Project/Area Number |
21K10364
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 58010:Medical management and medical sociology-related
|
Research Institution | Okayama University (2022-2023) National Cancer Center Japan (2021) |
Principal Investigator |
|
Project Period (FY) |
2021-04-01 – 2024-03-31
|
Project Status |
Completed (Fiscal Year 2023)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 経済毒性 / 乳癌 / QOL |
Outline of Research at the Start |
本研究はWeb調査法を用いて、医療介入に対する乳癌患者の経済毒性をComprehensive Score for Financial Toxicity Toolを用いて定量的に評価する。さらに選好に基づく尺度であるEuroQOL 5 dimensions 5-level(EQ-5D-5L)を用いたQOL値の測定および、患者の乳癌の病状、社会的背景、受療行動、治療選択肢の意思決定の詳細も同時に調査する。これらを分析することで経済毒性のリスク因子を明らかにするとともに、経済毒性のGradeと患者の受療行動、治療選択への意思決定について影響を分析し、経済毒性が患者の生存に与える影響について解明する。
|
Outline of Final Research Achievements |
A total of 1558 patients who had undergone breast cancer treatment in Japan were included in the study. The objective financial toxicity was defined as economic toxicity when medical expenses exceeded 20% of household income, and the subjective financial toxicity was defined as Grade 1-3 on the COST scale. Objective financial toxicity was evaluated as presence of economic toxicity in 271 (17.4%) of 1558 patients. Subjective financial toxicity was evaluated as financial toxicity in 1020 (65.7%) of 1552 valid responses. There was a large discrepancy between the prevalence of objective financial toxicity and subjective financial toxicity.
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Academic Significance and Societal Importance of the Research Achievements |
本研究から、経済毒性(Financial toxicity:FT)は客観的FTと主観的FTで有病率におおきな乖離があることが分かった。今回検討に用いた定義は、いずれも米国で一般的に用いられているものである。米国とは医療提供体制、公的医療保険を含む社会保障制度が異なるわが国においてFTを検討する際には、わが国の現状に合ったFTの定義を検討する必要性がある事が示唆された。
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