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Investigation of tumor immune status and development of new immunotherapy for bone and soft tissue sarcoma

Research Project

Project/Area Number 21K09198
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionKanazawa University

Principal Investigator

Miwa Shinji  金沢大学, 医学系, 助教 (40753455)

Co-Investigator(Kenkyū-buntansha) 土屋 弘行  金沢大学, 医学系, 協力研究員 (40227434)
武内 章彦  金沢大学, 附属病院, 助教 (70512218)
山本 憲男  金沢大学, 医薬保健学総合研究科, 特任教授 (90332668)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords肉腫 / 腫瘍免疫 / 免疫療法 / 免疫チェックポイント / 骨軟部腫瘍 / 転移 / 免疫 / 骨軟部肉腫
Outline of Research at the Start

我々は,腫瘍破砕物質で刺激した樹状細胞を患者に注射することで腫瘍免疫が活性化することを報告してきたが,臨床試験において樹状細胞療法の有効性は一部の患者に限られた.一方,液体窒素処理骨移植が腫瘍免疫を活性化させることを報告してきたが,液体窒素処理骨による腫瘍免疫活性化のメカニズムを明らかにすることで,肉腫における新たな治療アプローチを検討する.本研究では,肉腫における腫瘍免疫の抑制メカニズムを解明することにより肉腫特有の治療標的を特定する.さらに,液体窒素処理した腫瘍組織による腫瘍免疫の活性化メカニズムを調査する.これらの研究結果をもとに,骨軟部肉腫に対する新たな免疫療法の開発を目標とする.

Outline of Final Research Achievements

This study enrolled patients with metastatic and/or recurrent sarcomas who underwent DC-based immunotherapy. Patients who were PD-L2 (+) showed lower increases of IFN-γ and IL-12 after DC-based immunotherapy than patients who were PD-L2 (-). The disease control (partial response or stable disease) rates of patients who were PD-L1 (+) and PD-L1 (-) were 0% and 22%, respectively. Disease control rates of patients who were PD-L2 (+) and PD-L2 (-) were 13% and 22%, respectively. Patients who were PD-L1 (+) tumors had significantly poorer overall survival compared with patients who were PD-L1 (-). No associations of HLA class I expression with the immune response or oncological outcomes were observed.
This study suggests that PD-L1 and PD-L2 are promising biomarkers of DC-based immunotherapy, and that addition of immune checkpoint inhibitors to DC-based immunotherapy may improve the outcomes of DC-based immunotherapy.

Academic Significance and Societal Importance of the Research Achievements

骨軟部肉腫における免疫療法では,有効性を示す患者は一部に限られるが,多くの免疫療法は高額の費用を要する.有効性を示す患者を予測する方法,有効性を高める方法が求められる.本研究では,PD-L1,PD-L2の発現が高い患者では樹状細胞療法の有効性が低い傾向がみられた.この結果から,免疫チェックポイントの状態が免疫療法の効果を予測するためのバイオマーカーである可能性,免疫チェックポイントの制御が免疫療法の有効性を高める可能性が示唆された.

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (57 results)

All 2023 2022 2021

All Journal Article (44 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 41 results,  Open Access: 27 results) Presentation (13 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] High Clinical Concordance of Drug Resistance in Patient-derived Orthotopic Xenograft (PDOX) Mouse Models: First Step to Validated Precise Individualized Cancer Chemotherapy2023

    • Author(s)
      HIGUCHI TAKASHI、YAMAMOTO NORIO、HAYASHI KATSUHIRO、MIWA SHINJI、IGARASHI KENTARO、TSUCHIYA HIROYUKI、HOFFMAN ROBERT M.
    • Journal Title

      Anticancer Research

      Volume: 43 Issue: 10 Pages: 4277-4284

    • DOI

      10.21873/anticanres.16622

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Graft Survivals after Reconstruction Using Tumor-Bearing Frozen Bone in the Extremities2023

    • Author(s)
      Miwa Shinji、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Igarashi Kentaro、Bangcoy Martin Louie S.、Taniguchi Yuta、Morinaga Sei、Asano Yohei、Tsuchiya Hiroyuki
    • Journal Title

      Cancers

      Volume: 15 Issue: 15 Pages: 3926-3926

    • DOI

      10.3390/cancers15153926

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A validation study for the utility of serum microRNA as a diagnostic and prognostic marker in patients with osteosarcoma2023

    • Author(s)
      Yoshihiro Araki, Naofumi Asano, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Kensaku Abe, Yuta Taniguchi, Hirotaka Yonezawa, Sei Morinaga, Yohei Asano, Takeshi Yoshida, Rikinari Hanayama, Juntaro Matsuzaki, Takahiro Ochiya, Akira Kawai, Hiroyuki Tsuchiya
    • Journal Title

      Oncology Letters

      Volume: 25(6); 222 Issue: 6 Pages: 222-222

    • DOI

      10.3892/ol.2023.13808

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical Benefits of LigaSure? for Surgical Amputation Without Tourniquet Use in Patients With Musculoskeletal Tumor2023

    • Author(s)
      BANGCOY MARTIN LOUIE S.、MIWA SHINJI、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、IGARASHI KENTARO、TANIGUCHI YUTA、MORINAGA SEI、ASANO YOHEI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 43 Issue: 5 Pages: 2127-2133

    • DOI

      10.21873/anticanres.16374

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
  • [Journal Article] Novel predictors of immune checkpoint inhibitor response and prognosis in advanced non‐small‐cell lung cancer with bone metastasis2023

    • Author(s)
      Asano Yohei、Yamamoto Norio、Demura Satoru、Hayashi Katsuhiro、Takeuchi Akihiko、Kato Satoshi、Miwa Shinji、Igarashi Kentaro、Higuchi Takashi、Taniguchi Yuta、Morinaga Sei、Sone Takashi、Okuda Miho、Matsumoto Isao、Yano Seiji、Tsuchiya Hiroyuki
    • Journal Title

      Cancer Medicine

      Volume: 12 Issue: 11 Pages: 12425-12437

    • DOI

      10.1002/cam4.5952

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antibacterial effect and biological reaction of calcium phosphate cement impregnated with iodine for use in bone defects2023

    • Author(s)
      Morinaga Sei、Yamamoto Norio、Tokoro Masaharu、Hayashi Katsuhiro、Takeuchi Akihiko、Miwa Shinji、Igarashi Kentaro、Taniguchi Yuta、Asano Yohei、Nojima Takayuki、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Biomaterials Applications

      Volume: 37 Issue: 10 Pages: 1716-1723

    • DOI

      10.1177/08853282231164827

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sarcoma: Molecular Pathology, Diagnostics, and Therapeutics2023

    • Author(s)
      Miwa Shinji、Yamamoto Norio、Tsuchiya Hiroyuki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 6 Pages: 5833-5833

    • DOI

      10.3390/ijms24065833

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
  • [Journal Article] Clinical Outcomes of Soft Tissue Sarcoma around the Elbow Joint: A Retrospective Single Institution Study2022

    • Author(s)
      Azurin Edelyn S.、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Tada Kaoru、Miwa Shinji、Igarashi Kentaro、Higuchi Takashi、Yonezawa Hirotaka、Morinaga Sei、Asano Yohei、Saito Shiro、Tsuchiya Hiroyuki
    • Journal Title

      Sarcoma

      Volume: 2022 Pages: 1-8

    • DOI

      10.1155/2022/1087726

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Primary Osteosarcoma in Patients Over 75 Years of Age: A Case Series and Literature Review2022

    • Author(s)
      ARAKI YOSHIHIRO、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、HIGUCHI TAKASHI、ABE KENSAKU、TANIGUCHI YUTA、YONEZAWA HIROTAKA、MORINAGA SEI、ASANO YOHEI、NOJIMA TAKAYUKI、TSUCHIYA HIROYUKI
    • Journal Title

      In Vivo

      Volume: 36 Issue: 6 Pages: 2899-2909

    • DOI

      10.21873/invivo.13031

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Viability Analysis of Tumor-Bearing Frozen Autograft for the Reconstruction After Resection of Malignant Bone Tumors Using 99mTc-MDP Scintigraphy2022

    • Author(s)
      Araki Yoshihiro、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Miwa Shinji、Igarashi Kentaro、Higuchi Takashi、Abe Kensaku、Taniguchi Yuta、Yonezawa Hirotaka、Morinaga Sei、Asano Yohei、Nojima Takayuki、Taki Junichi、Tsuchiya Hiroyuki
    • Journal Title

      Clinical Nuclear Medicine

      Volume: 48 Issue: 1 Pages: 25-34

    • DOI

      10.1097/rlu.0000000000004436

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Family cancer history and smoking habit associated with sarcoma in a Japanese population study2022

    • Author(s)
      Araki Yoshihiro、Yamamoto Norio、Tanzawa Yoshikazu、Higashi Takahiro、Kuchiba Aya、Hayashi Katsuhiro、Takeuchi Akihiko、Miwa Shinji、Igarashi Kentaro、Endo Makoto、Kobayashi Eisuke、Tsuchiya Hiroyuki、Kawai Akira
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 17129-17129

    • DOI

      10.1038/s41598-022-21500-0

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Randomized placebo-controlled double-blind phase II study of zaltoprofen for patients with diffuse-type and unresectable localized tenosynovial giant cell tumors: The REALIZE study2022

    • Author(s)
      Takeuchi Akihiko、Endo Makoto、Kawai Akira、Nishida Yoshihiro、Terauchi Ryu、Matsumine Akihiko、Aiba Hisaki、Nakamura Tomoki、Tandai Susumu、Ozaki Toshifumi、Hoshi Manabu、Kayano Daiki、Okuda Miho、Yamamoto Norio、Hayashi Katsuhiro、Miwa Shinji、Igarashi Kentaro、Yoshimura Kenichi、et al.
    • Journal Title

      Frontiers in Oncology

      Volume: 12 Pages: 900010-900010

    • DOI

      10.3389/fonc.2022.900010

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surgical Site Infection after Bone Tumor Surgery: Risk Factors and New Preventive Techniques2022

    • Author(s)
      Miwa Shinji、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Igarashi Kentaro、Tsuchiya Hiroyuki
    • Journal Title

      Cancers

      Volume: 14 Issue: 18 Pages: 4527-4527

    • DOI

      10.3390/cancers14184527

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Outcomes of Limb-sparing Tumor Surgery With Vascular Reconstruction for Bone and Soft-tissue Tumors2022

    • Author(s)
      ASANO YOHEI、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、TANIGUCHI YUTA、MORINAGA SEI、TADA KAORU、NOJIMA TAKAYUKI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 42 Issue: 9 Pages: 4619-4626

    • DOI

      10.21873/anticanres.15966

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tumor-Specific Immunoenhancing Effects after Local Cryoablation for Metastatic Bone Tumor in a Mouse Model2022

    • Author(s)
      Annen Ryohei、Kato Satoshi、Demura Satoru、Miwa Shinji、Yokka Akira、Shinmura Kazuya、Yokogawa Noriaki、Yonezawa Noritaka、Kobayashi Motoya、Kurokawa Yuki、Gabata Toshifumi、Tsuchiya Hiroyuki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 16 Pages: 9445-9445

    • DOI

      10.3390/ijms23169445

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Review: Precise sarcoma patient-derived orthotopic xenograft (PDOX) mouse models enable identification of novel effective combination therapies with the cyclin-dependent kinase inhibitor palbociclib: A strategy for clinical application2022

    • Author(s)
      Higuchi Takashi、Igarashi Kentaro、Yamamoto Norio、Hayashi Katsuhiro、Kimura Hiroaki、Miwa Shinji、Bouvet Michael、Tsuchiya Hiroyuki、Hoffman Robert M.
    • Journal Title

      Frontiers in Oncology

      Volume: 12 Pages: 957844-957844

    • DOI

      10.3389/fonc.2022.957844

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Do Liquid Nitrogen?treated Tumor-bearing Nerve Grafts Have the Capacity to Regenerate, and Do They Pose a Risk of Local Recurrence? A Study in Rats2022

    • Author(s)
      Yonezawa Hirotaka、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Miwa Shinji、Igarashi Kentaro、Morinaga Sei、Asano Yohei、Saito Shiro、Tada Kaoru、Nojima Takayuki、Tsuchiya Hiroyuki
    • Journal Title

      Clinical Orthopaedics & Related Research

      Volume: 480 Issue: 12 Pages: 2442-2455

    • DOI

      10.1097/corr.0000000000002336

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Compartment-specific Clinical Outcomes in Patients With Soft Tissue Sarcomas of the Thigh2022

    • Author(s)
      MORINAGA SEI、TAKEUCHI AKIHIKO、YAMAMOTO NORIO、HAYASHI KATSUHIRO、MIWA SHINJI、IGARASHI KENTARO、YONEZAWA HIROTAKA、ASANO YOHEI、SAITO SHIRO、NOJIMA TAKAYUKI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 42 Issue: 6 Pages: 3143-3150

    • DOI

      10.21873/anticanres.15803

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reverse lateral upper arm flaps for treating large soft tissue defects extending from the elbow to the forearm2022

    • Author(s)
      Okamoto Hideki、Kawaguchi Yohei、Miwa Shinji、Aiba Hisaki、Senda Hiroya、Murakami Satona、Hayakawa Kazuo、Joyo Yuji、Murakami Hideki、Kimura Hiroaki
    • Journal Title

      Case Reports in Plastic Surgery and Hand Surgery

      Volume: 9 Issue: 1 Pages: 145-150

    • DOI

      10.1080/23320885.2022.2076683

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Therapeutic Effect and Clinical Outcome of Immune Checkpoint Inhibitors on Bone Metastasis in Advanced Non-Small-Cell Lung Cancer2022

    • Author(s)
      Asano Yohei、Yamamoto Norio、Demura Satoru、Hayashi Katsuhiro、Takeuchi Akihiko、Kato Satoshi、Miwa Shinji、Igarashi Kentaro、Higuchi Takashi、Yonezawa Hirotaka、Araki Yoshihiro、Morinaga Sei、Saito Shiro、Sone Takashi、Kasahara Kazuo、Tsuchiya Hiroyuki
    • Journal Title

      Frontiers in Oncology

      Volume: 12 Pages: 871675-871675

    • DOI

      10.3389/fonc.2022.871675

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Monostotic Fibrous Dysplasia in the Femur Strongly Expressing RANKL With Concomitant Osteoporotic Vertebral Compression Fracture: A Case Report2022

    • Author(s)
      AZURIN EDELYN S.、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、HIGUCHI TAKASHI、YONEZAWA HIROTAKA、MORINAGA SEI、ASANO YOHEI、SAITO SHIRO、TSUCHIYA HIROYUKI
    • Journal Title

      Cancer Diagnosis & Prognosis

      Volume: 2 Issue: 1 Pages: 93-100

    • DOI

      10.21873/cdp.10082

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Primary total knee arthroplasty assisted by computed tomography-free navigation for secondary knee osteoarthritis following massive calcium phosphate cement packing for distal femoral giant-cell bone tumor treatment: a case report2022

    • Author(s)
      Takeuchi A, Yamamoto N, Ohmori T, Hayashi K, Miwa S, Igarashi K, Higuchi T, Abe K, Yonezawa H, Morinaga S, Araki Y, Asano Y, Saito S, Tsuchiya H.
    • Journal Title

      BMC Musculoskeletal Disorders

      Volume: 22 Issue: 1 Pages: 170-170

    • DOI

      10.1186/s12891-022-05131-0

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Therapeutic Targets and Emerging Treatments in Advanced Chondrosarcoma2022

    • Author(s)
      Miwa Shinji、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Igarashi Kentaro、Tsuchiya Hiroyuki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 3 Pages: 1096-1096

    • DOI

      10.3390/ijms23031096

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pretreatment Neutrophil Count and Platelet-lymphocyte Ratio as Predictors of Metastasis in Patients With Osteosarcoma2022

    • Author(s)
      ARAKI YOSHIHIRO、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、HIGUCHI TAKASHI、ABE KENSAKU、TANIGUCHI YUTA、YONEZAWA HIROTAKA、MORINAGA SEI、ASANO YOHEI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 42 Issue: 2 Pages: 1081-1089

    • DOI

      10.21873/anticanres.15570

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] A scoring system combining clinical, radiological, and histopathological examinations for differential diagnosis between lipoma and atypical lipomatous tumor/well-differentiated liposarcoma2022

    • Author(s)
      Asano Yohei、Miwa Shinji、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Igarashi Kentaro、Yonezawa Hirotaka、Araki Yoshihiro、Morinaga Sei、Nojima Takayuki、Ikeda Hiroko、Tsuchiya Hiroyuki
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 237-237

    • DOI

      10.1038/s41598-021-04004-1

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Tumor Growth Speed of Primary Lesions on the Clinical Outcomes of Appendicular Skeletal Metastases2021

    • Author(s)
      ASANO YOHEI、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、YONEZAWA HIROTAKA、ARAKI YOSHIHIRO、MORINAGA SEI、SAITO SHIRO、NOJIMA TAKAYUKI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 42 Issue: 1 Pages: 229-236

    • DOI

      10.21873/anticanres.15477

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics of patients with undergoing unplanned excisions of malignant soft tissue tumors2021

    • Author(s)
      Morinaga Sei、Miwa Shinji、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Igarashi Kentaro、Tada Kaoru、Langit Mickhael B、Yonezawa Hirotaka、Araki Yoshihiro、Asano Yohei、Tsuchiya Hiroyuki
    • Journal Title

      Journal of Orthopaedic Surgery

      Volume: 29 Issue: 3 Pages: 1-12

    • DOI

      10.1177/23094990211057597

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Osteosarcoma Patient-derived Orthotopic Xenograft (PDOX) Models Used to Identify Novel and Effective Therapeutics: A Review2021

    • Author(s)
      HIGUCHI TAKASHI、IGARASHI KENTARO、YAMAMOTO NORIO、HAYASHI KATSUHIRO、KIMURA HIROAKI、MIWA SHINJI、BOUVET MICHAEL、TSUCHIYA HIROYUKI、HOFFMAN ROBERT M.
    • Journal Title

      Anticancer Research

      Volume: 41 Issue: 12 Pages: 5865-5871

    • DOI

      10.21873/anticanres.15406

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multikinase-Inhibitor Screening in Drug-resistant Osteosarcoma Patient-derived Orthotopic Xenograft Mouse Models Identifies the Clinical Potential of Regorafenib2021

    • Author(s)
      HIGUCHI TAKASHI、IGARASHI KENTARO、YAMAMOTO NORIO、HAYASHI KATSUHIRO、KIMURA HIROAKI、MIWA SHINJI、BOUVET MICHAEL、TSUCHIYA HIROYUKI、HOFFMAN ROBERT M.
    • Journal Title

      Cancer Genomics - Proteomics

      Volume: 18 Issue: 5 Pages: 637-643

    • DOI

      10.21873/cgp.20286

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clinical outcomes of frozen autograft reconstruction for the treatment of primary bone sarcoma in adolescents and young adults2021

    • Author(s)
      Araki Yoshihiro、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Miwa Shinji、Igarashi Kentaro、Higuchi Takashi、Abe Kensaku、Taniguchi Yuta、Yonezawa Hirotaka、Morinaga Sei、Asano Yohei、Tsuchiya Hiroyuki
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 17291-17291

    • DOI

      10.1038/s41598-021-96162-5

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Radiological Scoring System for Differentiation between Enchondroma and Chondrosarcoma2021

    • Author(s)
      Miwa Shinji、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Igarashi Kentaro、Tada Kaoru、Yonezawa Hirotaka、Morinaga Sei、Araki Yoshihiro、Asano Yohei、Saito Shiro、Okuda Miho、Taki Junichi、Ikeda Hiroko、Nojima Takayuki、Tsuchiya Hiroyuki
    • Journal Title

      Cancers

      Volume: 13 Issue: 14 Pages: 3558-3558

    • DOI

      10.3390/cancers13143558

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Different patterns of pneumothorax in patients with soft tissue tumors treated with pazopanib: A case series analysis2021

    • Author(s)
      Aiba Hisaki、Kimura Hiroaki、Yamada Satoshi、Okamoto Hideki、Hayashi Katsuhiro、Miwa Shinji、Kawaguchi Yohei、Saito Shiro、Sakai Takao、Tatematsu Tsutomu、Nakanishi Ryoichi、Murakami Hideki
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 7 Pages: 254866-254866

    • DOI

      10.1371/journal.pone.0254866

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of perioperative chemotherapy for synovial sarcoma: a retrospective analysis of a Nationwide database in Japan2021

    • Author(s)
      Xu Gang、Aiba Hisaki、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Miwa Shinji、Higuchi Takashi、Abe Kensaku、Taniguchi Yuta、Araki Yoshihiro、Saito Shiro、Yoshimura Kenichi、Murakami Hideki、Tsuchiya Hiroyuki、Kawai Akira
    • Journal Title

      BMC Cancer

      Volume: 21 Issue: 1 Pages: 773-773

    • DOI

      10.1186/s12885-021-08485-1

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Delayed Initiation of Treatment Is Associated With Metastasis of Malignant Bone Tumor2021

    • Author(s)
      ARAKI YOSHIHIRO、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、HIGUCHI TAKASHI、ABE KENSAKU、TANIGUCHI YUTA、YONEZAWA HIROTAKA、MORINAGA SEI、ASANO YOHEI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 41 Issue: 6 Pages: 2993-2999

    • DOI

      10.21873/anticanres.15081

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Osteosarcoma-Derived Small Extracellular Vesicles Enhance Tumor Metastasis and Suppress Osteoclastogenesis by miR-146a-5p2021

    • Author(s)
      Yoshihiro Araki, Hisaki Aiba, Takeshi Yoshida, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Tuan D. Nguyen, Kiyo-aki Ishii, Takayuki Nojima, Satoru Takahashi, Hideki Murakami, Hiroyuki Tsuchiya and Rikinari Hanayama
    • Journal Title

      Frontiers in Oncology

      Volume: 11 Pages: 667109-667109

    • DOI

      10.3389/fonc.2021.667109

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bone and Soft Tissue Tumors: New Treatment Approaches2021

    • Author(s)
      Miwa Shinji、Yamamoto Norio、Tsuchiya Hiroyuki
    • Journal Title

      Cancers

      Volume: 13 Issue: 8 Pages: 1832-1832

    • DOI

      10.3390/cancers13081832

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complete Response of Bone Metastasis in Non-small Cell Lung Cancer With Pembrolizumab: Two Case Reports2021

    • Author(s)
      ASANO YOHEI、YAMAMOTO NORIO、HAYASHI KATSUHIRO、TAKEUCHI AKIHIKO、MIWA SHINJI、IGARASHI KENTARO、YONEZAWA HIROTAKA、ARAKI YOSHIHIRO、MORINAGA SEI、KASAHARA KAZUO、SONE TAKASHI、TSUCHIYA HIROYUKI
    • Journal Title

      Anticancer Research

      Volume: 41 Issue: 3 Pages: 1693-1699

    • DOI

      10.21873/anticanres.14933

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Abscopal Effect of Frozen Autograft Reconstruction Combined with an Immune Checkpoint Inhibitor Analyzed Using a Metastatic Bone Tumor Model2021

    • Author(s)
      Yonezawa Noritaka、Murakami Hideki、Demura Satoru、Kato Satoshi、Miwa Shinji、Yoshioka Katsuhito、Shinmura Kazuya、Yokogawa Noriaki、Shimizu Takaki、Oku Norihiro、Kitagawa Ryo、Handa Makoto、Annen Ryohei、Kurokawa Yuki、Fushimi Kazumi、Mizukoshi Eishiro、Tsuchiya Hiroyuki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 4 Pages: 1973-1973

    • DOI

      10.3390/ijms22041973

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations of PD-L1, PD-L2, and HLA class I expression with responses to immunotherapy in patients with advanced sarcoma: post hoc analysis of a phase 1/2 trial2021

    • Author(s)
      Miwa S.、Nojima T.、Alomesen A. A.、Ikeda H.、Yamamoto N.、Nishida H.、Hayashi K.、Takeuchi A.、Igarashi K.、Higuchi T.、Yonezawa H.、Araki Y.、Morinaga S.、Asano Y.、Tsuchiya H.
    • Journal Title

      Clinical and Translational Oncology

      Volume: 23 Issue: 8 Pages: 1620-1629

    • DOI

      10.1007/s12094-021-02559-z

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combination Methionine-methylation-axis Blockade: A Novel Approach to Target the Methionine Addiction of Cancer2021

    • Author(s)
      HIGUCHI TAKASHI、HAN QINGHONG、SUGISAWA NORIHIKO、YAMAMOTO JUN、YAMAMOTO NORIO、HAYASHI KATSUHIRO、KIMURA HIROAKI、MIWA SHINJI、IGARASHI KENTARO、BOUVET MICHAEL、SINGH SHREE RAM、TSUCHIYA HIROYUKI、HOFFMAN ROBERT M.
    • Journal Title

      Cancer Genomics - Proteomics

      Volume: 18 Issue: 2 Pages: 113-120

    • DOI

      10.21873/cgp.20246

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Long-term survival in a patient with Hutchinson-Gilford progeria syndrome and osteosarcoma: A case report2021

    • Author(s)
      Hayashi Katsuhiro、Yamamoto Norio、Takeuchi Akihiko、Miwa Shinji、Igarashi Kentaro、Araki Yoshihiro、Yonezawa Hirotaka、Morinaga Sei、Asano Yohei、Tsuchiya Hiroyuki
    • Journal Title

      World Journal of Clinical Cases

      Volume: 9 Issue: 4 Pages: 854-863

    • DOI

      10.12998/wjcc.v9.i4.854

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significant Improvement After Surgery for a Symptomatic Osteoblastoma in a Patient with Camurati?Engelmann Disease: Case Report and Literature Review2021

    • Author(s)
      Yonezawa Hirotaka、Hayashi Katsuhiro、Yamamoto Norio、Takeuchi Akihiko、Tada Kaoru、Miwa Shinji、Igarashi Kentaro、Kimura Hiroaki、Aoki Yu、Morinaga Sei、Araki Yoshihiro、Asano Yohei、Sakurakichi Keisuke、Ikeda Hiroko、Nojima Takayuki、Tsuchiya Hiroyuki
    • Journal Title

      Calcified Tissue International

      Volume: 108 Issue: 6 Pages: 819-824

    • DOI

      10.1007/s00223-021-00813-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reconstruction using a frozen autograft for a skull and humeral lesion of synchronous multicentric osteosarcoma after undergoing successful neoadjuvant chemotherapy: a case report and review of the literature2021

    • Author(s)
      Araki Yoshihiro、Hayashi Katsuhiro、Yamamoto Norio、Takeuchi Akihiko、Miwa Shinji、Igarashi Kentaro、Higuchi Takashi、Abe Kensaku、Taniguchi Yuta、Yonezawa Hirotaka、Morinaga Sei、Asano Yohei、Nojima Takayuki、Tsuchiya Hiroyuki
    • Journal Title

      BMC Surgery

      Volume: 21 Issue: 1 Pages: 51-51

    • DOI

      10.1186/s12893-020-01018-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The number of osteoclasts in a biopsy specimen can predict the efficacy of neoadjuvant chemotherapy for primary osteosarcoma2021

    • Author(s)
      Araki Yoshihiro、Yamamoto Norio、Hayashi Katsuhiro、Takeuchi Akihiko、Miwa Shinji、Igarashi Kentaro、Higuchi Takashi、Abe Kensaku、Taniguchi Yuta、Yonezawa Hirotaka、Morinaga Sei、Asano Yohei、Ikeda Hiroko、Nojima Takayuki、Tsuchiya Hiroyuki
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 1989-1989

    • DOI

      10.1038/s41598-020-80504-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Development and validation of a risk scoring system to predict surgical-site infection after soft-tissue sarcoma resection: Case controlled study2023

    • Author(s)
      Miwa S, Yamamoto N, Hayashi K, Takeuchi A, Igarashi K, Taniguchi Y, Morinaga S, Tsuchiya H
    • Organizer
      The 14th Asia Pacific Musculoskeletal Tumor Society (APMSTS) meeting (Taipei, Taiwan, October 4-7, 2023)
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 悪性骨腫瘍手術における術後感染の危険因子と抗菌加工インプラント2023

    • Author(s)
      三輪真嗣,山本憲男,林克洋,武内章彦,五十嵐健太郎,米澤宏隆,森永整,淺野陽平,齋藤志朗,土屋弘行
    • Organizer
      第46回日本骨・関節感染症学会(津,6月23-24日)
    • Related Report
      2023 Annual Research Report
  • [Presentation] 液体窒素処理骨を用いて再建した四肢悪性骨腫瘍における処理骨生存の予測因子2023

    • Author(s)
      三輪真嗣,山本憲男,林克洋,武内章彦,五十嵐健太郎,谷口裕太,森永整,淺野陽平,土屋弘行
    • Organizer
      第96回日本整形外科学会学術総会(横浜,5月11-14日)
    • Related Report
      2023 Annual Research Report
  • [Presentation] 液体窒素処理骨を用いて再建した四肢悪性骨腫瘍における処理骨生存の予測因子2023

    • Author(s)
      三輪真嗣,山本憲男,林克洋,武内章彦,五十嵐健太郎,谷口裕太,森永整,淺野陽平,土屋弘行
    • Organizer
      第56回日本整形外科学会骨・軟部腫瘍学術集会(東京7月14-15日)
    • Related Report
      2023 Annual Research Report
  • [Presentation] 軟部肉腫術後感染の危険因子とスコアリングシステムの考案2023

    • Author(s)
      三輪真嗣,山本憲男,林克洋,武内章彦,五十嵐健太郎,谷口裕太,森永整,淺野陽平,土屋弘行
    • Organizer
      第56回日本整形外科学会骨・軟部腫瘍学術集会(東京7月14-15日)
    • Related Report
      2023 Annual Research Report
  • [Presentation] Risk factors for surgical-site infection after soft-tissue sarcoma resection and development of a risk scoring system2022

    • Author(s)
      Miwa S, Yamamoto N, Hayashi K, Takeuchi A, Igarashi K, Taniguchi Y, Morinaga S, Tsuchiya H
    • Organizer
      21st General Meeting of the International Society of Limb Salvage
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] A radiological scoring system for differentiation between enchondroma and chondrosarcoma2022

    • Author(s)
      Miwa S, Yamamoto N, Hayashi K, Takeuchi A, Igarashi K, Taniguchi Y, Morinaga S, Tsuchiya H
    • Organizer
      21st General Meeting of the International Society of Limb Salvage
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] 骨軟部腫瘍における術後感染の危険因子2022

    • Author(s)
      三輪真嗣,山本憲男,林克洋,武内章彦,五十嵐健太郎,米澤宏隆,森永整,淺野陽平,齋藤志朗,土屋弘行
    • Organizer
      第45回日本骨・関節感染症学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 横紋筋肉腫の薬物療法2022

    • Author(s)
      三輪真嗣,山本憲男,林克洋,武内章彦,五十嵐健太郎,谷口裕太,森永整,淺野陽平,土屋弘行
    • Organizer
      第139回中部日本整形外科災害外科学会・学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 骨軟部腫瘍における術中迅速病理診断の正確性の検討2022

    • Author(s)
      三輪真嗣,山本憲男,林克洋,武内章彦,五十嵐健太郎,米澤宏隆,森永整,淺野陽平,齋藤志朗,野島孝之,土屋弘行
    • Organizer
      第55回日本整形外科学会骨・軟部腫瘍学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 骨軟部肉腫における治療標的2021

    • Author(s)
      三輪真嗣,山本憲男,林克洋,武内章彦,五十嵐健太郎,米澤宏隆,森永整,淺野洋平,齋藤志朗,野島孝之,土屋弘行
    • Organizer
      第94回日本整形外科学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 軟骨性腫瘍の鑑別における画像所見の有用性評価と新しいスコアリングシステムの考案2021

    • Author(s)
      三輪真嗣,山本憲男,林克洋,武内章彦,五十嵐健太郎,米澤宏隆,森永整,淺野陽平,斉藤志朗,土屋弘行
    • Organizer
      第54回日本整形外科学会骨・軟部腫瘍学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] The diagnostic accuracy of frozen section diagnosis in bone and soft tissue tumors2021

    • Author(s)
      Miwa S, Yamamoto N, Hayashi K, Takeuchi A, Igarashi K, Taniguchi Y, Yonezawa H, Morinaga S, Ikeda H, Nojima T, Tsuchiya H
    • Organizer
      The 13th Asia Pacific Musculoskeletal Tumor Society Meeting
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research

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Published: 2021-04-28   Modified: 2025-01-30  

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