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Prospective observational study examining the financial toxicity and quality of life of medical intervention in breast cancer patients.

Research Project

Project/Area Number 21K10364
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 58010:Medical management and medical sociology-related
Research InstitutionOkayama University (2022-2023)
National Cancer Center Japan (2021)

Principal Investigator

Iwatani Tsuguo  岡山大学, 大学病院, 講師 (90771379)

Project Period (FY) 2021-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords経済毒性 / 乳癌 / QOL
Outline of Research at the Start

本研究はWeb調査法を用いて、医療介入に対する乳癌患者の経済毒性をComprehensive Score for Financial Toxicity Toolを用いて定量的に評価する。さらに選好に基づく尺度であるEuroQOL 5 dimensions 5-level(EQ-5D-5L)を用いたQOL値の測定および、患者の乳癌の病状、社会的背景、受療行動、治療選択肢の意思決定の詳細も同時に調査する。これらを分析することで経済毒性のリスク因子を明らかにするとともに、経済毒性のGradeと患者の受療行動、治療選択への意思決定について影響を分析し、経済毒性が患者の生存に与える影響について解明する。

Outline of Final Research Achievements

A total of 1558 patients who had undergone breast cancer treatment in Japan were included in the study. The objective financial toxicity was defined as economic toxicity when medical expenses exceeded 20% of household income, and the subjective financial toxicity was defined as Grade 1-3 on the COST scale.
Objective financial toxicity was evaluated as presence of economic toxicity in 271 (17.4%) of 1558 patients. Subjective financial toxicity was evaluated as financial toxicity in 1020 (65.7%) of 1552 valid responses.
There was a large discrepancy between the prevalence of objective financial toxicity and subjective financial toxicity.

Academic Significance and Societal Importance of the Research Achievements

本研究から、経済毒性(Financial toxicity:FT)は客観的FTと主観的FTで有病率におおきな乖離があることが分かった。今回検討に用いた定義は、いずれも米国で一般的に用いられているものである。米国とは医療提供体制、公的医療保険を含む社会保障制度が異なるわが国においてFTを検討する際には、わが国の現状に合ったFTの定義を検討する必要性がある事が示唆された。

Report

(4 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (10 results)

All 2023 2022 2021

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Open Access: 4 results) Presentation (2 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Prospective analysis of patient‐reported outcomes and physician‐reported outcomes with gynecologic cancer chemotherapy2023

    • Author(s)
      Takenaga Tomo、Kuji Shiho、Tanabe Ken‐ichiro、Kanamori Ryo、Imai Haruka、Takeuchi Jun、Kondo Haruhiro、Ohara Tatsuru、Iwatani Tsuguo、Suzuki Nao
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 50 Issue: 1 Pages: 75-85

    • DOI

      10.1111/jog.15811

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Pathologic method for extracting good prognosis group in triple negative breast cancer after neoadjuvant chemotherapy.2022

    • Author(s)
      Eguchi Y, Nakai T, Kojima M, Wakabayashi M, Sakamoto N, Sakashita S, Miyazaki S, Taki T, Watanabe R, Watanuki R, Yamauchi C, Iwatani T, Mukohara T, Onishi T, Ishii G.
    • Journal Title

      Cancer Science

      Volume: 113(4) Issue: 4 Pages: 1507-1518

    • DOI

      10.1111/cas.15273

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Case of Brachial Lymph Node Recurrences after the Resection of Locally Advanced Breast Cancer2022

    • Author(s)
      Onishi Kayono、Watanuki Rurina、Yokoe Takamichi、Iwatani Tsuguo、Yamauchi Chisako、Onishi Tatsuya
    • Journal Title

      Case Reports in Oncology

      Volume: 15 Issue: 2 Pages: 738-744

    • DOI

      10.1159/000525295

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] The path for medical associations to sponsor trustworthy guidelines: is it feasible?2022

    • Author(s)
      Pagano Domenico、Home Philip、Irs Alar、Ledermann Jonathan、Curigliano Giuseppe、Iwatani Tsuguo、Mandrola John、Freemantle Nick
    • Journal Title

      Journal of the Royal Society of Medicine

      Volume: 115 Issue: 7 Pages: 252-256

    • DOI

      10.1177/01410768221095240

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prospective observational study estimating willingness-to-pay for breast cancer treatments through contingent valuation method in Japanese breast cancer patients (JCOG1709A).2021

    • Author(s)
      Iwatani T, Hara F, Shien T, Sasaki K, Katayama H, Fukuda H, Shiroiwa T, Iwata H
    • Journal Title

      Jpn J Clin Oncol

      Volume: 51 Issue: 3 Pages: 498-503

    • DOI

      10.1093/jjco/hyaa241

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validation of the predictive accuracy of health-state utility values based on the Lloyd model for metastatic or recurrent breast cancer in Japan2021

    • Author(s)
      Iwatani Tsuguo、Inoue Eisuke、Tsugawa Koichiro
    • Journal Title

      BMJ Open

      Volume: 11 Issue: 12 Pages: e046273-e046273

    • DOI

      10.1136/bmjopen-2020-046273

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in Health State Utility Values in Japanese Patients with End-Stage Breast Cancer2021

    • Author(s)
      Iwatani Tsuguo、Noto Shinichi、Tsugawa Koichiro
    • Journal Title

      Current Oncology

      Volume: 28 Issue: 5 Pages: 4203-4212

    • DOI

      10.3390/curroncol28050356

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 乳癌患者におけるQALY算出のためのQOL値の推移の検討2021

    • Author(s)
      岩谷胤生、井上永介、津川浩一郎
    • Organizer
      第29回日本乳癌学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Estimation of willingness-to-pay for breast cancer treatments through contingent valuation method in Japanese breast cancer patients (JCOG1709A) The main study findings.2021

    • Author(s)
      watani T, Hara F, Shien T, Takahashi M, Masuda N, Sagara Y, Sasaki K, Mizusawa J, Fukuda H, Shiroiwa T, Iwata H.
    • Organizer
      44th San Antonio Breast Cancer Symposium
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Book] 乳癌薬物療法の要点と盲点2023

    • Author(s)
      岩谷胤生
    • Total Pages
      292
    • Publisher
      文光社
    • Related Report
      2023 Annual Research Report

URL: 

Published: 2021-04-28   Modified: 2025-01-30  

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