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Comprehensive analysis of the association of treatment efficacy from immune checkpoint inihibitors with host-HLA and tumor environment

Research Project

Project/Area Number 21K09359
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56030:Urology-related
Research InstitutionTokyo Women's Medical University

Principal Investigator

Kondo Tsunenori  東京女子医科大学, 医学部, 教授 (50301544)

Co-Investigator(Kenkyū-buntansha) 雑賀 寛  東京女子医科大学, 医学部, 非常勤講師 (10815004)
福田 洋典  東京女子医科大学, 医学部, 助教 (60848951)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords腎癌 / HLA / 腫瘍微小環境 / 免疫細胞 / 網羅的遺伝子発現解析
Outline of Research at the Start

本研究では、免疫チェックポイント阻害剤の奏功データと紐づいた腎細胞がんの臨床検体に対して、HLAタイピング、腫瘍浸潤免疫細胞のフローサイトメトリー解析及び腫瘍微小環境に関する網羅的遺伝子発現解析を行い、それらのデータと免疫チェックポイント阻害剤の効果との関連性について統合的に解析する。

Outline of Final Research Achievements

In this study, we analyzed whether HLA (human leukocyte antigen) and the tumor microenvironment correlate with the efficacy of immune checkpoint inhibitors (ICIs). We extracted DNA from peripheral blood of 39 cases of renal cell carcinoma patients treated with ICIs and performed HLA typing using next-generation sequencing. By analyzing the correlation between this data and treatment outcomes and prognosis information, we were able to identify HLA-C subtypes associated with treatment efficacy. Furthermore, by analyzing tumor-infiltrating immune cells using flow cytometry and integrating with ICI treatment outcomes, we suggested that ICIs have a higher treatment efficacy in cases with abundant immune cell infiltration.

Academic Significance and Societal Importance of the Research Achievements

この研究の社会的意義は、ICI治療におけるHLAと腫瘍微小環境の重要性を明らかにすることで今後の個別化されたがん治療に向けた情報として重要な点にある。特定のHLAサブタイプや免疫細胞浸潤の程度が治療効果に影響を与える可能性を示し、将来的にはICI治療の効果を最大化し、患者の生活の質を向上させる治療戦略を開発する基盤を提供することが期待される。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (1 results)

All 2024

All Presentation (1 results)

  • [Presentation] Impact of Gender on the Efficacy of Immune Checkpoint Inhibitor Therapy in Solid Tumors, Including Renal Cell Carcinoma2024

    • Author(s)
      Hironori Fukuda, Hiroki Ishihara, Yukihiro Mizoguchi, Makiko Yamashita, Kazunori Aoki, Ryo Ishiyama, Takashi Ikeda, Yuki Nemoto, Hiroaki Shinmura, Yasunobu Hashimoto, Kazuhiko Yoshida, Toshihito Hirai, Junpei Iizuka, Daisuke Tokita, Tsunenori Kondo, Yoji Nagashima, Toshio Takagi
    • Organizer
      第111回日本泌尿器科学会総会
    • Related Report
      2023 Annual Research Report

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Published: 2021-04-28   Modified: 2025-01-30  

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