Clarification of the mechanism of the treatment-resistance of allergic diseases and establishment of the strategy of the treatment for it

• Project/Area Number: 21K08476
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54020:Connective tissue disease and allergy-related
• Research Institution: Saga University
• Principal Investigator: 出原 賢治 佐賀大学, 医学部, 教授 (00270463)
• Co-Investigator(Kenkyū-buntansha): 布村 聡 佐賀大学, 医学部, 准教授 (70424728) ; 南里 康弘 (宮内康弘) 佐賀大学, 医学部, 助教 (00382218)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2023: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: アレルギー / アトピー性皮膚炎 / 痒み / 皮膚炎 / マウス / ペリオスチン / マトリセルラータンパク質 / バイオマーカー / アトピー性角結膜炎 / アイソフォーム / 線維芽細胞

Outline of Research at the Start

線維化形成，あるいは線維芽細胞を基軸としたアレルギー疾患の難治化機序の解明とそれに対する治療戦略の構築は，アレルギー領域における非常に重要かつ，未解明の部分が多い課題である。ペリオスチン研究はその分野における先駆的研究であると言える。本研究によりペリオスチン研究をさらに発展させ，アレルギー疾患の難治化機序の解明とそれに対する治療戦略の構築の課題に対して，プロトタイプ（原型）となる解答を示すことを目的とする。

Outline of Annual Research Achievements

アレルギー疾患における難治化機序の解明とそれに対する治療戦略の構築は, 当該領域における重要な課題である。我々は，線維芽細胞から産生されるマトリセルラータンパク質であるペリオスチンが，さまざまな炎症疾患に関与するとともに, 炎症における線維化形成に深く関与していることを明らかにしてきた。これに基づき, ペリオスチンがアレルギー疾患における新規の創薬標的となるとともに, アレルギー病態を反映するバイオマーカーとなることを示してきた。本研究では，ペリオスチン研究をさらに発展させ，アレルギー疾患の難治化機序の解明とそれに対する治療戦略の構築の課題に対するプロトタイプ（原型）となる解答を示すことを目指している。
本研究における昨年度の代表的な研究成果として，以下があげられる。我々は，以前，顔面に限局した皮膚炎と激しい痒みによる引っ掻き行動を示すFADS（Facial Atopic Dermatitis with Scratching）マウスを確立した。生まれつきペリオスチン遺伝子を欠損するFADSマウスを作成したところ, 皮膚炎と引っ掻き行動が改善したことから, FADSマウスにおいてペリオスチンが皮膚炎と痒みの発症に重要であることを明らかにした（Nunomura, Cell Rep, 42, 111933, 2023）。さらに, 低分子化合物であるCP4715を投与すると皮膚炎と引っ掻き行動が改善したことから, CP4715はアトピー性皮膚炎に対する創薬となる可能性を示した。
この研究成果は，ペリオスチンを標的としたアトピー性皮膚炎に対する新規の創薬に応用できる点で, 非常に有用であると考えられる。

Research Products

• [Int'l Joint Research] インデイアナ大学(米国)
• [Int'l Joint Research] カロリンスカ研究所(スウェーデン)
• [Journal Article] Periostin activates distinct modules of inflammation and itching downstream of the type 2 inflammation pathway (2023)
  • Author(s): Nunomura Satoshi、Uta Daisuke、Kitajima Isao、Nanri Yasuhiro、Matsuda Kosuke、Ejiri Naoko、Kitajima Midori、Ikemitsu Hitoshi、Koga Misaki、Yamamoto Sayaka、Honda Yuko、Takedomi Hironobu、Andoh Tsugunobu、Conway Simon J.、Izuhara Kenji
  • Journal Title: Cell Reports Volume: 42 Issue: 1 Pages: 111933-111933
  • DOI: 10.1016/j.celrep.2022.111933
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A novel assay for improved detection of sputum periostin in patients with asthma (2023)
  • Author(s): Ono Junya、Takai Masayuki、Kamei Ayami、Ohta Shoichiro、Nair Parameswaran、Izuhara Kenji、Dahl?n Sven-Erik、James Anna、on behalf of the BIOAIR consortium
  • Journal Title: PLOS ONE Volume: 18 Issue: 2 Pages: e0281356-e0281356
  • DOI: 10.1371/journal.pone.0281356
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pretreatment Frequency of Circulating Th17 Cells and FeNO Levels Predicted the Real-World Response after 1 Year of Benralizumab Treatment in Patients with Severe Asthma (2023)
  • Author(s): Sandhu Yuuki、Harada Norihiro、Sasano Hitoshi、Harada Sonoko、Ueda Shoko、Takeshige Tomohito、Tanabe Yuki、Ishimori Ayako、Matsuno Kei、Abe Sumiko、Nagaoka Tetsutaro、Ito Jun、Chiba Asako、Akiba Hisaya、Atsuta Ryo、Izuhara Kenji、Miyake Sachiko、Takahashi Kazuhisa
  • Journal Title: Biomolecules Volume: 13 Issue: 3 Pages: 538-538
  • DOI: 10.3390/biom13030538
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Exploring biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab (B‐PAD study). (2023)
  • Author(s): Nakahara T, Izuhara K, Onozuka D, Saeki H, Nunomura S, Takenaka M, Matsumoto M, Kataoka Y, Fujimoto R, Kaneko S, Morita E, Tanaka A, Hide M, et al.
  • Journal Title: Clinical and Experimental Allergy Volume: 53 Issue: 2 Pages: 233-238
  • DOI: 10.1111/cea.14267
  • Peer Reviewed / Open Access
• [Journal Article] Dupilumab improves long-term outcomes in patients with uncontrolled, moderate-to-severe GINA-based type 2 asthma, irrespective of allergic status (2023)
  • Author(s): Rabe K, Pavord I, Busse W, Chupp G, Izuhara K, Altincatal A, Gall R, Pandit-Abid N, Deniz Y, Rowe P, Jacob-Nara JA, Radwan A
  • Journal Title: Allergy Volume: 78 Issue: 8 Pages: 2148-2156
  • DOI: 10.1111/all.15747
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Anaphylaxis associated with eosinophilic sialodochitis via periostin upregulation and mast cell activation (2023)
  • Author(s): Maruyama Ayano、Tamagawa-Mineoka Risa、Ueki Shigeharu、Masuda Koji、Yasuda Makoto、Konishi Eiichi、Nunomura Satoshi、Izuhara Kenji、Arima Misaki、Katoh Norito
  • Journal Title: Allergology International Volume: 72 Issue: 2 Pages: 354-356
  • DOI: 10.1016/j.alit.2022.10.008
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Baseline FeNO independently predicts the dupilumab response in patients with moderate-to-severe asthma (2023)
  • Author(s): Pavord ID, Deniz Y, Corren J, Casale TB, FitzGerald JM, Izuhara K, Daizadeh N, Ortiz B, Johnson RR, Harel S, Djandji M, Goga L, Crikelair N, Rowe P, Busse WW.
  • Journal Title: Journal of Allergy and Clinical Immunology: In Practice Volume: 11 Issue: 4 Pages: 1213-1220
  • DOI: 10.1016/j.jaip.2022.11.043
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The functional role and the clinical application of periostin in chronic rhinosinusitis. (2023)
  • Author(s): Izuhara K, Fujieda S, Ohta N.
  • Journal Title: Expert Rev Clin Immunol. Volume: 30 Issue: 8 Pages: 1-10
  • DOI: 10.1080/1744666x.2023.2192928
  • Peer Reviewed / Open Access
• [Journal Article] Immunohistochemical Localization of D-<i>β</i>-Aspartic Acid and Periostin in Vocal Fold Polyps (2023)
  • Author(s): Tateda Y, Ikeda R, Kakuta R, Izuhara K, Ogawa T, Ise K, Shimada H, Murakami K, Murakami K, Nakamura Y, Katori Y, Ohta N.
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 260 Issue: 3 Pages: 223-230
  • DOI: 10.1620/tjem.2023.J035
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nomenclature of allergic diseases and hypersensitivity reactions: adapted to modern needs: An EAACI Position Paper (2023)
  • Author(s): Jutel M, Agache I, et al
  • Journal Title: Allergy Volume: 78 Issue: 11 Pages: 2851-2874
  • DOI: 10.1111/all.15889
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Novel mechanisms by which benralizumab suppresses IgE expression in human B cells in humanized mice (2023)
  • Author(s): Nunomura Satoshi、Ito Ryoji、Nanri Yasuhiro、Ohno Yusuke、Honda Yuko、Takedomi Hironobu、Izuhara Kenji
  • Journal Title: Allergy Volume: 78 Issue: 12 Pages: 3271-3273
  • DOI: 10.1111/all.15914
  • Peer Reviewed
• [Journal Article] A Prospective Cohort Study of Periostin as a Serum Biomarker in Patients with Idiopathic Pulmonary Fibrosis Treated with Nintedanib Therapy (2023)
  • Author(s): Masaki Okamoto, Kiminori Fujimoto, Takeshi Johkoh, Atsushi Kawaguchi, Hiroshi Mukae, Noriho Sakamoto, Takashi Ogura, Satoshi Ikeda, Kazuhiro Kondoh, Yasuhiko Yamano, Kosaku Komiya, Kenji Umeki, Hirotaka Nishikiori, Yoshinori Tanino, et al.
  • Journal Title: Sci Rep Volume: 13 Issue: 1 Pages: 22977-22977
  • DOI: 10.1038/s41598-023-49180-4
  • Peer Reviewed / Open Access
• [Journal Article] Periostin Is a Biomarker of Rheumatoid Arthritis-Associated Interstitial Lung Disease (2023)
  • Author(s): Matama Goushi、Okamoto Masaki、Fujimoto Kiminori、Johkoh Takeshi、Tominaga Masaki、Mukae Hiroshi、Sakamoto Noriho、Komiya Kosaku、Umeki Kenji、Komatsu Masamichi、Shimizu Yasuo、Takahashi Koichiro、Tokisawa Saeko、Zaizen Yoshiaki、Matsuo Norikazu、Nouno Takashi、Kaieda Shinjiro et al
  • Journal Title: Journal of Clinical Medicine Volume: 12 Issue: 22 Pages: 7100-7100
  • DOI: 10.3390/jcm12227100
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Biomarkers enable prediction of tacrolimus resistance in patients with severe allergic conjunctivitis (2022)
  • Author(s): Okada Naoko、Yazu Hiroyuki、Shimizu Eisuke、Fukagawa Kazumi、Nunomura Satoshi、Saito Hirohisa、Matsumoto Kenji、Kawaguchi Atsushi、Izuhara Kenji、Fujishima Hiroshi
  • Journal Title: Allergy Volume: 78 Issue: 1 Pages: 319-321
  • DOI: 10.1111/all.15535
  • Peer Reviewed
• [Journal Article] A positive loop formed by SOX11 and periostin upregulates TGF-β signals leading to skin fibrosis (2022)
  • Author(s): Nanri Yasuhiro、Nunomura Satoshi、Honda Yuko、Takedomi Hironobu、Yamaguchi Yukie、Izuhara Kenji
  • Journal Title: Journal of Investigative Dermatology Volume: - Issue: 6 Pages: 989-998
  • DOI: 10.1016/j.jid.2022.12.008
  • Peer Reviewed
• [Journal Article] Periostin-related progression of different types of experimental pulmonary hypertension: A role for M2 macrophage and FGF-2 signalling (2022)
  • Author(s): Yoshida T, Nagaoka T, Nagata Y, Suzuki Y, Tsutsumi T, Kuriyama S, Watanabe J, Togo S, Takahashi F, Matsushita M, Joki Y, Konishi H, Nunomura S, Izuhara K, Conway SJ, Takahashi K.
  • Journal Title: Respirology Volume: online ahead of print Issue: 7 Pages: 00-00
  • DOI: 10.1111/resp.14249
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Further evidence for association of YKL-40 with severe asthma airway remodeling (2022)
  • Author(s): Kimura H, Shimizu K, Tanabe N, Makita H, Taniguchi N, Kimura H, Suzuki M, Abe Y, Matsumoto-Sasaki M, Oguma A, Takimoto-Sato M, Takei N, Matsumoto M, Goudarzi H, Sato S, Ono J, Izuhara K, Hirai T, Nishimura M, Konno S
  • Journal Title: Annals of Allergy, Asthma &amp; Immunology Volume: - Issue: 6 Pages: 682-688
  • DOI: 10.1016/j.anai.2022.03.016
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] In search of biomarkers: Can serum periostin predict bronchopulmonary dysplasia in premature infants? (2022)
  • Author(s): Go H, Ono J, Ohto H, Nollet KE, Sato K, Kume Y, Maeda H, Chishiki M, Haneda K, Ichikawa H, Kashiwabara N, Kanai Y, Ogasawara K, Sato M, Hashimoto K, Nunomura S, Izuhara K, Hosoya M
  • Journal Title: Pediatric Research Volume: 92 Issue: 4 Pages: 1108-1114
  • DOI: 10.1038/s41390-021-01912-w
  • Peer Reviewed / Open Access
• [Journal Article] Establishment of a novel ELISA system for measuring periostin independently of formation of the IgA complex (2022)
  • Author(s): Takai Masayuki、Ono Junya、Okamoto Masaki、Fujimoto Kiminori、Kamei Ayami、Nunomura Satoshi、Nanri Yasuhiro、Ohta Shoichiro、Hoshino Tomoaki、Azuma Arata、Izuhara Kenji
  • Journal Title: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine Volume: 59 Issue: 5 Pages: 347-356
  • DOI: 10.1177/00045632221106068
  • Peer Reviewed / Open Access
• [Journal Article] Dupilumab is effective in patients with moderate-to-severe uncontrolled GINA-defined type 2 asthma irrespective of an allergic asthma phenotyp (2022)
  • Author(s): Rabe KF, FitzGerald JM, Bateman ED, Castro M, Pavord ID, Maspero JF, Busse WW, Izuhara K, Daizadeh N, Ortiz B, Pandit-Abid N, Rowe PJ, Deniz Y
  • Journal Title: Journal of Allergy and Clinical Immunology: In Practice Volume: 10 Issue: 11 Pages: 2916-2924
  • DOI: 10.1016/j.jaip.2022.06.036
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Expression of Periostin in Vocal Fold Polyps (2022)
  • Author(s): Tateda Y, Ikeda R, Kakuta R, Ono J, Izuhara K, Ogawa T, Ise K, Shimada H, Murakami K, Murakami K, Nakamura Y, Katori Y, Ohta N
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 258 Issue: 1 Pages: 55-62
  • DOI: 10.1620/tjem.2022.J055
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access
• [Journal Article] Nasal polyp eosinophilia and FeNO may predict asthma symptoms development after endoscopic sinus surgery in CRS patients without asthma (2021)
  • Author(s): Kurokawa R et al.
  • Journal Title: J Asthma Volume: Mar 15 Issue: 6 Pages: 1-9
  • DOI: 10.1080/02770903.2021.1897837
  • Peer Reviewed / Open Access
• [Journal Article] Clinical characteristics of patients with not well-controlled severe asthma in Japan: Analysis of the Keio Severe Asthma Research Program in Japanese population (KEIO-SARP) registry (2021)
  • Author(s): Tanosaki T, Kabata H, Matsusaka M, Miyata J, Masaki K, Mochimaru T, Okuzumi S, Kuwae M, Watanabe R, Suzuki Y, Sayama K, Izuhara K, Asano K, Fukunaga K
  • Journal Title: Allergology International Volume: 70 Issue: 1 Pages: 61-67
  • DOI: 10.1016/j.alit.2020.06.002
  • NAID: 130007966775
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of serum periostin level as a predictor of requirement for intensive treatment for type-2 inflammation in asthmatics in future: A follow-up study of the KiHAC cohort (2021)
  • Author(s): Sunadome H, Matsumoto H, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Iwanaga T, Hozawa S, Niimi A, Kanemitsu Y, Nagasaki T, Tashima N, Ishiyama Y, Morimoto C, Oguma T, Tajiri T, Ito I, Ono J, Ohta S, Izuhara K, Hirai T.
  • Journal Title: Allergology International Volume: 70 Issue: 2 Pages: 252-254
  • DOI: 10.1016/j.alit.2020.10.006
  • NAID: 130008024341
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Epithelial SOX11 regulates eyelid closure during embryonic eye development (2021)
  • Author(s): Nunomura S, Nanri Y, Lefebvre V, Izuhara K
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 549 Pages: 27-33
  • DOI: 10.1016/j.bbrc.2021.02.075
  • Peer Reviewed / Open Access
• [Journal Article] Lung function fluctuation patterns unveil asthma and COPD phenotypes unrelated to type 2 inflammation (2021)
  • Author(s): Delgado-Eckert E, James A, Meier-Girard D, Kupczyk M, Andersson LI, Bossios A, Mikus M, Ono J, Izuhara K, Middelveld R, Dahle;n B, Gaga M, Siafakas NM, Papi A, Beghe B, Joos G, Rabe KF, Sterk PJ, Bel EH, Johnston SL, Chanez P, Gjomarkaj M, Howarth PH, Ni&#380;ankowska-Mogilnicka E, Dahl&#233;n S-E, Frey U
  • Journal Title: The Journal of Allergy and Clinical Immunology Volume: 148 Issue: 2 Pages: 407-419
  • DOI: 10.1016/j.jaci.2020.12.652
  • Peer Reviewed / Open Access
• [Journal Article] Association of serum monomeric periostin level with outcomes of acute exacerbation of idiopathic pulmonary fibrosis and fibrosing nonspecific interstitial pneumonia (2021)
  • Author(s): Shimizu H, Sakamoto S, Okamoto M, Isshiki T, Ono J, Shimizu S, Hoshino T, Izuhara K, Homma S
  • Journal Title: Annals of Translational Medicine Volume: 9 Issue: 9 Pages: 739-739
  • DOI: 10.21037/atm-21-414
  • Peer Reviewed / Open Access
• [Journal Article] T1 invasive lung adenocarcinoma: Thin-section CT solid score and histological periostin expression predict tumor recurrence (2021)
  • Author(s): Iwamoto Ryoji、Tanoue Shuichi、Nagata Shuji、Tabata Kazuhiro、Fukuoka Junya、Koganemaru Masamichi、Sumi Akiko、Chikasue Tomonori、Abe Toshi、Murakami Daigo、Takamori Shinzo、Ishii Hidenobu、Ohshima Koichi、Ohta Shoichiro、Izuhara Kenji、Fujimoto Kiminori
  • Journal Title: Molecular and Clinical Oncology Volume: 15 Issue: 5 Pages: 228-228
  • DOI: 10.3892/mco.2021.2391
  • Peer Reviewed / Open Access
• [Journal Article] Serum concentrations of antigen-specific IgG4 in patients with Japanese cedar pollinosis (2021)
  • Author(s): Kitaya S, Ohta N, Yuta A, Ogawa Y, Suzuki Y, Ichihara S, Ikeda R, Enomoto T, Kouzaki H, Shimizu T, Ono J, Izuhara K, Okamoto Y
  • Journal Title: Allergies Volume: 1 Pages: 140-149
  • Peer Reviewed / Open Access
• [Journal Article] Pathological roles and clinical usefulness of periostin in type 2 inflammation and pulmonary fibrosis (2021)
  • Author(s): Ono J, Takai M, Kamei A, Azuma Y, Izuhara K
  • Journal Title: Biomolecules Volume: 11 Issue: 8 Pages: 1084-1084
  • DOI: 10.3390/biom11081084
  • Peer Reviewed / Open Access
• [Journal Article] Precision medicine reaching out to the patients in allergology - a German-Japanese workshop report (2021)
  • Author(s): Pfaar O, Blumchen K, Boateng E, Hamelmann E, Iinuma T, Jakob T, Krauss-Etschmann S, Nagase H, Nakajima S, Nakano T, Renz H, Sato S, Taube C, Wagenmann M, Werfel T, Worm M, Izuhara K
  • Journal Title: Allergologie select Volume: 5 Issue: 01 Pages: 162-179
  • DOI: 10.5414/alx02234e
  • Peer Reviewed / Open Access
• [Journal Article] The FADS mouse: A novel mouse model of atopic keratoconjunctivitis (2021)
  • Author(s): Nunomura S, Kitajima I, Nanri Y, Kitajima M, Ejiri N, Lai IS, Okada N, Izuhara K
  • Journal Title: The Journal of Allergy and Clinical Immunology Volume: 148 Issue: 6 Pages: 1596-1602
  • DOI: 10.1016/j.jaci.2021.05.017
  • Peer Reviewed / Open Access
• [Journal Article] Squamous cell carcinoma antigens are sensitive biomarkers for atopic dermatitis in children and adolescents: a cross-sectional study (2021)
  • Author(s): Hirayama Junya、Fujisawa Takao、Nagao Mizuho、Kuwabara Yu、Kainuma Keigo、Azuma Yoshinori、Ono Junya、Ohta Shoichiro、Hirayama Masahiro、Izuhara Kenji
  • Journal Title: Asia Pacific Allergy Volume: 11 Issue: 4 Pages: e42-e42
  • DOI: 10.5415/apallergy.2021.11.e42
  • Peer Reviewed / Open Access
• [Journal Article] Expression profile of periostin isoforms in systemic sclerosis (2021)
  • Author(s): Nanri Y, Nunomura S, Watanabe T, Ohta S, Yamaguchi Y, Izuhara K
  • Journal Title: J Dermatol Sci Volume: 104(3) Issue: 3 Pages: 210-212
  • DOI: 10.1016/j.jdermsci.2021.10.005
  • Peer Reviewed / Open Access
• [Journal Article] High serum free IL-18 is associated with decreased omalizumab efficacy: findings from a 2-year omalizumab treatment study (2020)
  • Author(s): Morimoto C, Matsumoto H, et al.
  • Journal Title: J Asthma Volume: 20 Issue: 9 Pages: 1-10
  • DOI: 10.1080/02770903.2020.1766061
  • Peer Reviewed / Open Access
• [Presentation] Updated information about the roles of IL-13 in atopic dermatitis (2023)
  • Author(s): Kenji Izuhara
  • Organizer: 1st International Societies for Investigative Dermatology Meeting
  • Int'l Joint Research / Invited
• [Presentation] 基礎・臨床からみたアトピー性皮膚炎 ―基礎から視たアトピー性皮膚炎― (2023)
  • Author(s): 出原賢治
  • Organizer: 日本皮膚科学会 第87回佐賀地方会学術集会
  • Invited
• [Presentation] アトピー性皮膚炎における痒みの機序 (2023)
  • Author(s): 出原賢治
  • Organizer: 日本機能水学会第21回学術大会
  • Invited
• [Presentation] アトピー性皮膚炎における痒みの機序 (2023)
  • Author(s): 出原賢治
  • Organizer: 日本産業皮膚衛生協会・会員研修会
  • Invited
• [Presentation] 2型炎症皮膚疾患における痒みとペリオスチンの役割 (2023)
  • Author(s): 出原賢治
  • Organizer: 第53回日本皮膚免疫アレルギー学会学術大会
  • Invited
• [Presentation] How does itching occur and how can we treat it? (2023)
  • Author(s): Kenji Izuhara
  • Organizer: Scientific Exchange Seminar with University of Phayao, Thailand
  • Int'l Joint Research / Invited
• [Presentation] アトピー性皮膚炎におけるインテグリンを介する新規の痒み機序 (2023)
  • Author(s): 出原 賢治
  • Organizer: 第96回日本生科学会大会
  • Invited
• [Presentation] アトピー性皮膚炎におけるペリオスチンによる痒みの機序と創薬の試み (2023)
  • Author(s): 出原 賢治
  • Organizer: 順天堂大学環境医学研究所・順天堂かゆみ研究センター第9回学術シンポジウム
  • Invited
• [Presentation] 痒みの発症機序と創薬の試み (2023)
  • Author(s): 出原 賢治
  • Organizer: 第97回日本薬理学会年会
  • Invited
• [Presentation] アトピー性皮膚炎における痒みの機序と創薬の試み (2023)
  • Author(s): 出原 賢治
  • Organizer: 第43回阿蘇シンポジウム
  • Invited
• [Presentation] 小児のアトピー性皮膚炎に対する新規体外診断薬の開発 (2022)
  • Author(s): 出原賢治
  • Organizer: 第62回日本臨床化学会年次学術集会
  • Invited
• [Presentation] 最新のアレルギー研究の動向 (2022)
  • Author(s): 出原賢治
  • Organizer: 第62回日本臨床化学会年次学術集会
  • Invited
• [Presentation] The basis of severe asthma -Biomarkers- (2021)
  • Author(s): Izuhara K
  • Organizer: International Severe Asthma Forum (ISAF) Digital 2021
  • Int'l Joint Research / Invited
• [Presentation] SCCA2：小児のアトピー性皮膚炎に対する新規バイオマーカー (2021)
  • Author(s): 出原 賢治
  • Organizer: 第120回日本皮膚科学会総会
  • Invited
• [Presentation] The up-to-date information of periostin, a key mediator and a promising biomarker for allergic disease (2021)
  • Author(s): Izuhara K
  • Organizer: The Asia Pacific Association of Allergy, Asthma and Clinical Immunology (APAAACI) 2021 International Conference Joint the Taiwan Academy of Allergy, Asthma and Clinical Immunology (TAAACI)
  • Int'l Joint Research / Invited
• [Presentation] アトピー性皮膚炎における痒みの分子機序 (2021)
  • Author(s): 出原 賢治
  • Organizer: 第33回日本神経免疫学会
  • Invited
• [Presentation] Efficacy of Omalizumab Against Aspirin-hypersensitivity and Leukotriene Overproduction in Aspirin-exacerbated Respiratory Disease: A Randomized Trial (2021)
  • Author(s): Hayashi H, Fukutomi Y, Mitsui C, Kajiwara K, Watai K, Kamide Y, Nakamura Y, Hamada Y, Tomita Y, Sekiya K, Tsuburai T, Izuhara K, Wakahara K, Hashimoto N, Hasegawa Y, Taniguchi M
  • Organizer: AAAI（American Academy of Allergy Asthma & Immunology） Virtual Annual Meeting
  • Int'l Joint Research
• [Presentation] Dupilumab Efficacy in Patients with GINA-Identified Type 2 Asthma in the Phase 3 QUEST Study (2021)
  • Author(s): Rabe KF, FitzGerald JM, Bateman ED, Castro M, Pavord ID, Maspero JF, Busse WW, Izuhara K, Daizadeh N, Ortiz B, Pandit-Abid N, Rowe PJ, Deniz Y
  • Organizer: EAACI Hybrid Congress 2021
  • Int'l Joint Research
• [Presentation] Novel predictive biomarkers for mepolizumab treatment in patients with severe asthma (2021)
  • Author(s): Sasano H, Harada N, Sandhu Y, Tanabe Y, Harada S, Watanabe T, Sato Y, Nishimaki T, Abe S, Ueda S, Takeshige T, Matsuno K, Ito J, Nagaoka T, Atsuta R, Chiba A, Akiba H, Izuhara K, Miyake S, Takahashi K
  • Organizer: The 25th Congress of the Asian Pacific Society of Respirology
  • Int'l Joint Research
• [Presentation] Serum periostin levels and periostin immunostaining were useful in the evaluation of eosinophilic granulomatosis with polyangiitis patients (2021)
  • Author(s): Ito J, Kamide Y, Fukutomi Y, Watai K, Sekiya K, Hayashi T, Saito I, Ono J, Nunomura S, Izuhara K, Harada N, Atsuta R, Takahashi K, Taniguchi M
  • Organizer: The 25th Congress of the Asian Pacific Society of Respirology
  • Int'l Joint Research
• [Presentation] マクロファージ遊走を介したペリオスチンのPAH病態進展への関与 (2021)
  • Author(s): 吉田隆司，長岡鉄太郎，永田祐一，鈴木宣史，堤建男，栗山祥子，松下雅和，小西博応，出原賢治，Simon J. Conway ，高橋和久
  • Organizer: 第6回日本肺高血圧・肺循環学会学術集会
• [Presentation] 重症気管支喘息におけるメポリズマブ治療の効果予測に関する新規バイオマーカー (2021)
  • Author(s): 笹野仁史，原田紀宏，三道ユウキ，田辺悠記，原田園子，渡邉敬康，佐藤良彦，西牧孝泰，安部寿美子，上田翔子，竹重智仁，松野圭，伊藤潤，長岡鉄太郎，熱田了，千葉麻子，秋葉久弥，出原賢治，三宅幸子，高橋和久
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] FADSマウス：アトピー性角結膜炎の新たなマウスモデル (2021)
  • Author(s): 布村聡，北島勲，南里康弘，北島緑，江尻直子，I Shuan Lai，岡田直子，出原賢治
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] 線維素性唾液管炎に伴う蕁麻疹の機序についての検討 (2021)
  • Author(s): 丸山彩乃，峠岡理沙，益田浩司、加藤則人，安田誠，小西英一，植木重治，布村聡，出原賢治
  • Organizer: 第51回日本皮膚免疫アレルギー学会総会学術大会
• [Presentation] SCCA2:小児のアトピー性皮膚炎に対する新規バイオマーカー (2021)
  • Author(s): 出原 賢治
  • Organizer: 第3回日本アレルギー学会九州・沖縄支部地方会
  • Int'l Joint Research
• [Presentation] FADSマウス：アトピー性角結膜炎の新規マウスモデル (2021)
  • Author(s): 布村聡，北島勲，南里康弘，北島緑，江尻直子，賴以&#29764;，出原賢治
  • Organizer: 第3回日本アレルギー学会九州・沖縄支部地方会
• [Book] 内科学 第12版III (2022)
  • Author(s): 出原賢治
  • Total Pages: 490
  • Publisher: 朝倉書店
  • ISBN: 9784254322804
• [Remarks] 佐賀大学医学部分子生命科学講座分子医化学分野
  • URL: https://www.biomol.med.saga-u.ac.jp/medbiochem/