yoshida T, Takagi Y, Tsukamoto H, Takashima K, Kouwaki T, Makino K, Fukushima S, Nakamura K, Oshiumi H.
  • Journal Title: NPJ Vaccines Volume: 7 Issue: 1 Pages: 16-16
  • DOI: 10.1038/s41541-022-00439-3
  • Peer Reviewed / Open Access
• [Journal Article] A protocol for quantifying lymphocyte-mediated cytotoxicity using an impedance-based real-time cell analyzer (2022)
  • Author(s): Kanemaru Hisashi、Mizukami Yukari、Kaneko Akira、Kajihara Ikko、Fukushima Satoshi
  • Journal Title: STAR Protocols Volume: 3 Issue: 1 Pages: 101128-101128
  • DOI: 10.1016/j.xpro.2022.101128
  • Peer Reviewed / Open Access
• [Journal Article] Circulating Janus kinase family DNA levels in psoriasis: elevated JAK2 DNA copy number in cell‐free DNA (2021)
  • Author(s): Kashiwada‐Nakamura Kayo、Myangat Tselmeg Mijiddorj、Kajihara Ikko、Kanemaru Hisashi、Sawamura Soichiro、Makino Katsunari、Aoi Jun、Masuguchi Shinichi、Fukushima Satoshi
  • Journal Title: The Journal of Dermatology Volume: 49 Issue: 3
  • DOI: 10.1111/1346-8138.16245
  • Peer Reviewed
• [Journal Article] TIGIT/CD155 axis mediates resistance to immunotherapy in patients with melanoma with the inflamed tumor microenvironment (2021)
  • Author(s): Kawashima S, Inozume T, Kawazu M, Ueno T, Nagasaki J, Tanji E, Honobe A, Ohnuma T, Kawamura T, Umeda Y, Nakamura Y, Kawasaki T, Kiniwa Y, Yamasaki O, Fukushima S, Ikehara Y, Mano H, Suzuki Y, Nishikawa H, Matsue H, Togashi Y.
  • Journal Title: Journal for ImmunoTherapy of Cancer Volume: 9 Issue: 11 Pages: e003134-e003134
  • DOI: 10.1136/jitc-2021-003134
  • NAID: 120007175403
  • Peer Reviewed / Open Access
• [Journal Article] Microsatellite instability analysis using Promega panel in cutaneous squamous cell carcinoma (2021)
  • Author(s): Myangat Tselmeg Mijiddorj、Wada Shoma、Sawamura Soichiro、Kajihara Ikko、Kimura Toshihiro、Kashiwada‐Nakamura Kayo、Makino Katsunari、Aoi Jun、Masuguchi Shinichi、Fukushima Satoshi
  • Journal Title: The Journal of Dermatology Volume: 49 Issue: 2
  • DOI: 10.1111/1346-8138.16238
  • Peer Reviewed
• [Journal Article] Textbook case of onychomycosis caused by Scopulariopsis brevicaulis (2021)
  • Author(s): Noguchi Hiromitsu、Matsumoto Tadahiko、Kimura Utako、Hiruma Masataro、Kano Rui、Yaguchi Takashi、Kashiwada‐Nakamura Kayo、Fukushima Satoshi
  • Journal Title: The Journal of Dermatology Volume: 49 Issue: 1
  • DOI: 10.1111/1346-8138.16220
  • Peer Reviewed
• [Journal Article] Genomic landscape of circulating tumour DNA in metastatic extramammary Paget's disease (2021)
  • Author(s): S. Sawamura, T. Mijiddorj Myangat, I. Kajihara, K. Tanaka, M. Ide, R. Sakamoto, S. Otsuka-Maeda, H. Kanemaru, Y. Nishimura, S. Kanazawa-Yamada, K. Kashiwada-Nakamura, N. Honda, K. Makino, J. Aoi, T. Igata, T. Makino, S. Masuguchi, S. Fukushima, H. Ihn
  • Journal Title: Experimental Dermatology Volume: － Issue: 3 Pages: 341-348
  • DOI: 10.1111/exd.14476
  • Peer Reviewed
• [Journal Article] Real-world efficacy of anti-PD-1 antibody or combined anti-PD-1 plus anti-CTLA-4 antibodies, with or without radiotherapy, in advanced mucosal melanoma patients: A retrospective, multicenter study (2021)
  • Author(s): Umeda Y, Yoshikawa S, Kiniwa Y, Maekawa T, Yamasaki O, Isei T, Matsushita S, Nomura M, Nakai Y, Fukushima S, Saito S, Takenouchi T, Tanaka R, Kato H, Otsuka A, Matsuya T, Baba N, Nagase K, Inozume T, Onuma T, Kuwatsuka Y, Fujimoto N, Kaneko T, Onishi M, Namikawa K, Yamazaki N, Nakamura Y.
  • Journal Title: Eur J Cancer Volume: 157 Pages: 361-372
  • DOI: 10.1016/j.ejca.2021.08.034
  • Peer Reviewed
• [Journal Article] Ungual hyalohyphomycosis caused by Penicillium citrinum successfully treated with fosravuconazole (2021)
  • Author(s): Noguchi Hiromitsu、Matsumoto Tadahiko、Kimura Utako、Hiruma Masataro、Kano Rui、Yaguchi Takashi、Kashiwada‐Nakamura Kayo、Fukushima Satoshi
  • Journal Title: The Journal of Dermatology Volume: 48 Issue: 12
  • DOI: 10.1111/1346-8138.16172
  • Peer Reviewed
• [Journal Article] A mechanism of cooling hot tumors: Lactate attenuates inflammation in dendritic cells (2021)
  • Author(s): Hisashi Kanemaru, Yukari Mizukami, Akira Kaneko, Hidemi Tagawa, Toshihiro Kimura, Haruka Kuriyama, Soichiro Sawamura, Ikko Kajihara, Katsunari Makino, Azusa Miyashita, Jun Aoi, Takamitsu Makino, Shinichi Masuguchi, Satoshi Fukushima, Hironobu Ihn
  • Journal Title: iScience Volume: 24 Issue: 9 Pages: 103067-103067
  • DOI: 10.1016/j.isci.2021.103067
  • Peer Reviewed / Open Access
• [Journal Article] Retrospective analysis of adjuvant therapy using dabrafenib plus trametinib in Japanese patients with advanced melanoma: analysis of 36 cases. (2021)
  • Author(s): Amagai R, Muto Y, Kato H, Matsushita S, Maekawa T, Fukushima S, Yoshino K, Uchi H, Fujisawa Y, Yamamoto Y, Ohuchi K, Kambayashi Y, Fujimura T.
  • Journal Title: Melanoma Research Volume: 31 Issue: 6 Pages: 575-578
  • DOI: 10.1097/cmr.0000000000000770
  • Peer Reviewed
• [Journal Article] Cluster infection caused by a terbinafine-resistant dermatophyte at a group home: class FormattedString { value: The first case series in Japan } (2021)
  • Author(s): Noguchi H、Matsumoto T、Hiruma M、Kimura U、Kashiwada-Nakamura K、Kubo M、Yaguchi T、Fukushima S、Kano R
  • Journal Title: Acta Dermato Venereologica Volume: 101 Issue: 9 Pages: 563-563
  • DOI: 10.2340/00015555-3926
  • URL: https://localhost/en/publications/63eb5607-17e8-4632-9c6e-00004d9b1e92
  • Peer Reviewed
• [Journal Article] Clinical significance of skin colonization of Pseudomonas aeruginosa in cutaneous squamous cell carcinoma (2021)
  • Author(s): Itsuki Takei, Soichiro Sawamura, Tselmeg Mijiddorj Myangat, Ikko Kajihara, Hisashi Kanemaru, Kayo Kashiwada-Nakamura, Katsunari Makino, Jun Aoi, Sinichi Masuguchi, Satoshi Fukushima
  • Journal Title: The Journal of Dermatology Volume: － Issue: 12
  • DOI: 10.1111/1346-8138.16148
  • Peer Reviewed
• [Journal Article] Amelanotic melanoma of the nail apparatus complicated with digital mucous cyst (2021)
  • Author(s): Takei Itsuki、Sawamura Soichiro、Kimura Toshihiro、Makino Takamitsu、Aoi Jun、Kajihara Ikko、Nishimura Yuki、Igata Toshikatsu、Masuguchi Shinichi、Fukushima Satoshi
  • Journal Title: Australasian Journal of Dermatology Volume: 63 Issue: 1
  • DOI: 10.1111/ajd.13679
  • Peer Reviewed
• [Journal Article] Overexpression of tumor endothelial marker 8 protein predicts poor prognosis in angiosarcoma (2021)
  • Author(s): Kusaba Yudo、Kajihara Ikko、Sakamoto Ryoko、Maeda‐Otsuka Saki、Yamada‐Kanazawa Saori、Sawamura Soichiro、Makino Katsunari、Aoi Jun、Masuguchi Shinichi、Fukushima Satoshi
  • Journal Title: The Journal of Dermatology Volume: 48 Issue: 10
  • DOI: 10.1111/1346-8138.16069
  • Peer Reviewed
• [Journal Article] Malignant mixed tumor of the skin on the anterior chest (2021)
  • Author(s): Nakashima Hitomi、Sawamura Soichiro、Yamada Rin、Fukushima Satoshi
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 51 Issue: 10 Pages: 1597-1598
  • DOI: 10.1093/jjco/hyab106
  • Peer Reviewed
• [Journal Article] Liquid biopsy-based analysis by ddPCR and CAPP-Seq in melanoma patients (2021)
  • Author(s): Akira Kaneko, Hisashi Kanemaru, Ikko Kajihara, Tselmeg Mijiddorj, Hitomi Miyauchi, Haruka Kuriyama, Toshihiro Kimura, Soichiro Sawamura, Katsunari Makino, Azusa Miyashita, Jun Aoi, Takamitsu Makino, Shinichi Masuguchi, Satoshi Fukushima, Hironobu Ihn
  • Journal Title: Journal of Dermatological Science Volume: 102 Issue: 3 Pages: 158-166
  • DOI: 10.1016/j.jdermsci.2021.04.006
  • Peer Reviewed
• [Journal Article] Topical efinaconazole: A sequential combination therapy with oral terbinafine for refractory tinea unguium (2021)
  • Author(s): Noguchi Hiromitsu、Kubo Masahide、Kashiwada‐Nakamura Kayo、Makino Katsunari、Aoi Jun、Fukushima Satoshi
  • Journal Title: The Journal of Dermatology Volume: 48 Issue: 9 Pages: 1401-1404
  • DOI: 10.1111/1346-8138.15973
  • Peer Reviewed / Open Access
• [Journal Article] Status of microsatellite stability in angiosarcoma: Angiosarcoma is a microsatellite stable tumor (2021)
  • Author(s): Maeda‐Otsuka Saki、Myangat Tselmeg Mijiddorj、Kajihara Ikko、Sakamoto Ryoko、Yamada‐Kanazawa Saori、Sawamura Soichiro、Makino Katsunari、Masuguchi Shinichi、Fukushima Satoshi、Ihn Hironobu
  • Journal Title: The Journal of Dermatology Volume: 48 Issue: 8
  • DOI: 10.1111/1346-8138.15938
  • Peer Reviewed
• [Journal Article] Overexpression of Janus kinase 2 protein in extramammary Paget's disease (2021)
  • Author(s): Saki Otsuka-Maeda, Myangat Tselmeg Mijiddorj, Ikko Kajihara, Ryoko Sakamoto, Saori Yamada-Kanazawa, Hisashi Kanemaru, Yuki Nishimura, Soichiro Sawamura, Katsunari Makino, Jun Aoi, Takamitsu Makino, Shinichi Masuguchi, Satoshi Fukushima, Hironobu Ihn
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 51 Issue: 7 Pages: 1176-1178
  • DOI: 10.1093/jjco/hyab062
  • Peer Reviewed
• [Journal Article] Subcutaneous cystic phaeohyphomycosis caused by Phaeoacremonium minimum (2021)
  • Author(s): Kashiwada‐Nakamura Kayo、Noguchi Hiromitsu、Matsumoto Tadahiko、Yaguchi Takashi、Kamei Katsuhiko、Suzuki Takahisa、Makino Takamitsu、Kajihara Ikko、Fukushima Satoshi、Ihn Hironobu
  • Journal Title: The Journal of Dermatology Volume: 48 Issue: 5
  • DOI: 10.1111/1346-8138.15847
  • Peer Reviewed
• [Journal Article] Five-year survival with nivolumab in previously untreated Japanese patients with advanced or recurrent malignant melanoma (2021)
  • Author(s): Uhara H, Kiyohara Y, Uehara J, Fujisawa Y, Takenouchi T, Otsuka M, Uchi H, Fukushima S, Minami H, Hatsumichi M, Yamazaki N.
  • Journal Title: J Dermatol . Volume: 48 Issue: 5 Pages: 592-599
  • DOI: 10.1111/1346-8138.15804
  • Peer Reviewed / Open Access
• [Journal Article] Nucleosome assembly protein 1-like 4, a new therapeutic target for proliferation and invasion of melanoma cells (2021)
  • Author(s): Mizuhashi S, Fukushima S, Ishibashi T, Kuriyama H, Kimura T, Kanemaru H, Kajihara I, Makino K, Miyashita A, Aoi J, Kita K, Ihn H.
  • Journal Title: J Dermatol Sci . Volume: - Issue: 1 Pages: 16-24
  • DOI: 10.1016/j.jdermsci.2021.02.001
  • Peer Reviewed
• [Presentation] iPS細胞由来マクロファージによるがん免疫療法 (2023)
  • Author(s): 福島聡
  • Organizer: 第39回日本皮膚悪性腫瘍学会 シンポジウム３
• [Presentation] 皮膚悪性腫瘍の最前線 (2023)
  • Author(s): 福島聡
  • Organizer: 第39回日本臨床皮膚科医会総会・臨床学術大会 シンポジウム５
• [Presentation] Immunotherapy for skin cancers in Japan (2022)
  • Author(s): Satoshi Fukushima
  • Organizer: The 12th Asian Dermatological Congress
  • Int'l Joint Research / Invited
• [Presentation] Recent Progress in the treatment for non melanoma skin tumor (2022)
  • Author(s): Satoshi Fukushima
  • Organizer: The 12th Asian Dermatological Congress
  • Int'l Joint Research / Invited
• [Presentation] マクロファージと樹状細胞 これまでとこれから (2022)
  • Author(s): 福島聡
  • Organizer: 第50回日本臨床免疫学会総会
• [Presentation] メラノーマ新規治療の展望 腫瘍溶解性ウイルスとiPS細胞医薬 (2022)
  • Author(s): 福島聡
  • Organizer: 第60日本癌治療学会学術集会
• [Presentation] A Phase 1 Study of Safety/Efficacy of T-VEC in Unresectable Stage IIIB-IV Melanoma Patients in Japan (2021)
  • Author(s): Satoshi Fukushima, Taiki Isei, Yoshio Kiyohara, Hiroshi Koga, Takashi Kojima, Tatsuya Takenouchi, Kenji Yokota, Min Yi, Alissa Keegan,Naoya Yamazaki
  • Organizer: 第37回日本皮膚悪性腫瘍学会学術大会
• [Presentation] Efficacy of S-1 plus docetaxel chemotherapy in metastatic extramammary Paget’s disease (2021)
  • Author(s): Yui Hirano, Shigeto Matsushita, Kazuyasu Fujii, Ikko Kajihara, Megumi Aoki, Kentaro Yamamura, Koichi Tada, Takuro Kanekura, Jun Aoi, Satoshi Fukushima
  • Organizer: 10th world congress of melanoma /17th EADO congress
  • Int'l Joint Research
• [Presentation] Comparing the clinical efficacies of anti-PD-1 antibody monotherapy and anti-PD-1 and anti-CTLA-4 combination therapy as first-line immunotherapy in Japanese advanced acral melanoma: A retrospective, multicenter study (JAMP-neo study) (2021)
  • Author(s): Yasuhiro Nakamura, Satoshi Fukushima et al.
  • Organizer: ASCO Annual Meeting
  • Int'l Joint Research
• [Presentation] First-line anti-PD-1 antibody monotherapy versus anti-PD-1 plus anti-CTLA-4 combination therapy in Japanese mucosal melanoma: A retrospective, multicenter study (JMAC study) (2021)
  • Author(s): Yasuhiro Nakamura, Kenjiro Namikawa, Shusuke Yoshikawa, Yukiko Kiniwa, Takeo Maekawa, Osamu Yamasaki, Taiki Isei, Shigeto Matsushita, Motoo Nomura, Yasuo Nakai, Satoshi Fukushima et al.
  • Organizer: ESMO Congress 2021
  • Int'l Joint Research
• [Book] 皮膚悪性腫瘍（第二版）上 基礎と臨床の最新研究動向 Iメラノーマ 2. メラノーマの分類と病理組織学 （3）分子病理学およびゲノミクス (2021)
  • Author(s): 福島聡
  • Publisher: 日本臨床社