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Elucidating mechanism of invasive pneumococcal disease by using opacity transformed colonies

Research Project

Project/Area Number 21K08506
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 54030:Infectious disease medicine-related
Research InstitutionUniversity of the Ryukyus (2022-2023)
Nagasaki University (2021)

Principal Investigator

山本 和子  琉球大学, 医学(系)研究科(研究院), 教授 (10398167)

Co-Investigator(Kenkyū-buntansha) 井手口 周平  独立行政法人国立病院機構(長崎医療センター臨床研究センター), 呼吸器内科, 医師 (50796224)
小川 道永  国立感染症研究所, 細菌第一部, 室長 (80361624)
Project Period (FY) 2021-04-01 – 2025-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2023: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords肺炎球菌 / 肺炎 / 莢膜 / 侵襲性肺炎球菌感染症
Outline of Research at the Start

肺炎球菌の菌体表面を覆う莢膜は主要な病原因子で、莢膜型はIPDの病態に関係し、肺炎球菌ワクチンの標的として重要である。一方で肺炎球菌は莢膜の発現量によって異なる膜光透過性(Opaque型, Transparent型)を示す。過去の報告と我々の研究によりOpaque型はIPDを起こしやすいという結果を得た。タイプⅠ制限修飾システムの再構成により肺炎球菌の膜光透過性を固定し、これがマウス肺炎モデルにおいてIPDの起因となる病原因子・免疫反応を起こすか明らかにしたい。莢膜型非依存性の肺炎球菌の新しい病原因子の抽出と、IPDの免疫メカニズムに迫ることで、新規ワクチン開発や治療のブレークスルーに繋げる

Outline of Annual Research Achievements

肺炎球菌は、肺炎および侵襲性肺炎球菌感染症(IPD)の主要な原因菌であるが、その重篤度や侵襲の機序は未だ解明されていない。肺炎球菌のコロニーは莢膜光透過性のvariantを有し(Opaque型とTransparent型)、動物実験において侵襲性感染(Opaque型)および鼻腔内コロニー形成(Transparent型)と関連していることが示された。本研究では、肺炎球菌コロニーの莢膜光透過性と肺炎球菌性肺炎の臨床像との関連性を評価した。研究は、4つの3次医療機関で2012年から2019年の間に肺炎球菌性肺炎で入院した成人患者を対象とした。下気道検体から得られた肺炎球菌株の血清型と実体顕微鏡でコロニー莢膜光透過性を評価し、肺炎の重症度との関連性を解析した。ムコイドコロニー表現型の血清型3および37は、研究対象から除外した。合計92人の患者を対象とし、多くは高齢者(年齢中央値:72歳)で男性(67%)、59%が市中肺炎であった。92例中、肺炎球菌コロニーにOpaque型、Transparent型、Mix型がそれぞれ41例(45%)、12例(13%)、39例(42%)存在した。Opaque型、Transparent型は、患者背景が異なっていたが、血清型分布に差はなかった。肺炎重症度は2群で差がなかったが、菌血症の発生率はOpaque型で有意に高かった。Opaque型は、ヒトにおいて侵襲性感染症を引き起こす可能性が高いことが示唆された。この研究はIPDの病態解明に役立ち、肺炎球菌コロニーの莢膜光透過性の評価はIPDの予測因子として役立つ可能性がある。本研究成果は、Journal of Medical Microbiology 2024;73:001784.に報告した。共同研究者の国立感染症研究所第一細菌部と協力し、さらに菌株19F型の莢膜変異株を作成している

Current Status of Research Progress
Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

マウスで肺炎球菌肺炎を形成する菌株19F型(EF3030)の莢膜変異株を作成したが、莢膜透過性について安定性に乏しく、遺伝子組み替え法および複数種の菌株を国立感染症研究所と共同で作製している。代表者が2022年10月に琉球大学へ異動し、実験環境の準備のため研究が遅れていたが、まず第1報の論文が受理された。

Strategy for Future Research Activity

19F型(EF3030)のみならず、複数の血清型菌株を用いて、hsdS組換え株を作製する。莢膜透過性が継代によっても安定した株を用いて、マウス肺炎モデルを作製する。In vitroにおけるhsdS組換え株の微生物学的な病原性の評価(増殖能とバイオフィルム形成能の評価、マクロファージ貪食能、NF-kB誘導能、発現受容体の評価)を行い、さらにIn vivoマウス肺炎モデルでのhsdS組換え株の侵襲性と病原性評価(鼻腔定着率と肺炎への進展率の評価、経気管投与(i.t.)による肺炎モデルの生存率と体重の評価、肺内菌数、菌血症、肺内好中球の遊走、肺内炎症性サイトカインの評価)を行う。

Report

(3 results)
  • 2023 Research-status Report
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (65 results)

All 2024 2023 2022 2021

All Journal Article (22 results) (of which Peer Reviewed: 22 results,  Open Access: 16 results) Presentation (36 results) (of which Int'l Joint Research: 10 results,  Invited: 5 results) Book (6 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Clinical features relating to pneumococcal colony phase variation in hospitalized adults with pneumonia.2024

    • Author(s)
      Ideguchi S, Yamamoto K, Takazono T, Fukuda Y, Tashiro T, Shizukuishi S, Chang B, Ogawa M, Izumikawa K, Yanagihara K, Yatera K, Mukae H.
    • Journal Title

      J Med Microbiol

      Volume: 73 Issue: 1 Pages: 001784-001784

    • DOI

      10.1099/jmm.0.001784

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel ex vivo lung cancer model based on bioengineered rat lungs.2023

    • Author(s)
      Mizoguchi S, Tsuchiya T, Doi R, Obata T, Iwatake M, Hashimoto S, Matsumoto H, Yukawa H, Hayashi H, Li TS, Yamamoto K, Matsumoto K, Miyazaki T, Tomoshige K, Nagayasu T.
    • Journal Title

      Front Bioeng Biotechnol

      Volume: 11 Pages: 1179830-1179830

    • DOI

      10.3389/fbioe.2023.1179830

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic profile of thymic epithelial tumors in the Japanese population: an exploratory study examining potential therapeutic targets.2023

    • Author(s)
      Shimada M, Taniguchi H, Yamaguchi H, Gyotoku H, Sasaki D, Kaku N, Senju C, Senju H, Imamura E, Takemoto S, Yamamoto K, Sakamoto N, Obase Y, Tsuchiya T, Fukuda M, Soda H, Ashizawa K, Fukuoka J, Nagayasu T, Yanagihara K, Mukae H.
    • Journal Title

      Transl Lung Cancer Res

      Volume: 12 Issue: 4 Pages: 707-718

    • DOI

      10.21037/tlcr-22-794

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A high α1-antitrypsin/interleukin-10 ratio predicts bacterial pneumonia in adults with community-acquired pneumonia: a prospective cohort study.2023

    • Author(s)
      Miyazaki T, Fukushima K, Hashiguchi K, Ide S, Kobayashi T, Sawai T, Yatera K, Kohno Y, Fukuda Y, Futsuki Y, Matsubara Y, Koga H, Mihara T, Sasaki E, Ashizawa N, Hirayama T, Takazono T, Yamamoto K, Imamura Y, Kaku N, Kosai K, Morinaga Y, Yanagihara K, Mukae H.
    • Journal Title

      Pneumonia (Nathan)

      Volume: 15 Issue: 1 Pages: 16-16

    • DOI

      10.1186/s41479-023-00118-4

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of voluntary human mobility restrictions on vector-borne diseases during the COVID-19 pandemic in Japan: A descriptive epidemiological study using a national database (2016 to 2021).2023

    • Author(s)
      Hibiya K, Shinzato A, Iwata H, Kinjo T, Tateyama M, Yamamoto K, Fujita J.
    • Journal Title

      PLoS One

      Volume: 18 Issue: 5 Pages: e0285107-e0285107

    • DOI

      10.1371/journal.pone.0285107

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum cytokines usefulness for understanding the pathology in allergic bronchopulmonary aspergillosis and chronic pulmonary aspergillosis.2022

    • Author(s)
      Ito Y, Takazono T, Obase Y, Fukahori S, Ashizawa N, Hirayama T, Tashiro M, Yamamoto K, Imamura Y, Hosogaya N, Fukushima C, Morinaga Y, Yanagihara K, Izumikawa K, Mukae H.
    • Journal Title

      Journal of Fungi

      Volume: 8 Issue: 5 Pages: 436-436

    • DOI

      10.3390/jof8050436

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Favorable Humoral Response to Third Dose of BNT162b2 in Patients Undergoing Hemodialysis.2022

    • Author(s)
      Mineaki Kitamura,Takahiro Takazono,Kosei Yamaguchi,Hideshi Tomura,Kazuko Yamamoto,Takashi Harada,Satoshi Funakoshi,Hiroshi Mukae,Tomoya Nishino
    • Journal Title

      Journal of clinical medicine

      Volume: 11 Issue: 8 Pages: 2090-2090

    • DOI

      10.3390/jcm11082090

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A comparison of liposomal amphotericin B alone and in combination with flucytosine in the treatment of non-HIV Cryptococcal meningitis: A nationwide observational study.2022

    • Author(s)
      Takazono T, Hidaka Y, Morimoto S, Tashiro M, Ashizawa N, Hirayama T, Takeda K, Iwanaga N, Hosogaya N, Yamamoto K, Fushimi K, Yanagihara K, Mukae H, Izumikawa K.
    • Journal Title

      Mycoses

      Volume: 65 Issue: 9 Pages: 897-902

    • DOI

      10.1111/myc.13493

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Parameters affecting prognosis after hemodialysis withdrawal: experience from a single center.2022

    • Author(s)
      Yamaguchi K, Kitamura M, Takazono T, Yamamoto K, Hashiguchi J, Harada T, Funakoshi S, Mukae H, Nishino T.
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 26 Issue: 10 Pages: 1022-1029

    • DOI

      10.1007/s10157-022-02242-9

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characteristics and clinical ocular manifestations in patients with acute corneal graft rejection after receiving the COVID-19 vaccine: a systematic review.2022

    • Author(s)
      Fujio K, Sung J, Nakatani S, Yamamoto K, Iwagami M, Fujimoto K, Shokirova H, Okumura Y, Akasaki Y, Nagino K, Midorikawa-Inomata A, Hirosawa K, Miura M, Huang T, Morooka Y, Kuwahara M, Murakami A, Inomata T.
    • Journal Title

      Journal of Clinical Medicine

      Volume: 11 Issue: 15 Pages: 4500-4500

    • DOI

      10.3390/jcm11154500

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Differentiation of Severe Fever with Thrombocytopenia Syndrome from Japanese Spotted Fever.2022

    • Author(s)
      Nakada N, Yamamoto K, Tanaka M, Ashizawa H, Yoshida M, Umemura A, Fukuda Y, Katoh S, Sumiyoshi M, Mihara S, Kobayashi T, Ito Y, Ashizawa N, Takeda K, Ide S, Iwanaga N, Takazono T, Tashiro M, Tanaka T, Nakamichi S, Morimoto K, Ariyoshi K, Morita K, Kurihara S, Yanagihara K, Furumoto A, Izumikawa K, Mukae H.
    • Journal Title

      Viruses

      Volume: 14 Issue: 8 Pages: 1807-1807

    • DOI

      10.3390/v14081807

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of Lactococcus lactis strain plasma (LC-Plasma) in easing symptoms in patients with mild coronavirus disease (COVID-19): protocol for an exploratory, multicenter, double-blinded, randomized controlled trial (PLATEAU study).2022

    • Author(s)
      Yamamoto K, Hosogaya N, Inoue T, Jounai K, Tsuji R, Fujiwara D, Yanagihara K, Izumikawa K, Mukae H.
    • Journal Title

      BMJ Open

      Volume: 12 Issue: 9 Pages: e061172-e061172

    • DOI

      10.1136/bmjopen-2022-061172

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of a triage checklist for mild COVID-19 outpatients in predicting subsequent emergency department visits and hospitalization during the isolation period: a single center retrospective study.2022

    • Author(s)
      Tanaka Y, Yamamoto K, Morimoto S, Nabeshima T, Matsushima K, Ishimoto H, Ashizawa N, Hirayama T, Takeda K, Gyotoku H, et al.
    • Journal Title

      Journal of Clinical Medicin

      Volume: 11 Issue: 18 Pages: 5444-5444

    • DOI

      10.3390/jcm11185444

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations between chest CT abnormalities and clinical features in patients with the severe fever with thrombocytopenia syndrome.2022

    • Author(s)
      Ashizawa H, Yamamoto K, Ashizawa N, Takeda K, Iwanaga N, Takazono T, Sakamoto N, Sumiyoshi M, Ide S, Umemura A, Yoshida M, Fukuda Y, Kobayashi T, Tashiro M, Tanaka T, Katoh S, Morimoto K, Ariyoshi K, Morimoto S, Tun MMN, Inoue S, Morita K, Kurihara S, Izumikawa K, Yanagihara K, Mukae H.
    • Journal Title

      Viruses

      Volume: 14 Issue: 2 Pages: 279-279

    • DOI

      10.3390/v14020279

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment of oral health in elderly patients with dementia by measuring volatile sulfur compounds and its relationship with pneumonia development: A pilot study.2022

    • Author(s)
      Koga S, Takazono T, Serita T, Ashizawa N, Hirayama T, Tashiro M, Hosogaya N, Yamamoto K, Imamura Y, Yamaguchi H, Sakamoto N, Obase Y, Yanagihara K, Izumikawa K, Mukae H
    • Journal Title

      Respiratory Investigation

      Volume: 60 Issue: 1 Pages: 162-166

    • DOI

      10.1016/j.resinv.2021.08.006

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Infectious Pneumonia and Lower Airway Microorganisms in Patients with Rheumatoid Arthritis2021

    • Author(s)
      Ideguchi Shuhei、Yamamoto Kazuko、Tahara Masahiro、Koga Tomohiro、Ide Shotaro、Hirayama Tatsuro、Takazono Takahiro、Imamura Yoshifumi、Miyazaki Taiga、Sakamoto Noriho、Morimoto Shimpei、Izumikawa Koichi、Yanagihara Katsunori、Ashizawa Kazuto、Aoki Takatoshi、Kawakami Atsushi、Yatera Kazuhiro、Mukae Hiroshi
    • Journal Title

      Journal of Clinical Medicine

      Volume: 10 Issue: 16 Pages: 3552-3552

    • DOI

      10.3390/jcm10163552

    • NAID

      120007172259

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] HLA-B54 is an independent risk factor for pneumonia in Japanese patients with interstitial lung disease: A multicenter retrospective cohort study2021

    • Author(s)
      Sakamoto Noriho、Ishimoto Hiroshi、Tahara Masahiro、Kido Takashi、Hara Atsuko、Miyamura Takuto、Okuno Daisuke、Tokito Takatomo、Yoshioka Sumako、Morimoto Shimpei、Takazono Takahiro、Yamamoto Kazuko、Yamaguchi Hiroyuki、Obase Yasushi、Ishimatsu Yuji、Yatera Kazuhiro、Mukae Hiroshi
    • Journal Title

      Respiratory Medicine

      Volume: 188 Pages: 106612-106612

    • DOI

      10.1016/j.rmed.2021.106612

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of clarithromycin in patients with mild COVID-19 pneumonia not receiving oxygen administration: protocol for an exploratory, multicentre, open-label, randomised controlled trial (CAME COVID-19 study)2021

    • Author(s)
      Yamamoto Kazuko、Hosogaya Naoki、Sakamoto Noriho、Yoshida Haruo、Ishii Hiroshi、Yatera Kazuhiro、Izumikawa Koichi、Yanagihara Katsunori、Mukae Hiroshi
    • Journal Title

      BMJ Open

      Volume: 11 Issue: 9 Pages: e053325-e053325

    • DOI

      10.1136/bmjopen-2021-053325

    • NAID

      120007175559

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mycobacterium abscessusによる肺抗酸菌症の予後因子の検討.2021

    • Author(s)
      巖水 慧,山本和子,井手口周平,井手昇太郎,高園貴弘,高橋健介,赤松紀彦,泉川公一,栁原克紀,迎 寛.
    • Journal Title

      日本呼吸器学会雑誌

      Volume: 10 Pages: 449-456

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diagnostic evaluation of serum (1,3)-b-D-glucan levels using the Fungitec G-Test MK kit for Pneumocystis jirovecii pneumonia (PCP) in non-HIV patients.2021

    • Author(s)
      Ideguchi S, Yamamoto K, Hirayama T, Takazono T, Imamura Y, Miyazaki T, Sakamoto N, Izumikawa K, Yanagihara K, Morimoto S, Mukae H.
    • Journal Title

      Medical Mycology

      Volume: 59 Issue: 6 Pages: 616-623

    • DOI

      10.1093/mmy/myaa101

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of surgical masks on droplet dispersion under various oxygen delivery modalities.2021

    • Author(s)
      Takazono T, Yamamoto K (co-first author), Okamoto R, Morimoto S, Izumikawa K, Mukae H.
    • Journal Title

      Critical Care

      Volume: 25 Issue: 1 Pages: 89-89

    • DOI

      10.1186/s13054-021-03512-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of four commercial severe acute respiratory coronavirus 2 antibody tests2021

    • Author(s)
      Ashizawa Nobuyuki、Takazono Takahiro、Ohyama Kaname、et al
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 27 Issue: 7 Pages: 1033-1038

    • DOI

      10.1016/j.jiac.2021.03.008

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Presentation] 細菌叢と免疫2023

    • Author(s)
      山本和子
    • Organizer
      第97回日本感染症学会総会・学術講演会 第71回日本化学療法学会学術集会合同学会
    • Related Report
      2023 Research-status Report
  • [Presentation] 肺炎球菌感染症の病態を踏まえた予防戦略.2023

    • Author(s)
      山本和子
    • Organizer
      第63回日本呼吸器学会学術講演会
    • Related Report
      2023 Research-status Report
  • [Presentation] 高齢者肺炎のマネジメント2023

    • Author(s)
      山本和子
    • Organizer
      第69回信越支部生涯教育講演会
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] 肺炎球菌感染症の課題と予防戦略2023

    • Author(s)
      山本和子
    • Organizer
      第97回日本感染症学会総会・学術講演会 第71回日本化学療法学会学術集会合同学会
    • Related Report
      2023 Research-status Report
  • [Presentation] 沖縄の環境とウイルス感染症の流行との関係2023

    • Author(s)
      山本和子
    • Organizer
      第76回 日本薬理学会西南部会
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] 新型コロナウイルス感染症とインフルエンザ 3年間のシーズンを振り返って2023

    • Author(s)
      山本和子
    • Organizer
      第63回日本呼吸器学会学術講演会
    • Related Report
      2023 Research-status Report
  • [Presentation] COVID-19治療の変遷とこれからの主役2023

    • Author(s)
      山本和子
    • Organizer
      第76回日本薬理学会西南部会
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] 生活習慣病と呼吸器感染症.診断、治療、予防のポイント2023

    • Author(s)
      山本和子
    • Organizer
      日本内科学会学術集会 第51回内科学の展望
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] 抗酸菌感染症における臨床検査2023

    • Author(s)
      山本和子
    • Organizer
      第70回日本臨床検査医学会学術集会
    • Related Report
      2023 Research-status Report
  • [Presentation] Host backgrounds and outcomes associating co-infections with SARS-CoV-22023

    • Author(s)
      山本和子
    • Organizer
      U.S-Japan Cooperative Medical Sciences Program (USJCMSP) International Conference on Emerging Infectious Diseases (EID) in the Pacific Rim, 2023
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of Lactococcus lactis strain plasma (LC-Plasma) on immune response and symptoms in patients with mild COVID-19. Result of the multicenter, double-blinded, randomized controlled trial (PLATEAU study).2023

    • Author(s)
      山本和子
    • Organizer
      IDWeek 2023
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Bacterial Coinfections in COVID-19 Patients With Acute Respiratory Failure: Japan National Registry Survey.2023

    • Author(s)
      山本和子
    • Organizer
      ATS 2023
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Efficacy of clarithromycin in patients with mild COVID-19 pneumonia patients: an exploratory, multicenter, open-label, randomized controlled trial.2023

    • Author(s)
      山本和子
    • Organizer
      APSR 2023
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Immunological response to anti-SARS-CoV-2 mRNA vaccines in patients with rheumatoid arthritis2022

    • Author(s)
      山本和子
    • Organizer
      第66回日本リウマチ学会・学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] SARS-CoV-2ワクチンの現状と考え方2022

    • Author(s)
      山本和子
    • Organizer
      第62回 日本呼吸器学会学術講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] COVIREGI-JPデータを用いた COVID-19呼吸不全患者における 非侵襲的呼吸管理法の実態調査と 有用性の検討2022

    • Author(s)
      山本和子
    • Organizer
      第62回 日本呼吸器学会学術講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] 日本のCOVID-19診療における非侵襲的呼吸管理の実態と感染対策2022

    • Author(s)
      山本和子
    • Organizer
      第62回 日本呼吸器学会学術講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] 呼吸器ウイルス感染症に合併する細菌感染症  疫学と治療戦略2022

    • Author(s)
      山本和子
    • Organizer
      第62回 日本呼吸器学会学術講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] COVIREGI-JPデータを用いた COVID-19呼吸不全患者における 細菌合併感染の実態調査と予後の検討2022

    • Author(s)
      山本和子
    • Organizer
      第96回 日本感染症学会総会・学術講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] 免疫不全に伴う非結核性抗酸菌症2022

    • Author(s)
      山本和子
    • Organizer
      第97回日本結核・非結核性抗酸菌症学会学術講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] 関節リウマチ患者におけるSARS-CoV-2 mRNAワクチンに対する免疫原性の評価2022

    • Author(s)
      山本和子
    • Organizer
      第92回日本感染症学会西日本地方会学術集会・第70回日本化学療法学会西日本支部総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 新型コロナウイルス感染症と免疫治療2022

    • Author(s)
      山本和子
    • Organizer
      第92回日本感染症学会西日本地方会学術集会・第70回日本化学療法学会西日本支部総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 高齢者/基礎疾患を有する患者の呼吸器感染症治療2022

    • Author(s)
      山本和子
    • Organizer
      第92回日本感染症学会西日本地方会学術集会・第70回日本化学療法学会西日本支部総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 非侵襲的呼吸管理の実態と感染管理2022

    • Author(s)
      山本和子
    • Organizer
      第32回 日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] A national survey of noninvasive modalities in the respiratory management of COVID-19 patients with acute respiratory failure using COVIREGI-JP database.2022

    • Author(s)
      Kazuko Yamamoto
    • Organizer
      American Thoracic Society International Conference
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Triage of outpatients and management of in-hospital viral dispersion.2022

    • Author(s)
      Kazuko Yamamoto
    • Organizer
      The 17th Congress of Asian Society of Clinical Pathology and Laboratory Medicine
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] A national survey of non-invasive respiratory management in COVID-19 patients with acute respiratory failure using COVIREGI-JP database.2022

    • Author(s)
      Kazuko Yamamoto
    • Organizer
      The 26th Congress of the Asian Society of Respirology
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] SARS-CoV-2ワクチンの現状と考え方、第6波に備える2021

    • Author(s)
      山本和子
    • Organizer
      日本呼吸器学会 COVID-19シンポジウム
    • Related Report
      2021 Research-status Report
  • [Presentation] インフルエンザ診療の進歩:インフルエンザ関連肺炎の病態と治療2021

    • Author(s)
      山本和子
    • Organizer
      第91回日本感染症学会西日本地方会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] COVID-19第5波をどう乗り越えるか、ロナプリーブの提言2021

    • Author(s)
      山本和子
    • Organizer
      第61回臨床呼吸機能講習会
    • Related Report
      2021 Research-status Report
  • [Presentation] 呼吸器感染症における感染免疫の重要性:新型コロナウイルス感染症を含めて2021

    • Author(s)
      山本和子
    • Organizer
      第95回日本感染症学会学術講演会
    • Related Report
      2021 Research-status Report
  • [Presentation] COVID-19診療における呼吸管理と感染対策:飛沫・エアロゾル定量研究結果を踏まえて2021

    • Author(s)
      山本和子
    • Organizer
      第95回日本感染症学会学術講演会
    • Related Report
      2021 Research-status Report
  • [Presentation] COVID-19診療における現場の疑問点を考察する:呼吸器学会FAQ広場に寄せられた質問を中心に2021

    • Author(s)
      山本和子
    • Organizer
      第61回日本呼吸器学会学術講演会
    • Related Report
      2021 Research-status Report
  • [Presentation] Relationship between the opacity variance of Streptococcus pneumoniae colonies and the clinical features of adult pneumococcal pneumonia.2021

    • Author(s)
      Yamamoto K, Ideguchi S, Ashizawa N, Takeda K, Iwanaga N, Takazono T, Izumikawa K, Yanagihara K, Fukuda Y, Yatera K, Chang B, Ogawa M, Mukae H.
    • Organizer
      The 3rd Asian Pneumococcal Symposium
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Bacterial and fungal infection in COVID-19 patients- experience from Japan.2021

    • Author(s)
      Yamamoto K
    • Organizer
      The 25th Congress of the Asian Pacific Society of Respirology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of droplet and aerosol dispersion under high flow nasal cannula with or without surgical mask2021

    • Author(s)
      Yamamoto K, Takazono T, Okamoto R, Morimoto S, Hosogaya N, Tashiro M, Miyazaki T, Yanagihara K, Izumikawa K, Mukae H.
    • Organizer
      American Thoracic Society 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Book] 昭和学士会雑誌2023

    • Author(s)
      山本和子
    • Total Pages
      182
    • Publisher
      昭和大学学士会
    • Related Report
      2023 Research-status Report
  • [Book] 医学のあゆみ2023

    • Author(s)
      山本和子
    • Total Pages
      128
    • Publisher
      医歯薬出版
    • Related Report
      2023 Research-status Report
  • [Book] 今日の治療指針2023

    • Author(s)
      山本和子
    • Total Pages
      1440
    • Publisher
      南江堂
    • ISBN
      9784524207688
    • Related Report
      2023 Research-status Report
  • [Book] 月刊カレントテラピー 特集 肺炎の最近の動向 ―感染症から特殊な肺炎まで―2022

    • Author(s)
      井手口周平、山本和子
    • Total Pages
      2
    • Publisher
      ライフメディコム
    • Related Report
      2022 Research-status Report
  • [Book] 私の治療[2021-22年度版]2022

    • Author(s)
      井手口周平、山本和子
    • Total Pages
      1
    • Publisher
      日本医事新報社
    • ISBN
      9784784946525
    • Related Report
      2022 Research-status Report
  • [Book] 誤嚥性肺炎の包括的アプローチ2021

    • Author(s)
      山本和子
    • Total Pages
      6
    • Publisher
      医歯薬出版
    • Related Report
      2021 Research-status Report
  • [Patent(Industrial Property Rights)] 新型コロナウイルス治療剤2023

    • Inventor(s)
      山本和子、迎 寛
    • Industrial Property Rights Holder
      山本和子、迎 寛
    • Industrial Property Rights Type
      特許
    • Filing Date
      2023
    • Related Report
      2023 Research-status Report
    • Overseas

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Published: 2021-04-28   Modified: 2024-12-25  

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