Study on nutrition intake and its association with obesity, glucose metabolism, and puberty in Japanese students.

• Project/Area Number: 21K10466
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Gifu University
• Principal Investigator: Wada Keiko 岐阜大学, 大学院医学系研究科, 准教授 (00532673)
• Project Period (FY): 2021-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2023: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2021: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 学校保健 / 栄養 / 肥満 / 耐糖能 / 二次性徴 / 栄養摂取 / 小児 / 糖代謝 / 思春期

Outline of Research at the Start

本研究では、6歳から15歳（小学1年から中学3年）までの小児期コホート研究を実施する（ベースライン調査参加者3,141名）。児童、生徒を対象に、縦断的に生活習慣調査、空腹時採血、採尿を行い、小児期の栄養摂取量（各栄養素、食品群の他、糖質組成、アミノ酸組成、脂肪酸組成、イソフラボンの栄養成分摂取など）と食行動（食べる速さ、食事の摂取時刻、孤食と欠食の状況など）が、その後の体格変化や二次性徴、肥満、耐糖能にどのような影響を与えるかを解明する。

Outline of Final Research Achievements

A prospective study of lifestyle and health was conducted in children aged 6 to 15 years. During the study period 2021-2023, about 1800 children in each of grades 4, 7, and 9 participated in the surveys, including a lifestyle questionnaire and medical check-ups. The intakes of nutrients, food groups, isoflavones, carbohydrate composition, glycemic index, and glycemic load were estimated from food frequency questionnaires. The associations between diet and other lifestyle factors and height, weight, waist circumference, blood pressure, glucose tolerance, lipid metabolism, and pubertal status were examined. In addition, the impact of school closures due to the COVID-19 pandemic on children's lifestyle and health was investigated.

Academic Significance and Societal Importance of the Research Achievements

小学1年生から中学3年生までを縦断的に追跡し、生活習慣や身体指標を評価した研究は少ない。特に、小児期の様々な栄養摂取量を推定し健康状態との関連を評価することで、小児期の食事の摂取がどうあるべきかを示唆し、食育につなげることができる。また、2020年のコロナ禍における学校一斉休校が子ども達の生活習慣や健康に与えた影響を調べることは、将来の健康危機における学校のあり方に示唆を与える。

Research Products

• [Journal Article] Dietary melatonin and liver cancer incidence in Japan: From the Takayama study. (2024)
  • Author(s): Wada K, Hattori A, Maruyama Y, Mori T, Sugino M, Nakashima Y, Yamakawa M, Yamamoto M, Hori A, Seishima M, Tanabashi S, Matsushita S, Nagata C.
  • Journal Title: Cancer Science Volume: － Issue: 5 Pages: 1688-1694
  • DOI: 10.1111/cas.16103
  • Peer Reviewed / Open Access
• [Journal Article] Association of dietary fibre intake with subsequent fasting glucose levels and indicators of adiposity in school-age Japanese children (2023)
  • Author(s): Wada Keiko、Nagata Chisato、Yamakawa Michiyo、Nakashima Yuma、Koda Sachi、Uji Takahiro、Tsuji Michiko、Nagai Hideshi、Itakura Naoko、Harada Kou、Takahara Osamu、Yamanaka Hiromichi
  • Journal Title: Public Health Nutrition Volume: 26 Issue: 8 Pages: 1617-1625
  • DOI: 10.1017/s136898002300099x
  • Peer Reviewed / Open Access
• [Journal Article] Rice-Based Diet and Cardiovascular Disease Mortality in Japan: From the Takayama Study. (2022)
  • Author(s): Wada K, Oba S, Nagata C.
  • Journal Title: Nutrients Volume: 14(11) Issue: 11 Pages: 2291-2291
  • DOI: 10.3390/nu14112291
  • Peer Reviewed / Open Access
• [Journal Article] Dietary advanced glycation end products and cancer risk in Japan: From the Takayama study. (2022)
  • Author(s): Wada K, Nakashima Y, Yamakawa M, Hori A, Seishima M, Tanabashi S, Matsushita S, Tokimitsu N, Nagata C.
  • Journal Title: Cancer Sci. 2022 Aug;113(8):2839-2848. doi: 10.1111/cas.15455. Volume: 113(8) Issue: 8 Pages: 2839-2848
  • DOI: 10.1111/cas.15455
  • Peer Reviewed / Open Access
• [Presentation] BMI and breast cancer (2023)
  • Author(s): Keiko Wada
  • Organizer: Asia Cohort Consortium General Membership Meeting in Nagoya
  • Int'l Joint Research
• [Presentation] 小学4年生の麻疹・風疹抗体の保有状況 (2023)
  • Author(s): 森知花、和田恵子、杉野正晃、山川路代、永田知里
  • Organizer: 第34回日本疫学会学術総会
• [Presentation] COVID-19流行前後での小学4年生の健診所見と栄養摂取量の比較 (2023)
  • Author(s): 杉野正晃、和田恵子、山川路代、森知花、永田知里
  • Organizer: 第34回日本疫学会学術総会
• [Presentation] Dietary melatonin intake and the risk of liver cancer: the Takayama study (2022)
  • Author(s): 和田恵子, 永田知里
  • Organizer: 第81回日本癌学会学術総会
• [Presentation] Living environment factors and subsequent cancer risk in children (2022)
  • Author(s): 和田恵子, 永田知里
  • Organizer: 第81回日本癌学会学術総会
  • Invited
• [Presentation] Equol産生に関わる腸内細菌叢の検討 (2022)
  • Author(s): 和田恵子, 須田亙, 上野友美, 増岡弘晃, 山川路代, 中島佑麻, 杉野正晃, 内山成人, 服部正平, 永田知里
  • Organizer: 第33回日本疫学会学術総会
• [Presentation] 学童期の食物繊維摂取と3年後の空腹時血糖、体重変化の関連 (2022)
  • Author(s): 和田恵子, 山川路代, 中島佑麻, 小多沙知, 宇治敬浩, 大沼紗希子, 辻美智子, 永田知里
  • Organizer: 第32回日本疫学会学術総会
• [Presentation] Dietary intake of advanced glycation end products and the risk of stomach cancer: the Takayama study (2021)
  • Author(s): 和田恵子、永田知里
  • Organizer: 第80回日本癌学会学術総会