Real-time precision functional network mapping of the human brain for neurosurgical applications
| Project/Area Number |
21K09149
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 56010:Neurosurgery-related
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| Research Institution | Nagoya University |
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Principal Investigator |
Bagarinao E. 名古屋大学, 医学系研究科(保健), 准教授 (00443218)
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| Co-Investigator(Kenkyū-buntansha) |
礒田 治夫 聖隷クリストファー大学, リハビリテーション科学研究科, 臨床教授 (40223060)
前澤 聡 名古屋大学, 医学部附属病院, 助教 (90566960)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | precision mapping / functional connectivity / real-time fMRI / essential tremor / resting state fMRI / human connectome / neurosurgery |
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| Outline of Research at the Start |
Advances in brain imaging research have significantly improved our understanding of the brain's functions and its functional organization, yet their clinical applications remain very limited. This research aims to bridge this gap by developing a system that can be used to generate individualized, highly reliable, and reproducible functional connection profile of the human brain in real-time that can be used for neurosurgical applications including preoperative planning and during online intraoperative assessment.
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| Outline of Annual Research Achievements |
For FY2023, we have completed the analysis of the acquired MRI data for both healthy volunteers and patients with essential tremor. As reported last year, the reliability of the generated FCOR maps, as measured by the similarity metric, generally exhibited an initial exponential increase with the number of included volumes and then plateaued, suggesting an upper limit and an optimal number of volumes to achieve this limit. For the FCOR analysis of patients with essential tremor, we have identified cerebellar and thalamic connector hubs that exhibited more extensive connections with the sensorimotor and visual networks in patients compared to controls. These altered connections were also negatively correlated with cognitive, tremor, and motor function improvement scores.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Cerebellar and thalamic connector hubs facilitate the involvement of visual and cognitive networks in essential tremor2024
Author(s)
Epifanio Bagarinao, Satoshi Maesawa, Sachiko Kato, Manabu Mutoh, Yoshiki Ito, Tomotaka Ishizaki, Takafumi Tanei, Takashi Tsuboi, Masashi Suzuki, Hirohisa Watanabe, Minoru Hoshiyama, Haruo Isoda, Masahisa Katsuno, Gen Sobue, Ryuta Saito
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Journal Title
Parkinsonism & Related Disorders
Volume: 121
Pages: 106034-106034
DOI
Related Report
Peer Reviewed
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[Journal Article] Functional connector hubs in the cerebellum2022
Author(s)
Kawabata Kazuya、Bagarinao Epifanio、Watanabe Hirohisa、Maesawa Satoshi、Mori Daisuke、Hara Kazuhiro、Ohdake Reiko、Masuda Michihito、Ogura Aya、Kato Toshiyasu、Koyama Shuji、Katsuno Masahisa、Wakabayashi Toshihiko、Kuzuya Masafumi、Hoshiyama Minoru、Isoda Haruo、Naganawa Shinji、Ozaki Norio、Sobue Gen
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Journal Title
NeuroImage
Volume: 257
Pages: 119263-119263
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Characteristics of the aging brain of healthy older adults: A longitudinal study2022
Author(s)
Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Kazuya Kawabata, Kazuhiro Hara, Reiko Ohdake, Aya Ogura, Daisuke Mori, Shuji Koyama, Masahisa Katsuno, Minoru Hoshiyama, Haruo Isoda, Shinji Naganawa, Norio Ozaki, Gen Sobue
Organizer
45th Annual Meeting of the Japan Neuroscience Society
Related Report
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