• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigation of Stability Requirements for Deep Learning-Based Image Processing of Sparse Medical Imaging in Radiation Therapy

Research Project

Project/Area Number 21K12121
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 62010:Life, health and medical informatics-related
Research InstitutionThe University of Tokyo

Principal Investigator

Imae Toshikazu  東京大学, 医学部附属病院, 副診療放射線技師長 (80420222)

Co-Investigator(Kenkyū-buntansha) 名和 要武  東京大学, 医学部附属病院, 助教 (00456914)
鍛冶 静雄  九州大学, マス・フォア・インダストリ研究所, 教授 (00509656)
竹中 重治  東京大学, 医学部附属病院, 診療放射線技師 (10623564)
仲本 宗泰  北海道大学, 保健科学研究院, 助教 (10808877)
尾崎 翔  東京大学, 理学(系)研究科(研究院), 研究員 (60615326)
山下 英臣  東京大学, 医学部附属病院, 准教授 (70447407)
Project Period (FY) 2021-04-01 – 2025-03-31
Project Status Completed (Fiscal Year 2024)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords放射線治療 / 疎な / 医用画像情報 / 深層画像 / 安定要件
Outline of Research at the Start

本研究では,放射線治療で得られる疎な医用画像情報に着目し,安全かつ有効に利用可能な深層画像処理の要件を勘案した上で,深層画像処理の安定化を図ることを目的とする.研究期間内には,①深層画像処理法の構築,②深層画像処理法の安定化に必要な要件の探索,③探索結果の評価を実施することによって,疎な医用画像情報に対する深層学習処理の課題や臨床利用の可能性を明確にする.

Outline of Final Research Achievements

This study aimed to stabilize and evaluate deep learning-based image processing techniques for the safe and effective application to sparse medical images in radiation therapy. We performed data acquisition, enhanced image quality for MVCT, proposed a deep learning-based iterative reconstruction method for CT, conducted organ segmentation and prognosis prediction, and extracted dose-related features associated with recurrence. These results demonstrate the clinical applicability and utility of deep image processing methods.

Academic Significance and Societal Importance of the Research Achievements

本研究では,放射線治療で得られる疎な医用画像情報に対し,安全かつ有効に利用可能な深層画像処理の要件を勘案した上で,深層画像処理の安定化を図ることを念頭に置いたデータ解析法や画質改善法,また,適切な学習データ数に関する提案を行った.医用画像に対する深層学習の適用範囲は広く,本研究の成果は,放射線治療で得られる医用画像に対する深層学習の適用方法を示したことであり,研究の実施によって得られた知見は学会発表や論文投稿を通して公表した.

Report

(5 results)
  • 2024 Annual Research Report   Final Research Report ( PDF )
  • 2023 Research-status Report
  • 2022 Research-status Report
  • 2021 Research-status Report
  • Research Products

    (20 results)

All 2025 2024 2023 2022 2021 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (14 results) (of which Int'l Joint Research: 6 results,  Invited: 4 results) Remarks (2 results)

  • [Journal Article] Dosiomic predictors of biochemical failure in patients with localized prostate cancer treated with Iodine-125 low-dose-rate brachytherapy2025

    • Author(s)
      Nakano Masahiro、Kaji Shizuo、Kawakami Shogo、Tsumura Hideyasu、Imae Toshikazu、Tanaka Yuichi、Fujii Kyohei、Kainuma Takuro、Yamazaki Ryosuke、Uchida Ayaka、Kaneko Hijiri、Fujino Mako、Hata Chizu、Murakami Yu、Hashimoto Masatoshi、Ishiyama Hiromichi
    • Journal Title

      Radiation Oncology

      Volume: 20 Issue: 1 Pages: 56-56

    • DOI

      10.1186/s13014-025-02619-6

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neurological prognosis prediction for cardiac arrest patients using quantitative imaging biomarkers from brain computed tomography2024

    • Author(s)
      Nakamoto Takahiro、Nawa Kanabu、Nishiyama Kei、Yoshida Kosuke、Saito Daizo、Horiguchi Masahito、Shinya Yuki、Ohta Takeshi、Ozaki Sho、Nozawa Yuki、Minamitani Masanari、Imae Toshikazu、Abe Osamu、Yamashita Hideomi、Nakagawa Keiichi
    • Journal Title

      Physica Medica

      Volume: 125 Pages: 103425-103425

    • DOI

      10.1016/j.ejmp.2024.103425

    • Related Report
      2024 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cone-beam computed-tomography-based delta-radiomic analysis for investigating prognostic power for esophageal squamous cell cancer patients undergoing concurrent chemoradiotherapy2024

    • Author(s)
      Nakamoto Takahiro、Yamashita Hideomi、Jinnouchi Haruka、Nawa Kanabu、Imae Toshikazu、Takenaka Shigeharu、Aoki Atsushi、Ohta Takeshi、Ozaki Sho、Nozawa Yuki、Nakagawa Keiichi
    • Journal Title

      Physica Medica

      Volume: 117 Pages: 103182-103182

    • DOI

      10.1016/j.ejmp.2023.103182

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Training of deep cross‐modality conversion models with a small dataset, and their application in megavoltage CT to kilovoltage CT conversion2022

    • Author(s)
      Ozaki S, Kaji S, Nawa K, Imae T, Aoki A, Nakamoto T, Ohta T, Nozawa Y, Yamashita H, Haga A, Nakagawa K
    • Journal Title

      Medical Physics

      Volume: - Issue: 6 Pages: 1-14

    • DOI

      10.1002/mp.15626

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] パーシステントホモロジーを用いた医用画像解析2024

    • Author(s)
      鍛冶静雄
    • Organizer
      データサイエンスと生命医科学研究のフロンティア
    • Related Report
      2024 Annual Research Report
    • Invited
  • [Presentation] Iterative CT reconstruction with diffusion model2024

    • Author(s)
      S. Ozaki, S. Kaji, K. Nawa, T. Imae, and K. Nakagawa
    • Organizer
      The 3rd International Conference on Radiological Physics and Technology (ICRPT)
    • Related Report
      2024 Annual Research Report
    • Int'l Joint Research
  • [Presentation] デノイジング拡散確率モデルを用いたCT画像再構成の研究2024

    • Author(s)
      尾崎翔、鍛冶静雄、名和要武、今江禄一、中川恵一
    • Organizer
      第43回医用画像工学会大会
    • Related Report
      2024 Annual Research Report
  • [Presentation] 救急医療における頭部CT画像のRadiomics解析2023

    • Author(s)
      名和 要武
    • Organizer
      第4回『医学と数理』研究会
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] 深層ニューラルネットワーク及び拡散モデルを用いた逆問題解析手法の開発とそのCT画像再構成への応用2023

    • Author(s)
      尾崎 翔
    • Organizer
      第4回『医学と数理』研究会
    • Related Report
      2023 Research-status Report
    • Invited
  • [Presentation] Iterative CT reconstruction with deep neural networks2023

    • Author(s)
      S. Ozaki, S. Kaji, K. Nawa, T. Imae, and K. Nakagawa
    • Organizer
      The 2nd International Conference on Radiological Physics and Technology (ICRPT)
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] Iterative reconstruction of MVCT with deep neural networks2023

    • Author(s)
      S. Ozaki, S. Kaji, K. Nawa, T. Imae, and K. Nakagawa
    • Organizer
      The European Society for Radiotherapy and Oncology (ESTRO) 2023
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] 強度変調放射線回転照射法を適用した全身照射における位置誤差に関する検討2023

    • Author(s)
      今江禄一,三枝茂輝,中田健太,境紀行,野沢勇樹,山下英臣,岩永秀幸,阿部修.
    • Organizer
      第51回日本放射線技術学会秋季学術大会
    • Related Report
      2023 Research-status Report
  • [Presentation] Computed tomography-based radiomics for classifying neurological prognosis of cardiac arrest patients2023

    • Author(s)
      T. Nakamoto, K. Nawa, K. Nishiyama, K, Yoshida, D. Saito, M. Horiguchi, Y. Shinya, K. Nakagawa
    • Organizer
      The 2nd International Conference on Radiological Physics and Technology (ICRPT)
    • Related Report
      2023 Research-status Report
    • Int'l Joint Research
  • [Presentation] 深層学習によるCT画像変換2022

    • Author(s)
      鍛冶静雄
    • Organizer
      第3回 京大―ハイデルベルク大―理研 ワークショップ 「医学と数理」
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] Image quality enhancement of medical images by use of deep learning with a small amount of training data2022

    • Author(s)
      Ozaki S, Kaji S, Nawa K, Imae T, Aoki A, Nakamoto T, Ohta T, Nozawa Y, Haga A, Nakagawa K.
    • Organizer
      Interdisciplinary Science Conference in Okinawa (ISCO 2023) -Physics and Mathematics meet Medical Science-
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Denoising and Contrast Enhancement of MVCT Using Deep Learning-based Methods2021

    • Author(s)
      Ozaki S, Kaji S, Nawa K, Imae T, Aoki A, Nakamoto T, Ohta T, Nozawa Y, Haga A, Nakagawa K
    • Organizer
      第121回日本医学物理学会学術大会, 神奈川, 2021.4.15-18
    • Related Report
      2021 Research-status Report
  • [Presentation] Training modality conversion models with small data and its application to MVCT to kVCT conversion2021

    • Author(s)
      Ozaki S, Kaji S, Nawa K, Imae T, Aoki A, Nakamoto T, Ohta T, Nozawa Y, Haga A, Nakagawa K
    • Organizer
      ESTRO 2021 Annual Meeting
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 深層学習を用いて画質改善した位置合わせ用CBCT上における線量分布の再構築2021

    • Author(s)
      今江禄一,青木淳,竹中重治,松田佳奈子,三枝茂輝,鍛冶静雄,岩永秀幸,阿部修
    • Organizer
      第49回日本放射線技術学会秋季学術大会
    • Related Report
      2021 Research-status Report
  • [Remarks] researchmap: 今江禄一

    • URL

      https://researchmap.jp/m035402

    • Related Report
      2024 Annual Research Report 2023 Research-status Report 2022 Research-status Report 2021 Research-status Report
  • [Remarks] 東京大学医学部附属病院 放射線科 放射線治療部門 > 研究・業績

    • URL

      http://u-tokyo-rad.jp/works/index.html

    • Related Report
      2021 Research-status Report

URL: 

Published: 2021-04-28   Modified: 2026-01-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi