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Development of an intelligent matrix for controlled drug-release system by minimally invasive external stimulus

Research Project

Project/Area Number 21K10023
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 57050:Prosthodontics-related
Research InstitutionNagasaki University

Principal Investigator

ABE Shigeaki  長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (40374566)

Co-Investigator(Kenkyū-buntansha) 高田 知哉  公立千歳科学技術大学, 理工学部, 教授 (00342444)
兵野 篤  旭川工業高等専門学校, 物質化学工学科, 助教 (20554299)
江良 裕子  埼玉県立大学, 保健医療福祉学部, 助教 (00825309)
Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsハイドロゲル / ゾル-ゲル / 赤外照射 / 薬剤徐放 / 非侵襲性 / 赤外応答性 / インテリジェントDDS / 外部刺激応答 / 低侵襲性 / ゾルーゲル
Outline of Research at the Start

本研究では、外部刺激としての赤外光に応答して「必要なタイミング」で「必要な量」の薬剤を放出可能な薬剤徐放材料の開発を試みる。
典型的な温度応答性ポリマーとは異なり、温度上昇によりゾルへの相転移を示す、Upper Critical Solution Temperature(UCST)型のポリマーを用いる事で、加温により内包した薬剤が放出されるシステムを構築する。このシステムを外部刺激により効率的に動作するため、赤外光照射に対して高い発熱応答を示すカーボンナノチューブと融合する事により、赤外光を照射した部分のみが速やかにゾルへと相転移を示し、薬剤を放出する「外部刺激応答性を持つ低侵襲インテリジェントDDS」を開発する。

Outline of Final Research Achievements

In this study, we investigated in a polyacrylamide-based hydrogel composite materials that performed a reversible sol-gel phase transition when were induced to a temperature conversion under an external stimulus. Carbon nanotubes (CNTs), known to have efficient light-to-heat conversion properties, were selected as the trigger for the temperature conversion in this composite, and an attempt was made to composite CNTs with hydrogel. To achieve composite with hydrogel, hydrophilized CNTs were produced by chemically modifying the surface. The CNT-containing hydrogel composite thus obtained exhibited a reversible physical properties conversion induced by sol-gel phase transition under exposed to infrared light on/off.

Academic Significance and Societal Importance of the Research Achievements

本研究では、外部刺激としての赤外光に応答して「必要なタイミング」で「必要な量」の薬剤を放出可能な「低侵襲外部刺激により薬剤徐放を行うインテリジェントマトリックスの創製」を試みる。典型的な温度応答性ポリマーとは異なり、温度上昇によりゾルへの相転移を示す、UCST型のポリマーを用いる事で、加温により内包した薬剤が放出されるシステムを構築する。このシステムを外部刺激により効率的に動作するため、赤外光照射に対して高い発熱応答を示すカーボンナノチューブと融合する事により、赤外光を照射した部分のみが速やかにゾルへと相転移を示し、薬剤を放出を試みる。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (21 results)

All 2024 2023 2022 2021

All Journal Article (11 results) (of which Peer Reviewed: 11 results,  Open Access: 10 results) Presentation (10 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Mechanical and swelling properties of polyacrylamide/polyacrylic acid composite hydrogels: The effects of network structure and carbon nanotube reinforcement2024

    • Author(s)
      Takada Tomoya、Morikawa Yuuto、Kikuchi Yasuki、Miyamoto Daiki、Hayasaka Yuuki、Abe Shigeaki
    • Journal Title

      Carbon Reports

      Volume: 3 Issue: 1 Pages: 29-36

    • DOI

      10.7209/carbon.030103

    • ISSN
      2436-5831
    • Year and Date
      2024-03-01
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel thermos responsible hydrogel composite: Controlled by infra-red irradiation2023

    • Author(s)
      S. Abe, M. NNesabi, S. Safaee, E. Seitoku, Y. Yato, A. Hyono, K. Nakanishi, Y. Era, M. Nakamura, T. Kusaka, A. Valanezhad, T. Takada, and I. Watanabe
    • Journal Title

      Molecular Crystals and Liquid Crystals

      Volume: 755 Issue: 1 Pages: 1-7

    • DOI

      10.1080/15421406.2023.2194600

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aluminum-Doping Effects on the Electronic States of Graphene Nanoflake: Diffusion and Hydrogen Storage Mechanism2023

    • Author(s)
      Tachikawa Hiroto、Izumi Yoshiki、Iyama Tetsuji、Abe Shigeaki、Watanabe Ikuya
    • Journal Title

      Nanomaterials

      Volume: 13 Issue: 14 Pages: 2046-2046

    • DOI

      10.3390/nano13142046

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Density functional theory study on the interaction of C<sub>60</sub> fullerene with PCBM2023

    • Author(s)
      Abe Shigeaki、Tachikawa Hiroto、Iyama Tetsuji、Safaee Sirus、Nesabi Mahdis、Valanezhad Alireza、Watanabe Ikuya
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 63 Issue: 1 Pages: 01SP31-01SP31

    • DOI

      10.35848/1347-4065/ad0305

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative evaluation of three nanofilled resin-based dental composites: cytotoxicity, surface roughness and flexural properties2022

    • Author(s)
      S. Jafarnia, A. Valanezhad*, T. Odatsu, M. Nesabi, S. Safaee, S. Abe, M. Khodaei, S. Shahabi, and I. Watanabe
    • Journal Title

      Polymers and Polymer Composites

      Volume: 30 Pages: 1-8

    • DOI

      10.1177/09673911221087586

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel coating layer on zirconia using modified zinc phosphatizing method2021

    • Author(s)
      KODAMA Kouta、VALANEZHAD Alireza、KHODAEI Mohammad、SAFAEE Sirus、JAFARNIA Shiva、NESABI Mahdis、ABE Shigeaki、WATANABE Ikuya、MURATA Hiroshi
    • Journal Title

      Dental Materials Journal

      Volume: 40 Issue: 4 Pages: 870-876

    • DOI

      10.4012/dmj.2020-253

    • NAID

      130008069736

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2021-07-25
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fabrication of bioactive glass coating on pure titanium by sol-dip method: Dental applications2021

    • Author(s)
      SAFAEE Sirus、VALANEZHAD Alireza、NESABI Mahdis、JAFARNIA Shiva、SANO Hideaki、SHAHABI Sima、ABE Shigeaki、WATANABE Ikuya
    • Journal Title

      Dental Materials Journal

      Volume: 40 Issue: 4 Pages: 949-956

    • DOI

      10.4012/dmj.2020-323

    • NAID

      130008069758

    • ISSN
      0287-4547, 1881-1361
    • Year and Date
      2021-07-25
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physical and mechanical characteristics of short fiber-reinforced resin composite in comparison with bulk-fill composites2021

    • Author(s)
      Jafarnia Shiva、Valanezhad Alireza、Shahabi Sima、Abe Shigeaki、Watanabe Ikuya
    • Journal Title

      Journal of Oral Science

      Volume: 63 Issue: 2 Pages: 148-151

    • DOI

      10.2334/josnusd.20-0436

    • NAID

      130008009607

    • ISSN
      1343-4934, 1880-4926
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel multi-structural reinforced treatment on Ti implant utilizing a combination of alkali solution and bioactive glass sol2021

    • Author(s)
      Nesabi Mahdis、Valanezhad Alireza、Safaee Sirus、Odatsu Tetsurou、Abe Shigeaki、Watanabe Ikuya
    • Journal Title

      Journal of the Mechanical Behavior of Biomedical Materials

      Volume: 124 Pages: 104837-104837

    • DOI

      10.1016/j.jmbbm.2021.104837

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ion Capture and Release Ability of Glass Ionomer Cement Containing Nanoporous Silica Particles with Different Pore and Particle Size2021

    • Author(s)
      Endo Ryoshun、Nakanishi Ko、Bando Yosuke、Abe Shigeaki、Maruoka Haruhi、Nakamura Mariko、Akasaka Tsukasa、Yoshida Yasuhiro、Sato Yoshiaki
    • Journal Title

      Materials

      Volume: 14 Issue: 19 Pages: 5742-5742

    • DOI

      10.3390/ma14195742

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bone Formation Ability and Cell Viability Enhancement of MC3T3-E1 Cells by Ferrostatin-1 a Ferroptosis Inhibitor of Cancer Cells2021

    • Author(s)
      Valanezhad Alireza、Odatsu Tetsurou、Abe Shigeaki、Watanabe Ikuya
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 22 Pages: 12259-12259

    • DOI

      10.3390/ijms222212259

    • NAID

      120007186858

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] カーボンナノチューブ添加積層ハイドロゲルの温度応答変形2024

    • Author(s)
      佐々木一織,高田知哉,阿部薫明
    • Organizer
      化学系学協会北海道支部2024年冬季研究発表会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Interaction of C60 fullerene with alkyl functionalized C60: A density functional theory study2024

    • Author(s)
      S. Abe, S. Safaee, I. Watanabe and H. Tachikawa
    • Organizer
      ISPlasma 2024
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 表面化学修飾による選択的薬剤徐放キャリアの開発2023

    • Author(s)
      阿部薫明,サファイー シルス,江良裕子,バラネザハド アリレザ,渡邊郁哉
    • Organizer
      第81回日本歯科理工学会学術討論会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Development of medical adhesive materials with removability by external stimulation2023

    • Author(s)
      S. Safaee, K. Nakanishi, S. Abe, M. Nesabi, Y. Era, M. Nakamura, A. Hyono, A. Valanezhad, T. Takada, I. Watanabe and H. Murata
    • Organizer
      KJF-ICOMEP 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] チタンインプラントのさまざまな個別治療および複合治療の評価2023

    • Author(s)
      S. Safaee, M. Nesabi, 阿部薫明, 岡﨑ひとみ, 吉田和弘, 渡邊郁也, 村田比呂司
    • Organizer
      日本補綴歯科学会 九州支部学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Density functional theory (DFT) study on molecular design of organic radical-functionalized graphene2023

    • Author(s)
      S. Abe, I. Watanabe and H. Tachikawa
    • Organizer
      ISPlasma 2023
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] A novel thermos responsible hydrogel composite: Controlled by infra-red irradiation2022

    • Author(s)
      S. Abe, M. Nesabi, S. Safaee, A. Hyono, Y. Era, M. Nakamura, A. Valanezhad, and I. Watanabe:
    • Organizer
      KJF-ICOMEP 2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of thermos responsible composite hydrogels using Carbon Nanotube derivatives2021

    • Author(s)
      Shigeaki Abe, Yuko Era, Alireza Valanezhad, Mariko Nakamura, Tomoya Takada, and Ikuya Watanabe
    • Organizer
      KJF-ICOMEP 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Sustainable drug-release property of dental resin composite using nano-porous silica particles2021

    • Author(s)
      Sirus Safaee, Mahdis Nesabi, Shiva Jafarnia, Alireza Valanezhad, Yuko Era, Shigeaki Abe, and Ikuya Watanabe
    • Organizer
      第78回日本歯科理工学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 薬剤徐放能を持つ歯科用コンポジット材料の開発2021

    • Author(s)
      Safaee,Shiva Jafarnia, 岩沼健児, 成徳英理, 中西 康, 江良祐子, Alireza Valanezhad, 中村光一, 高田知哉, 佐藤嘉晃, 渡邊郁
    • Organizer
      第43回日本バイオマテリアル学会大会
    • Related Report
      2021 Research-status Report

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Published: 2021-04-28   Modified: 2025-01-30  

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