ADAMTS13 gene polymorphism genome editing creation of vascular endothelial cells and exploration for new leukemia therapies

• Project/Area Number: 21K08427
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: Aichi Medical University
• Principal Investigator: Akiyoshi Takami 愛知医科大学, 医学部, 教授 (80324078)
• Co-Investigator(Kenkyū-buntansha): 花村 一朗 愛知医科大学, 医学部, 教授 (70440740)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 白血病 / ゲノム編集 / 造血幹細胞移植 / 多発性骨髄腫 / 遺伝子多型 / 移植片対宿主病

Outline of Research at the Start

ADAMTS13遺伝子多型が、血管内皮細胞におけるADAMTS13誘導能と抗白血病効果にかかわる分子機序を、網羅的に解明する。本研究の成果は、白血病に対する新規分子標的薬の開発にとどまらず、病態特異的遺伝子多型が関わるがん診療全般や自己免疫疾患、感染免疫、臓器移植の分野にも貢献できると考える。

Outline of Final Research Achievements

This study analyzed TLR and ADAMTS13 gene polymorphisms in allogeneic hematopoietic stem cell transplantation. The UNC-93B1 polymorphism rs308328 significantly affected disease-free survival rates post-transplantation. The ADAMTS13 polymorphism rs2285489 was linked to reduced leukemia relapse, but attempts to modify endothelial cells through genome editing were unsuccessful. Introducing the FLT3-ITD gene into K562 cells using CRISPR-Cas9 increased CD52 expression, and alemtuzumab induced specific ADCC in these cells. ARK5 gene knockout in multiple myeloma cells caused mitochondrial fusion, unlike the fission seen in wild-type cells, highlighting ARK5's role in mitochondrial dynamics. These findings reveal critical genetic factors affecting transplant outcomes and suggest new therapeutic targets for leukemia and other malignancies.

Academic Significance and Societal Importance of the Research Achievements

本研究は、同種造血幹細胞移植における遺伝子多型の影響を解明し、移植後の無病生存率や白血病再発抑制に関連する遺伝子を特定した。特に、UNC-93B1およびADAMTS13遺伝子多型の解析により、移植後の治療効果予測と個別化医療の実現に貢献する可能性がある。また、FLT3-ITD遺伝子の導入やARK5遺伝子のノックアウトにより、新規治療標的を発見し、白血病および多発性骨髄腫の治療法開発に資する重要な知見を提供した。これらの成果は患者の予後改善に直結し、将来的な治療法の進展に寄与することが期待される。

Research Products

• [Journal Article] Pseudocarcinomatous Hyperplasia of the Nose and Necrotic Tracheitis Associated with Acute Myeloid Leukemia (2024)
  • Author(s): Kajikawa Shigehisa、Murakami Satsuki、Takami Akiyoshi、Satou Akira、Tsuzuki Toyonori、Ogisu Tomoyuki、Yonezawa Toshiyuki、Tanaka Hiroyuki、Kubo Akihito、Ito Satoru
  • Journal Title: Internal Medicine Volume: 63 Issue: 14 Pages: 2063-2067
  • DOI: 10.2169/internalmedicine.2625-23
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2024-07-15
  • Peer Reviewed
• [Journal Article] Allogeneic hematopoietic cell transplantation for acute myeloid leukemia with <i>BCR::ABL1</i> fusion (2024)
  • Author(s): Mizuno Shohei、Takami Akiyoshi、Kawamura Koji、Harada Kaito、Masayoshi Masuko、Yano Shingo、Ito Ayumu、Ozawa Yukiyasu、Ouchi Fumihiko、Ashida Takashi、Nawa Yuichiro、Ichinohe Tatsuo、Fukuda Takahiro、Atsuta Yoshiko、Yanada Masamitsu
  • Journal Title: eJHaem Volume: 5 Issue: 2 Pages: 369-378
  • DOI: 10.1002/jha2.877
  • Peer Reviewed
• [Journal Article] ARK5 enhances cell survival associated with mitochondrial morphological dynamics from fusion to fission in human multiple myeloma cells. (2024)
  • Author(s): Karnan S, Hanamura I, Ota A, Vu LQ, Uchino K, Horio T, Murakami S, Mizuno S, Rahman ML, Wahiduzzaman M, Hasan MN, Biswas M, Hyodo T, Ito H, Suzuki A, Konishi H, Tsuzuki S, Hosokawa Y, Takami A.
  • Journal Title: Cell Death Discov. Volume: 10(1):56. Issue: 1 Pages: 56-56
  • DOI: 10.1038/s41420-024-01814-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Nationwide prospective survey of secondary myelofibrosis in Japan: superiority of DIPSS-plus to MYSEC-PM as a survival risk model (2023)
  • Author(s): Shide K, Takenaka K, Kitanaka A, Numata A, Kameda T, Yamauchi T, Inagaki A, Mizuno S, Takami A, Ito S, Hagihara M, Usuki K, Maekawa T, Sunami K, Ueda Y, Tsutsui M, Ando M, Komatsu N, Ozawa K, Kurokawa M, Arai S, Mitani K, Akashi K, Shimoda K
  • Journal Title: Blood Cancer Journal Volume: 13 Issue: 1 Pages: 110-110
  • DOI: 10.1038/s41408-023-00869-9
  • Peer Reviewed / Open Access
• [Journal Article] Efficient detection of somatic UBA1 variants and clinical scoring system predicting patients with variants in VEXAS syndrome (2023)
  • Author(s): Maeda Ayaka、Tsuchida Naomi、Uchiyama Yuri、Horita Nobuyuki、Kobayashi Satoshi、Kishimoto Mitsumasa et al.
  • Journal Title: Rheumatology Volume: 63 Issue: 8 Pages: 2056
  • DOI: 10.1093/rheumatology/kead425
  • Peer Reviewed / Open Access
• [Journal Article] Autoimmune Thyroiditis Shifting from Hashimoto’s Thyroiditis to Graves’ Disease (2023)
  • Author(s): Daramjav Narantsatsral、Takagi Junko、Iwayama Hideyuki、Uchino Kaori、Inukai Daisuke、Otake Kazuo、Ogawa Tetsuya、Takami Akiyoshi
  • Journal Title: Medicina Volume: 59 Issue: 4 Pages: 757-757
  • DOI: 10.3390/medicina59040757
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Establishment of Mucoepidermoid Carcinoma Cell Lines from Surgical and Recurrence Biopsy Specimens (2023)
  • Author(s): Yamanaka S, Suzuki S, Ito H, Sivasundaram K, Hanamura I, Okubo I, Yoshikawa K, Ono S, Takahara T, Satou A, Tsuzuki T, Ueda R, Ogawa T, Fujimoto Y.
  • Journal Title: International journal of molecular sciences Volume: 24 Issue: 2 Pages: 1722-1722
  • DOI: 10.3390/ijms24021722
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of In Vitro Digestion on Anti-α-Amylase and Cytotoxic Potentials of Sargassum spp. (2022)
  • Author(s): Un Sovannary、Quan Nguyen Van、Anh La Hoang、Lam Vu Quang、Takami Akiyoshi、Khanh Tran Dang、Xuan Tran Dang
  • Journal Title: Molecules Volume: 27 Issue: 7 Pages: 2307-2307
  • DOI: 10.3390/molecules27072307
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Successful preventive treatment with cyclosporine in a patient with relapsed/refractory immune-mediated thrombotic thrombocytopenic purpura: a case report and review of the literature (2022)
  • Author(s): Uchino Kaori、Sakai Kazuya、Shinohara Saki、Matsuhisa Akifumi、Iida Yusuke、Nakano Yuta、Matsumura Saori、Kanasugi Jo、Takasugi Soichi、Nakamura Ayano、Horio Tomohiro、Murakami Satsuki、Mizuno Shohei、Yamamoto Hidesuke、Hanamura Ichiro、Matsumoto Masanori、Takami Akiyoshi
  • Journal Title: International Journal of Hematology Volume: 1 Issue: 2 Pages: 1-10
  • DOI: 10.1007/s12185-022-03319-7
  • Peer Reviewed
• [Journal Article] VEXAS syndrome (2022)
  • Author(s): Uchino Kaori、Kanasugi Jo、Enomoto Megumi、Kitamura Fumiya、Tsuchida Naomi、Uchiyama Yuri、Maeda Ayaka、Kirino Yohei、Matsumoto Naomichi、Takami Akiyoshi
  • Journal Title: International Journal of Hematology Volume: 116 Issue: 4 Pages: 463-464
  • DOI: 10.1007/s12185-022-03448-z
  • Peer Reviewed
• [Journal Article] Molecular Immunology in Hematological Disorders (2022)
  • Author(s): Takami Akiyoshi
  • Journal Title: International Journal of Molecular Sciences Volume: 23 Issue: 17 Pages: 9584-9584
  • DOI: 10.3390/ijms23179584
  • Peer Reviewed / Open Access
• [Journal Article] Anti-Diabetes, Anti-Gout, and Anti-Leukemia Properties of Essential Oils from Natural Spices Clausena indica, Zanthoxylum rhetsa, and Michelia tonkinensis (2022)
  • Author(s): Quan Nguyen Van、Anh La Hoang、Lam Vu Quang、Takami Akiyoshi、Teschke Rolf、Khanh Tran Dang、Xuan Tran Dang
  • Journal Title: Molecules Volume: 27 Issue: 3 Pages: 774-774
  • DOI: 10.3390/molecules27030774
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy and safety of modified BLd therapy for Japanese patients with transplant-ineligible multiple myeloma (2022)
  • Author(s): Murakami Satsuki、Hanamura Ichiro
  • Journal Title: International Journal of Hematology Volume: 116 Issue: 4 Pages: 563-569
  • DOI: 10.1007/s12185-022-03379-9
  • Peer Reviewed
• [Journal Article] Autologous hematopoietic cell transplantation for myeloma patients with hepatitis B virus or hepatitis C virus in the era of novel agents (2022)
  • Author(s): Mizuno Shohei、Takami Akiyoshi、Takamatsu Hiroyuki、Hanamura Ichiro、Shimazu Yutaka、Hangaishi Akira、Tsukada Nobuhiro、Kako Shinichi、Kikuchi Taku、Ota Shuichi、Shimizu Hiroaki、Iida Shinsuke、Yoshioka Satoshi、Sawa Masashi、Fukuda Takahiro、Kanda Yoshinobu、Atsuta Yoshiko、Kawamura Koji
  • Journal Title: Bone Marrow Transplantation Volume: 1 Issue: 5 Pages: 1-10
  • DOI: 10.1038/s41409-022-01640-7
  • Peer Reviewed
• [Journal Article] Favorable Outcome with Conditioning Regimen of Flu/Bu4/Mel in Acute Myeloid Leukemia Patients in Remission Undergoing Cord Blood Transplantation. (2022)
  • Author(s): Mizuno S, Takami A, Kawamura K, Shimomura Y, Arai Y, Konuma T, Ozawa Y, Sawa M, Ota S, Takahashi S, Anzai N, Hiramoto N, Onizuka M, Nakamae H, Tanaka M, Murata M, Kimura T, Kanda J, Fukuda T, Atsuta Y, Yanada M.
  • Journal Title: Transplant Cell Ther Volume: 28 Issue: 11 Pages: 775.e1-775.e9
  • DOI: 10.1016/j.jtct.2022.07.026
  • Peer Reviewed
• [Journal Article] Final analysis of randomized phase II study optimizing melphalan, prednisolone, bortezomib in multiple myeloma (JCOG1105) (2022)
  • Author(s): Maruyama D, Iida S, Machida R, Kusumoto S, Fukuhara N, Yamauchi N, Miyazaki K, Yoshimitsu M, Kuroda J, Tsukamoto N, Tsujimura H, Usuki K, Yamauchi T, Utsumi T, Mizuno I, Takamatsu Y, Nagata Y, Ota S, Ohtsuka E, Hanamura I, Suzuki Y, Yoshida S, Yamasaki S, Suehiro Y, Kamiyama Y, Fukuhara S, Tsukasaki K, Nagai H.
  • Journal Title: Cancer Science Volume: 113 Issue: 9 Pages: 3267-3270
  • DOI: 10.1111/cas.15484
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy of a 365?nm Ultraviolet A1 light Emitting Diode (UVA1‐LED) in <i>in?vitro</i> Extracorporeal Photopheresis (2022)
  • Author(s): Maeda Akira、Yamamoto Riho、Mizuno Shohei、Miki Shigeichiro、Sakamoto Yasuhiro、Kogata Shuhei、Toyama Chiyoshi、Sato Kazuki、Okamatsu Chizu、Ando Takanori、Iida Minako、Watsuji Toru、Sato Toshinobu、Miyagawa Shuji、Okuyama Hiroomi、Takami Akiyoshi、Kodera Yoshitaka
  • Journal Title: Photochemistry and Photobiology Volume: 1 Issue: 5 Pages: 1-10
  • DOI: 10.1111/php.13613
  • Peer Reviewed
• [Journal Article] Cytotoxicity of Callerya speciosa Fractions against Myeloma and Lymphoma Cell Lines (2022)
  • Author(s): Lam Vu Quang、Anh La Hoang、Quan Nguyen Van、Xuan Tran Dang、Hanamura Ichiro、Uchino Kaori、Karnan Sivasundaram、Takami Akiyoshi
  • Journal Title: Molecules Volume: 27 Issue: 7 Pages: 2322-2322
  • DOI: 10.3390/molecules27072322
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Donor lymphocyte infusion after haploidentical hematopoietic stem cell transplantation for acute myeloid leukemia (2022)
  • Author(s): Harada Kaito、Mizuno Shohei、Yano Shingo、Takami Akiyoshi、Ishii Hiroto、Ikegame Kazuhiro、Najima Yuho、Kako Shinichi、Ashida Takashi、Shiratori Souichi、Ota Shuichi、Onizuka Makoto、Fukushima Kentaro、Fukuda Takahiro、Ichinohe Tatsuo、Atsuta Yoshiko、Yanada Masamitsu
  • Journal Title: Annals of Hematology Volume: 101 Issue: 3 Pages: 643-653
  • DOI: 10.1007/s00277-021-04731-5
  • Peer Reviewed
• [Journal Article] Multiple myeloma with high-risk cytogenetics and its treatment approach (2022)
  • Author(s): Hanamura Ichiro
  • Journal Title: International Journal of Hematology Volume: 115 Issue: 6 Pages: 762-777
  • DOI: 10.1007/s12185-022-03353-5
  • Peer Reviewed
• [Journal Article] Cytotoxic Mechanism of Momilactones A and B against Acute Promyelocytic Leukemia and Multiple Myeloma Cell Lines (2022)
  • Author(s): Anh La Hoang、Lam Vu Quang、Takami Akiyoshi、Khanh Tran Dang、Quan Nguyen Van、Xuan Tran Dang
  • Journal Title: Cancers Volume: 14 Issue: 19 Pages: 4848-4848
  • DOI: 10.3390/cancers14194848
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Impact of NLRP3 Activation on Hematopoietic Stem Cell Transplantation (2021)
  • Author(s): Espinoza J. Luis、Kamio Kosuke、Lam Vu Quang、Takami Akiyoshi
  • Journal Title: International Journal of Molecular Sciences Volume: 22 Issue: 21 Pages: 11845-11845
  • DOI: 10.3390/ijms222111845
  • Peer Reviewed / Open Access
• [Journal Article] CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia (2021)
  • Author(s): Karnan Sivasundaram、Hanamura Ichiro、Uchino Kaori、Murakami Satsuki、Wahiduzzaman Md、Quang Vu Lam、Rahman Md Lutfur、Hasan Muhammad Nazmul、Hyodo Toshinori、Konishi Hiroyuki、Tsuzuki Shinobu、Yoshikawa Kazuhiro、Suzuki Susumu、Ueda Ryuzo、Ejiri Masayuki、Hosokawa Yoshitaka、Takami Akiyoshi
  • Journal Title: Cell Death Discovery Volume: 7 Issue: 1 Pages: 1-10
  • DOI: 10.1038/s41420-021-00446-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparison of Transplantation Outcomes after Foscarnet and Ganciclovir Administration as First-Line Anti-Cytomegalovirus Preemptive Therapy (2021)
  • Author(s): Miyao K, Terakura S, Ozawa Y, Sawa M, Kohno A, Kasahara S, Iida H, Ino K, Kusumoto S, Kasai M, Takami A, Kurahashi S, Kajiguchi T, Morishita T, Nishida T, Murata M; Nagoya Blood and Marrow Transplantation Group.
  • Journal Title: Transplant Cell Ther Volume: 27(4) Issue: 4 Pages: 342.e1-342.e10
  • DOI: 10.1016/j.jtct.2020.12.012
  • Peer Reviewed
• [Journal Article] Allogeneic Hematopoietic Cell Transplantation for Adolescent and Young Adult Patients with Acute Myeloid Leukemia (2021)
  • Author(s): Mizuno Shohei、Takami Akiyoshi、Kawamura Koji、Arai Yasuyuki、Kondo Tadakazu、Kawata Takahito、Uchida Naoyuki、Marumo Atsushi、Fukuda Takahiro、Tanaka Masatsugu、Ozawa Yukiyasu、Yoshida Shuro、Ota Shuichi、Takada Satoru、Sawa Masashi、Onizuka Makoto、Kanda Yoshinobu、Ichinohe Tatsuo、Atsuta Yoshiko、Yanada Masamitsu
  • Journal Title: Transplantation and Cellular Therapy Volume: 27 Issue: 4 Pages: 314.e1-314.e10
  • DOI: 10.1016/j.jtct.2020.12.013
  • Peer Reviewed
• [Journal Article] Allogeneic hematopoietic cell transplantation efficacy in patients with Philadelphia chromosome-positive acute myeloid leukemia in complete remission (2021)
  • Author(s): Mizuno Shohei、Yanada Masamitsu、Kawamura Koji、Masuko Masayoshi、Uchida Naoyuki、Ozawa Yukiyasu、Iwato Koji、Ohashi Kazuteru、Ikegame Kazuhiro、Kim Sung-Won、Tanaka Masatsugu、Eto Tetsuya、Kanda Yoshinobu、Fukuda Takahiro、Atsuta Yoshiko、Yano Shingo、Takami Akiyoshi
  • Journal Title: Bone Marrow Transplantation Volume: 56 Issue: 1 Pages: 232-242
  • DOI: 10.1038/s41409-020-01011-0
  • Peer Reviewed
• [Journal Article] Synergistic Effects of Venetoclax and Daratumumab on Antibody-Dependent Cell-Mediated Natural Killer Cytotoxicity in Multiple Myeloma (2021)
  • Author(s): Nakamura Ayano、Suzuki Susumu、Kanasugi Jo、Ejiri Masayuki、Hanamura Ichiro、Ueda Ryuzo、Seto Masao、Takami Akiyoshi
  • Journal Title: International Journal of Molecular Sciences Volume: 22 Issue: 19 Pages: 10761-10761
  • DOI: 10.3390/ijms221910761
  • Peer Reviewed / Open Access
• [Journal Article] Immunological and Preventive Effects of Hochuekkito and Kakkonto Against Coronavirus Disease in Healthcare Workers: A Retrospective Observational Study (2021)
  • Author(s): Ogawa-Ochiai Keiko、Ishikawa Hideki、Li Hongyang、Vu Quang Lam、Kimoto Izumi、Takamura Mitsuyuki、Hongawa Tetsuya、Hane Yasuyuki、Suzuki Susumu、Okajima Masaki、Mori Keita、Ito Masanori、Takami Akiyoshi
  • Journal Title: Frontiers in Pharmacology Volume: 12 Pages: 1-10
  • DOI: 10.3389/fphar.2021.766402
  • Peer Reviewed / Open Access
• [Journal Article] Primary cutaneous methotrexate-associated B-cell lymphoproliferative disorders other than EBV-positive mucocutaneous ulcer: clinical, pathological, and immunophenotypic features (2021)
  • Author(s): Satou Akira、Banno Shogo、Kohno Kei、Takahara Taishi、Takahashi Emiko、Nobata Hironobu、Iwagaitsu Shiho、Watanabe Daisuke、Hanamura Ichiro、Takami Akiyoshi、Ito Yasuhiko、Nakamura Shigeo、Tsuzuki Toyonori
  • Journal Title: Pathology Volume: - Issue: 5 Pages: 595-601
  • DOI: 10.1016/j.pathol.2020.10.019
  • Peer Reviewed / Open Access
• [Journal Article] Pretreatment Immature Platelet Fraction as a Surrogate of Reticulated Platelets Predicts the Response to Corticosteroids in Adults with Immune Thrombocytopenia (2021)
  • Author(s): Takami Akiyoshi、Mizuno Shohei、Nakamura Ayano、Kanasugi Jo、Yamamoto Hidesuke、Vu?Quang Lam、Nakagami Yuya、Nakano Yuta、Yamada Saki、Matsumura Saori、Takasugi Souichi、Uchino Kaori、Horio Tomohiro、Murakami Satsuki、Oohigashi Yuka、Nakayama Takayuki、Tani Hiroya、Enomoto Megumi、Hanamura Ichiro
  • Journal Title: Acta Haematologica Volume: 144 Issue: 3 Pages: 345-349
  • DOI: 10.1159/000510460
  • Peer Reviewed / Open Access
• [Journal Article] Reference intervals of red blood cell parameters and platelet count for healthy adults in Japan (2021)
  • Author(s): Takami Akiyoshi、Watanabe Shinichiro、Tohyama Kaoru、On behalf of The Japanese Society for Laboratory Hematology Standardization Committee (JSLH-SC) and Joint Working Group of the JSLH and the Japanese Association of Medical Technologists (JWG-JSLH-JAMT).
  • Journal Title: International Journal of Hematology Volume: 114 Issue: 3 Pages: 373-380
  • DOI: 10.1007/s12185-021-03166-y
  • Peer Reviewed
• [Journal Article] Reference intervals of white blood cell parameters for healthy adults in japan (2021)
  • Author(s): Takami Akiyoshi、Watanabe Shinichiro、Tohyama Kaoru、The Japanese Society for Laboratory Hematology subcommittee on Standardization of Blood Cell Morphology (JSLH‐SBCM)
  • Journal Title: International Journal of Laboratory Hematology Volume: 43 Issue: 5 Pages: 948-958
  • DOI: 10.1111/ijlh.13486
  • Peer Reviewed
• [Journal Article] Cytopenia associated with copper deficiency (2021)
  • Author(s): Uchino Kaori、Quang Lam Vu、Enomoto Megumi、Nakano Yuta、Yamada Saki、Matsumura Saori、Kanasugi Jo、Takasugi Soichi、Nakamura Ayano、Horio Tomohiro、Murakami Satsuki、Goto Mineaki、Mizuno Shohei、Yamamoto Hidesuke、Watarai Masaya、Hanamura Ichiro、Takami Akiyoshi
  • Journal Title: eJHaem Volume: 2 Issue: 4 Pages: 729-737
  • DOI: 10.1002/jha2.278
  • Peer Reviewed / Open Access
• [Journal Article] Donor UNC-93 Homolog B1 genetic polymorphism predicts survival outcomes after unrelated bone marrow transplantation. (2021)
  • Author(s): Uchino K, Vu Quang L, Mizuno S, Horio T, Yamamoto H, Hanamura I, Kodera Y, Luis Espinoza J, Onizuka M, Kashiwase K, Morishima Y, Fukuda T, Doki N, Miyamura K, Mori T, Morishita E, Nakao S, Takami A
  • Journal Title: Genes and Immunity Volume: 24 Issue: 1 Pages: 1-9
  • DOI: 10.1038/s41435-021-00122-y
  • Peer Reviewed / Open Access
• [Presentation] Phase 1/2 Study of TP-3654, a Selective PIM1 Kinase Inhibitor: Preliminary Data Showed Clinical Activity and Cytokine Reductions in Relapsed/Refractory Myelofibrosis Patients (2023)
  • Author(s): Rein LAM, Takami A, et al.
  • Organizer: American Society of Hematology meeting
  • Int'l Joint Research
• [Presentation] MPN-439 Preliminary Data From the Phase 1/2 Study of TP-3654, an Investigational Selective PIM1 Kinase Inhibitor, Showed Cytokine Reduction and Clinical Responses in Relapsed/Refractory Myelofibrosis (MF). (2023)
  • Author(s): El Chaer F, Takami A, et al.
  • Organizer: The Society of Hematologic Oncology 2023 Annual Meeting
  • Int'l Joint Research
• [Presentation] Preliminary Data from the Phase 1/2 Study of Tp-3654, an Investigational Selective Pim1 Kinase Inhibitor, Showed Cytokine Reduction and Clinical Responses in Relapsed/Refractory Myelofibrosis. (2023)
  • Author(s): El Chaer F, Takami A, et al.
  • Organizer: European Hematology Association Congress
  • Int'l Joint Research
• [Presentation] 肝炎ウィルス(HBV、HCV)感染を伴う多発性骨髄腫患者の自家造血細胞移植成績 (2021)
  • Author(s): 水野昌平、高見昭良、花村一朗、河村浩二、島津裕、半下石明、塚田信弘、賀古真一、菊池拓、太田秀一、土岐典子、飯田真介、吉岡聡、澤正吏、福田隆浩、神田善伸、熱田由子、高松博幸
  • Organizer: 第83回日本血液学会学術集会
• [Presentation] メトトレキサート関連リンパ増殖性疾患（ホジキンリンパ腫）の検討 (2021)
  • Author(s): 村上五月, 坂野章吾, 佐藤啓, 花村一朗, 山本英督, 水野昌平, 堀尾知弘, 内野かおり, 高見昭良
  • Organizer: 第83回日本血液学会学術集会
• [Presentation] メトトレキサート関連リンパ増殖性疾患（ホジキンリンパ腫）の検討 (2021)
  • Author(s): 村上五月、坂野章吾、花村一朗、高見昭良
  • Organizer: 第61回リンパ網内系学会
• [Presentation] ベネトクラクスは BCL2 高発現の多発性骨髄腫細胞株に対するダラツムマブの抗体依存性細胞傷害活性を増強させる (2021)
  • Author(s): 中村文乃、鈴木進、瀬戸加大、高杉壮一、金杉丈、花村一朗、上田龍三、高見昭良
  • Organizer: 第46回日本骨髄腫学会学術集会
• [Presentation] 再発難治性血栓性血小板減少性紫斑病患者におけるシクロスポリンの有用性 (2021)
  • Author(s): 内野かおり 山田早紀 中野雄太 松村沙織 金杉丈 高杉壮一 中村文乃 村上五月 堀尾知弘 水野昌平 山本英督 花村一朗 酒井和哉 松本雅則 高見昭良
  • Organizer: 第83回日本血液学会学術集会
• [Presentation] 赤芽球癆を合併した血管免疫芽球性T細胞リンパ腫 (2021)
  • Author(s): 堀尾知弘 水野昌平 内野かおり 山本英督 村上五月 高杉壮一 中村文乃 金杉丈 松村沙織 中野雄太 花村一朗 高見昭良
  • Organizer: 第83回日本血液学会学術集会