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IgG4関連腎臓病における三次リンパ組織形成を介した病変進展と線維化機序の解明

Research Project

Project/Area Number 21K08473
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 54020:Connective tissue disease and allergy-related
Research InstitutionKanazawa University

Principal Investigator

川野 充弘  金沢大学, 医学系, 協力研究員 (20361983)

Co-Investigator(Kenkyū-buntansha) 柳田 素子  京都大学, 医学研究科, 教授 (70378769)
山田 和徳  金沢医科大学, 医学部, 教授 (90397224)
Project Period (FY) 2021-04-01 – 2025-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
KeywordsIgG4関連疾患 / IgG4関連腎臓病 / 花筵状線維化 / 三次リンパ組織 / Lat Y136F変異マウス / 線維化
Outline of Research at the Start

IgG4関連疾患における三次リンパ組織の役割については、リンパ濾胞が多数認められる涙腺や唾液腺病変に関して注目されていたが、リンパ濾胞の形成がほとんど認められない腎臓に着目した研究はなく意義不明であった。我々は、早期のIgG4関連腎臓病患者の腎摘出標本から、早期の腎病変進展もリンパ濾胞形成から始まることを見出した。本研究では、IgG4関連疾患の典型臓器病変の一つである腎病変において、病変進展と線維化促進に関与するリンパ濾胞の役割に着目し、リンパ濾胞内でのB細胞と線維芽細胞のクロストークの結果として起こる花筵状線維化形成機序をヒトの病理標本及びLat Y136Fマウスを使って解明する。

Outline of Annual Research Achievements

IgG4関連疾患における三次リンパ組織(リンパ濾胞: TLT)の役割については、リンパ濾胞が多数認められる涙腺や唾液腺病変に関して注目が集まっており、発症機序に関する基礎的研究が行われている。しかしながら、リンパ濾胞の形成がほとんど認められない腎臓に着目した研究はなく意義は不明である。本研究では、ヒト腎生検組織及びIgG4関連疾患モデルマウスを用いて、本疾患の典型臓器病変の一つである腎病変における病変進展と線維化促進に関与するリンパ濾胞の役割を明らかにする。
1.ヒト腎臓病理組織標本を用いたTLTの形成頻度の検討:ヒトIgG4関連尿細管間質性腎炎(IgG4-TIN)13例、コントロール11例(特発性間質性腎炎6例、薬剤性間質性腎炎3例、シェーグレン症候群の間質性腎炎1例、サルコイドーシスの間質性腎炎1例)に免疫染色を行い、TLTの形成に差があるかを比較検討した。TLTは、「Ki-67陽性細胞を含むCD20陽性細胞とCD3陽性細胞の密な集簇」と定義した。IgG4関連尿細管間質性腎炎のadvanced stage TLTは単位面積当たり0.27(IQR 0.09-
0.48)であり、コントロール群の0.00 (IQR 0.00-0.07)に比して有意に多かった(p=0.028)。さらに、IgG4-TINにおいて、advanced stage TLTの単位面積あたりの数はstoriform fibrosis の形成の程度と有意な性の相関を示した(p=0.007, R2=0.67)。
2.IgG4-RDの動物モデルであるLat Y136F変異マウスにTLT産生誘導の刺激を加えることによるIgG4関連尿細管間質性腎炎及び線維化形成機序の検討:IgG4-RDの動物モデルとしてLat Y136F変異マウスを用い、TLTを誘発する刺激として、片腎虚血再灌流による急性腎傷害誘発モデル、アデニンを用いた間質性腎炎誘発モデル(アデニン腎炎モデル)をそれぞれ5匹作成した。しかしながら、コントロールのLat Y136F変異マウスと比較してTLT形成を誘発する事はできなかった。

Current Status of Research Progress
Current Status of Research Progress

4: Progress in research has been delayed.

Reason

やっとLat Y136F変異マウスが実験に必要な数だけ生まれ、片腎虚血再灌流による急性腎傷害誘発モデル、アデニンを用いた間質性腎炎誘発モデル(アデニン腎炎モデル)をそれぞれ5匹作成したが、当初の想定に反して三次リンパ組織の形成率は、何も処置していないLat Y136F変異マウスと比較して差が認められなかった。理由として、Lat Y136F変異マウスの寿命が短いこと、片腎虚血再灌流による急性腎傷害誘発モデル、アデニンを用いた間質性腎炎誘発モデル(アデニン腎炎モデル)によるTLT形成には加齢の要素も重要であることから、今回、うまくいかなかった可能性が考えられた。現在、Lat Y136F変異マウスを用いた新たな研究計画を考案中である。

Strategy for Future Research Activity

現在、Lat Y136F変異マウスを用いた新たな研究計画を考案中である。

Report

(3 results)
  • 2023 Research-status Report
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (46 results)

All 2024 2023 2022 2021 2020

All Journal Article (22 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 22 results,  Open Access: 14 results) Presentation (24 results) (of which Int'l Joint Research: 6 results,  Invited: 11 results)

  • [Journal Article] Pediatric IgG4-related disease: a descriptive review.2024

    • Author(s)
      Hara S, Yoshida M, Sanada H, Suzuki Y, Sato Y, Mizushima I, Kawano M.
    • Journal Title

      Expert Rev Clin Immunol

      Volume: 20 Issue: 1 Pages: 97-119

    • DOI

      10.1080/1744666x.2023.2274358

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] High serum IgA levels in patients with IgG4-related disease are associated with mild inflammation, sufficient disease-specific features, and favourable responses to treatments.2024

    • Author(s)
      Tsuge S, Mizushima I, Horita M, Kawahara H, Sanada H, Yoshida M, Takahashi Y, Zoshima T, Nishioka R, Hara S, Suzuki Y, Ito K, Kawano M.
    • Journal Title

      Mod Rheumatol

      Volume: 34 Issue: 3 Pages: 621-631

    • DOI

      10.1093/mr/road056

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] PLA2R-positive membranous nephropathy in IgG4-related disease2024

    • Author(s)
      Ushio Y, Akihisa T, Karasawa K, Seki M, Kobayashi S, Miyabe Y, Kataoka H, Ito N, Taneda S, Akiyama S, Hebisawa A, Kawano M, Honda K, Hoshino J.
    • Journal Title

      BMC Nephrol.

      Volume: 25(1) Issue: 1 Pages: 66-71

    • DOI

      10.1186/s12882-024-03511-3

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of?immunoglobulin G4?related retroperitoneal fibrosis and?hypophysitis with antecedent respiratory disease followed by spontaneous remission and?recurrence2023

    • Author(s)
      Sakai Masato、Ohno Yuta、Kozuki Nana、Kawasaki Yuki、Yoshida Michiko、Ikeda Hiroyuki、Konishi Junji、Maeda Toshiki、Sugano Motoki、Kawakami Satoshi、Ito Isao、Yamaguchi Aina、Naiki Hironobu、Notohara Kenji、Akamizu Takashi、Kawano Mitsuhiro、Yoshida Haruyoshi
    • Journal Title

      Modern Rheumatology Case Reports

      Volume: 8 Issue: 1 Pages: 163-171

    • DOI

      10.1093/mrcr/rxad040

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Solitary recurrence of IgG4-related giant coronary aneurysm: Case report and review of the literature focusing on treatment strategies and complications.2023

    • Author(s)
      Kawahara H, Mizushima I, Matsumoto Y, Sakata K, Takamura M, Inoue D, Kasashima S, Kawano M.
    • Journal Title

      Mod Rheumatol Case Rep

      Volume: 8 Issue: 1 Pages: 182-194

    • DOI

      10.1093/mrcr/rxad065

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results2023

    • Author(s)
      Koshida Aoi、Karashima Shigehiro、Ogura Kohei、Miyajima Yuna、Ogai Kazuhiro、Mizoguchi Ren、Ikagawa Yasuo、Hara Satoshi、Mizushima Ichiro、Fujii Hiroshi、Kawano Mitsuhiro、Tsujiguchi Hiromasa、Hara Akinori、Nakamura Hiroyuki、Okamoto Shigefumi
    • Journal Title

      Frontiers in Cellular and Infection Microbiology

      Volume: 13 Pages: 1272398-1272398

    • DOI

      10.3389/fcimb.2023.1272398

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improved Renal Function in Initial Treatment Improves Patient Survival, Renal Outcomes, and Glucocorticoid-Related Complications in IgG4-Related Kidney Disease in Japan.2023

    • Author(s)
      Mizushima I, Saeki T, Kobayashi D, Sawa N, Hayashi H, Taniguchi Y, Nakata H, Yamada K, Matsui S, Yasuno T, Masutani K, Nagasawa T, Takahashi H, Ubara Y, Yanagita M, Kawano M.
    • Journal Title

      Kidney Int Rep

      Volume: 9 Issue: 1 Pages: 52-63

    • DOI

      10.1016/j.ekir.2023.10.016

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of risk factors for elevated serum IgG4 levels in subjects in a large-scale health checkup cohort study2023

    • Author(s)
      Tsuji Yoshika、Koga Tomohiro、Nonaka Fumiaki、Nobusue Kenichi、Kawashiri Shin-ya、Yamanashi Hirotomo、Maeda Takahiro、Arima Kazuhiko、Aoyagi Kiyoshi、Takahashi Meiko、Kawaguchi Shuji、Matsuda Fumihiko、Fujii Hiroshi、Kawano Mitsuhiro、Nakamura Hiroyuki、Kawakami Atsushi、Tamai Mami
    • Journal Title

      Frontiers in Immunology

      Volume: 14 Pages: 1124417-1124417

    • DOI

      10.3389/fimmu.2023.1124417

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of clinicopathological features between patients with and without hypocomplementemia in IgG4-related kidney disease2023

    • Author(s)
      Saeki T, Nagasawa T, Ubara Y, Taniguchi Y, Yanagita M, Nishi S, Nagata M, Yamaguchi Y, Saito T, Nakashima H, Kawano M
    • Journal Title

      Nephrology Dialysis Transplantation

      Volume: 38 Issue: 4 Pages: 1053-1056

    • DOI

      10.1093/ndt/gfac317

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterogeneity of antibody-secreting cells infiltrating autoimmune tissues2023

    • Author(s)
      Giovannini Diane、Belbezier Aude、Baillet Athan、Bouillet Laurence、Kawano Mitsuhiro、Dumestre-Perard Chantal、Clavarino Giovanna、Noble Johan、Pers Jacques-Olivier、Sturm Nathalie、Huard Bertrand
    • Journal Title

      Frontiers in Immunology

      Volume: 14 Pages: 1111366-1111366

    • DOI

      10.3389/fimmu.2023.1111366

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clues to mortality trends and their related factors in IgG4-related disease: A Japanese single-centre retrospective study2022

    • Author(s)
      Kawahara Hiroyuki、Mizushima Ichiro、Tsuge Shunsuke、Shin Seung、Yoshinobu Takahiro、Hoshiba Ryohei、Nishioka Ryo、Zoshima Takeshi、Hara Satoshi、Ito Kiyoaki、Kawano Mitsuhiro
    • Journal Title

      Modern Rheumatology

      Volume: - Issue: 6 Pages: 1154-1161

    • DOI

      10.1093/mr/roac132

    • Related Report
      2023 Research-status Report
    • Peer Reviewed
  • [Journal Article] Olfactory dysfunction in LATY136F knock-in mice2022

    • Author(s)
      Kaneda Misako、Yagi-Nakanishi Sayaka、Ozaki Fumi、Kondo Satoru、Mizuguchi Keishi、Kawano Mitsuhiro、Malissen Marie、Malissen Bernard、Yamada Kazunori、Yoshizaki Tomokazu
    • Journal Title

      Auris Nasus Larynx

      Volume: 49 Issue: 2 Pages: 209-214

    • DOI

      10.1016/j.anl.2021.07.009

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Amendment of the Japanese consensus guidelines for autoimmune pancreatitis, 20202022

    • Author(s)
      Okazaki K、Kawa S、Kamisawa T、Ikeura T、Itoi T、Ito T、Inui K、Irisawa A、Uchida K、Ohara H、Kubota K、Kodama Y、Shimizu K、Tonozuka R、Nakazawa T、Nishino T、Notohara Ki、Fujinaga Y、Masamune A、Yamamoto H、Watanabe T、Nishiyama T、Kawano M、Shiratori K、Shimosegawa T、Takeyama Y.
    • Journal Title

      Journal of Gastroenterology

      Volume: 57 Issue: 4 Pages: 225-245

    • DOI

      10.1007/s00535-022-01857-9

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nationwide Epidemiological survey of IgG4-related disease with malignancy in Japan2022

    • Author(s)
      Sumitomo K, Uchida K, Ikeura T, Hirano K, Yamamoto M, et al.
    • Journal Title

      J Gastroenterol Hepatol

      Volume: - Issue: 6 Pages: 1022-1033

    • DOI

      10.1111/jgh.15809

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent advances in IgG4-related kidney disease2022

    • Author(s)
      Kawano Mitsuhiro、Saeki Takako、Ubara Yoshifumi、Matsui Shoko
    • Journal Title

      Modern Rheumatology

      Volume: 33 Issue: 2 Pages: 242-251

    • DOI

      10.1093/mr/roac065

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lacrimal Gland and Orbital Lesions in Lat<sup>Y136F</sup> Knock-in Mice, a Model for Human IgG4-Related Ophthalmic Disease2022

    • Author(s)
      Hamaoka Shoko、Takahira Masayuki、Kawano Mitsuhiro、Yamada Kazunori、Ito Kiyoaki、Okuda Tetsuhiko、Hatake Sachiyo、Malissen Marie、Malissen Bernard、Sugiyama Kazuhisa
    • Journal Title

      Current Eye Research

      Volume: 47 Issue: 10 Pages: 1402-1409

    • DOI

      10.1080/02713683.2022.2103152

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Development of IgG4-related pancreatitis and kidney disease 7?years after the onset of undiagnosed lymphadenopathy: A case report2022

    • Author(s)
      Yoshida Misaki、Mizushima Ichiro、Tsuge Shunsuke、Takahashi Yoshinori、Zoshima Takeshi、Nishioka Ryo、Hara Satoshi、Ito Kiyoaki、Kawano Mitsuhiro
    • Journal Title

      Modern Rheumatology Case Reports

      Volume: 7 Issue: 1 Pages: 192-196

    • DOI

      10.1093/mrcr/rxac065

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of two or more sets of lacrimal glands and/or major salivary glands is related to greater systemic disease activity due to multi-organ involvement in IgG4-related dacryoadenitis/sialadenitis2021

    • Author(s)
      Takahashi Y, Mizushima I, Konishi M, Kawahara H, Sanada H, Suzuki K, Takeji A, Hara S, Ito K, Fujii H, Kawano M.
    • Journal Title

      Mod Rheumatol.

      Volume: 11 Issue: 6 Pages: 1-10

    • DOI

      10.1080/14397595.2021.1878623

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum IgG4 levels at diagnosis can predict unfavorable outcomes of untreated patients with IgG4-related disease2021

    • Author(s)
      Mizushima Ichiro、Konishi Masahiro、Sanada Hajime、Suzuki Kazuyuki、Takeji Akari、Zoshima Takeshi、Hara Satoshi、Ito Kiyoaki、Fujii Hiroshi、Yamada Kazunori、Kawano Mitsuhiro
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 13341-13341

    • DOI

      10.1038/s41598-021-92814-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Renal Involvement in Retroperitoneal Fibrosis: Prevalence, Impact and Management Challenges2021

    • Author(s)
      Mizushima Ichiro、Kawano Mitsuhiro
    • Journal Title

      International Journal of Nephrology and Renovascular Disease

      Volume: Volume 14 Pages: 279-289

    • DOI

      10.2147/ijnrd.s239160

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pathogenic roles and therapeutic potential of the CCL8-CCR8 axis in a murine model of IgG4-related sialadenitis2021

    • Author(s)
      Honda Fumika、Tsuboi Hiroto、Ono Yuko、Abe Saori、Takahashi Hiroyuki、Ito Kiyoaki、Yamada Kazunori、Kawano Mitsuhiro、Kondo Yuya、Asano Kenichi、Tanaka Masato、Malissen Marie、Malissen Bernard、Matsumoto Isao、Sumida Takayuki
    • Journal Title

      Arthritis Research & Therapy

      Volume: 23 Issue: 1 Pages: 214-214

    • DOI

      10.1186/s13075-021-02597-6

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Positive disease-specific autoantibodies have limited clinical significance in diagnosing IgG4-related disease in daily clinical practice2020

    • Author(s)
      Ichiro Mizushima 1, Takahiro Yamano 1, Hiroyuki Kawahara 1, Shinya Hibino 1, Ryo Nishioka 1, Takeshi Zoshima 1, Satoshi Hara 1, Kiyoaki Ito 1, Hiroshi Fujii 1, Hideki Nomura 2, Mitsuhiro Kawano 1
    • Journal Title

      Rheumatology (Oxford)

      Volume: 12 Issue: 7 Pages: 3317-3325

    • DOI

      10.1093/rheumatology/keaa783

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Update in IgG4‐related disease ; recent pathogenetic and therapeutic advances2024

    • Author(s)
      Kawano M
    • Organizer
      . Advances in Targeted Therapies 2024 (Spain)
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] IgG4関連疾患・キャッスルマン病・TAFRO症候群のupdate2023

    • Author(s)
      川野充弘
    • Organizer
      第67回日本リウマチ学会総会・学術集会
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] Revisiting malignant lymphoma in Sjogren’s disease2023

    • Author(s)
      Kawano M
    • Organizer
      APLAR Ground Round
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] IgG4-Related Disease: update2023

    • Author(s)
      Kawano M
    • Organizer
      RheumaAlex 2023 (Egypt)
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] 低補体血症の有無によるIgG4関連腎臓病 (IgG4-RKD) の臨床・腎臓病理所見の違い2022

    • Author(s)
      佐伯敬子、長澤将、乳原善文、谷口義典、柳田素子、西慎一、長田道夫、山口裕、斉藤喬雄、中島衡、川野充弘
    • Organizer
      第66回日本リウマチ学会総会・学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 住民検診データを用いた一般人口における血清IgG4高値に関わる因子とIgG4関連疾患発症に関する検討2022

    • Author(s)
      柘植俊介、藤井博、玉井慎美、水島伊知郎、吉田美咲、鈴木信博、高橋芳徳、竹治明梨、堀田成人、藤澤雄平、松永貴弘、蔵島乾、西岡亮、額裕海、原怜史、谷悠紀子、鈴木康倫、伊藤清亮、山田和徳、中崎聡、池田啓、中島裕史、川上純、川野充弘
    • Organizer
      第66回日本リウマチ学会総会・学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] IgG4関連疾患における死亡率とその関連因子の検討2022

    • Author(s)
      川原寛之、水島伊知郎、柘植俊介、小市真琴、眞田創、吉田美咲、高橋芳徳、西岡亮、蔵島乾、原怜史、伊藤清亮、川野充弘
    • Organizer
      第66回日本リウマチ学会総会・学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] Immunoglobulin G4-related kidney disease’s predisposition to chronic renal dysfunction, complications of malignancy, and mortality: a long-term nationwide multicenter study in Japan2022

    • Author(s)
      Mizushima I, Saeki T, Kobayashi D, Hayashi H, Taniguchi Y, Nakata H, Matsui S, Nagasawa T, Yanagita M, Kawano M
    • Organizer
      EULAR 2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Factors related to serum IgG4 elevation and development of IgG4-related disease: data from resident examination2022

    • Author(s)
      Tsuge S, Fujii H, Tamai M, Mizushima I, Yoshida M, Suzuki N, Takahashi Y, Takeji A, Horita S, Fujisawa Y, Matsunaga T, Zoshima T, Nishioka R, Nuka H, Hara S, Tani Y, Suzuki Y, Ito K, Yamada K, Nakazaki S, Kawakami A, Kawano M
    • Organizer
      EULAR 2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Comparison of clinicopathological features between patients with and without hypocomplementemia in IgG4-related kidney disease (IgG4-RKD): a multi-center study by the Japanese Society of Nephrology IgG4-RKD working group2022

    • Author(s)
      Saeki T, Nagasawa T, Ubara Y, Taniguchi Y, Yanagita M, Nishi S, Nagata M, Yamaguchi Y, Saito T, Nakashima H, Kawano M
    • Organizer
      EULAR 2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] IgG4関連腎臓病:診断基準の改訂及び長期予後の検討2022

    • Author(s)
      川野充弘
    • Organizer
      第65回日本腎臓学会学術総会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 低補体血症の有無によるIgG4関連腎臓病の臨床、病理学的差異2022

    • Author(s)
      佐伯敬子、長澤将、乳原善文、谷口義典、柳田素子、西慎一、長田道夫、山口裕、斉藤喬雄、中島衡、川野充弘
    • Organizer
      第65回日本腎臓学会学術総会
    • Related Report
      2022 Research-status Report
  • [Presentation] IgG4関連疾患の経過中にM型ホスホリパーゼA2受容体(PLA2R)関連膜性腎症を発症した一例2022

    • Author(s)
      小市真琴, 水島伊知郎, 川原寛之, 眞田創, 吉田美咲, 髙橋芳徳, 柘植俊介, 蔵島乾, 西岡亮, 原怜史, 伊藤清亮, 川野充弘
    • Organizer
      第33回中部リウマチ学会
    • Related Report
      2022 Research-status Report
  • [Presentation] IgG4関連腎臓病の長期予後調査2022

    • Author(s)
      水島伊知郎, 佐伯敬子, 小林大介, 林宏樹, 谷口義典, 中田紘介, 松井祥子, 長澤将, 柳田素子, 川野充弘
    • Organizer
      第30回日本シェーグレン症候群学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 緩徐に拡大傾向を示し加療方針に苦慮したIgG4関連冠動脈瘤の一例2022

    • Author(s)
      川原寛之, 水島伊知郎, 西岡亮, 川野充弘
    • Organizer
      第30回日本シェーグレン症候群学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 自己免疫性膵炎の加療中に出現し素の鑑別に苦慮した自己免疫性肝炎の一例2022

    • Author(s)
      宮永達人, 川原寛之, 水島伊知郎, 西岡亮, 川野充弘
    • Organizer
      第30回日本シェーグレン症候群学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] IgG4関連動脈周囲炎/後腹膜線維症の臨床2022

    • Author(s)
      川野充弘
    • Organizer
      第63回日本脈管学会総会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] IgG4関連腎臓病の診断と治療の最新戦略2022

    • Author(s)
      川野充弘
    • Organizer
      第52回日本腎臓学会西部学術大会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 寛解経過中に膜性腎症単独の発症を認めたIgG4関連腎臓病の1例2022

    • Author(s)
      水島伊知郎, 小市真琴, 朝倉啓太, 宮永達人, 干場涼平, 眞田創, 髙橋芳徳, 柘植俊介, 蔵島乾, 西岡亮, 原怜史, 伊藤清亮, 川野充弘
    • Organizer
      第52回日本腎臓学会西部学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] IgG4関連腎臓病(IgG4-RKD)における補体系の役割2022

    • Author(s)
      佐伯敬子、長澤将、乳原善文、谷口義典、柳田素子、西慎一、長田道夫、山口裕、斉藤喬雄、中島衡、川野充弘
    • Organizer
      第14回日本IgG4関連疾患学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] IgG4関連疾患 ―皮膚病変と他臓器病変ー2022

    • Author(s)
      川野充弘
    • Organizer
      第52回日本皮膚免疫アレルギー学会学術大会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] IgG4-related kidney disease and IgG4-related periaortitis/retroperitoneal fibrosis2021

    • Author(s)
      Kawano M.
    • Organizer
      23rd Asia-Pacific League of Associations for Rheumatology Congress
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] IgG4-related disease and multicentric Castleman disease2021

    • Author(s)
      Kawano M.
    • Organizer
      The 1st International Symposium on Castleman Disease
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Are two types of pathophysiology happening at the same time in IgG4-related kidney disease?2021

    • Author(s)
      Kawano M.
    • Organizer
      4th International Symposium on IgG4-related diseases
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2021-04-28   Modified: 2024-12-25  

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