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Attempt to define sentinel node micrometastasis in oral squamous cell carcinoma

Research Project

Project/Area Number 21K09620
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56050:Otorhinolaryngology-related
Research InstitutionAsahi University

Principal Investigator

MATSUZUKA Takashi  朝日大学, 保健医療学部, 教授 (80336461)

Co-Investigator(Kenkyū-buntansha) 長谷川 泰久  朝日大学, 歯学部, 教授 (10261207)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2023: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
KeywordsSentinel lymph node / Lymphatic metastasis / Neck dissection / Micrometastases / Oral carcinoma / 微小転移 / 頭頸部がん / 口腔癌 / センチネルリンパ節 / 病期分類
Outline of Research at the Start

リンパ節転移の病理像は数個の腫瘍細胞が存在する状態から占拠した状態まで様々である。乳がん領域ではリンパ節の微小転移を定義し治療方針を区別している。現在のところ頭頸部がんではその定義はなく取り扱いも定まっていない。そこで本研究ではふたつの先行試験の対象からセンチネルリンパ節(SN)の情報を取得し、データベースの臨床情報を照合して予後と転移病巣の関係について解析し、頭頸部がんにおける微小転移を定義する。そしてSNが微小転移とみなされた場合に頸部郭清の省略が可能かを検証する前向き比較試験をデザインする。

Outline of Final Research Achievements

This sentinel node (SN) biopsy trial,included 55 patients from three previous trials, aimed to assess its effectiveness in identifying predictive factors of micrometastases and to determine whether elective neck dissection (END) is necessary in oral squamous cell carcinoma. The relationship between the sizes of the metastatic focus and metastasis in non-sentinel node (NSN) was investigated.
The difference of prevalence between negative- and positive-NSN was statistically significant with regard to age, long diameter of primary site and number of cases with regional recurrence. In comparing the size of largest metastatic focus dividing the number of positive SN, with metastaic focus range of < 3.0 mm in one-positive SN group, there were 18 (33%) negative-NSN and no positive-NSN. Regarding prognosis,3-year overall survival rate of this group and other were 94 % and 73 % (p=0.04), and 3-year recurrence free survival rate of this group and other were 94 % and 51 % (p=0.03), respectively.

Academic Significance and Societal Importance of the Research Achievements

潜在転移リスクのない微小転移の定義についての提案は①SN転移が単発であり②SN内の病巣が3.0 mmかそれより小さいときである。これからもSNの情報を収集し頭頸部癌の微小転移を定義したい。本研究結果からSNの転移が微小であるとき、SNより下流の郭清を省略できる可能性がある。この結果を基にSNが微小転移であった際に、頸部郭清を省略するか、画一的な頸部郭清術を行うかとの治療法の比較・検証を行う前向き比較試験をデザインし次の研究に継承する。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (16 results)

All 2024 2023 2022 2021

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 5 results) Presentation (8 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Predictive factors for dissection-free sentinel node micrometastases in early oral squamous cell carcinoma2023

    • Author(s)
      Matsuzuka Takashi、Tsukahara K、Yoshimoto S、Chikamatsu K、Shiotani A、Oze I、Murakami Y、Shinozaki T、Enoki Y、Ohba S、Kawakita D、Hanai Nobuhiro、Koide Yusuke、Sawabe Michi、Nakata Yusuke、Fukuda Y、Nishikawa D、Takano G、Kimura T、Oguri K、Hirakawa H、Hasegawa Yasuhisa
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 6188-6188

    • DOI

      10.1038/s41598-023-33218-8

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Indications for sentinel lymph node biopsy in node‐negative oral cancers2023

    • Author(s)
      Ozawa Taijiro、Oze I、Matsuzuka Takashi、Sasaki E、Yokoyama J、Sano Y、Tomifuji M、Araki K、Kogashiwa Y、Tateya I、Agena S、Sakashita T、Tsuzuki H、Terada H、Suzuki H、Nishikawa D、Beppu S、Matoba T、Mukoyama N、Oguri K、Hasegawa Yasuhisa
    • Journal Title

      Head & Neck

      Volume: 45 Issue: 10 Pages: 2533-2543

    • DOI

      10.1002/hed.27477

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macroscopic and multiple metastases in sentinel lymph node biopsy are respectively associated with poor prognosis in early oral cancer2023

    • Author(s)
      Kondo Takahito、Tsukahara Kiyoaki、Kawakita Daisuke、Yoshimoto Seiichi、Miura Kouki、Sugasawa Masashi、Chikamatsu Kazuaki、Matsuzuka Takashi、Oze Isao、Kitamura Morimasa、Murakami Yoshiko、Otozai Shinji、Shinozaki Takeshi、Ohba Shinichi、Araki Koji、Mizumachi Takatsugu、et al
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 28 Issue: 4 Pages: 512-520

    • DOI

      10.1007/s10147-023-02305-1

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictive factors for false negatives following sentinel lymph node biopsy in early oral cavity cancer2022

    • Author(s)
      Miura Kouki、Kawakita Daisuke、Oze Isao、Suzuki Motoyuki、Sugasawa Masashi、Endo Kazuhira、Sakashita Tomohiro、Ohba Shinichi、Suzuki Mikio、Shiotani Akihiro、Kohno Naoyuki、Maruo Takashi、Suzuki Chiaki、Iki Takehiro、Hiwatashi N、Matsumoto F、Kobayashi K、Toyoda M、Hanyu K、Koide Y、Murakami Y、Hasegawa Yasuhisa
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 1-1

    • DOI

      10.1038/s41598-022-10594-1

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distribution pattern and pathologic analysis of metastatic sentinel and non-sentinel lymph nodes in lymphatic basin dissection for clinical T2/T3 oral cancer with clinical N0 status2022

    • Author(s)
      Hirakawa Hitoshi、Matsuzuka Takashi、Uemura Hirokazu、Yoshimoto Seiichi、Miura Kouki、Shiotani Akihiro、Sugasawa Masashi、Homma Akihiro、Yokoyama Junkichi、Tsukahara Kiyoaki、Yoshizaki Tomokazu、Hanai Nobuhiro、Suzuki Hidenori、Suzuki Mikio、Hasegawa Yasuhisa
    • Journal Title

      Auris Nasus Larynx

      Volume: 49 Issue: 4 Pages: 680-689

    • DOI

      10.1016/j.anl.2021.11.010

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neoadjuvant Superselective Intra-Arterial Cisplatin Chemoradiotherapy Combined With Surgery in Patients With T4 Squamous Cell Carcinoma of the Maxillary Sinus2022

    • Author(s)
      Ikeda Masakazu、Suzuki Masahiro、Matsuzuka Takashi、Ishii Shiro、Sato Hisashi、Murono Shigeyuki
    • Journal Title

      Journal of Oral and Maxillofacial Surgery

      Volume: 80 Issue: 8 Pages: 1445-1450

    • DOI

      10.1016/j.joms.2022.04.014

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sentinel node navigation surgery as a diagnosis and treatment tool to find occult metastasis for early oral cancer2022

    • Author(s)
      Matsuzuka Takashi、Hasegawa Yasuhisa
    • Journal Title

      Toukeibu Gan

      Volume: 48 Issue: 3 Pages: 257-260

    • DOI

      10.5981/jjhnc.48.257

    • ISSN
      1349-5747, 1881-8382
    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Reply to P. Kaul et al2021

    • Author(s)
      Hasegawa Yasuhisa、Tsukahara Kiyoaki、Yoshimoto Seiichi、Miura Kouki、Yokoyama Junkichi、Hirano Shigeru、Uemura Hirokazu、Sugasawa Masashi、Yoshizaki Tomokazu、Homma Akihiro、Chikamatsu Kazuaki、...Kosuda Shigeru、Yatabe Yasushi(20番目)
    • Journal Title

      Journal of Clinical Oncology

      Volume: 39 Issue: 31 Pages: 3518-3519

    • DOI

      10.1200/jco.21.01554

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Neck Management Based on the Subsites of Oral Cavity Cancers: Indication, Extent, and Technique of Neck Dissection2024

    • Author(s)
      Matsuzuka Takashi
    • Organizer
      19th Korea-Japan Joint Meeting of Otorhinolaryngology-Head and Neck Surgery
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 微小な口腔癌センチネルリンパ節転移は頸部郭清を省略できるか2023

    • Author(s)
      松塚 崇、塚原清彰、吉本世一、近松一朗、塩谷彰浩、尾瀬功、村上善子、篠崎剛、榎木祐一郎、大峡慎一、川北大介、花井信広、小出悠介、中多祐介、福田裕次郎、西川大祐、高野学、木村隆浩、平川仁、長谷川泰久
    • Organizer
      第25回SNNS研究会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 頭頸部癌・婦人科癌領域におけるテクネフチン酸を用いたセンチネルリンパ節生検2023

    • Author(s)
      松塚 崇
    • Organizer
      第25回SNNS研究会学術集会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] センチネルリンパ節ナビゲーション手術(SNNS)における微小転移の診断と治療2022

    • Author(s)
      松塚 崇、長谷川泰久
    • Organizer
      第46回日本頭頸部癌学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 口腔癌のSNNSにおける偽陰性率改善の取り組みと微小転移の取り扱い2022

    • Author(s)
      松塚 崇、長谷川泰久、花井 信広、吉本 世一、大峡 慎一、塚原 清彰、近松 一朗、榎木 祐一郎、塩谷 彰浩、篠﨑 剛、尾瀬 功
    • Organizer
      第24回SNNS研究会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 口腔がんの腫瘍径と深達度と頸部転移割合の関係2022

    • Author(s)
      松塚 崇、花井 信広、小林 謙也、大峡 慎一、塚原 清彰、近松 一朗、榎木 祐一郎、荒木 幸仁、篠﨑 剛、長谷川 泰久
    • Organizer
      第31回日本頭頸部外科学会
    • Related Report
      2021 Research-status Report
  • [Presentation] センチネルリンパ節ナビゲーション手術(SNNS)における口腔癌のリンパ節転移巣の大きさの検討2021

    • Author(s)
      松塚 崇、長谷川泰久、花井 信広、小林 謙、大峡 慎一、塚原 清彰、近松 一朗、榎木 祐一郎、荒木 幸仁、篠﨑 剛、尾瀬 功
    • Organizer
      第45回頭頸部癌学会
    • Related Report
      2021 Research-status Report
  • [Presentation] SNNSにおける口腔癌のリンパ節転移巣の大きさの検討2021

    • Author(s)
      松塚 崇、長谷川泰久、花井 信広、小林 謙、大峡 慎一、塚原 清彰、近松 一朗、榎木 祐一郎、荒木 幸仁、篠﨑 剛、尾瀬 功
    • Organizer
      第23回SNNS研究会学術集会
    • Related Report
      2021 Research-status Report
    • Invited

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Published: 2021-04-28   Modified: 2025-01-30  

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