| Project/Area Number |
21K10142
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 57060:Surgical dentistry-related
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 口腔扁平上皮癌 / 免疫チェックポイント阻害剤 / 治療マーカー / 免疫チェックポイント阻害薬 / 感受性マーカー / 口腔癌 / 細胞外小胞 / OSCC / ICIs / 治療抵抗性 |
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| Outline of Research at the Start |
口腔癌におけるICIs耐性機序の解明および新たな治療戦略の開発を目的として、実際に免疫チェックポイント阻害薬を投与した患者検体やPatient Derived Xenograft: PDXモデルを使用し、新たな分子機構の解明行う。
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| Outline of Final Research Achievements |
As the efficacy of immune checkpoint inhibitors (ICIs) in oral squamous cell carcinoma has been attracting attention, we explored the possibility of PDL1, a marker of ICIs, as a treatment prognostic factor. The PD-L1EVs-high group had a worse prognosis in PFS, PFS2, and OS compared to the PD-L1EVs-low group, and PD-L1EVs was an independent prognostic factor for OS. Next, we analyzed the relationship between nutritional indicators and T cell exhaustion in peripheral blood, and found that patients with low OPNI values had more advanced T cell exhaustion of CTLs in peripheral blood, suggesting that poor nutritional status may affect the immune status of the whole body.
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| Academic Significance and Societal Importance of the Research Achievements |
治療予後因子の解明により、患者1人1人に適した抗腫瘍薬を選択することが可能になり、治療効果向上が期待される。また、根治的加療が不可能である進行例においても、効果的な薬剤の使用や、補助療法の併用にてQOLの維持に繋がると思われる。
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