| Project/Area Number |
21K10397
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 58020:Hygiene and public health-related: including laboratory approach
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| Research Institution | Yamaguchi University |
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Principal Investigator |
Hossain Mahbub 山口大学, 大学院医学系研究科, 講師 (80535336)
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| Co-Investigator(Kenkyū-buntansha) |
長谷 亮佑 山口大学, 大学院医学系研究科, 講師 (30711262)
田邉 剛 山口大学, 大学院医学系研究科, 教授 (80260678)
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| Project Period (FY) |
2021-04-01 – 2024-03-31
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| Project Status |
Granted (Fiscal Year 2022)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2023: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | Exercise / Diet / Brain training / Plasma free amino acids / Gut microbiota / gut microbiota |
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| Outline of Research at the Start |
We aim to investigate the hitherto unknown changes in physical and cognitive functions in the elderly from exposure to exercise, diet and brain training-based cocktail intervention, and also the concomitant alterations in plasma free amino acids and gut microbiota. The findings should help to establish a novel non-pharmalogical intervention aimed at preventing or improving aging-associated physical frailty and cognitive impairments, and might be crucial for countries like Japan with a super-aging society.
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| Outline of Annual Research Achievements |
We have completed data collection at baseline, and at 6th and 12th months of intervention in three groups of elderly (aged between 75 to 83 years) volunteers: 1) Exercise Intervention Group (40 people); 2) Yogurt Ingestion Group (20 people); and 3) Control Group (40 people). Also, we have completed the statistical analysis of relevant data on demographic and clinical variables collected at baseline and after 6th months of intervention.
Now we are performing the analysis of the relevant data on cognitive function and balance tests. Furthermore, the quantitative measurements of plasma free amino acid concentrations (PFAA) in blood samples collected at baseline and after 6th month of intervention, and baseline gut microbiota have been completed.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
Three groups included in this study have completed their 18 months of intervention (a combination of strength, balance, and endurance training, cognitive function training; or ingestion of 100 g of yogurt containing arginine in combination with bifidobacterial LKM512; or maintenance of usual lifestyle including dietary and exercise habits). Now we are involved in collection of the final data. We are continuing the statistical analysis of the data on clinical variables, and also on cognitive function and balance tests. Furthermore, we are conducting the statistical analysis of data on PFAA profiles collected at baseline and after 6th months of intervention. Simultaneously, the work on quantitative measurements of PFAA concentrations in stored blood samples, collected at later time-points of intervention is going on.
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| Strategy for Future Research Activity |
In line with the hypotheses of the current study, the collected data are going to be analyzed for possible changes in different variables from baseline to 6th, 12th, and 18th months of intervention as applicable; and the data will be statistically compared within and between the group/s. We are going to prepare the first manuscript on the preliminary findings of this study for publication in a peer-reviewed journal. Also, the findings will be presented at domestic and international conferences. The final report will be prepared including what is being achieved during the research project and what should be done in future in light of our findings.
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