| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We investigated the virucidal effects of a polyvinyl alcohol iodine, PAI, against 16 types of human mastadenovirus (HAdV). Fifty microliters of PAI were exposed to 10 micro L each containing HAdV virus stock solution of 1× 106 copies/μL of HAdV-1, -2, -3, -4, 5, -6, -7, -8, -11, -37, -53, -54, -56, -64, -81, and -85 for 10 s, 30 s, 1 min, and 3 min. Virucidal effects were calculated relative to the positive control on days 7 to 211;10 and observed until 30 days post-infection. PAI satisfied the EN-14476 criterion for virucidal effects (>99.99%) for all HAdV types at all exposure times. All types of HAdVs that reacted for > 1 min achieved 99.99% reduction, including after 30 days. PAI displayed virucidal effects against all tested HAdV types. Currently, with no specific medication available for HAdVs in ocular infection, this could be an option to prevent the spread of keratoconjunctivitis.
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