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Biomarkers for parotid cancer; grade diagnosis and personalized treatment by abnormal gene

Research Project

Project/Area Number 21K09641
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 56050:Otorhinolaryngology-related
Research InstitutionOsaka Medical and Pharmaceutical University

Principal Investigator

Kawata Ryo  大阪医科薬科大学, 医学部, 教授 (40224787)

Co-Investigator(Kenkyū-buntansha) 栗栖 義賢  大阪医科薬科大学, 医学部, 准教授 (30319529)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords耳下腺癌 / 悪性度 / HER2 / AR / 組織型 / 生存率 / 新規治療 / 個別化治療 / PD-L1 / アンドロゲンリセプター / バイオマーカー / 異常遺伝子
Outline of Research at the Start

耳下腺癌は症例数が少なく、かつ病理組織や悪性度が多彩である。申請者は過去21年間に耳下腺癌約210例の治療例を経験して詳細な臨床データを蓄積してきた。進行癌や高悪性癌の予後は不良であり、低/中悪性癌においても手術の際の顔面神経の温存の可否が問題になる。そのため大きな予後因子である悪性度診断が治療にあたって重要であるが、確立された悪性度マーカーがなく、新規バイオマーカーや異常遺伝子の検討が期待される。これらの検討は分子標的薬や免疫チェックポイント阻害薬の開発につながっていく。外科的切除が主な治療である本疾患に対して、予後不良かつ機能的温存が強く求められる耳下腺癌に対する個別化治療を目指したい。

Outline of Final Research Achievements

The subjects were 268 patients with parotid carcinoma treated at our department during the 24-year. The 5-year disease-specific survival rate (DSS) was 100% for patients in stage I, 98.6% in stage II, 85.0% in stage III, and 56.9% in stage IV. 30 patients were human epidermal growth factor receptor type 2 (HER2) positive. 35 patients were androgen receptor (AR) positive. Immunohistological investigation showed patients with HER-2 or AR-positive tumors had a significantly worse prognosis. PD-L1 expression was found in 34.6% of parotid carcinomas, with the expression being higher in tumors with a higher stage and a higher grade. The 5-year DSS in grade and stage showed no significant difference. The 10-year DSS rates were as follows: MEC, 34.9%; SDC, 22.6%; CXPA, 47.1%; and AdCC, 56.3%. Each histological type was found to have its own pathological and clinical features, so diagnosis, treatment, and follow-up should be performed accordingly.

Academic Significance and Societal Importance of the Research Achievements

耳下腺癌の予後は必ずしも良好ではなく、現状では手術以外に有効な手段がない。また顔面神経が耳下腺内を走行しており、その温存・切除により術後の生活に質(QOL)を大きく左右する。今回の研究において耳下腺癌に対して、組織別、悪性度別の腫瘍特性を探索することおよびバイオマーカーから新規薬物治療の可能性を見出すことが、生命予後の改善だけでなく患者のQOLに大きく貢献できると考えられる。多彩である耳下腺癌に対する個別化治療を確立することが最終目標である。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (37 results)

All 2023 2022 2021

All Journal Article (23 results) (of which Peer Reviewed: 10 results,  Open Access: 3 results) Presentation (13 results) Book (1 results)

  • [Journal Article] Proposal for a novel classification of benign parotid tumors based on localization2023

    • Author(s)
      Nishimura Hiromi、Kawata Ryo、Kinoshita Ichita、Higashino Masaaki、Terada Tetsuya、Haginomori Shin-Ichi、Tochizawa Takeshi
    • Journal Title

      Auris Nasus Larynx

      Volume: 50 Issue: 5 Pages: 790-798

    • DOI

      10.1016/j.anl.2023.01.010

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Predicting postoperative facial nerve paralysis by using intraoperative nerve monitoring during parotid surgery2023

    • Author(s)
      Higashino Masaaki、Kinoshita Ichita、Jinnin Tsuyoshi、Terada Tetsuya、Kawata Ryo
    • Journal Title

      European Archives of Oto-Rhino-Laryngology

      Volume: 280 Issue: 8 Pages: 3855-3860

    • DOI

      10.1007/s00405-023-07973-3

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Management and outcome of adenoid cystic carcinoma of the major salivary glands: the 22-year experience of a single institution2023

    • Author(s)
      Ozaki Akiko、Kawata Ryo、Kinoshita Ichita、Higashino Masaaki、Terada Tetsuya、Haginomori Shin-ichi、Kurisu Yoshitaka、Hirose Yoshinobu
    • Journal Title

      Acta Oto-Laryngologica

      Volume: 143 Issue: 6 Pages: 536-542

    • DOI

      10.1080/00016489.2023.2220371

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Facial nerve dissection in parotid surgery: a microscopic investigation study2023

    • Author(s)
      Jinnin Tsuyoshi、Futaki Sugiko、Hirata Azumi、Kuwabara Hiroko、Higashino Masaaki、Kondo Yoichi、Kawata Ryo
    • Journal Title

      Anatomical Science International

      Volume: 99 Issue: 1 Pages: 90-97

    • DOI

      10.1007/s12565-023-00737-3

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2.耳下腺腫瘍の臨床―体系的な診断・治療から得た新知見と将来展望―2022

    • Author(s)
      河田 了
    • Journal Title

      Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo)

      Volume: 125 Issue: 4 Pages: 447-451

    • DOI

      10.3950/jibiinkotokeibu.125.4_447

    • ISSN
      2436-5793, 2436-5866
    • Year and Date
      2022-04-20
    • Related Report
      2022 Research-status Report
  • [Journal Article] Benign Parotid Tumor Located Directly Above the Main Trunk of the Facial Nerve: Ingenuity in Nerve Identification2022

    • Author(s)
      Kawata Ryo
    • Journal Title

      Nippon Jibiinkoka Tokeibugeka Gakkai Kaiho(Tokyo)

      Volume: 125 Issue: 3 Pages: 296-300

    • DOI

      10.3950/jibiinkotokeibu.125.3_296

    • ISSN
      2436-5793, 2436-5866
    • Year and Date
      2022-03-20
    • Related Report
      2022 Research-status Report
  • [Journal Article] Fine-Needle Aspiration Cytology for Parotid Tumors2022

    • Author(s)
      Taniuchi Masataka、Terada Tetsuya、Kawata Ryo
    • Journal Title

      Life

      Volume: 12 Issue: 11 Pages: 1897-1897

    • DOI

      10.3390/life12111897

    • Related Report
      2022 Research-status Report
  • [Journal Article] Role of Intra-Parotid Lymph Node Metastasis in Primary Parotid Carcinoma2022

    • Author(s)
      Terada Tetsuya、Kawata Ryo
    • Journal Title

      Life

      Volume: 12 Issue: 12 Pages: 2053-2053

    • DOI

      10.3390/life12122053

    • Related Report
      2022 Research-status Report
  • [Journal Article] In Response to Risk Factors of Postoperative Facial Palsy for Benign Parotid Tumors: Outcome of 1,018 Patients2022

    • Author(s)
      Kawata Ryo、Kinoshita Ichita、Omura Shuji、Higashino Masaaki、Nishikawa Shuji、Terada Tetsuya、Haginomori Shin‐Ichi、Kurisu Yoshitaka、Hirose Yoshinobu、Tochizawa Takeshi
    • Journal Title

      The Laryngoscope

      Volume: 132 Issue: 3

    • DOI

      10.1002/lary.29883

    • Related Report
      2022 Research-status Report
  • [Journal Article] Management and outcome of parotid mucoepidermoid carcinoma by histological grade: A 21‐year review2022

    • Author(s)
      Taniuchi Masataka、Kawata Ryo、Terada Tetsuya、Higashino Masaaki、Nishimura Hiromi、Kurisu Yoshitaka、Kuwabara Hiroko、Hirose Yoshinobu
    • Journal Title

      Laryngoscope Investigative Otolaryngology

      Volume: 7 Issue: 3 Pages: 766-773

    • DOI

      10.1002/lio2.809

    • Related Report
      2022 Research-status Report
  • [Journal Article] Management for Warthin Tumor of the Parotid Gland: Surgery or Observation. A 21-Year Retrospective Study of 387 Cases2022

    • Author(s)
      Nishimura Hiromi、Kawata Ryo、Kinoshita Ichita、Higashino Masaaki、Terada Tetsuya、Haginomori Shin-Ichi、Tochizawa Takeshi
    • Journal Title

      Ear, Nose & Throat Journal

      Volume: - Issue: 12 Pages: 779-786

    • DOI

      10.1177/01455613221080927

    • Related Report
      2022 Research-status Report
  • [Journal Article] BDNF/TRKB axis provokes EMT progression to induce cell aggressiveness via crosstalk with cancer-associated fibroblasts in human parotid gland cancer2022

    • Author(s)
      Moriwaki Kazumasa、Wada Masaki、Kuwabara Hiroko、Ayani Yusuke、Terada Tetsuya、Higashino Masaaki、Kawata Ryo、Asahi Michio
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 17553-17553

    • DOI

      10.1038/s41598-022-22377-9

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The implicated clinical factors for outcomes in 304 patients with salivary duct carcinoma: Multi‐institutional retrospective analysis in Japan2022

    • Author(s)
      Kusafuka Kimihide、Sato Yoko、Nakatani Eiji、Baba Satoshi、Maeda Matsuyoshi、Kawata Ryo
    • Journal Title

      Head & Neck

      Volume: 44 Issue: 6 Pages: 1430-1441

    • DOI

      10.1002/hed.27034

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 耳下腺手術における筋弛緩モニターの有用性2022

    • Author(s)
      東野正明,菊岡祐介,萩森伸一,河田 了
    • Journal Title

      Facial N Res Jpn

      Volume: 42

    • Related Report
      2022 Research-status Report
  • [Journal Article] 耳下腺浅葉切除術―安全・確実な術式―2021

    • Author(s)
      Kawata Ryo
    • Journal Title

      Nippon Jibiinkoka Gakkai Kaiho

      Volume: 124 Issue: 2 Pages: 81-85

    • DOI

      10.3950/jibiinkoka.124.81

    • NAID

      130007993623

    • ISSN
      0030-6622, 1883-0854
    • Year and Date
      2021-02-20
    • Related Report
      2021 Research-status Report
  • [Journal Article] Salivary mucoepidermoid carcinoma: histological variants, grading systems, CRTC1/3-MAML2 fusions, and clinicopathological features2021

    • Author(s)
      Nakano Satsuki、Okumura Yoshihide、Murase Takayuki、Nagao Toshitaka、Kusafuka Kimihide、Urano Makoto、Yamamoto Hidetaka、Kano Satoshi、Tsukahara Kiyoaki、Okami Kenji、Kawakita Daisuke、Nagao Toru、Hanai Nobuhiro、Iwai Hiroshi、Kawata Ryo、Tada Yuichiro、Nibu Ken‐Ichi、Inagaki Hiroshi
    • Journal Title

      Histopathology

      Volume: 80 Issue: 4 Pages: 729-735

    • DOI

      10.1111/his.14586

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increase in Chymase-Positive Mast Cells in Recurrent Pleomorphic Adenoma and Carcinoma Ex Pleomorphic Adenoma of the Parotid Gland2021

    • Author(s)
      Kinoshita Ichita、Jin Denan、Higashino Masaaki、Terada Tetsuya、Kurisu Yoshitaka、Takai Shinji、Kawata Ryo
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 23 Pages: 12613-12613

    • DOI

      10.3390/ijms222312613

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Symptoms and signs of parotid tumors and their value for diagnosis and prognosis: a 20-year review at a single institution2021

    • Author(s)
      Inaka Yuko、Kawata Ryo、Haginomori Shin-ichi、Terada Tetsuya、Higashino Masaaki、Omura Shuji、Kikuoka Yusuke
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 26 Issue: 7 Pages: 1170-1178

    • DOI

      10.1007/s10147-021-01901-3

    • Related Report
      2021 Research-status Report
  • [Journal Article] Effective surgical management of anterior tumors of the parotid gland: Main trunk method vs. peripheral Smethod2021

    • Author(s)
      Omura Shuji、Kawata Ryo、Haginomori Shin-ichi、Terada Tetsuya、Higashino Masaaki、Yoshitaka Kurisu、Hirose Yoshinobu
    • Journal Title

      American Journal of Otolaryngology

      Volume: 42 Issue: 4 Pages: 102964-102964

    • DOI

      10.1016/j.amjoto.2021.102964

    • Related Report
      2021 Research-status Report
  • [Journal Article] Basal cell adenocarcinoma of the parotid gland: Comparison with basal cell adenoma for preoperative diagnosis2021

    • Author(s)
      Terada Tetsuya、Kawata Ryo、Higashino Masaaki、Kurisu Yoshitaka、Kuwabara Hiroko、Hirose Yoshinobu
    • Journal Title

      Auris Nasus Larynx

      Volume: 48 Issue: 2 Pages: 310-316

    • DOI

      10.1016/j.anl.2020.08.024

    • Related Report
      2021 Research-status Report
  • [Journal Article] Effectiveness of intraoperative facial nerve monitoring and risk factors related to postoperative facial nerve paralysis in patients with benign parotid tumors: A 20-year study with 902 patients2021

    • Author(s)
      Kinoshita Ichita、Kawata Ryo、Higashino Masaaki、Nishikawa Shuji、Terada Tetsuya、Haginomori Shin-Ichi
    • Journal Title

      Auris Nasus Larynx

      Volume: 48 Issue: 3 Pages: 361-367

    • DOI

      10.1016/j.anl.2020.09.003

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Risk Factors of Postoperative Facial Palsy for Benign Parotid Tumors: Outcome of 1,018 Patients2021

    • Author(s)
      Kawata Ryo、Kinoshita Ichita、Omura Shuji、Higashino Masaaki、Nishikawa Shuji、Terada Tetsuya、Haginomori Shin‐Ichi、Kurisu Yoshitaka、Hirose Yoshinobu、Tochizawa Takeshi
    • Journal Title

      The Laryngoscope

      Volume: 131 Issue: 12

    • DOI

      10.1002/lary.29623

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Extracapsular Dissection for Parotid Tumors: Comparison with Partial Superficial Parotidectomy2021

    • Author(s)
      Kawata Ryo、Terada Tetsuya、Higashino Masaaki、Nishikawa Shuji、Omura Shuji
    • Journal Title

      Nippon Jibiinkoka Gakkai Kaiho

      Volume: 124 Issue: 3 Pages: 205-210

    • DOI

      10.3950/jibiinkoka.124.205

    • NAID

      130008021271

    • Related Report
      2021 Research-status Report
  • [Presentation] 耳下腺癌の頸部リンパ節転移と頸部郭清術の検討2023

    • Author(s)
      河田 了
    • Organizer
      第32回日本頭頸部外科学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 耳下腺高悪性癌に対する診断と治療方針-個別化治療を目指して-.2023

    • Author(s)
      河田 了
    • Organizer
      第124回日本耳鼻咽喉科学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 当科における耳下腺癌250症例の治療成績-24年間の検討2023

    • Author(s)
      河田 了,谷内政崇,神人 彪,野呂恵起,東野正明,寺田哲也
    • Organizer
      第47回日本頭頸部癌学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 良性耳下腺腫瘍に対する術式分類案2023

    • Author(s)
      河田 了,木下一太,谷内政崇,鈴木英佑,神人 彪,東野正明,寺田哲也:
    • Organizer
      第36回日本口腔・咽頭科学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 耳下腺腫瘍の臨床―体系的な診断・治療から得た新知見と将来展望―2022

    • Author(s)
      河田 了
    • Organizer
      第123回日本耳鼻咽喉科頭頸部外科学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 良性耳下腺腫瘍に対する局在分類案2022

    • Author(s)
      河田 了,西村尋眸,木下一太,東野正明,寺田哲也
    • Organizer
      第31回日本頭頸部外科学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 耳下腺高悪性癌における組織型別の臨床像と治療の展開2022

    • Author(s)
      河田 了,木下一太,神人 彪,東野正明,粟飯原輝人,寺田哲也
    • Organizer
      第46回日本頭頸部癌学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 耳下腺癌に対する病理組織型からみた治療方針2022

    • Author(s)
      河田 了,佐々木彰紀,谷内政崇,東野正明,寺田哲也
    • Organizer
      第35回日本口腔・咽頭科学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 耳下腺癌221例の検討2021

    • Author(s)
      河田 了,寺田哲也,東野正明,大村修士,粟飯原輝人
    • Organizer
      第45回日本頭頸部癌学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 耳下腺腫瘍における新しい細胞診分類2021

    • Author(s)
      谷内政崇,野呂恵起,大村修士,菊岡祐介,東野正明,粟飯原輝人,寺田哲也,河田 了
    • Organizer
      第45回日本頭頸部癌学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 耳下腺癌ステージ4症例についての検討2021

    • Author(s)
      寺田哲也,大村修士,東野正明,粟飯原輝人,河田 了
    • Organizer
      第34回日本口腔・咽頭科学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 耳下腺唾液腺導管癌と多形腺腫由来癌症例の検討2021

    • Author(s)
      東野正明,大村修士,粟飯原輝人,寺田哲也,河田 了
    • Organizer
      第34回日本口腔・咽頭科学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 耳下腺粘表皮癌における融合遺伝子の発現と臨床的相関2021

    • Author(s)
      谷内政崇,西村尋眸,木下一太,古川昌吾,鈴木英佑,東野正明,粟飯原輝人,寺田哲也,河田 了
    • Organizer
      第359回日本耳鼻咽喉科学会大阪地方連合会
    • Related Report
      2021 Research-status Report
  • [Book] 今日の治療指針2021年度版(63巻)2021

    • Author(s)
      河田 了
    • Publisher
      医学書院
    • Related Report
      2021 Research-status Report

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Published: 2021-04-28   Modified: 2025-01-30  

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